ライフサイエンスコーパス: naturally occurring

1 We characterized the naturally occurring 3MC-associated MASP-3 mutants and fo

2 However, the tropism repertoire of naturally occurring AAVs is limited, prompting a search

3 onfirmed that UbFluor quantitatively detects naturally occurring activation states of PARKIN caused b

4 n of amide- and lactam-containing drugs, and naturally occurring alkaloids, as well as for the select

5 tification of neuroprotective genes based on naturally occurring allelic variations has the potential

6 Naturally occurring allergens are capable of inducing IL

7 amino ether ligands, readily accessible from naturally occurring alpha-amino- or alpha-hydroxy acids,

8 Recent evidence suggests that mtDNA undergo naturally occurring alterations, including mutations and

9 ndings highlight the importance of assessing naturally occurring alternative splicing for clinical ev

10 Isodesmosine (ISD) a rare naturally occurring amino acid and a biomarker for pulmo

11 However, limitations with naturally occurring amino acid-derived compounds, includ

12 e from yellow to orange, among all the other naturally occurring amino acids studied.

13 Here, we examine the use of the naturally occurring amnestic agent garcinol to manipulat

14 vity towards Pseudomonas aeruginosa than the naturally-occurring AMP LL-37 in human plasma.

15 Given the lack of known naturally occurring, amyloidogenic, single-point mutatio

16 ere we show that cholesterol sulfate (CS), a naturally occurring analog of cholesterol, inhibits CD3

17 the individual calls in isolation as well as naturally occurring and artificial sequences.

18 alpha-Methylene-gamma-butyrolactone (MBL), a naturally occurring and biomass-sourced bifunctional mon

19 yelin loss in all mammalian species, in both naturally occurring and experimental disease.

20 IL-18 activity is modulated in vivo by its naturally occurring antagonist, IL-18 Binding Protein (I

21 Consequently, it is important to identify naturally occurring antagonists of this channel.

22 receptor subtypes, endogenous agonists, and naturally occurring antagonists.

23 gnment of the absolute configuration of this naturally occurring antibiotic.

24 chemical properties very similar to those of naturally occurring antibodies.

25 The best known of the naturally occurring antimalarial compounds are quinine,

26 ibed herein are the first total syntheses of naturally occurring antitumor agents disorazoles A1 and

27 A streamlined total synthesis of the naturally occurring antitumor agents trioxacarcins is de

28 The naturally occurring antiviral protein IFN-alpha2 is used

29 ece of information, which is missing for all naturally occurring archaeal DNA polymerases, provides a

30 Fatty acid esterification, common in naturally occurring astaxanthin, has been suggested to i

31 's fire and lightning are two known forms of naturally occurring atmospheric pressure plasmas.

32 The synthetic product matched naturally occurring azaspiracid-3 by mass spectrometry,

33 atographically and spectroscopically matched naturally occurring azaspiracid-3, whereas the previousl

34 cating that similar mutations could arise in naturally occurring bacterial populations facing antibio

35 be responsible for the optical modulation of naturally occurring bacteriochlorophylls.

36 ology of BD torons allowing consideration of naturally occurring BD texture for applications in optic

37 Examples described herein are the naturally occurring benzofurans methyl wutaifuranate, wu

38 rface morphology of microthin fibers such as naturally occurring biofibers is essential for understan

39 Many naturally occurring biomolecules, such as amino acids, s

40 , fibrin, which is one of the most resilient naturally occurring biopolymers and forms the structural

41 Naturally occurring botulism is rare, but a large number

42 New nitrocatechol COMT inhibitors based on naturally occurring caffeic acid and caffeic acid phenet

43 matics and functional analyses, we show that naturally occurring cancer-associated SIRT2 mutations at

44 Many naturally occurring catalytic antibodies have since been

45 Furthermore, naturally occurring catalytic antibodies to microbial de

46 substrate, providing the first example of a naturally occurring catalytic antibody for polysaccharid

47 re provides insight into the binding mode of naturally occurring CB1 ligands, such as THC, and synthe

48 of sympathetic neurons during the period of naturally occurring cell death.

