ライフサイエンスコーパス: natural killer cell

1 precursor) and lineage (B cell, T cell, and natural killer cell).

2 cells, helper T cells, effector B cells, and natural killer cells).

3 f cytotoxic lymphocytes (mostly T CD8(+) and natural killer cells).

4 he function and the activation status of the natural killer cell.

5 f total lymphocytes because of a decrease in natural killer cells.

6 presumably by regulatory T cells but also by natural killer cells.

7 ereby sensitizing melanoma cells to lysis by natural killer cells.

8 terations in CD4+ T cells, CD8+ T cells, and natural killer cells.

9 P) that is produced by cytotoxic T cells and natural killer cells.

10 also found to be less sensitive to purified natural killer cells.

11 ot required for the development of classical natural killer cells.

12 of local dendritic cells, and activation of natural killer cells.

13 us antiviral immune responses of T cells and natural killer cells.

14 cial role in the development and activity of natural killer cells.

15 olic granules of cytotoxic T lymphocytes and natural killer cells.

16 o lysis by both antigen-specific T cells and natural killer cells.

17 not dividing, fibroblasts to cytotoxicity by natural killer cells.

18 es that bound H1 hemagglutinin and activated natural killer cells.

19 cognition by antibody-dependent clearance by natural killer cells.

20 ll-free virus, and develop susceptibility to natural killer cells.

21 lls, notably monocytes, dendritic cells, and natural killer cells.

22 tein for monocytes/macrophages, T cells, and natural killer cells.

23 which in turn enhances tumor elimination by natural killer cells.

24 e receptor expressed on the surface of mouse natural killer cells.

25 jor forms of lymphomas arising from B, T, or natural killer cells.

26 hoblast defects, and a deficiency of uterine natural killer cells.

27 by clonal expansion of cytotoxic T cells or natural killer cells.

28 r the NKp30-activating receptor expressed on natural killer cells.

29 efficacy is dependent upon T cells, but not natural killer cells.

30 onse, which also involves CD8(+) T cells and natural killer cells.

31 lymphoproliferative disease of mature T and natural killer cells.

32 inflammatory signaling initiated by CD160 in natural killer cells.

33 ate immune cell functions of macrophages and natural killer cells.

34 ly expanded without affecting CD4+, CD8+, or natural killer cells.

35 peptide inhibits HLA-E-mediated cytolysis by natural killer cells.

36 capes of lymphomas that arise from B, T, and natural killer cells.

37 ntributions from CD5- splenocytes, including natural killer cells.

38 t alone was not able to stimulate T cells or natural killer cells.

39 he presence of T cells, dendritic cells, and natural killer cells.

40 umor-reactive cytotoxic T lymphocytes and/or natural killer cells.

41 sistance to the shear stress and attack from natural killer cells.

42 bers of monocytes, B cells, CD4 T cells, and natural killer cells.

43 ure T and B cells and jak3 in T and putative Natural Killer cells.

44 Splenic natural killer cells activated upon Pseudomonas aerugino

45 and T lymphocyte attenuator (BTLA); and the natural killer cell-activating receptor CD160.

46 activation, IFNgamma response, CD16-mediated natural killer cell activation, and monocyte/macrophage

47 ytokine and chemokine levels, lymphocyte and natural killer cell activation, and viral antigen expres

48 lly, A5.1 ECs enhanced NKG2D interaction and natural killer cell activation, promoting NKG2D-dependen

49 Natural killer cell activities were clustered in clinica

50 ole of IL-12 and IL-15 in the enhancement of natural killer cell activity was reported.

51 munological defense, including inhibition of natural killer cell activity with ongoing lowering of Ig

52 nosuppression was an opportunity to discover natural killer cell alloreactions that eradicated acute

53 KIR/HLA-I interactions allow predicting natural killer cell alloreactivity in hematopoietic stem

54 expression profiles of a receptor protein in natural killer cells among donors infected with human cy

55 set involving phagosome formation as well as natural killer cell and IL-3 signaling.

