ライフサイエンスコーパス: natural mutation

1 nd functional avidities for both SL9 and its natural mutations.

2 By contrast, the Y447C natural mutation abolished the transport of organic cati

3 base substitutions tested, which include six natural mutations and 14 artificially introduced ones, h

4 e, conformational changes induced by keratin natural mutations and extensive tissue injury result in

5 We have used this natural mutation, and the cGMP phosphodiesterase inhibit

6 ent to predict the CD40-binding site, to map natural mutations, and to rationalize their effects.

7 ntrolled by CTRC in a manner that individual natural mutations are unlikely to increase stability eno

8 A natural mutation at codon 151 (Gln --> Met; Q151M) of HI

9 We have identified a natural mutation at the -30 amino acid position of the a

10 A natural mutation D351YERalpha enhances 4-OHT agonist act

11 is was performed to create 7 TM mutants with natural mutations either previously identified (Ala25Thr

12 sly suspected and illustrates the utility of natural mutations for defining functional domains in pro

13 The only known natural mutation found in mature human IAPP is a Ser20-t

14 The majority of natural mutations identified in this and other Na(+)/sol

15 These natural mutations identify tyrosine residues possibly in

16 The E452K mutation is the first natural mutation in a mammalian cotransporter affecting

17 4 must be functionally important because its natural mutation in cone photoreceptor CNG channels is a

18 in-like CTRC variant highlights how the same natural mutation in homologous pancreatic serine proteas

19 A natural mutation in Ppd-H1 prevalent in spring barley de

20 Kinetic studies have demonstrated that this natural mutation in the coenzyme-binding site decreases

21 C3H/HeJ mice harbor a natural mutation in the gene that encodes Toll-like rece

22 Infected db/db mice, bearing a natural mutation in the leptin receptor, have a markedly

23 entity of three such residues that underwent natural mutations in a transgenic mouse line.

24 activity and correlating with the absence of natural mutations in regions bordering the third cluster

25 ues in airway smooth muscle, suggesting that natural mutations in the PDE4D gene have profound effect

26 chemical evidence that certain (but not all) natural mutations in the TM gene reduce expression and i

27 This study illustrates the power of using natural mutations in transgenes as guides for studying s

28 The natural mutation increased the concentration of sodium r

29 nts regulate alpha globin expression and how natural mutations interfere with this mechanism to cause

30 e expression in pancreatic beta-cells due to natural mutation is responsible for susceptibility to vi

31 In this study, we investigated whether natural mutations occurring in this locus in FQ-resistan

32 a molecular basis for the observation that a natural mutation of Arg-57 in humans is associated with

33 drophobic pocket that binds Val-6(beta), the natural mutation of HbS, and the latter site is a promin

34 Further, a natural mutation of the gene encoding NIK in alymphoplas

35 We found that asebia mice homozygous for a natural mutation of the gene for SCD1 (SCD-/-) are defic

36 This natural mutation of the TSH-beta subunit confirms the im

37 y, and immunodeficiency represents the first natural mutation of this transcription factor in a human

38 Natural mutations of CCR5 that impair surface expression

39 emoval of the palmitate or site-directed and natural mutations of the modified cysteine result in los

40 We show that natural mutations of these residues in maple syrup urine

41 Loss of function of VRN2, whether by natural mutations or deletions, resulted in spring lines

42 s, but abnormal conditions, such as specific natural mutations or oxidation, produce an altered state

43 S237 and D299 as well as at the site of the natural mutation R274L.

44 differences in C. albicans and delineates a natural mutation that alters the balance between commens

45 Moreover, a natural mutation that resulted in longer Sda1 and SdaD a

46 affect the nervous system provide a host of natural mutations that can be deployed in the quest to u

47 cts of gene regulation have been revealed by natural mutations that downregulate globin gene expressi

48 Natural mutations that impair either defense activation

49 nvestigate the heterogeneity in the types of natural mutations that occur in covR and covS and the ph

50 We used alanine scanning mutagenesis and natural mutations to map the subregion of the MH1 domain

51 actor IX (residues 403-415) contains several natural mutations which result in mild to severe forms o

52 c stem/progenitor (CD34+) cells to emulate a natural mutation, which deletes the MCS-R2 alpha-globin

53 tural frameworks can be derived by using non-natural mutations, which differ from those found in came

54 We aim to characterize the impact of natural mutations within the RBDs of civet-CoVs on viral