ライフサイエンスコーパス: natural product

1 the biosynthesis of this important bioactive natural product.

2 is of a representative norlignan cyclobutane natural product.

3 of 1 do not match the data reported for the natural product.

4 te from the values reported for the isolated natural product.

5 t and stereoselective total synthesis of the natural product.

6 at has permitted a scalable synthesis of the natural product.

7 oid (-)-galipeine, do not match those of the natural product.

8 calable synthesis of a polycyclic brominated natural product.

9 gram-scale total synthesis of a guaianolide natural product.

10 to the biosynthetic origins of this class of natural product.

11 es by small molecules, peptide mimetics, and natural products.

12 core structure of a wide array of bioactive natural products.

13 dling different substrates to generate novel natural products.

14 ic investigations into the origin of related natural products.

15 X-X bond containing functional groups within natural products.

16 ge in the synthesis of complex materials and natural products.

17 lationally modified peptide (RiPP) family of natural products.

18 recycling of muropeptides, cell-wall-derived natural products.

19 ereotriads are frequently observed motifs in natural products.

20 s that occur as structural motifs in various natural products.

21 hetic platform for ring system alteration of natural products.

22 variety of biologically active molecules and natural products.

23 e (RiPP) pathways produce a diverse array of natural products.

24 ns unclear for many members of this class of natural products.

25 to explore the diversity and distribution of natural products.

26 major impact on the biological activities of natural products.

27 limited understanding of microbiome-derived natural products.

28 scribed all of the chemical space covered by natural products.

29 roxyl group among many in unprotected polyol natural products.

30 oup of structurally and functionally diverse natural products.

31 catalyst templates, therapeutic agents, and natural products.

32 on the biological activity of the resulting natural products.

33 streamlining the discovery pipeline for new natural products.

34 f all published microbial and marine-derived natural products.

35 chemodiversity of more than 80000 terpenoid natural products.

36 quiterpenes constitute an important group of natural products.

37 ludane, mellolide, and marasmane families of natural products.

38 eries of designed analogues of these complex natural products.

39 oles (MBPs and DMBPs) were the most abundant natural products.

40 to the engineered biosynthesis of prenylated natural products.

41 thetic pathways of many structurally complex natural products.

42 carbon cross-link in the streptide family of natural products.

43 identify and elucidate additional classes of natural products.

44 ound broad application in total synthesis of natural products.

45 o key structural motifs present in bioactive natural products.

46 the biosynthesis of 7-deazapurine containing natural products.

47 ploited for the synthesis of phenylpropanoid natural products.

48 dologies in the total synthesis of THP-based natural products.

49 the genetic basis and architecture of plant natural products.

50 te-selective modifications of highly complex natural products.

51 onyls given their preponderance in bioactive natural products.

52 plants and functional studies of the plant's natural products.

53 pendent enzymes involved in the synthesis of natural products.

54 The title natural products 2-7 have been prepared by reductive cyc

55 tolysates led to the identification of a new natural product, 5-phenylpentyl isothiocyanate (PhPeITC)

56 plified with the preparation of 16 different natural products across 10 different families.

57 The macrolactone natural product (-)-albocycline is a promising antibioti

58 rence and function of organophosphonic acids natural products along with the mechanisms of the enzyme

59 of reviews and books on biologically active natural products already exists, mostly from N. tabacum,

60 ic pathways have been engineered to generate natural product analogs for over two decades.

61 Macrolactonization of natural product analogs presents a significant challenge

62 The natural product analogues are nanomolar inhibitors of Mt

63 ndation for the development of uridylpeptide natural product analogues as new TB drug candidates that

64 sessment for the validation of core-modified natural product analogues is discussed.

65 l overview of approaches to the synthesis of natural product analogues is presented.

66 ion of crocagin A and provides access to the natural product and derivatives thereof for further biol

67 However, the recent identification of natural product and synthetic modulators of RNA splicing

68 applied to the late-stage diversification of natural products and a marketed drug under mild conditio

69 ely used in the clinic, including many plant natural products and analogues derived from these produc

70 approaches provide a series of lissoclimide natural products and analogues that expand the structure

71 s, since these reactions are vital to access natural products and biologically active compounds.

72 ives rise to adducts which are found in many natural products and biologically active molecules, and

73 Holthausen et al. mined this soup of natural products and discovered a peptide that destroys

74 ld be further transformed into the bioactive natural products and human microflora metabolites of die

75 ol (BINOL), are key components of catalysts, natural products and medicines.