56 ction, which results in increased peripheral natural killer cell and macrophage activities, elevated

57 their fusion machinery, leading to impaired natural killer cell and/or T lymphocyte degranulation an

58 y and adhesion molecule, expressed mainly by natural killer cells and CD8(+) T cells at steady state

59 Type I and II IFNs, as well as natural killer cells and CD8(+) T cells, were indispensi

60 Levels of serum IgM and IgA and circulating natural killer cells and class-switched memory B cells w

61 etic defects leading to impaired function of natural killer cells and cytotoxic T cells.

62 Natural killer cells and cytotoxic T-lymphocytes deploy

63 45 does reduce the viability of normal T and natural killer cells and decrease activated T-cell produ

64 T correlated with an increased proportion of natural killer cells and effector memory CD4(+) and CD8(

65 -cell subset frequencies, but an increase in natural killer cells and eosinophils occurred with IL-2

66 y clonal expansion of CD3+ T cells or CD3(-) natural killer cells and frequently is associated with a

67 tous response involving monocytes as well as natural killer cells and gammadelta T cells.

68 ILCs consist of conventional natural killer cells and helper-like cells (ILC1, ILC2 a

69 eatment reduced this suppressive function of natural killer cells and increased survival of mice with

70 so in mice, mimics the cytotoxic activity of natural killer cells and increases the surface area avai

71 unodeficiency characterized by lack of T and natural killer cells and infant death from infection.

72 Natural killer cells and injured grafts may play a recip

73 producers of IL-22 post-PH are conventional natural killer cells and innate lymphoid cells type 1.

74 After INT-747 treatment, natural killer cells and interferon-gamma expression mar

75 inflammatory cytokine that stimulates T and natural killer cells and is critical for their survival

76 in MDA5(-/-) mice, but perforin induction by natural killer cells and levels of interferon gamma, int

77 OX in regulating development of CD4 T cells, natural killer cells and lymphoid tissue inducer cells,

78 s of innate lymphoid cells with conventional natural killer cells and lymphoid tissue inducer cells.

79 otentially by suppressing IFNgamma-producing natural killer cells and M1-polarized macrophages.

80 r cells, and binding to Fcgamma receptors on natural killer cells and macrophages.

81 by complement deposition and accumulation of natural killer cells and monocytes/macrophages in capill

82 -bearing mice, and increased the activity of natural killer cells and of intratumoral-activated CD8(+

83 ng hepatic macrophages, T and B lymphocytes, natural killer cells and platelets, as well as key effec

84 eased IL-17 production by CD4(+) T cells and natural killer cells and recruited regulatory cells and

85 -I (HLA-I) ligands and regulate functions of natural killer cells and subsets of T cells.

86 The NKG2D stimulatory receptor expressed by natural killer cells and T cell subsets recognizes cell

87 -H3 (CD276) is both an inhibitory ligand for natural killer cells and T cells and a tumor antigen tha

88 Subsets of natural killer cells and T cells selectively induced nuc

89 cytes, impairing activation and functions of natural killer cells and T cells.

90 0-dependent elimination of dendritic cell by natural killer cells and that hydrocortisone improves ou

91 development of innate lymphocytes, including natural killer cells and the recently identified innate

92 of several immune cell populations, such as natural killer cells and virus-specific T cells.

93 g FcgammaRIIIa (expressed on macrophages and natural killer cells) and FcgammaRIIIb (expressed on neu

94 increased expression of IFNgamma-inducible, natural killer cell, and T cell transcripts, but less ex

95 , treatment-induced expansion of T cells and natural killer cells, and activation of interferon-gamma

96 n of several immune cells including T cells, natural killer cells, and antigen-presenting cells.

97 on most immune cells, including neutrophils, natural killer cells, and B cells.

98 ve transfer of ex-vivo-activated T cells and natural killer cells, and cancer vaccines.

99 e activation of dendritic cells, mast cells, natural killer cells, and CD8 T cells to mount an antitu

100 Teffs, natural killer cells, and eosinophils also responded, wi

101 challenge, including monocytes, neutrophils, natural killer cells, and eosinophils.

102 genes with correlated expression in T cells, natural killer cells, and erythroblasts.

103 ype CD4 T cells, reduced T-bet expression by natural killer cells, and expansion of blood monocytes w

104 ed B cells to FcgammaR-expressing monocytes, natural killer cells, and granulocytes via trogocytosis.

105 ures tracking CD8 and CD4 T-cell activation, natural killer cells, and IFN activation associated sign

106 ted, altered in tropism, more susceptible to natural killer cells, and less pathogenic.

