ライフサイエンスコーパス: ncRNA

1 ncRNAs are a large family of functionally important RNA

2 ncRNAs are emerging as key regulators of physiological a

3 4 713 associations between 142 NSDs and 8593 ncRNAs in 11 species, curated from more than 1300 articl

4 results suggest that APeg3 has evolved as a ncRNA gene and controls the function of its sense gene P

5 sting that APeg3 may have been selected as a ncRNA gene during eutherian evolution.

6 saRNAs recognized target chromatin through a ncRNA stemming from it.

7 rboring JARID1C mutations exhibited aberrant ncRNA expression and increased genomic rearrangements co

8 Non-coding ribonucleic acids (ncRNA) are functional RNA molecules that are not transla

9 ht the importance of Mediator and activating ncRNA association in human disease.

10 ator complex as the transducer of activating ncRNAs and highlight the importance of Mediator and acti

11 In addition, ncRNAs are released into the circulation where they are

12 Many, though not all, ncRNAs exploit the power of base pairing to selectively

13 Among ncRNA, the long ncRNA and small ncRNA can affect histone

14 of Eco 6S RNA for Esigma(70) and show how an ncRNA can mimic B-form DNA to directly regulate transcri

15 nt RNA polymerase activity that regulates an ncRNA inhibitor of transcription.

16 ges and their effects on mRNA expression and ncRNA expression were derived, including a simple rule g

17 iptional activity as well as enriched TF and ncRNA binding across diverse cell types, which may be cr

18 f both high-quality protein coding genes and ncRNAs, we considered the associations between pseudogen

19 ptimal expression dynamics of many mRNAs and ncRNAs.

20 ) non-coding RNAs; (iii) genes, pathways and ncRNAs that are involved in tolerating drugs or induce d

21 s database for different splice variants and ncRNAs, such as microRNAs and lincRNAs.

22 e per se is a poor predictor of function, as ncRNAs dramatically vary in length and structure and oft

23 to define enhancers and enhancer-associated ncRNAs that are involved in a TF-dependent regulatory ne

24 wever, an outlier subset of tumor-associated ncRNAs, typically of recent evolutionary origin, has mot

25 ly been used to uncover many novel bacterial ncRNA classes in recent years.

26 he newest findings in the field of bacterial ncRNAs shows how examples in model pathogens could pave

27 Thus, existing CFG-based ncRNA identification tools usually ignore pseudoknots du

28 of the human genome is insufficient because ncRNA variants have been associated with important human

29 cell genome, thereby creating a link between ncRNA transcription and overall maintenance of B-cell ge

30 (lncRNAs) in mammalian cells, bidirectional ncRNAs are transcribed on enhancers, and are thus referr

31 provides insight into the function of brain ncRNAs regulating synaptic transmission, plasticity and

32 insights into the biochemistry performed by ncRNAs.

33 Here we investigate the role played by ncRNAs in the stress response of Schizosaccharomyces pom

34 ocus on the multitude of functions played by ncRNAs produced by animal viruses.

35 resolve, isolate and quantify all canonical ncRNAs in a single sample of cells or tissue, as well as

36 a whole can accurately distinguish canonical ncRNAs from CDSs and UTRs (accuracies: >92% in human, mo

37 s with feature patterns similar to canonical ncRNAs (e.g. tRNA, snRNA, miRNA, etc) on approximately 7

38 on biological characteristics of circulating ncRNAs and highlight their value as potential biomarker

39 the origin and function of such circulating ncRNAs, these molecules are increasingly recognized as n

40 signal for introns and various RNA classes (ncRNA, snRNA, snoRNA) and less variability after degrada

41 strategy favors the discovery of more common ncRNA classes, whereas progressively rarer classes are c

42 o reveals many previously unreported cryptic ncRNAs induced by specific carbon sources, showing that

43 osis-related EECTG (MEIOB) and its nearby CT-ncRNA have a role in tumorigenesis in lung adenocarcinom

44 lation and close non-coding RNAs (namely, CT-ncRNAs) may be two mechanisms to reactivate EECTG gene e

45 Tbx5-dependent ncRNA transcription provided a quantitative metric of Tb

46 Tbx5-dependent ncRNAs emanated from regions that are enriched for TBX5-

47 Tbx5-dependent ncRNAs were enriched for tissue-specific marks of active

48 tria, identifying 2600 novel Tbx5-dependent ncRNAs.

49 tRNA-derived ncRNAs show differential expression profiles and play ro

50 pecific expression profiles for tRNA-derived ncRNAs.

