ライフサイエンスコーパス: necessity

1 e findings on the wider society has become a necessity.

2 ship practices are growing in popularity and necessity.

3 ation of noninvasive analytical methods is a necessity.

4 itors to treat this devastating disease is a necessity.

5 ous levels and spatiotemporal distribution a necessity.

6 negative tuberculosis, from LTBI is a great necessity.

7 rding DNA enrichment efficiency and antibody necessity.

8 and discovery of new therapies is a pressing necessity.

9 , adrenaline auto-injector prescription is a necessity.

10 ogression, withdrawal of consent, or medical necessity.

11 gh throughput and reproducible evaluations a necessity.

12 moneduloides), use tools depending on their necessity.

13 In a reverse approach, eliminations of these necessities allow the modified oleosin to enter the ER l

14 To obviate the necessity and complexity of conjugating two macromolecul

15 uestioned on the basis of eventual treatment necessity and concerns of safety; however, the role of a

16 wn bodies, we are discovering the unexpected necessity and daunting complexity of our microbial partn

17 To establish the necessity and function of RLPFC in this task, participan

18 h neural manipulations that allow testing of necessity and sufficiency claims.

19 These results demonstrate the necessity and sufficiency of cortical activity for enact

20 future studies are needed to demonstrate the necessity and sufficiency of these potential drivers of

21 no current evidence-based guidelines on its necessity and use for periodontal treatment planning.

22 , hypertension and hypercholesterolemia is a necessity as those risk factors frequently occur in comb

23 e likely to be doing an activity of economic necessity at the time of injury.

24 Neither medication necessity (beta = 0.044; P = .138) nor illness beliefs (

25 cedural preparedness were based on practical necessities, but comparative evidence was not identified

26 f balancing varied electronic and structural necessities can be an important route to further develop

27 This complexity emphasizes the necessity cell-type specific genetic approaches towards

28 y in patient tumors, the autophagy is not of necessity cytoprotective in function.

29 mice but also in WT mice, highlighting their necessity during nerve degeneration in the peripheral ne

30 Because a solar absorber by necessity faces the sky, it also naturally has radiative

31 The irrigation necessities for grapefruit production are very high.

32 small molecules into cells and point to the necessity for a more complex model.

33 us functional misannotation and supports the necessity for a reclassification of these enzymes under

34 is segment with the beta subunit explain the necessity for a second highly conserved His residue with

35 is facing multiple challenges including the necessity for a substantial increase in production to me

36 We reveal an independent necessity for active-beta-catenin in the fusion and diff

37 x differences in disease susceptibility, the necessity for adjuvants in experimental animal models, a

38 The necessity for an accurate, but at the same time, inexpen

39 Despite their necessity for Bcl11b expression, these inputs act in a s

40 een developed are examined, highlighting the necessity for better data to parameterise and fit these

41 These data emphasize the necessity for biopsy at the first recurrence of FL.

42 The necessity for bone marrow aspiration and the lack of hig

43 ing each of these pathways and testing their necessity for both extinction and relapse.

44 ular cysteine pairs in CSF3R and suggest the necessity for broader screening of CSF3R extracellular d

45 n common but may differ in the source of and necessity for Ca(2+) to trigger release and in the ident

46 Our findings highlight the necessity for careful upfront cellular enrichment in bio

47 The necessity for changes in allocation in response to chang

48 We highlight the necessity for consideration of alternative (e.g., hybrid

49 ariable changes that we report highlight the necessity for considering local factors such as topograp

50 ll- and large-scale laboratories suggest the necessity for continued microbiology-based understanding

51 This study emphasizes the necessity for declaration of funding source.

52 This study highlights the necessity for developing a parameterization of dust IRI

53 uitment of the 43S complex and alleviate the necessity for direct eIF4G/eIF3 interaction.

54 remotely gates the Orai1 channel without the necessity for direct STIM1 contact with the pore-forming

55 ns at such high frequencies, notably with no necessity for doping.