107 ting IFNgamma and Granzyme B CD4 T cells and natural killer cells, and lower number of FoxP3 regulato

108 , and activated interferon-stimulated genes, natural killer cells, and lymphocyte subsets.

109 e examine the roles of alveolar macrophages, natural killer cells, and neutrophils in antibody-mediat

110 The proliferation and production of B cells, natural killer cells, and plasmacytoid dendritic cells w

111 00R on macrophages, myeloid dendritic cells, natural killer cells, and T cells in SCC vs normal skin.

112 terized by increased numbers of macrophages, natural killer cells, and total T cells, but reduced fre

113 Natural killer cells are a primary mediator of this proc

114 Natural killer cells are a type of cytotoxic lymphocyte

115 Natural killer cells are able to directly lyse tumor cel

116 Natural killer cells are able to recognize and kill targ

117 Natural killer cells are innate lymphocytes that play vi

118 The immune responses of natural killer cells are regulated, in part, by killer c

119 T, B, and natural killer cells are required for normal immune resp

120 Neutrophils and natural killer cells are the likely targets of these pat

121 globulin-like receptors (KIRs) that regulate natural-killer cells are highly polymorphic.

122 were ineffective in ADCC assays with murine natural killer cells as effectors, whereas ADCP was equi

123 and discusses recent findings that identify natural killer cells as regulators of T cell function an

124 suppress the activation and cytotoxicity of natural killer cells as well as the activation, signalin

125 Natural killer cells assess target cell health via inter

126 innate immune cells (antitumor macrophages, natural killer cells) associated with clearance of senes

127 ile, it still revealed diversity in a set of natural killer cell-associated receptors.

128 itutive and alternate macrophage, B-cell and natural killer cell-associated transcripts (NKAT), indic

129 as immune checkpoint receptors in T cell and natural killer cell biology are just beginning to be unc

130 marily within antigen-experienced T cells or natural killer cells but less so in naive T or B cells.

131 s a distinct lineage from Th and circulating natural killer cells but shares circuitry devoted to fun

132 terestingly, tumor rejection did not involve natural killer cells but was associated instead with a m

133 The reduction of the interleukin-10 level in natural killer cells by hydrocortisone was partially dep

134 The human natural killer cell carbohydrate, HNK-1, plays function-

135 infiltrating Kupffer cells, mature activated natural killer cells (CD69+), and PD-1+ effector memory

136 ) IFN-gamma-producing group 1 ILCs (ILC1 and natural killer cells), CD8(+) cytotoxic T cells (TC1), a

137 Chronic lymphoproliferative disorders of natural killer cells (CLPD-NKs) and T-cell large granula

138 involved in the regulation of dendritic cell/natural killer cell cluster.

139 pinal fluid (including B cells, T cells, and natural killer cells) (cohort 1).

140 vealed only subtle changes in the T-cell and natural killer cell compartment, whereas B-cell differen

141 or the observed therapeutic effects and that natural killer cells constitute a critical human effecto

142 Natural killer cells constitute potent innate lymphoid c

143 Natural killer cells controlled early infection but were

144 Compared with pretreatment levels, Treg and natural killer cell counts rose >fivefold (P < .001) and

145 hydrocortisone modulates the dendritic cell/natural killer cell cross talk in the context of posttra

146 effects of hydrocortisone on dendritic cell/natural killer cell cross talk were studied in a mouse m

147 IL-2 additionally promotes CD8(+) T cell and natural killer cell cytolytic activity and modulates T c

148 cancer cell growth, including stimulation of natural killer cell cytotoxic activity and repression of

149 elongation (RTEL1) mutation causing isolated natural killer cell deficiency and mutations in ras-asso

150 s corresponding and co-orchestrating B-cell, natural killer cell, dendritic cell, and innate lymphoid

151 Specific natural killer cell depletion 24 hours pre-acute myocard

152 Natural killer cell depletion or codepletion of CD4(+) a

153 In contrast, decidual natural killer cell-derived IFN-gamma reverses such TNF-

154 Natural killer cell development and maturation were arre

155 ndent cell-mediated cytotoxicity produced by natural killer cells did not depend on AQP4 OAP assembly

156 Ultimately, mice depleted of natural killer cells displayed an increased neutrophil n

157 The interaction of noncytotoxic decidual natural killer cells (dNK) and extravillous trophoblasts

158 DS1 (KIR2DS1) expressed by maternal decidual natural killer cells (dNK) and the presence of its ligan

159 s of HLA-G+ EVT with sample matched decidual natural killer cells (dNK), macrophages, and CD4+ and CD

160 d KLRG1 molecules) were increased in splenic natural killer cells during Pseudomonas aeruginosa infec

161 iated by interferon activated cells, such as natural killer cells, during the innate immune response.