51 t methods have generally failed to determine ncRNA tertiary structures, even at the 1-nm resolution t

52 eals regulatory networks involving different ncRNA classes of importance in cancer.

53 factors, including many recently discovered ncRNAs.

54 Increasing evidence shows that diverse ncRNAs play a critical role in various NSDs.

55 Despite their conformational diversity, ncRNAs mostly preserve their secondary structure through

56 Because aberrant and excess ncRNAs are largely degraded by exoribonucleases, a key c

57 sistent 1-nm accuracy for intricately folded ncRNAs with lengths up to 188 nucleotides, including a b

58 se interactions bears crucial importance for ncRNA functional studies.

59 Moreover, we will discuss new roles for ncRNAs, as well as a novel Pol II RNA-dependent RNA poly

60 ChIRP-MS analysis of four ncRNAs captures key protein interactors, including a U1-

61 ich elevated antisense RNA arising both from ncRNAs and from 3'-overlapping convergent gene pairs is

62 potential role in mediating clock function, ncRNAs conserved between mouse and human showed rhythmic

63 ng yeast cells, we show that antisense GAL10 ncRNA transcription can switch between functional and sp

64 affected by transcription of antisense GAL10 ncRNA, even when both are present simultaneously at the

65 the free-living nematode C. elegans, it has ncRNA families that are enriched in parasites, and expre

66 e the consensus abstract shape of homologous ncRNAs and apply the predicted shape to structure predic

67 We discuss how ncRNAs inhibit spurious recombination among repetitive D

68 e ends of numerous fruitfly, mouse and human ncRNAs.

69 erspective, we will discuss newly identified ncRNAs that facilitate DNA looping, regulate transcripti

70 inate from direct interaction of immunogenic ncRNAs expressed in cancer cells with innate pattern rec

71 of the dozens of modified ribonucleosides in ncRNA, characterization of novel long ncRNA species, enh

72 hts into structure-function relationships in ncRNAs and can aid in the development of functional hypo

73 ase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal differentiation

74 In contrast, when GAL10 is not induced, ncRNA transcription is critical to prevent transcription

75 ferase 1 (DNMT1) co-purifies with inhibitory ncRNAs.

76 fy Neat1 as a p53-regulated large intergenic ncRNA (lincRNA) with a key role in suppressing transform

77 tly described vlincRNA (very long intergenic ncRNA) class are mainly activated.

78 ccupancy reported that many large intergenic ncRNAs (lincRNAs) are bound by ribosomes, raising the po

79 e focused on the long intergenic/intervening ncRNAs (lincRNAs), hidden within the large amount of inf

80 istered only a handful of conserved intronic ncRNAs of flowering plants.

81 ng it generally applicable for investigating ncRNAs.

82 nent of the spliceosome, and Malat1, a large ncRNA that localizes to nuclear speckles.

83 ed us to classify it as a putative tRNA-like ncRNA.

84 Here, we show that a long ncRNA, Uc.283+A, controls pri-miRNA processing.

85 sm orchestrated by the two alleles of a long ncRNA.

86 New long ncRNA species have been evaluated for the first time in

87 des in ncRNA, characterization of novel long ncRNA species, enhanced detection of rare transcript var

88 Among ncRNA, the long ncRNA and small ncRNA can affect histone modification, D

89 Here, we show that the long ncRNA CCAT2, located at the 8q24 amplicon on cancer risk

90 fting our perception on the role of the long ncRNA in regulating this imprinted domain.

91 Ps, snoRNPs, telomerase, microRNAs, and long ncRNAs.

92 as enhancer-derived RNAs (eRNAs) and as long ncRNAs (lncRNAs) have received much attention, but their

93 reads mapping to protein-coding genes, long ncRNAs, and antisense RNAs were due to DNA contamination

94 RNA, etc) on approximately 70% of human long ncRNAs (lncRNAs).

95 ated ncRNAs, including short microRNAs, long ncRNAs and circular RNAs, across various heart diseases

96 The poorly characterized subclass of long ncRNAs (lncRNAs) can epigenetically regulate protein-cod

97 ation of gene expression, more recently long ncRNAs (lncRNAs, >200 nucleotides) are recognized as bei

98 KEY MESSAGE: ncRNA PN_LNC_N13 shows contrasting expression in reprodu

99 tial expression of a family of mitochondrial ncRNAs (ncmtRNAs) that comprises sense and antisense mem

100 es to be revealed, we believe that many more ncRNA species and functions will be discovered.

