ライフサイエンスコーパス: necdin

1 ced in activated HSCs, is a direct target of necdin.

2 m23-H1 as well as the biological function of Necdin.

3 ic and antiproliferative effects mediated by Necdin.

4 confirmed by overexpression of ectopic Flag-necdin.

5 inted expression and methylation patterns of necdin, a gene outside the deletion region, indicate tha

6 Necdin, a melanoma antigen family protein, promotes neur

7 d method, we found that pre-IL-1 alpha binds necdin, a nuclear protein with growth suppressor activit

8 Furthermore, overexpression of necdin activates GnRH transcription through cis elements

9 These data suggest that changes in necdin and E2F4 expression after rosiglitazone exposure

10 whereas the transcriptionally inactive loci necdin and MyoD1 contained very little H3-meK79.

11 rmal HSCs, demonstrating the similar role of necdin and p53 in promoting HSC quiescence during steady

12 own in activated HSCs, causes suppression of necdin and Wnt, epigenetic derepression of Ppargamma, an

13 roduction of SSc fibroblasts through binding necdin, and by counteracting its effects on cell growth

14 brain development (e.g., Dlk1, Peg3, Ube3a, necdin, and Grb10).

15 matopoietic stem cells (HSCs) and identified necdin as a candidate p53 target gene.

16 Here we identify necdin as a potent PGC-1alpha stabilizer that promotes m

17 could change the subcellular localization of Necdin as well as rescue cells from the antiangiogenic a

18 the region of pre-IL-1 alpha responsible for necdin binding and found it to be localized near the N t

19 nRH transcription through these elements and necdin co-immunoprecipitates with Msx from GnRH neuronal

20 Necdin controls the HSC response to genotoxic stress via

21 The Necdin-deficient mouse is the only model that reproduces

22 Here, we report that Necdin deletion disturbs the migration of serotonin (5-H

23 We also show that Necdin directly interacts with Nm23-H1, resulting in mod

24 ogether, these results indicate that lack of necdin during development likely contributes to the hypo

25 Forced expression of necdin enhances mitochondrial function in primary cortic

26 promoter of the GnRH gene, and knock-down of necdin expression reduces GnRH gene expression.

27 tes with rosiglitazone did not alter E2F4 or necdin, expression of both genes was significantly alter

28 We conclude that necdin functions as a molecular switch in adult hematopo

29 Adult mice lacking necdin have reduced numbers of gonadotropin-releasing ho

30 To define the intrinsic role of necdin in adult hematopoiesis, in the present study, we

31 A3C can modulate the biological functions of Necdin in the context of EBV infection and transformatio

32 nstrated that pre-IL-1 alpha associates with necdin in the nuclei of mammalian cell lines and regulat

33 These studies suggest a role for Necdin in the regulation of downstream cellular targets

34 Moreover, overexpression of necdin in the substantia nigra in vivo of adult mice pro

35 Furthermore, Necdin is a cellular protein which is highly induced in

36 Necdin is a growth-suppressing protein and the gene enco

37 Finally, necdin is necessary for generation of the full complemen

38 Herein, we show that, although necdin is not expressed in an immature, migratory GnRH n

39 The present study demonstrates that necdin is selectively expressed in HSCs among different

40 ctivity is sufficient to cause the apneas in Necdin-KO pups, and that fluoxetine may offer therapeuti

41 In Necdin-KO pups, the genetic deletion of Slc6a4 or treatm

42 NDN gene, encoding the MAGE family protein, necdin, maps to the PWS chromosome region and is highly

43 sx from GnRH neuronal cells, indicating that necdin may activate GnRH gene expression by preventing r

44 endothelial growth factor promoter but also Necdin-mediated growth suppression and antiangiogenic ef

45 A3C and Nm23-H1 were able to rescue not only Necdin-mediated transcriptional repression of the downst

46 We show that necdin-null adult HSCs are less quiescent and more proli

47 specific proteins decreases significantly in necdin-null cortical neurons, where mitochondrial functi

48 iesis, in the present study, we transplanted necdin-null fetal liver cells into lethally irradiated r

49 wever, wild-type recipients repopulated with necdin-null hematopoietic stem/progenitor cells show enh

50 Moreover, necdin overexpression potently inhibited adipocyte diffe

51 These data reveal that necdin promotes mitochondrial biogenesis through stabili

52 rapamycin, mitogen-activated protein kinase, necdin, reactive oxygen species, and sphingolipids.

53 d NDN (which encodes the DNA-binding protein necdin; refs 7,8,9,10).

54 In fact, overexpression of Necdin relieves Msx repression of GnRH transcription thr

55 Necdin silencing abrogates three epigenetic signatures i

56 Necdin strongly stabilizes PGC-1alpha by inhibiting its

57 ld in muscle and 2.5-fold in adipose tissue; necdin was identified in adipose tissue only and increas

58 The levels of Necdin were consistently lower in EBV-positive cells, an

59 nscription factors E2F4 and the MAGE protein necdin were similarly altered in all subjects after rosi

60 ed through amino acid residues 191 to 222 of Necdin, which are also known to be important for nuclear

61 urotrophin receptor-dependent apoptosis, and necdin, which is a strong suppressor of cell proliferati

62 h suppressors, such as the Prader-Willi gene NECDIN, whose function was confirmed by overexpression o

63 Silencing of necdin with adenovirally expressed shRNA, reverses activ

64 dedifferentiation of adipocytes as such the necdin-Wnt pathway causes epigenetic repression of the m

65 Our results demonstrate a novel necdin-Wnt pathway, which serves to mediate antiadipogen