162 uced T cell effector functions, and variable natural killer cell dysfunctions.

163 16) report new mechanisms of human and mouse natural killer cell education by inhibitory and activati

164 Natural killer cells express a diverse range of polymorp

165 Natural killer cells express multiple receptors for majo

166 Cytotoxic T lymphocytes and natural killer cells expressing granulysin predominantly

167 Natural killer cells from acute myeloid leukaemia patien

168 In vitro, only natural killer cells from KIR3DS1(+)/HLA-Bw4-80Ile(+) he

169 ssed innate immune function, particularly of natural killer cells, from patients with unfavorable gen

170 Natural killer cell function is regulated by inhibitory

171 Among the 4 genes related to natural killer cell function, 2 (IL12A and CSF2) were co

172 veals that RAG endonuclease activity affects natural killer cell function, demonstrating that such do

173 glycoproteins, many of which interfere with natural killer cell function.

174 oantibody production in humans, and disrupts natural killer cell function.

175 from those alleles bind to HLA-E and mediate natural killer cell function.

176 tional T lymphocytes and T-regulatory cells, natural killer cells, gamma delta T cells, and other acc

177 ow that a network of diverse lymphoid cells (natural killer cells, gammadelta T cells, natural killer

178 FU treatment induced TSLP, HLA class II, and natural killer cell group 2D (NKG2D) ligand expression i

179 Immunologically, natural killer cells had an immature phenotype and impai

180 sfer of tumor-specific cytotoxic T cells and natural killer cells, have been clinically translated fo

181 of interferon-gamma (IFN-gamma) by activated natural killer cells, IL-34-Mphi and M-CSF-Mphi prevent

182 d novel associations between variants in the natural killer cell immune pathway and prematurity in th

183 ulate CD8 T cell, natural killer T cell, and natural killer cell immunity.

184 The engagement of natural killer cell immunoglobulin-like receptors (KIRs)

185 Malignant cells express ligands for the natural killer cell immunoreceptor NKG2D, which sensitiz

186 We assessed the role of systemic natural killer cells in a Pseudomonas aeruginosa mouse p

187 CAR-engineered HSCs may produce myeloid and natural killer cells in addition to T cells expressing t

188 increased activity of cytotoxic T cells and natural killer cells in BKVN and viremia samples resembl

189 The percentage of natural killer cells in granulomas was significantly dec

190 ferential effects on B and T lymphocytes and natural killer cells in humans.

191 review, we discuss evidence for the role of natural killer cells in multiple sclerosis and experimen

192 to provide some understanding of the role of natural killer cells in regulating inflammation in the c

193 AT4 mediates IFNgamma release in T cells and natural killer cells in response to interleukin 12 (IL12

194 MSCs significantly decreased natural killer cells in the heart and spleen and neutrop

195 as designed to evaluate the possible role of natural killer cells in the reactivation of cytomegalovi

196 Although the role of T cells and natural killer cells in tumor immunology has been establ

197 ased programmed death ligand 1 expression on natural killer cells (increased from 11.9% to 61.6%, P =

198 emorrhage-induced immunosuppression, splenic natural killer cells induced an interleukin-10-dependent

199 exDC-treated recipients showed a predominant natural killer cell infiltration and a presence of antib

200 ge in the balance of signals received by the natural killer cell influences its involvement in the en

201 Innate lymphocytes (gammadelta T cells, natural killer cells, innate lymphoid cells) are the maj

202 the utility of this microfluidic assay with natural killer cells interacting with tumor cells, and o

203 g., neutrophils, monocytes, macrophages, and natural killer cells) is followed by an adaptive immune

