ライフサイエンスコーパス: nearly abolish

1 ion of cortactin with the Arp2/3 complex was nearly abolished.

2 in wild-type cells, and resurgent current is nearly abolished.

3 deleted of both genes, these activities are nearly abolished.

4 ult, the constitutive release of Abeta40 was nearly abolished.

5 In addition, CAT activity in the heart was nearly abolished.

6 fected whereas the intestinal expression was nearly abolished.

7 titatively measure pH while the artifact was nearly abolished.

8 TAT4(-/-) animals, PPT A mRNA expression was nearly abolished.

9 t S-nitrosylation of the Myr- eNOS mutant is nearly abolished.

10 that the silencing of each of these proteins nearly abolished 17beta-estradiol-stimulated SNAT2 promo

11 vitro knockdown of Cav-1 in C6 glioma cells nearly abolished 5-HT(2A) receptor-mediated signal trans

12 esynaptic inhibition, whereas such treatment nearly abolishes adenosine-induced activation of postsyn

13 he second Ig domain deleted both resulted in nearly abolished adhesion.

14 0.7% versus 41.4+/-7.5%; P<0.001), which was nearly abolished after PPVI (3.6+/-5.6%; P<0.001).

15 anatomical cortical maps in these mice were nearly abolished along the nasotemporal (azimuth) axis o

16 T regulatory cells were nearly abolished and antitumor immunity was mediated by

17 ctivation and fos family gene expression was nearly abolished and could be restored by transducing ce

18 ely 37-fold decrease in the binding constant nearly abolishes Argos activity in vivo and in cellular

19 ime spent while hypoglycemic (<70 mg/dL) was nearly abolished as indicated by continuous glucose moni

20 onize over this pH range, ligand binding was nearly abolished at all pH values.

21 of Asp-143 allowed measurable biogenesis but nearly abolished ATP hydrolysis and proton transport.

22 of nox enzymes and found that this treatment nearly abolished bEnd.3 hemangioma growth in vivo.

23 of 8-oxoguanine, whereas mutation of Arg-109 nearly abolished binding of Fpg to damaged DNA.

24 Mutation within each segment reduced or nearly abolished binding, suggesting that these segments

25 nction-blocking monoclonal antibody Hermes-1 nearly abolishes binding of LS174T CD44 to fibrin, altho

26 the two NF-kappaB sites and of the AP-1 site nearly abolishes both basal and IL-1beta-induced express

27 y decreases after 3 months of age, and it is nearly abolished by 10 to 11 months, whereas outer retin

28 Phasic contractions and tone in the IAS were nearly abolished by ANO1 and CavL antagonists.

29 The current was nearly abolished by apamin and by UCL1684, suggesting me

30 multiple poly-N-acetyllactosamine repeats is nearly abolished by AZT concentrations as low as 2 micro

31 edia, glucose-stimulated IAPP-LI release was nearly abolished by blocking constitutive release with 1

32 This enhancement was nearly abolished by blocking the nuclear translocation o

33 rsistent action potential discharge that was nearly abolished by capsazepine (10 microM) and inhibite

34 he LpL inhibitor tetrahydrolipstatin but was nearly abolished by heparin, monoclonal anti-LpL antibod

35 A7r5 vascular smooth muscle cells, which was nearly abolished by knockdown of TRPC6 using a small int

36 mulated a rapid activation of PLD, which was nearly abolished by pertussis toxin (PTX) treatment, con

37 This inhibition was nearly abolished by PKC-IP, indicating that endothelin r

38 T activation capacity of apoA-I in vitro was nearly abolished by the helix 6 point (helix 6P-apoA-I[R

39 vasodilative reactions to both agonists was nearly abolished by the K(ATP) channel inhibitor glibenc

40 Inactivation of macroscopic Na+ currents was nearly abolished by the N1662A mutation and the combinat

41 mitochondria was markedly reduced by GTP and nearly abolished by the non-hydrolyzable GTP analogue, g

42 M markedly decreased SR Ca(2+) leak rate and nearly abolished Ca(2+) sparks.

43 Heterologous expression of Rem2 nearly abolished calcium currents arising from preexisti

44 h a His-tagged, Tat-filamin-A fusion protein nearly abolished CaR-mediated activation of ERK1/2 MAPK

45 antly reduced the number of EBV genomes, and nearly abolished cell proliferation in low serum.