76 X-X bonds are found in all major classes of natural products and often impart significant biological

77 cations toward the synthesis of nonribosomal natural products and other bioactive compounds.

78 are ubiquitous core structures of bioactive natural products and pharmaceutical drugs.

79 and yet are present in a number of bioactive natural products and synthetic pharmaceuticals.

80 n exists relevant to the thiol reactivity of natural products and their analogues possessing this moi

81 Diverse structural types of natural products and their mimics have served as targets

82 of how we have exploited a diverse range of natural products and their mimics to create, explore, an

83 the facile synthesis of a flavoring agent, a natural product, and a polymer precursor from simple ole

84 boronic acid to the preparation of a complex natural product, and the first example of this coupling

85 of active pharmaceutical ingredients (APIs), natural products, and commodity chemicals.

86 iew may be of interest for pharmacognosists, natural products, and ecological chemists.

87 ange of approaches for identifying microbial natural products, and elucidating their biosynthetic pat

88 frequently investigated for their bioactive natural products, and the ecological role of their speci

89 The first example of a PBD monomer, the natural product anthramycin, was discovered in the 1960s

90 ude of recent studies have demonstrated that natural-product antibiotics at subinhibitory concentrati

91 mine its application to the synthesis of the natural product aphanamal.

92 enolide-derived cembranoid and norcembranoid natural products are a family of congested, stereochemic

93 Several natural products are known to mediate microbial interact

94 The proteins needed to synthesize these natural products are often encoded by clusters of co-loc

95 , and scalable syntheses of the halichondrin natural products are reported.

96 en explored for their ability to dereplicate natural products as well as determine molecular structur

97 s are present in a wide variety of bioactive natural products as well as synthetic molecules that are

98 ponsible for the biosynthesis of halogenated natural products, as biocatalysts.

99 The first total synthesis of the marine natural product avrainvilleol is reported.

100 dependent of ROS generation, and unlike many natural product based HDAC inhibitors, 4a was found to b

101 lf-renewal or differentiation has arrived at natural product-based agents as an important class of mo

102 s on the relatively few instances in which a natural-product-based development candidate has been man

103 ic route to provide laboratory access to the natural product became a priority.

104 Our analyses demonstrate that most natural products being published today bear structural s

105 and begins from the abundant and inexpensive natural product betulin.

106 that showcase both the chemical diversity in natural product biosynthesis as well as the parallels wi

107 Recent innovations in peptide natural product biosynthesis reveal a surprising wealth

108 of complex biological processes ranging from natural product biosynthesis through to the mammalian vi

109 he chemical logic and enzymatic machinery of natural product biosynthesis, including antibiotics and

110 7-methoxy derivatives, and the O-prenylated natural products boropinols A and C.

111 struction of the potent antibacterial marine natural product bromophycoic acid E scaffold.

112 or cryptic gene clusters are sources of new natural products, but how they are silenced, and how the

113 We found that the natural product caffeic acid phenethyl ester (CAPE) disr

114 nerally observed and a variety of scents and natural products can be easily accessed.

115 rboxylic acids as well as a diverse range of natural-product carboxylic acids, thereby demonstrating

116 nd verification in synthetic, medicinal, and natural product chemistry.

117 d networking of clinicians, microbiologists, natural product chemists, and pharmacologists together w

118 The natural product class of iridoids, found in various spec

119 intermediate to serve as a precursor to each natural product class, and 3) a direct chemical conversi

120 d elegant total syntheses in virtually every natural product class: terpenes, alkaloids, prostaglandi

121 erization to exclusively deliver the desired natural product (-)-claulansine D in quantitative yield.

122 Natural products comprise a palette of multifunctional c

123 PUM is a natural product comprising a formamidinylated, N-hydroxy

124 Halogenated natural products constitute diverse and promising feedst

125 any biologically and pharmaceutically active natural products contain chlorine and thus, an understan

126 Several natural products containing a 1,4-oxazepane-2,5-dione-co

127 chea graminicola that belongs to a family of natural products containing a characteristic bicyclo[2.2

128 the synthesis of biologically active complex natural products containing contiguous stereogenic carbo

129 ogy, as well as guide efforts to uncover new natural products containing these structural features.

