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1 or SE therapy and diagnosis is important and necessary.
2 ing behavior to adjust task performance when necessary.
3 emic control and therefore new therapies are necessary.
4 quence variation elsewhere in the protein is necessary.
5 apid, yet inexpensive, on-site monitoring is necessary.
6 and are of low cost, are becoming even more necessary.
7 works suggests that full coverage may not be necessary.
8 ssion level, detailed anatomical studies are necessary.
9 s that contain special adhesive monomers are necessary.
10 eir mechanical response to dynamic strain is necessary.
11 plexity of the lignin structure also impedes necessary and decisive information to understand the rea
13 ochromatin, dephosphorylates H3S28 and it is necessary and sufficient for heterochromatin protein 1 b
14 TA-binding protein (TBP) subunit of TFIID is necessary and sufficient for in vitro transcription, the
16 nditioning, and cAMP signaling molecules are necessary and sufficient for normal memory in intrinsic
18 monstrate that mTORC1-regulated autophagy is necessary and sufficient for starvation-induced LD bioge
19 ACAP, and BNST PACAP receptor activation was necessary and sufficient for stress-induced reinstatemen
20 the oxidized sterol, ergosterol peroxide, is necessary and sufficient for Vms1 localization to mitoch
21 tween Xist RNA and Lamin B receptor (LBR) is necessary and sufficient for Xist spreading during X-chr
23 thesized that the conserved motif could be a necessary and sufficient minimal motif for translocation
24 40 via threonine 246 phosphorylation is both necessary and sufficient to cause exosome secretion with
25 family of helix-loop-helix proteins is both necessary and sufficient to direct cardiac mesoderm form
26 d in vivo targeting assays show that SecA is necessary and sufficient to direct the targeting and tra
28 We show that similar developmental stress is necessary and sufficient to extend Drosophila lifespan,
29 n conjunction with environmental cystine, is necessary and sufficient to increase glutamine catabolis
30 lasm and phosphorylates POS-1, which is both necessary and sufficient to increase POS-1 mobility.
33 n unstructured N-terminal region of Tim10 is necessary and sufficient to target the substrate to the
34 results show that a minimum level of grip is necessary before the upper limb plays an active role in
35 OS, whose expression is ZHOUPI dependent, is necessary both for the formation of a normal embryo shea
36 to get rid of components that are no longer necessary but might continue to exert their effects on r
37 Improving quality of medical care may be necessary, but not sufficient, to improve the full range
39 tion, and the transcription factor PqsR is a necessary component in the P. aeruginosa cell-to-cell si
42 value to each state, together capturing the necessary components for successful intertemporal choice
43 need to compile into discrete gate sets, the necessary computations can be performed in reasonable ti
45 tion, whose realistic reproduction appears a necessary condition for the onset of a convection collap
46 of declarative memory: Temporal binding is a necessary condition for the relational organization of d
51 nerate new propagons, the molecular entities necessary for [PSI(+) ] propagation in dividing cells an
58 leptomeningeal metastatic models and proved necessary for cancer growth within the leptomeningeal sp
59 We found that Ca(2+) influx through TRPV1 is necessary for capsaicin-induced ablation of nociceptive
60 nt on the C. elegans PINK1 homolog, which is necessary for cellular resistance to chronic malfunction
62 maged tissues upon acute sterile injuries is necessary for clearance of necrotic debris and for coord
63 ocytic response and elevation of Trem2, both necessary for clearing damaged myelin, were markedly red
65 d five upstream adenylates, and H4a/Psi3 was necessary for cooperative association of two other hairp
66 vide evidence that the mPFC-->NAc pathway is necessary for cue-induced reinstatement of alcohol seeki
68 hat, unlike the axolotl, Pax3 is present and necessary for development and that contrary to mammals,
69 ndesired effect on lactic bacteria which are necessary for development of aroma and chemical properti
70 Finally, although serum exposure was not necessary for drusen formation, COL4 accumulation in ECM
71 her, this work identifies Actr10 as a factor necessary for dynactin-mitochondria interaction, enhanci