46 ction of glutamate receptor antagonists that nearly abolished cough evoked from the trachea and laryn

47 ckdown of TxnRd1 in both HeLa and FaDu cells nearly abolished curcumin-mediated radiosensitization.

48 The G100V/C103V mutation nearly abolishes depolarization-evoked exocytosis (measu

49 esponses to electrical field stimulation are nearly abolished despite persistent nNOS expression, whe

50 Nitric oxide (NO) synthase inhibitor L-NAME nearly abolished dilations to bradykinin and flow and at

51 ment with antimurine IL-1alpha antibody (Ab) nearly abolished DMBA-induced IL-1alpha mRNA (P = 0.0001

52 the EC50 for dzp, and the Y159S substitution nearly abolished dzp-mediated potentiation.

53 ith the corresponding cyanobacterial protein nearly abolished electron transfer at low ionic strength

54 missense amino acid polymorphism in WRN that nearly abolishes enzymatic activity while leaving expres

55 Mutation of Lys48, Lys106, or His108 nearly abolishes EST activity, indicating that they play

56 ingly, Mn(2+)-ATPase in the Q783A mutant was nearly abolished, even at concentrations of up to 10 mic

57 ion of key genes of lens differentiation and nearly abolished expression of gamma-crystallin.

58 easures of viability, while deletion of tolC nearly abolished FFA production.

59 This effect is nearly abolished following selective genetic disruption

60 We found that CTK1 deletion nearly abolished H3K4 monomethylation yet caused a signi

61 by adherent cells; 2) depleting CD14+ cells nearly abolished HIV-1-induced IFN-alpha production; and

62 id showed that the complete deletion of hypB nearly abolished hup promoter activity, whereas the hist

63 A specific CaMK inhibitory peptide nearly abolished I(Ca) facilitation, but the facilitatio

64 ensities by 2-fold in HEK/Na(v)1.5 cells and nearly abolished I(Na) in mouse cardiomyocytes.

65 lism or signaling were fed KD, seizures were nearly abolished if mice had intact A1Rs, were reduced i

66 steines involved in covalent binding to heme nearly abolished immunodetectable protein.

67 Binding was nearly abolished in a cell line expressing the ldlA (Q40

68 ity to replicate the modified vector DNA was nearly abolished in a pol IV-deficient strain.

69 d beta-arrestin-2 (betaarr-2) because it was nearly abolished in betaarr-2-knockout (ko) mice.

70 e element-binding protein, at serine 133, is nearly abolished in CC2D1A mutant cells.

71 specificity binding to macrophages that was nearly abolished in competitive inhibition experiments.

72 y IFN-independent inhibition of IL-12p40 was nearly abolished in DCs deficient in IFN regulatory fact

73 ned gamma frequency oscillations, which were nearly abolished in deprived columns.

74 Expression of Shh and Fgf10 is nearly abolished in double mutant limb buds.

75 significantly attenuated in GalphaoGS/GS and nearly abolished in Galphai2GS/GS cells because of enhan

76 The sag and rebound were nearly abolished in Hcn1-deficient hair cells.

77 afish mutant cloche (clo), SCL expression is nearly abolished in hematopoietic and vascular tissues.

78 re decreased in orthotopic (14+/-0.9 mV) and nearly abolished in heterotopic allografts (2+/-1.2 mV).

79 pha or tumor necrosis factor (TNF)-alpha was nearly abolished in homozygous mutant (Shp-2(-/)-) fibro

80 BVE(Cyp24a1-null)-derived tumor cells to be nearly abolished in immunocompromised nude mice.

81 t for adenylyl cyclase activation [which was nearly abolished in lpa(1)((-/-)) fibroblasts], these re

82 is innate type 2 response to the allergen is nearly abolished in mice deficient in IL-33R (i.e., ST2)

83 whose expression is controlled by leptin and nearly abolished in ob/ob mice, inhibits bone resorption

84 he ATP-induced increases in [Ca(2+)](i) were nearly abolished in P2X(7)(-/-) submandibular acinar and

85 knockout mice, GABAA-mediated inhibition was nearly abolished in reticular nucleus, but was unaffecte

86 uring ischemia, whereas this interaction was nearly abolished in Sestrin2 KO hearts.