49 experimental vaccines have been derived from naturally occurring, cell culture-adapted, or geneticall

50 However, fluorescent sensing methods for naturally occurring cellular metabolites are relatively

51 hich could be inhibited by the addition of a naturally occurring chaperone and a nanobody designed to

52 Nucleic acids undergo naturally occurring chemical modifications.

53 also used the predictive models to convert a naturally occurring ChR incapable of mammalian localizat

54 nins are one class of versatile and abundant naturally occurring chromophores that produce different

55 Naturally occurring climate-driven TWS variability can t

56 This study utilizes a naturally occurring CO2 leaking site in the Qinghai-Tibe

57 Notably, the naturally occurring coagonist D-serine was able to atten

58 species with unknown requirements is to use naturally occurring combinations of growth factors.

59 These data provide strong evidence that the naturally occurring compound, garcinol, may be a potenti

60 Through this process, we identified another naturally occurring compound, withaferin A, that also ac

61 the protecting groups in the synthesis of a naturally occurring compound.

62 dies, we report that methyl benzoate (MB), a naturally-occurring compound in many plants, may possess

63 mia; and summarizes LOX-1 modulation by some naturally occurring compounds and efforts toward develop

64 mplex history reflected in both selection on naturally occurring compounds and historical trade route

65 propyl)phosphate, which stood out from other naturally occurring compounds detected.

66 nition of triterpene glycosides, a family of naturally occurring compounds that act as chemical defen

67 en human medial temporal lobe epilepsy and a naturally occurring condition in wild sea lions and simu

68 Our study of this naturally occurring constellation of genetic markers has

69 c peptide maintained the overall fold of the naturally occurring cyclic peptide, was more effective a

70 the recent developments of the chemistry of naturally occurring cyclodextrins, along with a variety

71 Enantioselective first total synthesis of naturally occurring cytotoxic (+)-subincanadine E was al

72 represent a simple and appropriate model for naturally-occurring defects.

73 -stage vaccine candidate antigen; however, a naturally occurring deletion within an immunogenic domai

74 are man-made media that mimic properties of naturally occurring dielectric media, or even manifest p

75 s include passive targeting, which relies on naturally occurring differences between healthy and dise

76 a genetic score consisting of variants with naturally occurring discordance between levels of LDL-C

77 sis of strains and phenotypic variability in naturally occurring diseases, especially in humans, more

78 Interestingly, a naturally occurring DLX3 mutant that disrupts the carbox

79 ls the rate of damage per unit volume due to naturally occurring DNA breaks, whereas the volume fract

80 tein in proliferating cultures, we show that naturally occurring DNA damage incurred over S-phase cau

81 are then used to generate an alignment of 73 naturally occurring DnaE inteins that are predicted to b

82 membranes is a model system for the study of naturally occurring domains, such as rafts, in biologica

83 aracterize several CGRs that originated from naturally occurring DSBs at (GAA)n microsatellites in Sa

84 The recent discovery of a naturally occurring DSF turnover mechanism and its regul

85 illations that were neurofeedback-induced or naturally occurring during reaching tasks.

86 phene ring is fused with the skeleton of the naturally occurring dye isatin.

87 e same approach, we attempted to stabilize a naturally occurring efficiently cleaved clade C Env, nam

88 The naturally occurring endomorphins are also released by pr

89 g spermatogenesis, through the activity of a naturally-occurring endonuclease that targets a repetiti

90 HD is 5 kcal.mol(-1) higher than that of the naturally occurring engrailed-HD from Drosophila melanog

91 c transformations remain to be discovered in naturally occurring enzyme 'toolboxes'.

92 Naturally occurring enzyme homologues often display high

93 t plays a large and stabilizing role for the naturally occurring enzyme ketosteroid isomerase (KSI).

94 ut the catalytic activities or mechanisms of naturally occurring enzymes, or the evolutionary process

95 za virus evolution and transmission during a naturally occurring epidemic is still limited.

96 We report the first discovery of naturally occurring ESR1 (Y537C) and ESR1 (Y537S) mutati

97 No naturally occurring ESR1 mutations have been reported in

98 In theory, a few naturally occurring evolutionary changes in the genome o

99 Interestingly, naturally occurring extracellular electron transfer prot

100 To date, opportunistic studies of naturally occurring extreme precipitation years, combine

101 y, observations from coral communities under naturally occurring extremes have become central for imp

102 ers and is promiscuous-it binds catechins, a naturally occurring family of flavanols.