73 gene transcription, while glutaminolysis is necessary for early gene translation but not transcripti
75 egulator of the cellular ESCRT machinery, is necessary for efficient entry and egress of Autographa c
76 ar metabolic profiling revealed that PknG is necessary for efficient metabolic adaptation during hypo
80 ortholog of the plant protein Ycf4, which is necessary for expression of proteins of the photosynthet
81 homozygous variants in WNT7A and SMARCA4 are necessary for expression of TH and selection against the
82 werful, the process of tissue homogenization necessary for flow cytometry analysis introduces bias an
83 both S1-S2 and S3-S4 of NaV channels may be necessary for functional modulation, and that targeting
84 mechanisms that control the plant processes necessary for fungal colonisation and arbuscule developm
85 e positive charge of the lysine residues was necessary for fusion regulation, as alanine substitution
86 that sensory neurons express major proteins necessary for GABA synthesis and release and that sensor
88 in this study that mitochondrial fission is necessary for glucose-stimulated insulin secretion in mo
89 gest that therapeutic anticoagulation is not necessary for grade 1 and 2 arterial and grade 1 venous
90 ross talk between microbes and host cells is necessary for health, survival, and regulation of physio
91 yocytes (CMs) generate the mechanical output necessary for heart function through contractile mechani
92 repopulation ability, indicating that Erf is necessary for hematopoietic stem cell maintenance or dif
93 n, and IL-33-driven mast cell activation are necessary for induction of type 2 immunopathology and as
96 phosphorylation and nuclear localization are necessary for its role in promoting BRCA1 recruitment.
97 , Nedd8 binding site in Smurf is shown to be necessary for its ubiquitin ligase activity towards the
98 , and RNAs present at active centromeres are necessary for kinetochore assembly and cell-cycle progre
101 is a conserved Rhadinovirus protein that is necessary for long-term chronic infection by these virus
102 l stem cell quiescence and exhaustion and is necessary for long-term maintenance of the mammary gland
103 s key to the alteration of synaptic strength necessary for long-term potentiation, learning, and memo
105 tantly, dose adjustments for tacrolimus were necessary for maintaining sufficient trough levels.
106 priate methods of post-harvest treatment are necessary for maintaining these bioactive phytochemicals
108 gulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and ide
112 cell cycle regulators and that the KDM5s are necessary for mitotic clonal expansion in 3T3-L1 cells,
114 y Purkinje cells with contextual information necessary for motor learning, but how they encode this i
117 abolic labeling, we found that TbPSS2 (i) is necessary for normal growth of procyclic trypanosomes, (
120 lse-labeling experiments showed that RAD6 is necessary for overcoming cisplatin-induced replication f
124 Ezrin links CFTR and TLR4 signaling, and is necessary for PI3K/AKT signaling induction in response t
127 nd a minimal fusogenic peptide motif that is necessary for promoting cell-cell fusion with myomaker.
128 dicate that Tcf1-beta-catenin interaction is necessary for promoting thymocyte survival to maintain t
129 ate time and location in polarizing cells is necessary for proper establishment of epithelial polarit
130 found that miR-155 expression by T cells is necessary for proper tumor-associated macrophage express
132 FSS expressed higher levels of key proteins necessary for PT function, including ion transporters, r
138 S hot spots and the plasmonic nanostructures necessary for SM detection, the past and current methodo
140 ic T lymphocytes upon antigen stimulation is necessary for successful antiviral, and antitumor immune
142 three core multivalent molecular components necessary for such assembly: specific RNA molecules that
143 h an abundance of virulence factors that are necessary for survival within a host, including the prod
144 rotein affecting channel kinetics of AMPARs, necessary for synaptic hippocampal plasticity, and memor
145 nits, largely dispensable early in life, are necessary for terminating contraction (systole) in aged
148 role in chloroplast redox regulation, being necessary for the activity of diverse Trxs with unrelate
150 s sufficient but does not show whether it is necessary for the effects of exogenous GLP-1R agonists (
151 vergence of sponges and eumetazoans, and was necessary for the evolution of animal multicellularity.