87 The CVC response to whole-body heating was nearly abolished in sites pretreated with substance P co

88 Myogenin expression and myogenesis were nearly abolished in the absence of both AMPKalpha1 and A

89 Looping was nearly abolished in the absence of transcription activat

90 e single mutants was greatly reduced and was nearly abolished in the double mutants in both in vivo a

91 steoblasts and encoding bone ECM proteins is nearly abolished in transgenic mice, and ex vivo assays

92 cells with attenuated Foxp3 expression were nearly abolished in vitro and in vivo, whereas their ane

93 - and alpha(2)-mediated vasoconstriction was nearly abolished in young and older adults (DeltaFVC app

94 enetic knockdown of AXL in a glial cell line nearly abolished infection.

95 letion of ARHI's unique N-terminal extension nearly abolished its inhibitory effect on cell growth, s

96 rocarbonate (DEPC) modification of isoform E nearly abolishes its cytoplasmic membrane binding capaci

97 in the B6.Sle1.Sle3 multigenic model of SLE nearly abolished key disease manifestations including an

98 and ATP-sensitive potassium (KATP) channels nearly abolished lactate-induced vasodilation.

99 c acid (5 microM) or thapsigargin (5 microM) nearly abolished (<20% control) the increase in [Ca2+]i

100 Mertk elimination nearly abolished macrophage apoptotic cell phagocytosis;

101 ural analysis to interact with E960-NKA also nearly abolished NKA-PLM FRET.

102 RNA interference knockdown of C/EBPalpha nearly abolished OHT-ERalpha-induced apoptosis.

103 ntaining 285 base pairs of upstream sequence nearly abolished promoter activity, and co-transfection

104 However, mutation of the AP-1 site alone nearly abolished promoter activity.

105 ction in chondrogenesis, as blockage of ECM1 nearly abolishes PTHrP regulation of chondrocyte hypertr

106 PKC inhibitor GF109203X nearly abolished PTP in both control and cKO.

107 , whereas chronic synaptic activity blockade nearly abolished receptor recycling.

108 nges the phasing of a subset of rhythms, and nearly abolishes resetting of phase by a pulse of darkne

109 e eye during a critical period in early life nearly abolishes responses to that eye in visual cortex.

110 ffect was enhanced when combined (-87+/-4%), nearly abolishing RH.

111 LMP1 aggregation in the plasma membrane and nearly abolished signaling from LMP1 or the LMPCD40 chim

112 K in the first intracellular loop of TMEM16B nearly abolished slow gating, but, mutating 448 AVK451 t

113 in spinal expiratory (pectoralis) nerves and nearly abolished spinal inspiratory activity (serratus n

114 2Q decreased protein stability/synthesis and nearly abolished steady-state cell surface density of Ca

115 mg) and 300,000 IU of porcine lipase (18 g) nearly abolished steatorrhea.

116 synaptotagmin I's C(2)B Ca(2+)-binding motif nearly abolish synaptic transmission and decrease the ap

117 TSA nearly abolishes TF-kappaB binding without affecting NF-

118 ue 1 mouse-IgG2aFc (B7-H1-Ig) fusion protein nearly abolish TH17, but not TH1 and TH2, differentiatio

119 plastid-targeted BVR expression was found to nearly abolish the qualitative inhibition of flowering b

120 Deletion of residues 24-53 nearly abolished the ability of CaD to inhibit actin fil

121 t many mutations in the FIMAC and SP domains nearly abolished the ability of FI to degrade C4b and C3

122 TP to aspartate (M159D) or glutamate (M159E) nearly abolished the ability of PLTP to remove cellular

123 u-478, on the C-terminal domain to glutamine nearly abolished the activity of the enzyme.