101 f provides the biological function, but most ncRNAs operate as RNA-protein complexes, including ribos

102 Quantification of cellular miRNA and mRNA/ncRNA target pool levels indicates that miRNA:target poo

103 We present a new global factor, called mRNA:ncRNA avoidance, and provide evidence that avoidance inc

104 GFP) mRNAs with different potential for mRNA:ncRNA interactions, we demonstrate that GFP levels corre

105 lection for the avoidance of stochastic mRNA:ncRNA interactions across prokaryotes, and that these ha

106 Therefore, taking stochastic mRNA:ncRNA interactions into account enables precise modulati

107 ll nuclear (sn)RNA (U1) is a multifunctional ncRNA, known for its pivotal role in pre-mRNA splicing a

108 We observed that multiple ncRNAs induced expression of skin barrier repair genes,

109 time, to our knowledge, in human and murine ncRNAs, determining that most have motif use consistent

110 ne proteins that transiently protect nascent ncRNA ends from exoribonucleases, with partner proteins

111 nting these methods, we discovered 224 novel ncRNA classes, which include ROOL RNA, an RNA class aver

112 sample of cells or tissue, as well as novel ncRNA species.

113 rious ncRNA sub-types and characterize novel ncRNAs, we have developed a method, RNAfeature, to inves

114 owing us to boost the performance of de novo ncRNA predictors, such as RNAz.

115 ion page for researchers to submit novel NSD-ncRNA associations.

116 Mining and summarizing NSD-ncRNA association data can help researchers discover use

117 ay in which unprocessed and unneeded nuclear ncRNAs are exported to the cytoplasm for degradation.

118 w focuses on the mechanisms by which nuclear ncRNAs directly contribute to the maintenance of genome

119 e learned by amplification-based analysis of ncRNA sequence and quantity, there is a significant need

120 ns to more rigorously explore the biology of ncRNA species in mycobacteria.

121 lied our method for reliable construction of ncRNA-protein interaction networks.

122 tention on chromatin, delayed degradation of ncRNA, and restricted Pol II CTD Ser2 phosphorylation an

123 the transcription-factor-(TF)-dependence of ncRNA expression to define enhancers and enhancer-associ

124 y applications and enable the elucidation of ncRNA functions.

125 The flexibility of ncRNA provides a challenge for probing their complex 3D

126 Here, we review knowledge of ncRNA in bladder cancer, with a focus upon their role in

127 nd the functions and molecular mechanisms of ncRNA involved in NSDs.

128 points to their involvement in a network of ncRNA-ncRNA interactions.

129 e has been a rapid increase in the number of ncRNA sequences deposited in various databases over the

130 Here, we describe the pathway of ncRNA research, where every established "rule" seems des

131 We propose that RNA exosome regulation of ncRNA recruits AID to single-strand DNA-forming sites of

132 This release of ncRNA triggers inflammation in the skin following UV dam

133 several observations concerning the role of ncRNA expression in cancers and their relationship to th

134 and an emerging appreciation for the role of ncRNA in RNA epigenetics.

135 es, the method produces all major species of ncRNA in high yield and with high integrity, enabling di

136 Suppression of ncRNA transcription by strand-specific CRISPR/dCas9 resu

137 Experimental results on tens of thousands of ncRNA sequences available from the Rfam database indicat

138 We describe an extensive array of ncRNAs with trans associations that have the potential t

139 valuable information about the boundaries of ncRNAs.

140 The microRNA (miRNA) class of ncRNAs are ubiquitously expressed throughout the brain a

141 riefly describe most of the known classes of ncRNAs and then we discuss the design and the applicatio

142 curacy of the native structure derivation of ncRNAs is still not satisfactory, especially on sequence

143 tool for the modulation of the expression of ncRNAs.

144 ertiary structures and thus the functions of ncRNAs.

145 of the evolutionary and discovery history of ncRNAs, as far as they are relevant for the identificati

146 Intermolecular interactions of ncRNAs are at the core of gene regulation events, and id

147 As the multifaceted nature of ncRNAs continues to be revealed, we believe that many mo

148 translation and physiological regulation of ncRNAs has not been conducted.

149 vant for the identification and selection of ncRNAs with likely therapeutic potential.

150 primary sequence and secondary structure of ncRNAs is important for understanding their functions.