103 Chronic wasting disease (CWD) is a naturally occurring, fatal neurodegenerative disease of

104 Glycerol Monolaurate (GML) is a naturally occurring fatty acid widely utilized in food,

105 genic process and assess the interference of naturally occurring fatty acids with the transport proce

106 nanoparticles made of a eutectic mixture of naturally occurring fatty acids.

107 Naturally occurring flavonoids, delphinidin, pelargonidi

108 uarding appropriate RA concentration despite naturally occurring fluctuations in RDH10 and DHRS3.

109 physiological models and robust against the naturally occurring fluctuations in the metabolic respon

110 l variants of Anabaena flavodoxin, where the naturally occurring FMN cofactor is substituted by diffe

111 Ska depletion increases the frequency of naturally occurring, force-dependent P kinetochore detac

112 ohydrate polymers is rooted in the fact that naturally occurring forms of starch, cellulose, and chit

113 cin A or methylenecyclopropylglycine (MCPG), naturally-occurring fruit-based toxins that cause hypogl

114 Epichloe spp. are naturally occurring fungal endophytic symbionts of many

115 ic Population Resource (DSPR) as a source of naturally occurring genetic perturbation, we uncover abu

116 Studies of naturally occurring genetic variation can be used to ant

117 e of collections of wild C. elegans to study naturally occurring genetic variation, paving the way fo

118 cs of lithium extraction and production from naturally occurring geothermal and other brines for ener

119 is of galanal A and B has been achieved from naturally occurring geraniol.

120 presence of many structural isomers in most naturally occurring glycan mixtures.

121 e the high fluorescence quantum yield of the naturally occurring green fluorescence protein (GFP, Phi

122 ositions 158 to 160 of the HA protein of two naturally occurring H5N1 viruses as an important virulen

123 up M HIV-1 isolates, CRF01_AE strains have a naturally occurring histidine at this position (H375).

124 vitro screening of small molecule mimics of naturally occurring host defense peptides (HDP), we have

125 Thus, naturally occurring human autoantibodies may actively li

126 There are limited reported naturally occurring human mAbs to site II; therefore, th

127 Treatment with the naturally occurring human plasma proteins haptoglobin or

128 plete Cre-loxP recombination, thus mimicking naturally occurring human tumors resulting from one or a

129 Our data indicate that naturally occurring immunity to HSV-2 may be protective

130 Mutations in the MexAB-OprM efflux system, naturally occurring in cystic fibrosis (CF) isolates, ha

131 ar mechanisms that cause drug resistance are naturally occurring in less susceptible species and are

132 el mechanobiology concept that could exploit naturally occurring in vivo forces for improving stem ce

133 nitrosylation and S-sulfhydration, which are naturally occurring in vivo.

134 ar more abundant isobaric galactosyl epimers naturally occurring in white matter.

135 We analyzed the complete genomes of 16 naturally occurring infectious P-MLVs, 12 of which were

136 nome-wide association study, we identified a naturally occurring insertion in a regulatory DNA elemen

137 the concept of intrinsic ignition, which are naturally occurring intrinsic perturbations reflecting t

138 cule representative of a large proportion of naturally occurring islet-infiltrating B-lymphocytes in

139 The present study showed that naturally occurring isoforms of Amb a 1 possess differen

140 Sulforaphane (SFN) is a naturally occurring isothiocyanate found in cruciferous

141 Here we show that sulforaphane (SFN), a naturally occurring isothiocyanate, promotes osteoblast

142 ge, corrects the raw MS spectra both for the naturally occurring isotopes and for the overlapping of

143 signed the Doppler-broadened features of two naturally occurring isotopes of rubidium atoms ((87)Rb a

144 uires special care, such as a correction for naturally occurring isotopes, or overlapping mass spectr

145 d spectra of metabolites containing only the naturally occurring isotopes.

146 play toolkit to diversify the complexity of naturally occurring ketones.

147 that are strikingly similar to those of the naturally occurring left-handed Z-form of DNA.