56 d by chromatin-remodeling factors, and their necessity for efficient DDR has recently been demonstrat

57 This highlights the necessity for efficient glutamate clearance from these r

58 Growing necessity for efficient nuclear waste management is a dr

59 ing such miniband conduction properties is a necessity for engineering novel transport behaviors in s

60 udies with prevalent exposures will remain a necessity for epidemiology.

61 xibility of the filter that demonstrates the necessity for extended simulations to study conduction i

62 oninnocent NO ligand in electron uptake, the necessity for Fe'-S bond breaking (or the hemilability o

63 sts that simple, symmetric linkers are not a necessity for formation of crystalline extended structur

64 growth in recent decades, thus implying the necessity for further investigations on both the interna

65 This study highlights the necessity for further research focused on recurrence pre

66 similarity, and it probably results from the necessity for fusion to occur to establish the primary p

67 rehensive 2D gas chromatography (GCxGC): the necessity for individual compounds to be chromatographic

68 enges for any future hydrogen economy is the necessity for large scale hydrogen production not involv

69 f the guide-specific approach highlights the necessity for meticulous guide design and assessment, as

70 l in treating hepatocellular carcinomas, the necessity for multiple treatments, injection of large fl

71 nt discontinuation with current therapy, the necessity for new therapies targeting CML stem cells to

72 Overall, our results highlight the necessity for open data sharing to provide a more solid

73 sence of this bond in the aggregates and its necessity for oxidative aggregation under physiological

74 ration of the samples isolated; and (iii) no necessity for postsynthesis purification.

75 of an effective HIV vaccine remains a global necessity for preventing HIV infection and reducing the

76 g target for sensitive detection without the necessity for prior in vitro amplification.

77 dministration has limitations, including the necessity for purification and multiple injections for e

78 ic fracture, spinal cord compression, or the necessity for radiation or surgery to bone metastasis ca

79 take into account specific goals of therapy, necessity for rapid disease control, risk of treatment-r

80 rting and cloning methods by eliminating the necessity for repetitive purification steps and increasi

81 This supports the necessity for semantic cognition in internal processes o

82 inhibition of glial TLR4 and illustrate the necessity for sex-specific research and individualized t

83 PR2 dependency for chemokine release and the necessity for signal transducer and activator of transcr

84 he development of new therapies, such as the necessity for spatial and temporal control in neural rep

85 Landscape change is not a necessity for speciation in this model.

86 human pathogenic bacteria has increased the necessity for the discovery of novel, yet unexplored ant

87 Here we address catalytic necessity for the first time, using the prototypic inver

88 tions, leading to price fluctuations and the necessity for the industry to find high quality cocoa bu

89 ior neuraminidase treatment highlighting the necessity for the presence of available acceptors with t

90 collection efficiencies of ion chambers is a necessity for the proper evaluation of radiation quantit

91 Access to high-quality antibodies is a necessity for the study of histones and their posttransl

92 o and nano resonators has become an imminent necessity for their successful implementation in practic

93 However, the necessity for translation of genetic changes restricts t

94 sterior ROP (kappa = 0.35); moderate for the necessity for treatment (kappa = 0.41); and fair for the

95 sterior ROP (kappa = 0.60), moderate for the necessity for treatment (kappa = 0.47), and substantial

96 sease, presence of aggressive posterior ROP, necessity for treatment, and suggested treatment.

97 or aggressive posterior ROP, and 25% for the necessity for treatment.

98 ow that B7 deprivation in mice overrides the necessity for Tregs in averting systemic autoimmunity an

99 The results showed the necessity for using samples with an original concentrati

100 network structure from small sample sizes, a necessity given the technical difficulty inherent in sim

101 wever, evidence supporting its physiological necessity has only just started to emerge.

102 val of particles before measurement, often a necessity in point of care diagnostics.

103 the scans were obtained without any medical necessity (indication 12).