151 modeling factor, suppresses transcription of ncRNAs from approximately 57,000 nucleosome-depleted reg

152 Novel therapeutic strategies are based on ncRNAs, and we discuss here RNA interference as a highly

153 of transcripts, but are also found opposite ncRNAs, gene junctions, and the 3' ends.

154 abundance of the traditional linear mRNA or ncRNA transcript.

155 e reported roles of miRNAs, as well as other ncRNA classes, in the pathology of psychiatric disorders

156 any DNA and RNA viruses synthesize their own ncRNAs.

157 In particular, ncRNA-protein interactions play an important role in pos

158 In the most extreme case, pathogenic ncRNAs alone (such as viroids) can infect eukaryotic org

159 While a few pathogenic ncRNAs have been implicated in regulating gene expressio

160 expression, the functions of most pathogenic ncRNAs in host-pathogen interactions remain unclear.

161 ant immune systems can respond to pathogenic ncRNAs, which has broad implications for providing new o

162 to dissect host interactions with pathogenic ncRNAs, using comprehensive transcriptome analyses.

163 odel derived from animal species can predict ncRNAs in Arabidopsis (accuracy: 82%).

164 eases function with cofactors that recognize ncRNAs with accessible 5' or 3' ends and/or increase the

165 ccumulating evidence on aberrantly regulated ncRNAs, including short microRNAs, long ncRNAs and circu

166 and an imbalance in the levels of regulatory ncRNAs such as small nuclear and nucleolar RNAs (snRNAs

167 a strongly positioned nucleosome to repress ncRNA depends on its translational positioning.

168 anscription initiation, while non-repressive ncRNAs are displaced from Pol II by TFIIF.

169 Incorporation of repressive ncRNAs into pre-initiation complexes prevents transcript

170 A renewed interest in non-coding RNA (ncRNA) has led to the discovery of novel RNA species and

171 Accelerating discoveries of non-coding RNA (ncRNA) in myriad biological processes pose major challen

172 n cytoplasmic (BC1) RNA is a non-coding RNA (ncRNA) involved in neuronal translational control.

173 y yield the full spectrum of non-coding RNA (ncRNA) species.

174 is a highly conserved nuclear noncoding RNA (ncRNA) and a predictive marker for metastasis developmen

175 iptomes and identification of noncoding RNA (ncRNA) classes has been greatly facilitated by the adven

176 We identify Neat1, a noncoding RNA (ncRNA) constituent of paraspeckles, as a p53 target gene

177 skin leads to the release of noncoding RNA (ncRNA) from necrotic keratinocytes that activates Toll-l

178 ccharomyces cerevisiae, short noncoding RNA (ncRNA) generated by RNA polymerase II (Pol II) are termi

179 , thus generating exclusively noncoding RNA (ncRNA) that must hijack the machinery required for their

180 ant ribosome-associated 18 nt noncoding RNA (ncRNA), derived from the open reading frame of an mRNA,

181 ral classes of long and small noncoding RNA (ncRNA).

182 RNA including both coding and noncoding RNA (ncRNA).

183 has the potential to express noncoding RNA (ncRNA).

184 dentified several classes of noncoding RNAs (ncRNA) also associated with aging-related senescence and

185 NAs are shaped by regulatory noncoding RNAs (ncRNA).

186 and 2,367 non-coding genes/non-coding RNAs (ncRNAs) annotated in AceView.

187 Non-coding RNAs (ncRNAs) are frequent and prevalent across the taxa.

188 Non-coding RNAs (ncRNAs) are known to play important functional roles in

189 Non-coding RNAs (ncRNAs) are known to regulate gene expression at practic

190 tl2 locus produces multiple non-coding RNAs (ncRNAs) from the maternally inherited allele, including

191 The discovery of structured non-coding RNAs (ncRNAs) in bacteria can reveal new facets of biology and

192 Non-coding RNAs (ncRNAs) play major roles in proper chromatin organizatio

193 allenged by new findings on non-coding RNAs (ncRNAs) such as microRNAs (miRNAs).

194 argeting different types of non-coding RNAs (ncRNAs) to genomic loci.

195 he regulatory complexity of non-coding RNAs (ncRNAs), which occupy the bulk of the genome.

196 new class of m6A-containing non-coding RNAs (ncRNAs).

197 th protein coding genes and non-coding RNAs (ncRNAs).

198 serves as a source of short non-coding RNAs (ncRNAs).

199 overy of several classes of non-coding RNAs (ncRNAs).

