ライフサイエンスコーパス: neamine

1 nder acidic conditions produced the bicyclic neamine.

2 uginosa with 8- and 3-fold higher MIC than D-neamine.

3 lower potency (approximately 5-fold) than D-neamine.

4 ed survival of mice treated with neomycin or neamine.

5 6'-acylated kanamycin A (1) and 6'-acylated neamine (2) identified by two-dimensional combinatorial

6 e in vivo antitumor activity of neomycin and neamine (a nontoxic derivative of neomycin), BCBL-1 cell

7 lkyl derivatives of the small aminoglycoside neamine active against susceptible and resistant Gram-po

8 Interestingly, L-neamine also inhibits the growth of aminoglycoside-resis

9 or with one azaquinolone heterocycle and one neamine (Amt-Nea,Azq) as well as its combination with gu

10 sine linked covalently to the 3'-hydroxyl of neamine (an aminoglycoside) via all-methylene tethers of

11 The binding of naturally occurring D-neamine and its synthetic L-enantiomer was further evalu

12 pseudodisaccharide aminoglycoside scaffolds neamine and nebramine, ribosylated derivatives were both

13 s, 6''-azido-kanamycin A, 5-O-(2-azidoethyl)-neamine, and 6''-azido-tobramycin, the selected internal

14 Janus compounds with a small aminoglycoside, neamine, and its guanidinylated analogue have been synth

15 bind derivatives of kanamycin A, tobramycin, neamine, and neomycin B via two-dimensional combinatoria

16 e APH(3') types Ia and IIa with kanamycin A, neamine, and their respective difluorinated analogues 4'

17 In addition, both L- and D-neamine are bacteriocidal toward Gram-(-) bacteria.

18 lkyl derivatives of the small aminoglycoside neamine as broad spectrum antibacterial agents targeting

19 k stereospecifcity was again observed with L-neamine being the more potent binder by a factor of appr

20 Neomycin, paromomycin, ribostamycin and neamine bind in the major groove of the A-site RNA in a

21 The structure of neamine bound to the A site of the bacterial ribosomal R

22 ipophilic substituents to be attached to the neamine core and the corresponding required lipophilicit

23 out the role of the 6'-amine function of the neamine core in the antibacterial effects.

24 Results with the neamine derivative show that it binds a variety of loops

25 tobramycin derivative; 5'UNC3' loops for the neamine derivative; and 5'UNNG3' loops for the neomycin

26 ve bacteria of new amphiphilic 3',4'-dialkyl neamine derivatives and of their smaller analogues in th

27 ed to neomycin-paromomycin, ribostamycin and neamine-each bind to sites within h44 and H69 to perturb

28 The overall results indicated that Janus-neamine/guanidinoneamine showed some preference for the

29 The synthesis of amphiphilic paromamine and neamine homologous derivatives pointed out the role of t

30 L-Neamine inhibits the growth of E. coli and P. aeruginosa

31 3',6-Dinonyl neamine is an amphiphilic aminoglycoside derivative acti

32 derivatization of this intercalator with two neamine moieties (Amt-Nea,Nea) or with one azaquinolone

33 However, on a functional level, unnatural L-neamine proved to inhibit in vitro translation with sign

34 with neomycin, paromomycin, ribostamycin and neamine suggest similar structures for these complexes.

35 aminoglycosides are less potent binders with neamine, the core pharmacophore, displaying the lowest a

36 Moreover, L-neamine, the enantiomer of naturally occurring D-neamine

37 vivo, and targeting ANG function by neomycin/neamine to induce the apoptosis of cells latently infect

38 bind approximately 2-fold more weakly than D-neamine to the natural series decoding region construct,

39 oops that bind to derivatives of neomycin B, neamine, tobramycin, and kanamycin A.

40 caspase-3 were also observed in neomycin- or neamine-treated animal ascitic cells.

41 were significantly diminished by neomycin or neamine treatments.

42 Neamine was 150-fold more active (SC200 = 2 microM) than

43 ine, the enantiomer of naturally occurring D-neamine, was prepared and shown to bind approximately 2-

44 demonstrated the interaction of 3',6-dinonyl neamine with cardiolipin and phosphatidylglycerol, two n

45 des paromomycin, neomycin, ribostamycin, and neamine with the A-site RNA.

46 rget RNA comparably to the parent antibiotic neamine, with dissociation constants in the lower microm