124 ulfate (2 mg/kg, i.v.) or bilateral vagotomy nearly abolished the bradycardia and attenuated the hypo

125 e p47phox promoter) reduced PU.1 binding and nearly abolished the contribution of this element to pro

126 y adiposity; however, controlling for IP fat nearly abolished the differences in HTGC, indicating a c

127 PP2 (but not PP3) nearly abolished the effect of FN on channel activity, s

128 ites of the apoA-I promoter/apoCIII enhancer nearly abolished the expression of apoA-I and the report

129 TTX nearly abolished the expression of maternal retrieval of

130 studies demonstrated that NALCN alterations nearly abolished the expression of wild-type NALCN, sugg

131 ead mutants for each of these 3 TRP isoforms nearly abolished the flow-induced cation currents and Ca

132 ens to mouse skin before each UV irradiation nearly abolished the frequency of p53 mutations.

133 conserved GTP-binding motif of HypB (Lys59) nearly abolished the GTPase activity of the mutant prote

134 98059 for postoperative days 1-4 reduced and nearly abolished the initial GT upregulation in CCI rats

135 reas the combined application of both toxins nearly abolished the modulation.

136 Blockade of AMPA receptors nearly abolished the orthodromic component of the respon

137 Further addition of L-NA nearly abolished the relaxation response in the LM, but

138 BMS-200150 at 40 microm nearly abolished the secretion of endogenous apoB100-con

139 On the other hand, increasing the [Mg2+]i nearly abolished the stimulatory pressure effect.

140 ibition (10 micromol/L Y27632), in contrast, nearly abolished the sustained force but had a lesser ef

141 , a blocker of store-operated Ca2+ channels, nearly abolished the thapsigargin-induced rise in [Ca2+]

142 contrast, moderate activating mutation A456V nearly abolishes the GKRP inhibition (76-fold increase i

143 of the Ang II substrate in this brain region nearly abolishes the pressor and bradycardic effects of

144 s1, a member of the Ste20 family of kinases, nearly abolishes the sporulation-associated H4 S1ph modi

145 of a construct containing a PIP2 phosphatase nearly abolished them.

146 Acinar cells are nearly abolished through apoptosis by 100 hpf, though ne

147 odeling, while deletion of the TATA box that nearly abolishes transcription is permissive to 5'-end r

148 base pairs in the center of the dT-dA tract nearly abolishes transcription of snr6-Delta42, yet inve

149 siRNA knockdown (in BJ fibroblasts) of iNOS nearly abolished transdifferentiation, an effect that co

150 A disease-related TSC2 mutation (Y1571H) nearly abolished tuberin phosphorylation when stimulated

151 ckpoint blockade), and combination treatment nearly abolished tumor outgrowth.

152 -O-tetradecanoylphorbol-13-acetate treatment nearly abolished UVA-induced ERK and Ras activation.

153 the HLA-B27 anchor residue, R(2937) , which nearly abolished viral replication.

154 elongation is what matters, reinitiation was nearly abolished when a pseudoknot that causes a pause i

155 F(CFP)) by 21.5 +/- 4.1% (n = 13), an effect nearly abolished when co-expressing excess phospholemman

156 gonist AP-7, glutamate-dependent current was nearly abolished when high Ca2+ was substituted for high

157 , hVAChT expression on synaptic vesicles was nearly abolished when the hVMAT2 cytoplasmic tail was pr

158 inhibition of ENaC by hNedd4; inhibition was nearly abolished when WW domain 3 was mutated.

159 ols is blocked, norepinephrine secretion was nearly abolished whereas glutamate and GABA release was

160 Hepatic portal ascorbate accumulation was nearly abolished, whereas intestinal absorption was marg

161 (hypercapnia), postinspiratory discharge was nearly abolished, whereas laryngeal inspiratory discharg

162 of the DnaK T199A and DnaK K70A proteins are nearly abolished, while the ATPase activity of the DnaK

163 with F956A or F967A, reduced with L964A, and nearly abolished with E960A.

164 This effect was nearly abolished with fmgBC DNA fragments having a mutat

165 NAME (24 +/- 2%; P = 0.002 from l-NAME), and nearly abolished with l-NAME + TEA (13 +/- 2%; P = 0.001

166 e normalized protein density of Ca(V)2.3 was nearly abolished with the quadruple Ca(V)beta3 Leu mutan

167 Synaptic transmission is nearly abolished, with residual transmission delayed, hi

168 Of interest, Rga7 localization is nearly abolished without Rng10.