200 Noncoding RNAs (ncRNAs) accomplish a remarkable variety of biological fu

201 r encapsidated host RNAs are noncoding RNAs (ncRNAs) and members of the VL30 class of endogenous retr

202 Noncoding RNAs (ncRNAs) and RNA-binding proteins are potent post-transcr

203 identified transcribed novel noncoding RNAs (ncRNAs) and their cis-regulatory elements that function

204 Noncoding RNAs (ncRNAs) are a recently identified subgroup of RNAs whose

205 However, many noncoding RNAs (ncRNAs) are rapidly degraded after transcription, and re

206 Noncoding RNAs (ncRNAs) are remarkably powerful, flexible, and pervasive

207 ng-shaped protein that binds noncoding RNAs (ncRNAs) called Y RNAs.

208 Noncoding RNAs (ncRNAs) control cellular programs by affecting protein-c

209 ncer and promoter associated noncoding RNAs (ncRNAs) could stabilize deleterious secondary DNA struct

210 Aberrant expression of noncoding RNAs (ncRNAs) deregulates genes involved in B cell differentia

211 Many pathogens express noncoding RNAs (ncRNAs) during infection processes.

212 RNAs (tRNAs) and other small noncoding RNAs (ncRNAs) encapsulated within vesicles.

213 miRNAs are small (19-24 nt) noncoding RNAs (ncRNAs) found in metazoans, plants, and some viruses.

214 Noncoding RNAs (ncRNAs) function with associated proteins to effect comp

215 Noncoding RNAs (ncRNAs) generated from enhancers have been proposed as a

216 he discovery of thousands of noncoding RNAs (ncRNAs) has expanded our view on mammalian genomes and t

217 Noncoding RNAs (ncRNAs) have gained the attention of molecular biologist

218 l analyses of new classes of noncoding RNAs (ncRNAs) have revealed their widespread use in many pathw

219 nt transcription of a set of noncoding RNAs (ncRNAs) preferentially within tumors as opposed to norma

220 Noncoding RNAs (ncRNAs) regulate gene expression in all organisms.

221 Noncoding RNAs (ncRNAs) regulating virulence have been identified in mos

222 erase II (Pol II) of certain noncoding RNAs (ncRNAs) that are upregulated upon heat shock.

223 xpression of heterochromatic noncoding RNAs (ncRNAs) that in turn triggered genomic instability.

224 nteractions are used by many noncoding RNAs (ncRNAs) to achieve their diverse functions.

225 ed to produce mRNAs and some noncoding RNAs (ncRNAs) within mammalian cells.

226 ntially every mRNA, and some noncoding RNAs (ncRNAs), can be targeted to stress granules, the targeti

227 ta support the importance of noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and lncRNAs, which

228 pressed maternally imprinted noncoding RNAs (ncRNAs), such as Rian, Meg-3, and Mirg, which are implic

229 trons and several classes of noncoding RNAs (ncRNAs)--do not give rise to peptide products.

230 epigenetically controlled by noncoding RNAs (ncRNAs).

231 rs repressed by H-NS are for noncoding RNAs (ncRNAs).

232 e than 1,000 known and novel noncoding RNAs (ncRNAs).

233 ive, and potentially harmful noncoding RNAs (ncRNAs).

234 C; and transcribed mRNAs and noncoding RNAs (ncRNAs).

235 s system diseases (NSDs) and noncoding RNAs (ncRNAs).

236 RNAs are mostly repressed during senescence, ncRNAs belonging to the recently described vlincRNA (ver

237 Short ncRNAs underlie a programmable system of chromatin modif

238 Long and short ncRNAs play broadly complementary roles in these process

239 Both long and short ncRNAs play key roles in organization of complex genomes

240 Similarly, ncRNA and methylation profiles reproduce changes observe

241 signaling events that are modulated by SINE ncRNAs, particularly during gammaherpesvirus infection.

242 Here, we review the biology of these SINE ncRNAs, explore how DNA virus infection may lead to thei

243 role in the sorting of highly abundant small ncRNA species, including tRNAs, Y RNAs, and Vault RNAs.

244 Among ncRNA, the long ncRNA and small ncRNA can affect histone modification, DNA methylation t

245 enesis, making CBs the cellular hub of small ncRNA metabolism.

246 exRNA is enriched in small ncRNAs, such as miRNAs in exosomes, and precisely proces

247 including full-length tRNAs and other small ncRNAs.

248 ation pathways that protect the ends of some ncRNAs from nucleases.

249 ming to functionally characterize a specific ncRNA.

250 umerous methods for purification of specific ncRNA molecules.