104 28) when the scans were obtained for medical necessities (indications 1-11), and in 5.6% of the scans

105 s show that, although MADS box ripening gene necessity is conserved across diverse taxa (monocots to

106 Nervous systems (by necessity) may be most specifically adapted among biolog

107 hibald Garrod noted in 1931 that, "It is, of necessity, no easy matter to distinguish between immunit

108 The necessities of developing fast, portable, cheap and easy

109 assemblage of aaRSs oligomers that meet the necessities of the cell in each situation.

110 select the most optimal test indicating the necessity of a bone marrow biopsy in ISM-suspected patie

111 water analyzed on a CRDS instrument and the necessity of a correction procedure.

112 ity or local tissue hypoxia, pointing to the necessity of a functional brain oxygen sensor.

113 In accordance with the necessity of a GEF to promote GTP-binding and nuclear ex

114 studies using active site mutants reveal the necessity of a hexamer form with high alpha helical cont

115 ications are so far severely hampered by the necessity of a metallic surface to catalyze the reaction

116 without a negative charge, demonstrating the necessity of a negatively charged headgroup interaction

117 owth and Form, D'Arcy Thompson discussed the necessity of a physical and mathematical approach to und

118 rtant to anion specificity, most notably the necessity of a positive charge near the end of TMH1 in t

119 re used as the multivariate data without the necessity of a spatial array.

120 s in the presence of TBAF in DMF without the necessity of adding any ligands or additives to give 5-a

121 nestrations of the intimal flap per patient, necessity of additional aortic stent-graft implantation

122 emiological data and modelling underline the necessity of addressing latent tuberculosis infection if

123 The necessity of advanced techniques to maintain technical s

124 advantages of cumulative research; (ii) the necessity of aligning projects with research priorities;

125 Although the necessity of amygdala bdnf expression and TrkB activatio

126 Our work demonstrates the necessity of an intact cAMP-PDE4-PKA-LIMK-cofilin activa

127 This interface eliminates the necessity of an iterative layer-by-layer process, allowi

128 Our results indicate the necessity of antibiotics monitoring in bovine urine befo

129 The necessity of ascertaining actual facility capability and

130 Specifically, after first confirming the necessity of auditory cortical activity for fear learnin

131 outbreak by diverse EV-D68 strains, and the necessity of awareness and more surveillance on their ac

132 tralizing antibody was performed to test the necessity of BDNF release in driving scopolamine-induced

133 discussed, and a case is put forward for the necessity of biotechnological production methods such as

134 ical examination and Doppler ultrasound, the necessity of both MRI, MR angiography and intracavernosa

135 These observations reveal the necessity of building disease-specific classifiers that

136 quiring substantial user interaction and the necessity of building intuition, all of which are time a

137 onally, Kang et al. (2011) show the specific necessity of CD4+ T cells for immunoclearance of senesce

138 a more nuanced interaction that includes the necessity of cellular tumor suppressors for efficient vi

139 nce of even a few mutations demonstrates the necessity of clone screening during process development.

140 es accessible in high yields and without the necessity of column chromatography purification.

141 f Mendelian origins, whilst highlighting the necessity of complete mitochondrial genome sequencing in

142 We discuss the necessity of complex, codependent plasticity mechanisms

143 racteristics of UHI effect and emphasize the necessity of considering city- and time-specific FP when

144 This study shows the necessity of considering epistatic effects in soybean SD

145 etween young and old samples, suggesting the necessity of considering the age effects for personalize

146 fierce public and political disputes on the necessity of controlling badgers to limit the spread of

147 particle refractivity indices, delineate the necessity of creating a calibration curve to adjust the

148 Group-level traits (GLTs) clarify the necessity of cultural multilevel selection theory.

149 Perioperative necessity of deep sedation is inevitably associated with

150 f the Ad5 receptor in vivo and emphasize the necessity of demonstrating the nature of the receptor by

151 These findings highlight the necessity of developing guidelines and policies that con

152 of pediatric POC ultrasound, as well as the necessity of diverse research efforts, including the est

153 utilize the splicing machinery to bypass the necessity of Drosha cleavage for their biogenesis.