204 cted a study to ascertain the association of natural killer cell killer immunoglobulin-like receptors

205 The function of natural killer cells, lymphocyte phenotype, and serum im

206 s of immune cells including the conventional natural killer cells, lymphoid tissue inducers, type 1,

207 receptor 9 (TLR9), induces the activation of natural killer cells, macrophages, and antigen presentin

208 Here, I discuss how key immune cell types (natural killer cells, macrophages, dendritic cells, and

209 ting adenosine signaling is found to promote natural killer cell maturation and antitumor immunity an

210 nal data also indicate a function for HLA in natural killer cell-mediated innate immunity against HIV

211 -EMR1 IgG1 was evaluated in vitro by using a natural killer cell-mediated killing assay and in vivo i

212 type at diagnosis suggests CD8 T-cell and/or natural killer cell-mediated killing modulates humoral a

213 osylated anti-EMR1 mAb dramatically enhanced natural killer cell-mediated killing of eosinophils from

214 rate that mitophagy plays a critical role in natural killer cell memory formation following viral inf

215 ular mechanisms important to generate innate natural killer cell "memory" are poorly understood.

216 Other leukocyte populations, including natural killer cells, monocytes, and dendritic cells, sh

217 recruiting cytotoxic effector cells, such as natural killer cells, monocytes, and polymorphonuclear c

218 ter molecule Stimulator of Interferon Genes, natural killer cells, myeloid cells, and B cells.

219 ations of T cells, B cells, dendritic cells, natural killer cells, myeloid-derived suppressor cells,

220 her organs, including innate lymphoid cells, natural killer cells, natural killer T cells, mucosal-as

221 atory hepatic macrophage infiltration, while natural killer cells, natural killer T cells, neutrophil

222 ther activating or inhibitory effects during natural killer cell (NK cell) activation.

223 Natural killer cell (NK cell)-based immunotherapy of can

224 -2 abolish cytotoxic T lymphocytes (CTL) and natural killer cell (NK) cytotoxicity, and give rise to

225 A tissue-resident population of natural killer cells (NK cells) in the liver has recentl

226 Natural killer cells (NK) are a component of innate immu

227 Natural killer cells (NK) are highly enriched in the hum

228 Fluorescently labeled human T cells, natural killer cells (NK), and various target cells (NAL

229 ) T-cell ratio and increased CD16(+)CD56(hi) natural killer cells (NK), CD4(+) effector memory T cell

230 ident memory CD8(+) T cells (TRMs), resident natural killer cells (NKRs), and tumor-associated macrop

231 Natural killer cells (NKs) are important effectors of th

232 Natural killer cells (NKs) are involved in every stage o

233 She had decreased CD8(+) T and natural killer cells, normal CD4(+) T cells, high serum

234 hostatic intolerance, salivary cortisol, and natural killer cell number and function were similar bet

235 Natural killer cell number and status were assessed in s

236 pe with absent T cells and normal B-cell and natural killer cell numbers.

237 PMVDS stimulated both cytotoxic T cells and natural killer cells of cell-mediated immunity to provid

238 Recognition by natural killer cells of cells that had lost HLA expressi

239 Intriguingly, B cells, but not natural killer cells or CD8(+) T cells, were implicated

240 nal lymphoproliferations arising from either natural killer cells or cytotoxic T lymphocytes (CTLs).

241 set of 13 unique genes, highly expressed in natural killer cells (p = 0.03), were significantly expr

242 of Env-specific ADCC antibodies to activate natural killer cells (P<.001).

243 We observed that in human natural killer cells, PIP2 is highly enriched in membran

244 we found that innate immune factors, such as natural killer cells, plasmacytoid dendritic cells, and

245 Because alterations of dendritic cells and natural killer cells play a central role in trauma-induc

246 We report for the first time that natural killer cells play a major role in the mice susce

247 Natural killer cells play an important role in immunity

248 Moreover, CD8+ T-cell, CD4+ T-cell and NK (natural killer) cell populations in splenocytes were ele

249 ction of IFN-gamma by lymphocytes, including natural killer cells, probably accounting for the enhanc

250 th the frequencies of intrathecal CD56bright natural killer cells (r = 0.28; P = .007).