251 re depleted in genes with overlapping stable ncRNAs (SUTs), presumably to avoid degrading the non-cod

252 R (RE-Alignment for Prediction of structural ncRNA), which efficiently realigns whole genomes based o

253 ligners, which regularly misalign structural ncRNAs.

254 for a set of sequences including structured ncRNA, mRNA and randomized sequences.

255 ibility that novel noncoding RNA structures (ncRNAs) are embedded within intronic sequences and are c

256 occur over regions of RNA exosome substrate ncRNA expression.

257 presence of many novel RNA exosome substrate ncRNAs.

258 bonucleoprotein machine and demonstrate that ncRNA, by tethering a protein cofactor, can alter the su

259 hromatin at active genes, demonstrating that ncRNAs can use RNA-RNA interactions to target specific p

260 n 17 hematopoietic cell types, we found that ncRNAs expressed from the Dlk1-Gtl2 locus are predominan

261 rtain cellular stresses, we hypothesize that ncRNAs can serve viruses as barometers for cellular stre

262 across various heart diseases indicates that ncRNAs are critical contributors to cardiovascular patho

263 The ncRNA 7SL is upregulated in cancer cells, but its impact

264 e observed a marked cohesiveness in both the ncRNA and mRNA layers and the associations between them.

265 uantitatively significant differences in the ncRNA profiles of exponentially growing and non-replicat

266 hat KPNB1, an importin beta component of the ncRNA repressor of nuclear factor of activated T cells (

267 direct chemical and sequence analysis of the ncRNA species.

268 evidence that silencing depends, not on the ncRNA, but on the promoter sequence.

269 nd function of tight junctions, and that the ncRNA U1 acts in a TLR3-dependent manner to induce expre

270 So far, however, out of all the ncRNAs, only tRNA, miRNA and snoRNA can be predicted wit

271 Generally the ncRNAs function to regulate gene expression at the trans

272 es concerning the repressive activity of the ncRNAs analyzed must be due to the distinct character of

273 In another two cases we showed that the ncRNAs were further processed from their introns.

274 These ncRNAs arise from endogenous repetitive elements that ar

275 Knocking down these ncRNAs significantly inhibited proliferation and invasio

276 st decade, the biological functions of these ncRNAs are largely not well understood.

277 nd demonstrated that the expression of these ncRNAs from both strands represent some of the most rapi

278 We demonstrate that a key subset of these ncRNAs functions as immunostimulatory "self-agonists" an

279 Defining the sequences of these ncRNAs is essential for future studies aiming to functio

280 latory and immune-related functions of these ncRNAs may impact the viral life cycle.

281 to prevent lung cancer metastasis with this ncRNA serving as both predictive marker and therapeutic

282 In vivo, Mediator is recruited to ncRNA-a target genes and regulates their expression.

283 ocedure optimized for the isolation of total ncRNA, including 5S, 16S and 23S ribosomal RNA (rRNA) an

284 (RAP-RNA) and applied it to investigate two ncRNAs implicated in RNA processing: U1 small nuclear RN

285 of the precise boundaries of uncharacterized ncRNAs, facilitating further structure/function studies.

286 l transcribed regions (including unconserved ncRNAs), without requiring assembly of the full-length t

287 ffers a sequencing-based route to uncovering ncRNA 3D structure, applicable to functionally important

288 disorders; there are both common and unique ncRNA mechanisms that influence the various diagnoses.

289 e [methylated Lys9 on histone H3]), unstable ncRNAs are recognized by the RNA-binding protein Nrd1.

290 equencies in genes with overlapping unstable ncRNAs (CUTs), so limiting the availability of non-funct

291 by predicting more experimentally validated ncRNA-protein interaction pairs from different organisms

292 To find signature features shared by various ncRNA sub-types and characterize novel ncRNAs, we have d

293 iruses take advantage of both host and viral ncRNA regulation to balance replication and infectious s

294 Like their host counterparts, viral ncRNAs associate with proteins that are essential for th

295 transformation--have been ascribed to viral ncRNAs.

296 g-related senescence and cancer, but whether ncRNAs are also involved in short-telomere-induced senes

297 unexpected repertoire of mechanisms by which ncRNAs contribute to genome stability and even potential

298 yla, several highly conserved and widespread ncRNA classes with properties that suggest sophisticated

299 esBAF depletion is strongly correlated with ncRNA expression, suggesting that flanking nucleosomes f

300 o PRC1 via its SPM domain and interacts with ncRNAs through a novel RNA-binding region (RBR).