130 The kinamycin family of aromatic polyketide natural products contains an atypical angucycline ring s

131 all carbon atoms of the D and E ring of the natural product could be installed in three additional s

132 Antimicrobial susceptibility to natural products could also be easily tested.

133 ted structures of the rhamnofolane diterpene natural products curcusones I and J in racemic form were

134 le, striking colors associated with secreted natural products date back well over a century.

135 The compound 6E11, a natural product derivative, was characterized as a posit

136 stereoselective C-H silylations of a chiral, natural-product derivative containing multiple types of

137 s of biological activity assays of remodeled natural product derivatives are also presented.

138 LPA synthesis in vivo, providing a promising natural product derived scaffold for drug discovery.

139 This advanced design combines the merits of natural product-derived materials and functional, degrad

140 recent efforts to uncover microbiome-derived natural products, describe the key approaches that were

141 ich allowed an encoded (labelled) mixture of natural-product diastereomers to be prepared-enabled us

142 The natural product dihydrotanshinone-I (DHTS) prevents the

143 domain compositions should help guide future natural product discovery efforts.

144 e mining technologies to be applied to plant natural product discovery.

145 ar biology techniques to the acceleration of natural product discovery.

146 to create a tool, SMART, that can assist in natural products discovery efforts.

147 As the power of "meta-omics" approaches to natural products discovery further advance, we anticipat

148 there is a fervent need to reinvigorate the natural products discovery pipeline.

149 hemistry provides a powerful approach toward natural product diversification, combining the best of b

150 represents an intriguing mechanism by which natural product diversity arises.

151 nging antibacterial activities and potential natural product diversity, which proved that the bacteri

152 rione (1), proposed to be the antitubercular natural product eucapsitrione, has been synthesized in 4

153 Following the discovery that the guaianolide natural product eupalinilide E promotes the expansion of

154 The three natural products exhibited calcium-dependent antimicrobi

155 Since the syntheses do not rely on natural product extraction, our work addresses long-term

156 parations, post-metabolic tissue samples and natural product extracts.

157 he first total syntheses of members of these natural product families are reported as their racemates

158 synthetic efforts toward each member of the natural product family, including biomimetic, semisynthe

159 reamlined the production of pharmaceuticals, natural products, fine chemicals and other functional ma

160 ue platform for high throughput screening of natural products for specific glycosylation and pathogen

161 e biosynthesis of lanthipeptides, a class of natural products formed by post-translational modificati

162 ing this methodology, total syntheses of the natural products (+/-)-foveoglin A and (+/-)-perviridisi

163 -ethyl-1alpha-hydroxy-17-veratroyldictyzine) natural products from a common intermediate.

164 ducts was designed, aiming to access several natural products from a common synthetic intermediate re

165 work which offers access to highly oxidized natural products from an abundant and renewable terpene

166 First asymmetric synthesis of the marine natural product (-)-gracilioether F is described from a

167 Natural products harbor unique and complex structures th

168 ently isolated schinortriterpenoid family of natural products has attracted considerable synthetic at

169 s of the carbocyclic core of the berkeleyone natural products has been used to access protoaustinoid

170 The importance of microbial natural products has been widely demonstrated in the sea

171 ns, such as how the rate of discovery of new natural products has changed over the past decades, how

172 Stolonidiol, a marine natural product, has been reported to potentiate the act

173 Numerous classes of natural products have been subjected to these studies of

174 es and biological activity profiles of these natural products have captured the attention of chemists

175 Pterin-containing natural products have diverse functions in life, but an

176 iological activities, nonaromatic polyketide natural products have for decades attracted an enormous

177 These natural products have in common an E,Z-configured conjug

178 Natural products have served as powerful therapeutics ag

179 In studying the biosynthesis of the fungal natural product herqueinone, we identified an enzyme tha

180 Here we report that a small-molecule natural product, hinokitiol, can harness such gradients

181 six distinct oligomeric polypyrroloindoline natural products: hodgkinsine, hodgkinsine B, idiospermu

182 d control enabled efficient formation of the natural product in 69 % yield from the minor isomer pres

183 emphasizes the potential of metal-chelating natural products in antimicrobial therapy.

184 alable construction of a series of macrolide natural products in as few as 15 linear steps (21 total)

185 biosynthetic pathways of other basidiomycete natural products in ascomycete heterologous hosts, and o

186 , late stage C-7 hydroxylation provides both natural products in six and seven operations.