148 g in either the well-documented selection of naturally occurring, less susceptible fungal species, or

149 Exposure of C. bombi to naturally occurring levels of phytochemicals-either with

150 We isolated 12 naturally occurring mAbs with low half-maximal effective

151 functions over the last five decades, these naturally occurring macrocyclic systems have emerged onl

152 Rapamycin is a naturally occurring macrolide whose target is at the cor

153 ns of paleomagnetic observations assume that naturally occurring magnetic particles can retain their

154 Recently, naturally occurring magnetite (Fe3O4) has emerged as a n

155 Structural proteins from naturally occurring materials are an inspiring template

156 ity of this material supersedes also that of naturally occurring materials.

157 From the eight naturally occurring members of the vitamin E family, alp

158 and potentially the uncoupling mechanism of naturally occurring membrane proteins.

159 This review highlights a selection of naturally occurring membrane- and protein-based encapsul

160 iral Bronsted acid prepared in one step from naturally occurring (-)-menthol and readily available 1,

161 We manipulated water availability in two naturally occurring Mertensia ciliata (Boraginaceae) pop

162 showed decreased oxidation stability due to naturally occurring metals but stability increased to a

163 neity among driver gene mutations present in naturally occurring metastases-that is, treatment-naive

164 re either epimeric at C1 and C1' or lack the naturally occurring methyl group at those positions were

165 nation are increasingly appreciated to shape naturally occurring microbe populations, the underlying

166 ular concentrations typically encountered in naturally occurring microbial communities (10(3)-10(6) c

167 Biofilms, naturally occurring microbial consortia, play numerous i

168 One solution to this problem may lie within naturally occurring microdiversity; varying numbers of e

169 which appear to have occurred at regions of naturally occurring microhomology.

170 may regulate auxin levels and adds a novel, naturally occurring molecule to the chemical toolbox for

171 les such as peptides, pharmaceutical agents, naturally occurring molecules, proteins and alkaloids, a

172 Naturally occurring, multiple cysteine-containing peptid

173 e required for protective immunity against a naturally occurring murine pathogen that infects the thy

174 , stability, and lipid-binding properties of naturally occurring mutants of full-length human apoA-I

175 SR) calcium release in a mouse strain with a naturally occurring mutation in the myostatin gene (Comp

176 Many variants result from naturally occurring mutation.

177 at often rely on laborious selection of rare naturally occurring mutations in gene-regulatory regions

178 The goal of the TFT is to harness naturally occurring mutations in the mitochondrial genom

179 Naturally occurring mutations in the ribonucleoprotein r

180 logically significant electric fields and by naturally occurring mutations of human cyt c that, along

181 Naturally occurring mutations of the telomeric POT1-TPP1

182 d nucleic acid binding assays to explain how naturally occurring mutations within this portion of tel

183 These naturally occurring mutations, recapitulated in vitro, i

184 es a deletion that is indistinguishable from naturally occurring mutations.

185 unique discovery of an outbreak caused by a naturally occurring mutator bacterial pathogen provides

186 tituting Lys with Arg (or vice versa) in the naturally-occurring myosin-6 SAH similarly increased (or

187 and potentially about the physical basis of naturally occurring nanodomains such as lipid rafts.

188 Having uncovered this naturally occurring neural correlate of risk selection,

189 Canine degenerative myelopathy (DM) is a naturally occurring neurodegenerative disease with simil

190 Both heterocycles of carinatine A, a rare naturally occurring nitrone, were formed in a single ope

191 ology, virology, and genetic host factors of naturally occurring norovirus outbreaks.

192 the development of new antibiotics, as many naturally occurring nucleoside inhibitors with antibacte

193 ne (GlcNAc) is an abundant building block in naturally occurring oligosaccharides, but its incorporat

194 bovine papillomavirus is the smallest known naturally occurring oncoprotein.

195 tential for radiolabeling of any biological, naturally occurring, or synthetic organic molecule for i

196 There is a naturally-occurring organic crystal known as karpatite w

197 he detrimental denaturing effects of another naturally occurring osmolyte, urea.