154 g a tonal language, the results point to the necessity of early intervention for the individuals with

155 supporting declarative memory to assess the necessity of early memory to the later life development

156 ecific stable isotope analysis (CSIA) is the necessity of efficient sample treatment methods, allowin

157 The present findings highlight the necessity of ELMO2 for maintaining vascular integrity, s

158 The necessity of entanglement is re-affirmed in the stronger

159 int application, these results highlight the necessity of establishing combinatorial analytical appro

160 This elegant model demonstrates the necessity of feedforward and feedback interactions betwe

161 r studying complex biomolecular systems, the necessity of flexible and easy-to-use software tools for

162 ." Yet, remarkably little is known about the necessity of frontal sub-regions for such control.

163 and shortens the egg, which demonstrates the necessity of GC growth for elongation.

164 The necessity of GlcN acetylation and the presence of a sing

165 The results reveal the necessity of having the PEGylated lipids present during

166 However, the necessity of having to conduct multiple experiments to t

167 ord (+)-chloriolide in 65% yield without the necessity of high-dilution conditions.

168 As the functional necessity of hippocampal CA2 for social memory processin

169 le application of movement restrictions, and necessity of humanitarian support services to meet noncl

170 The control molecular study revealed the necessity of hydroxy quinoline and the amine group for L

171 nteractions, and point to the difficulty and necessity of identifying the patients at risk.

172 es in decoding AS patterns, highlighting the necessity of including the epigenetic properties when as

173 m the literature and further demonstrate the necessity of incorporating RNA tertiary structural infor

174 Mechanistically, our data reveal the necessity of inducible T-cell costimulator (ICOS)-ICOS l

175 ALDI) MSI, no study has so far addressed the necessity of instrumental mass resolving power in terms

176 These data prove the necessity of intact MTORC1 signaling to regulate two syn

177 sion into one effective value eliminates the necessity of integration over the primary beam energy ra

178 in AA TNBC patients, potentially due to the necessity of KIFC1 for migration in AA TNBC cells.

179 s of simplicity, cost-effectiveness, limited necessity of laboratory infrastructure and skilled perso

180 professional roles encompassed the perceived necessity of legal safeguards to determine legitimacy of

181 raft acceptance and (ideally) circumvent the necessity of lifelong immunosuppression.

182 Obesity is increasing, yet despite the necessity of maintaining muscle mass and function with a

183 However, the necessity of MASP-3 for pro-FD cleavage has been questio

184 Our results underline the necessity of measures targeted at specific vulnerable gr

185 Perceived necessity of medication, perceived impact of transplant

186 However, the functional necessity of minus-end-directed movement along actin is

187 Our collective results support the necessity of MMP-9-dependent H3NT proteolysis in regulat

188 ty pattern for plants exposed to Ag-NPs, the necessity of monitoring several markers to accurately ev

189 rthquake cause, our research underscores the necessity of monitoring subsurface wastewater formation

190 high aerosol concentrations and implies the necessity of MSE localization for extinction apportionme

191 Little is known about the necessity of multiple same-day intraocular pressure (IOP

192 The necessity of neuronal dystroglycan for functional innerv

193 conditions (60 degrees C, pH 2.0), avoiding necessity of neutralizing sample prior to injection in H

194 Motivated by the necessity of new and efficient methods for dietary glute

195 portance of assembly quality, suggesting the necessity of new technologies to comprehensively map eth

196 However, the necessity of NLGN3 for glioma growth, the proteolytic me

197 sistance to existing antimalarials makes the necessity of novel avenues to treat this disease an urge

198 rly and evolving MS lesions, and suggest the necessity of ongoing studies of the mechanisms underlyin

199 rrence of post-transplant complications, the necessity of operative revisions, the length of hospital

200 r organization in device performance and the necessity of optimizing it to take full advantage of the

201 These findings highlight the necessity of optimizing the Fc domain for this class of

202 idies in circulating fetal DNA; however, the necessity of parental haplotype construction is a primar

203 ral regions of the world has resulted in the necessity of performing keratoplasty with imported donor

204 The necessity of polymers on drug-eluting stent (DES) platfo

205 The use of oligos avoids the necessity of preparing adaptors and the problems associa

206 erall yield of 53% from 4 and eliminated the necessity of preparing the diamide 13.