187 Organophosphonic acids are unique as natural products in terms of stability and mimicry.

188 However, the diverse abundance of natural products in the marine environment could serve a

189 e Ca Entotheonella and some of the bioactive natural products in the sponge tissue.

190 e applied our route to the synthesis of four natural products in this class including two that have n

191 o generate a novel chlorinated coumarin "non-natural" product in E. coli.

192 iplinary impacts for catalytic remodeling of natural products, including contributions to SAR develop

193 s now made possible the syntheses of several natural products, including malbrancheamides B and C, no

194 point for the chemical synthesis of complex natural products, including many terpenes themselves.

195 Using this catalyst, we modify several natural products, including steroids and a vitamin E der

196 ed synthesis of the core of the norditerpene natural product ineleganolide.

197 apoptosis, thereby assisting development of natural-product-inspired drugs to treat metastatic RCC.

198 ive conversion of a single hydroxyl group in natural products into a ketone would enable the selectiv

199 in synthetic approaches aiming to reengineer natural products into potent antibiotics.

200 These results indicate that this natural product is likely the result of spontaneous (non

201 l-mediated methods to the total synthesis of natural products is discussed.

202 A major challenge to harnessing these natural products is that they are found in very low amou

203 ble resource available in the search for new natural products is the diverse microbial life that span

204 th disparate functional groups (for example, natural products) is a long-standing challenge that has

205 e unique t-butyl group found in a variety of natural products, is still poorly understood.

206 The motuporamines are natural products isolated from the New Guinea sea sponge

207 isomeric methylene homologues (including the natural product itself) were obtained using a one-pot mi

208 ation of the dihydropyran core of the fungal natural product, leporin.

209 covery of novel anti-adhesive molecules from natural product libraries will require the use of a high

210 skeletons to complex polycyclic systems and natural-product-like compounds.

211 a particular microbial strain, redox-active natural products likely play fundamental, underappreciat

212 The polycyclic natural product lingzhiol [(+/-)-1] was synthesized from

213 d the effects of chemical modifications to a natural product macrocycle upon its activity, 3D geometr

214 d action of two enzymes commonly involved in natural product metabolism-an alcohol dehydrogenase and

215 e, many organisms generate large families of natural product metabolites that have related molecular

216 nd demonstrate this strategy by syntheses of natural products methyl carlactonoate and carlactonic ac

217 Many marine natural products (MNPs)-for example, neoechinulin B-have

218 unusual instances of productive deep-seated natural product modifications and were introduced throug

219 port of this role and the discovery of small natural product molecules that probably target these enz

220 Significantly, the natural product neolignan was accomplished in one pot.

221 rated in the synthesis of novel analogues of natural product (-)-nicotine and antidepressant sertrali

222 f powerful, catalytic alterations of complex natural products now exists such that expansion of scope

223 beta-Lactone natural products occur infrequently in nature but posses

224 A small molecule natural product of as yet unknown structure, mycofactoci

225 structural feature frequently found in many natural products of clinical interest, including, but no

226 With an increase in antibiotic resistance, natural products once again hold promise for new antimic

227 l synthesis and the preparation of truncated natural products optimised for biological activity.

228 the synthesis of various unique cyclopropane natural products or use of cyclopropanes as versatile st

229 ity-generating biocatalytic reactions within natural product pathways.

230 Amide-containing molecules are ubiquitous in natural products, pharmaceuticals, and materials science

231 lation of a pharmacophore module to generate natural product-pharmacophore hybrids endowed with unkno

232 ables a concise, three-step synthesis of the natural products phenopyrrozin and p-hydroxyphenopyrrozi

233 Natural products preserved in the geological record can

234 The natural product probe was localized to mitochondria with

235 d rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase

236 Several natural product-relevant motifs are accessed in enantioe

237 e synthesis of this stereochemically complex natural product reported to date, and is well suited to

238 H up-to-date with the latest developments in natural product research and will further facilitate com

239 lic compounds are interesting chemotype with natural product resemblance and may find useful applicat

240 nthesized based on the core structure of the natural product sanglifehrin A.

241 ment pathways of simple 2,5-dienones and the natural product santonin were found to be effectively re

242 ules as catalysts for the diversification of natural product scaffolds is reviewed.

243 Natural product screening for new bioactive compounds ca

244 resents an advance in the miniaturization of natural products screening.