153 ial fluctuations in outcomes, whereas BLA is necessary for the facilitation of learning in response t
154 in which Bmpr1a signaling in chondrocytes is necessary for the formation of a pool or niche of osteop
156 pid transporter activity of ALA1/ALA2 may be necessary for the formation of similar invaginations for
157 se promotes the complete disassembly of MCC, necessary for the inactivation of the mitotic checkpoint
158 pression and/or repression of genes that are necessary for the initiation of gametocyte development i
159 not GATOR2, to the lysosomal surface; and is necessary for the interaction of GATOR1 with its substra
161 tionships in fitness-related traits, (3) are necessary for the maintenance of sexual dimorphism, (4)
162 changes, and stimuli-response behaviors, is necessary for the most basic functions of life, and over
163 ur data indicate that O-glycosylation is not necessary for the natural replication cycle of HIV and S
164 umour suppressor has long been recognised as necessary for the pathogenesis of clear cell renal cance
166 f these activities are generally accepted as necessary for the provision of quality care, but have no
167 sting that the enzymatic activity of PARN is necessary for the release of 18S-E from Bystin-associate
168 lmacher et al. (2017) show that autophagy is necessary for the release of free fatty acids from intra
169 and cell composition prior to the injury is necessary for the repair macrophage phenotypic transitio
170 Thus, the expression of Ifnlr1 by IECs is necessary for the response to both endogenous and exogen
171 ndoplasmic reticulum (ER) and peroxisomes is necessary for the synthesis and catabolism of lipids, th
173 ck channel expression at the DRG membrane is necessary for their characteristic firing accommodation
176 urons is endowed with specific cdhr proteins necessary for these cells to reach the developing AC.
179 Cadherin-mediated homophilic adhesion is necessary for trans-endocytosis, and adhesive junctional
180 scribed genes, the reshaping of DNA topology necessary for transcription process stimulates secondary
181 enic cell lines implicated variants in genes necessary for transcriptional regulation and function of
182 uclear cluster transcription factor CLR-1 is necessary for utilization of cellulose, a major, recalci
185 nge to the maintenance of cellular functions necessary for viral replication if continuous protein sy
188 taste perception modification, and point to necessary future directed sensory experiments needed to
189 ps in our knowledge, and make suggestions on necessary future studies to optimize organ transplantati
194 ide latitudinal and altitudinal gradients is necessary in order to gain a better understanding of pla
195 variability in climatic and biotic shifts is necessary in order to properly describe biodiversity res
196 abeled metabolites measured in two media are necessary: in a minimal medium containing only derivatiz
197 otoreceptors in the honey bee allows for the necessary input for an optimal color constancy solution
198 generation within soils and sediments is the necessary interaction of two low-solubility phases-Cr(II
199 f human cardiac progenitor cells (hCPCs) are necessary interventions to rejuvenate aged/diseased cell
200 tions include administration of oral and, as necessary, intravenous hydration; systematic monitoring
201 well (QW) has been developed to clarify the necessary means to achieve device quantum efficiency hig
204 ested that Afh mutants failed to exhibit the necessary phenotypic plasticity for adapting to temporal
206 during the care of diabetic retinopathy is a necessary precursor to fully understanding the underlyin
207 ng the robustness of these methods, which is necessary prior to use in drug development and regenerat
209 e for this conserved domain in providing the necessary stability to the envelope glycoprotein in orde
211 an inner-sphere adsorption complex may be a necessary step for the redox transformation via catalyti
213 however, ring-strain release can provide the necessary thermodynamic driving force to make such proce
214 , inactivation of both phoP and Sant_4061 is necessary to abrogate growth of this bacterium in an ins
217 Further development and improvement are necessary to achieve the ideal of a noninvasive image-ba
219 actors, synergy between multiple pathways is necessary to activate all the transcription factors nece
221 stablishing a timeline for GRN evolution, is necessary to answer questions about the rate at which GR
223 erstanding the fate and transport of DNAN is necessary to assess the risk it may represent to groundw
224 ankton species and microbial biodiversity is necessary to assess water ecosystem health and the quali