198 s plants that has been causatively linked to naturally occurring outbreaks of a biliary atresia (BA)-

199 elucidate the nature of sleep deficits in a naturally occurring ovine model of neuronal ceroid lipof

200 Vaults are naturally occurring ovoid nanoparticles constructed from

201 ted the effect of birnessite (delta-MnO2), a naturally occurring oxidant in soils, on the formation o

202 antigens to prevent onwards transmission of naturally occurring parasites to a local mosquito strain

203 ort in moss cells, but are orthogonal to the naturally occurring pathways.

204 e capabilities associated with a majority of naturally occurring peptaibols such as alamethicin.

205 Serelaxin, a recombinant form of the naturally occurring peptide hormone relaxin-2, is a plei

206 Antimicrobial peptides (AMPs) are naturally occurring peptides and promising candidates fo

207 Naturally occurring peptides and proteins often use dyna

208 ified an alternative binding conformation of naturally occurring peptides from Toxoplasma gondii boun

209 Naturally occurring, pharmacologically active peptides c

210 Monolayers play important roles in naturally occurring phenomena and technological processe

211 Revertant mosaicism (RM) is a naturally occurring phenomenon where the pathogenic effe

212 epialleles, and we extended our paradigm to naturally occurring phenotypes.

213 Anthocyanins are a class of naturally occurring pigments that produce red-purple-blu

214 Total syntheses of five naturally occurring polyacetylenes from three different

215 Described herein are syntheses of the naturally occurring polyketides (-)-tetrapetalones A and

216 Furthermore, phenotypic analysis of naturally occurring polymorphic NucS in a M. smegmatis s

217 By screening naturally occurring, polymorphic, non-human primate APOB

218 We found that one naturally occurring polymorphism in the oligomer interfa

219 ucture of EBNA1 with an interface subject to naturally occurring polymorphisms that modulate EBNA1 fu

220 the ability of thymosin alpha 1 (Talpha1)-a naturally occurring polypeptide with an excellent safety

221 determining helical stability in de novo and naturally-occurring polypeptides, giving new insight int

222 Flavonoids constitute a group of naturally occurring polyphenolic molecules with many bio

223 Although some naturally occurring polyphenols have been found to inhib

224 Experimental studies have shown that many naturally occurring polyphenols have inhibitory effect o

225 like oligomers in solution when triggered by naturally occurring polyphosphates (PIP2 and ATP) and ma

226 Second, emerging data that naturally occurring polyphosphates activate the contact

227 Naturally occurring polypurine mirror repeat sequences i

228 Naturally occurring populations of ribbed mussels were o

229 the potential for automated analysis of this naturally occurring post-translation modification in neu

230 Cysteine S-nitrosation and S-sulfination are naturally occurring post-translational modifications (PT

231 st, SR has been demonstrated in a variety of naturally occurring processes, including human perceptio

232 UMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tai

233 e by studying the geometry of beta sheets in naturally occurring protein structures and folding simul

234 An example is the naturally occurring protein-protective osmolyte trimethy

235 Naturally occurring, pseudoknot-insensitive viruses were

236 pe parasites grow in any one of a variety of naturally occurring purines, the proliferation of these

237 ccessfully applied to the total synthesis of naturally occurring pyrolidine alkaloids.

238 itutions, including the highly prevalent and naturally occurring Q80K polymorphism that impacts simep

239 knot aptamers were rendered insensitive by a naturally occurring R277K variant, providing the first d

240 gy of XFS and highlight a potential role for naturally occurring rare LOXL1 variants in disease biolo

241 postexposure) time scale, though not beyond naturally occurring rates of mortality.

242 iative and dissociative processes, mimicking naturally occurring reactions and giving rise to a decou

243 seroconvert in response to diverse IAVs, and naturally occurring reassortants of CIV-H3N2 and the 200

244 f development.SIGNIFICANCE STATEMENT Probing naturally occurring reciprocal copy number variation in

245 This naturally occurring recombination event may have broad i

246 typic-, and disease-specific consequences of naturally occurring regulatory gene mutations.

247 of asthma in wild-type (WT) mice, with both naturally occurring regulatory T (nTreg) cells and induc

248 rleukin-4-driven expansion of donor Foxp3(+) naturally occurring regulatory T cells (Tregs).