251 Natural killer cells readily kill target cells, and educ

252 Natural killer cell receptors and other genes related to

253 ntigens, forming ligands for cytotoxic T and natural killer cell receptors.

254 mmunity are Patr-B variants that engage with natural killer cell receptors.

255 antigens and reduced ligation of activating natural killer-cell receptors may explain the loss of gr

256 peptide complexes probably affect T-cell and natural killer cell recognition, providing a sound basis

257 Immune recovery, including CD8(+) T-cell and natural killer cell reconstitution, was enhanced with bo

258 nsplantation, innate immune cells, including natural killer cells, recovered with virus rebound.

259 rial from the lung vasculature, and promoted natural killer cell recruitment and activation.

260 In this setting, the role of natural killer cells remains controversial.

261 profile are due to a different proportion of natural killer cells responding in LUJV infection than t

262 might result from impaired CD8(+) T-cell and natural killer cell responses to EBV infection in these

263 pulmonary pathology, stronger and persistent natural killer cell responses, and the extended inductio

264 related to local and systemic recruitment of natural killer cells resulting in increased interferon-g

265 flammatory and regulatory cytokine profiles, natural killer cells showed a predominantly proinflammat

266 Natural killer cells showed reduced T-bet expression at

267 nduces the death of CD56(bright) NK cells, a natural killer cell subset whose expansion is correlated

268 ortion of CD4+ FoxP3+ T cells and CD56(high) natural killer cell subsets, which are cell subsets asso

269 altered composition of gammadelta T-cell and natural killer cell subsets.

270 eased Tregs without affecting CD4+, CD8+, or natural killer cells, suppressed inflammation, and great

271 ients have shown major shifts in circulating natural killer cells, T and B lymphocytes immediately af

272 roinflammatory cytokine responses by DCs and natural killer cells, Th1 development, phagocytic recept

273 cytokine-producing dendritic cells (DCs) and natural killer cells than Cd36(-/-) mice.

274 st of TLR3 and RLR to activate dendritic and natural killer cells that can kill tumor cells.

275 are more probable to be recipients than B or natural killer cells; that trogocytosis occurs independe

276 ccumulating evidence for the contribution of natural killer cells, the key mediators of antibody-depe

277 t that TRAIL is part of the armamentarium of natural killer cells, these observations identify a new

278 2B8T2M activates natural killer cells to enhance antibody-dependent cellu

279 RV144 vaccinee also inhibited the ability of natural killer cells to kill HIV-1-infected CD4(+) T cel

280 ng HGF-independent MET activity, and engaged natural killer cells to kill MET-expressing cancer cells

281 rated that anti-CD27 stimulated CD8(+) T and natural killer cells to release myeloid chemo-attractant

282 cytomegalovirus reactivation, the ability of natural killer cells to secrete interferon-gamma was sig

283 of tumoricidal effector cells, in particular natural killer cells, to the tumor stroma for antitumor

284 al immune cells, such as T helper type 1 and natural killer cells, to unleash neurotoxicity and infla

285 reased CD4(+) effector T-cell activation and natural killer cell tumor cytotoxicity.

286 Depletion of natural killer cells was achieved through an IV anti-asi

287 in protein and perforin delivered in situ by natural killer cells was determined.

288 IFN-gamma production, mainly by natural killer cells, was associated with protection, an

289 21R expression on CD8(+) T cells, but not on natural killer cells, was required for optimal anti-ErbB

290 major histocompatibility complex class I and natural killer cells were commonly downregulated in psor

291 acy was dependent on CD8(+) T cells, whereas natural killer cells were dispensable.

292 the lungs, indicating that mice depleted of natural killer cells were much more susceptible to infec

293 Natural killer cells were normal in number but not "lice

294 The blood levels of natural killer cells were not altered in brain-injured p

295 The immunophenotype and functions of natural killer cells were performed by flow cytometry, a

296 Specifically, T, B, and natural killer cells were severely depleted in the blood

297 Blood CD16 and CD56 natural killer cells were significantly more likely to b

298 trates of liver macrophages, neutrophils and natural killer cells, whereas hepatic CD4(+) T cells inc

299 roduction by IL-12p70-mediated activation of natural killer cells, whereas miR-146a and miR-146b over

300 (IFN-gamma) or TNF-alpha or cocultured with natural killer cells (which have been shown to induce an