225 ing structural controllability theory, it is necessary to balance the number of driver nodes and cont
226 rvational or experimental data, is therefore necessary to better understand observed cyclical pattern
227 developing immunomodulatory therapies, it is necessary to better understand the timing and complexity
229 ons mediate word and face recognition, it is necessary to characterize how stimuli are represented an
231 tion, however two samples of paired sera are necessary to confirm the diagnosis, since using only one
232 knockdown resistance in An. funestus, it is necessary to continue to monitor the contribution of the
233 mprehensive study of individual mutations is necessary to create a realistic picture of the evolution
235 ral differences in intestinal microbiota are necessary to define applicability of new strategies targ
236 chanisms of cooperative ligand binding it is necessary to define at a microscopic level the structura
241 ts and 83% of drug-resistant patients, it is necessary to develop a better understanding of where pat
242 oaccumulation in fish and seafood, making it necessary to develop methodologies to evaluate these com
245 ut this method lacks the temporal resolution necessary to distinguish pre- from poststimulus processe
248 as well as the standardization of parameters necessary to ensure valid comparisons between different
250 te that is, nonetheless, both sufficient and necessary to explain the speed of pCPI-17 dephosphorylat
251 losonate (Kdo)-lipid A domain in E. coli was necessary to facilitate chemical structure analysis and
253 ures below 233 K (-40 degrees C), conditions necessary to form cirrus clouds in the Earth's atmospher
254 ut for the chemical kinetic modeling that is necessary to fully extract physics from the observationa
256 stic target of rapamycin (mTOR) signaling is necessary to generate a mechanically induced increase in
257 m improve reproductive outcomes in women are necessary to guide public health policy for this emergin
258 esis in TBMs, and provides the critical data necessary to improve our ability to project the response
259 ir surrounding surface topographies, will be necessary to improve the yield of single quantum dot nan
260 umor activity from loss of self-tolerance is necessary to increase the therapeutic efficacy of checkp
261 otons, a fluence of 10(16) protons/cm(2) was necessary to induce a significant charge transfer from S
262 we demonstrate that the N terminus of E3 is necessary to inhibit an IFN-primed virus-induced necropt
265 cal association, so functional validation is necessary to make strong claims about gene function.
268 ablish that complete structural integrity is necessary to observe single-molecule fluorescence of GFP
269 in both the excited and the ground states is necessary to obtain a photocontrolled system rather than
271 of self-renewing cancer stem cells (CSCs) is necessary to permanently eradicate malignant tissues.
274 rocesses and microbial community dynamics is necessary to predict microbial response to perturbation.
275 will spark the cross-disciplinary discussion necessary to produce a cognitively plausible model of li
276 ities that provide a therapeutic level of NO necessary to promote angiogenesis and to protect ECs aga
277 first time that both eIF2alphaP and ATF4 are necessary to promote erythroid differentiation and to re
280 date pathogen actually causes disease, it is necessary to provide additional evidence of causality.
282 al but that additional constraints are still necessary to recover the observed growth rate distributi
283 ntify HSCs from in vitro sources, it will be necessary to refine markers of HSCs matured ex vivo.
284 As more RGENs become available, it will be necessary to refine their activity before they can be tr
286 fragments, but multiple ligations, which are necessary to segmentally label proteins of more than two
288 vation efforts to protect intact forests are necessary to slow deforestation rates and to avert a new
290 me with minimal or no instrumentation, it is necessary to streamline unit operations and store reagen
291 medical outcomes after live kidney donation necessary to support donor candidates in well informed d
292 oal of this strategy is to generate the data necessary to support US Food and Drug Administration cle
293 influx via plasma membrane channels is also necessary to sustain the oscillations over longer times.
296 ng that EGL-1 activity reaches the threshold necessary to trigger death only in daughter cells that a
298 on observed in humans, and that EVHP appears necessary to unmask distinguishing features of severely
299 fferent connected reactions; it is therefore necessary to use mathematical models for holistic studie
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