249 replicated with human polyclonally expanded naturally occurring regulatory T cells, which we have pr

250 Thus, our results show that naturally occurring regulatory variants of blw affect li

251 Wood as a renewable naturally occurring resource has been the focus of much

252 ively, our data rationalize the existence of naturally occurring RG4-assembling tRNA fragments and em

253 t immunological and anatomical evidence of a naturally occurring rod-monochromatic mammalian retina,

254 ion of our understanding of the diversity of naturally occurring Rubiscos.

255 ges is a platform for chemical remodeling of naturally occurring scaffolds that targets virtually all

256 n cell biology, directed by a limited set of naturally occurring signaling peptides.

257 Here we show that a naturally occurring single amino acid substitution (tyro

258 Naturally-occurring single alpha-helices (SAHs), are ric

259 folding via disulfide isomerization based on naturally occurring small molecules.

260 This analysis of the naturally occurring, sometimes pathogenic P-MLV recombin

261 In naturally occurring species with 4, 8, or even 16 flagel

262 igratory marine vertebrates, we measured the naturally occurring stable nitrogen isotope (delta(15) N

263 Here we demonstrate that the naturally occurring statin mevastatin reverses FPP's eff

264 e experimental evidence that NOD2 recognizes naturally occurring structural variants of MDP.

265 RNA-based three-way junctions (3WJs) are naturally occurring structures found in many functional

266 Bacterial microcompartments are naturally occurring subcellular organelles of bacteria a

267 We therefore investigated the role of these naturally occurring substitutions in BTX autoresistance

268 lar triangle, which is a shape distinct from naturally occurring supramolecular nanostructures.

269 First, naturally occurring supramolecular polymers are describe

270 mal protein import pathway orthogonal to the naturally occurring system.

271 Although these naturally occurring systems have been modified to change

272 A naturally occurring tandem duplication of the Alcohol de

273 Galloyl-D-Glucopyranose was reported to be a naturally occurring tannin.

274 MP) from Neisseria meninigitidis, PorB, is a naturally occurring TLR2 ligand and functions as an adju

275 perties in turn could facilitate identifying naturally occurring topologically nontrivial RNA molecul

276 Arsenic is a ubiquitous, naturally occurring toxic metalloid widely distributed i

277 Using Ricin Chain-A, a naturally occurring toxin, as a model analyte we report

278 onse of the aquifer system has not mobilized naturally occurring trace metals, including arsenic, chr

279 geting of histone modifications, which model naturally occurring transcriptional phenomena that contr

280 l fluctuations in NE efflux as a function of naturally occurring transitions in behavioral state and

281 There are only three known naturally occurring transmissible cancers, and these aff

282 the communities we detected associating with naturally occurring trees at the seedling source populat

283 vel of Foxp3 expression, or affiliation with naturally occurring Treg or induced Treg in the circulat

284 ligand-expressing MDCs, and increased donor naturally occurring Treg recovery (P < .01) compared wit

285 ausal link between aberrant FOS function and naturally occurring tumors has not yet been established.

286 Here we show that naturally occurring twin boundaries, with properties tha

287 natal mortality rates as well as the highest naturally occurring twin rates.

288 d the effect of DHA on aS-derived species: a naturally occurring variant, H50Q; an oxidized aS in whi

289 Additionally, R152K, a naturally occurring variation at the NA catalytic residu

290 The ability to generalize over naturally occurring variation in cues indicating food or

291 rtunity to identify genes that contribute to naturally occurring variation in quantitative traits.

292 discover and validate genes contributing to naturally occurring variation in quantitative traits.

293 ebs that include functional traits and their naturally occurring variation.

294 extensive heritable differences arising from naturally occurring variation.

295 ction pressure, APOBEC-mediated editing, and naturally occurring variation.

296 hydroxyvitamin D3 (1,25-D3 or calcitriol), a naturally occurring VDR agonist, VDR 4-1 therapy even at

297 itis virus (VSV), a transsynaptic tracer, or naturally occurring VSV-derived defective interfering pa

298 A naturally occurring Wolbachia strain (wAnga-Mali) was id

299 Using a mouse model with a naturally occurring WS-linked gain-of-function Cxcr4 mut

300 adaptive population, by taking advantage of naturally occurring X-linked somatic PIGA mutations in h