245 rt that Triptolide (C1572), a small-molecule natural product, selectively depletes CSCs in a dose-dep

246 , the incorrect structural assignment of the natural product serratin was identified.

247 compound with the presumed structure of the natural product serratin was obtained.

248 MS-Cluster tool routinely used on the Global Natural Product Social Molecular Networking platform (GN

249 h was demonstrated with the synthesis of the natural products, spruce alkaloid and (+)-241D.

250 anged over the past decades, how the average natural product structural novelty has changed as a func

251 polyladderene, a polymer inspired by a lipid natural product structure and prepared via direct metath

252 o acids, thereby increasing the diversity of natural product structure while also attenuating the ris

253 synthesized to give synthetic-bioinformatic natural products (syn-BNPs).

254 lm phenotypes further validating the role of natural product synthesis in the discovery of new biolog

255 This reflects a process of evolution of natural product synthesis which has accelerated in the y

256 The reaction can also be used in natural product synthesis.

257 hat are important to medicinal chemistry and natural product synthesis.

258 applications in bioorthogonal chemistry and natural product synthesis.

259 Polyketides are a large family of bioactive natural products synthesized by polyketide synthase (PKS

260 ynthesis of the E and F rings of the complex natural product target pectenotoxin 4.

261 hemoselective lactam reduction delivered the natural product target.

262 ming the first chemical synthesis of the two natural products Tasipeptin A and B.

263 broccoli juice was investigated to develop a natural product that could be of interest for food and/o

264 re then applied to convert deoxynybomycin, a natural product that is active only against Gram-positiv

265 We highlight several plant natural products that are either in the clinic or curren

266 synthetic intermediates, drug molecules and natural products that cannot be used in excessive quanti

267 lines are an interesting class of oligomeric natural products that consist of multiple cyclotryptamin

268 Natural products that contain functional groups with het

269 peptide in the ribosomally encoded family of natural products that exhibits potent antimicrobial effe

270 e physicochemical properties of the reported natural products that have bioactivity against drug-resi

271 This review provides a summary of natural products that have shown promise in controlling

272 f analogues of the sansanmycin uridylpeptide natural products that represent promising new TB drug le

273 Here we describe a natural product, the lasso peptide benenodin-1, which ex

274 nation opens a gateway into a rich family of natural products.The biosynthetic pathway of preakuammic

275 s are a common structural motif in bioactive natural products, therapeutic agents, and molecular cata

276 n more potent, antibacterial agents than the natural product, thereby setting the foundation for furt

277 shares a binding site with other imide-based natural product translation inhibitors, CL engages in a

278 ecological roles and biological activity of natural products, versus products from cured and process

279 ward the oridamycin and xiamycin families of natural products was designed, aiming to access several

280 is of thioviridamide, a thioamide-containing natural product, we hypothesized that the archaeal tfuA

281 ses of these base- and nucleophile-sensitive natural products, we conduct carefully orchestrated site

282 entative molecules of an in house library of natural products, we have designed and synthetized the c

283 Two new natural products were obtained namely quercetin and kaem

284 Microcystins (MCs) are highly toxic natural products which are produced by cyanobacteria.

285 underexplored class of disulfide-containing natural products, which exhibit potent antimicrobial act

286 termination of the relative configuration of natural products, which starts from the molecular formul

287 due to the presence of cannabinoids, unique natural products, whose pharmacology is going to gain in

288 e total synthesis of Xyridin A, an important natural product with antibacterial and antifungal activi

289 rivatives, such as thapsigargin, a cytotoxic natural product with potent antitumor activity.

290 id secondary metabolites are highly valuable natural products with a wide range of biotechnological a

291 oterpenoids constitute an important class of natural products with diverse biological properties and

292 ing new and existing laboratory syntheses of natural products with findings of the compounds' unique

293 continues to discover appreciable numbers of natural products with no structural precedent.

294 -guided fractionation identified two oxazole natural products with selective activity against this ce

295 s proven to be a very rich source of diverse natural products with significant antibacterial, antifun

296 access to a much wider family of polyketide natural products with stereochemistry being dialled in a

297 ructures of halogenated terpenoids and other natural products with the new parametric approach and de

298 cystobactamids are a family of antibacterial natural products with unprecedented chemical scaffolds t

299 nribosomally synthesized peptides (NRPs) are natural products with widespread applications in medicin

300 The nonaromatic polyketide natural product zincophorin methyl ester has attracted s