207 hich HCMV proteins interact with Rb, and the necessity of Rb for efficient HCMV lytic replication com

208 ious drawbacks, which were mainly due to the necessity of relocating the plants.

209 However, the necessity of renal replacement therapy during extracorpo

210 gistic regression analysis suggests that the necessity of renal replacement therapy prior to extracor

211 tists, since it is expected to eliminate the necessity of replenishing a damaged material.

212 es over bNAbs to E2 CD81bs, underscoring the necessity of rigidifying this antigenic region as a targ

213 These findings support the necessity of routine screening to find those who may ben

214 The necessity of S831 GluA1 was further demonstrated by the

215 To determine the necessity of satellite cells during muscle recovery foll

216 effect of DcRs in the tumour tissue and the necessity of selective targeting of the two death-induci

217 based on a least action method, without the necessity of simulating the steady-state distribution.

218 lymphocytes, which highlights the power and necessity of single-cell approaches.

219 The necessity of six similar but non-identical subunits has

220 ctivated by cisplatin in rats and reveal the necessity of specific hindbrain-forebrain projections fo

221 aviors of outer radial glia, demonstrate the necessity of STAT3 signaling for their cell cycle progre

222 tologous versus allogeneic) and indicate the necessity of strategies to improve functionality of aged

223 We make a case here for the necessity of such fertoprotective treatments.

224 lvement of HSV1 and cytomegalovirus (and the necessity of taking into account any marked differences

225 Necessity of the divalent ions to retain the suspension

226 subunit (Cavbeta) subunits in vitro, but the necessity of the interaction for current inhibition rema

227 We show the necessity of the pmf for motility and growth of C. jejun

228 therefore, be considered a test case for the necessity of the quantisation of the gravitational field

229 en subclinical; this invariably reflects the necessity of the virus to preserve its host, balanced wi

230 Here, we ruled out the necessity of these events for the beta-band modulation o

231 domains have been identified, the catalytic necessity of these kinase domains remains unknown.

232 The necessity of these projections was limited to situations

233 The physiological necessity of these quality control mechanisms in differe

234 rprisingly little attention, considering the necessity of this step for infections to propagate.

235 sticular cells to a MEC fate, indicating the necessity of tissue specific components of the mECM.

236 We tested directly the necessity of TPs for the anion effect by measuring respo

237 ective use of eDNA methods, highlighting the necessity of understanding these parameters for use in f

238 Structure-activity correlation indicated the necessity of unsubstituted triazoles and leucine linker

239 enemies on herbivorous insects, and thus the necessity of using a tri-trophic approach when studying

240 Meanwhile, the tests showed the necessity of using nucleic acid confirmatory tests to cl

241 Discussion: This study highlights the necessity of validating and deploying vector control mea

242 bO in the SRM analysis, which highlights the necessity of validating protein changes by more than one

243 ics, and Western blot analysis to define the necessity of various proteins involved in Siglec-8 funct

244 posure of live cells to the dyes without the necessity of washing.

245 commended for high-risk individuals, but the necessity of yearly low-dose CT in all eligible individu

246 enance of tool use in animals, either due to necessity or opportunity, but little is known about the

247 ity in industrial fermentations which are by necessity oxygen-constrained.

248 By necessity, participants were not masked to group allocat

249 tive factor is partly counterbalanced by the necessity, resulting from the same stabilization, to inj

250 Necessity-sufficiency testing and functional target scre

251 Necessity tests, using mature adipocyte-specific Prdm16

252 On one hand, adaptation is a physiological necessity that enables proper neuronal signaling and cel

253 f the inverse Faraday effect but removes the necessity that the opto-magnetic field is 10 s of Tesla

254 The success of this model reflects both "necessity"-the paucity of new therapies introduced throu

255 By necessity, the sampling is often stochastic, and must be

256 microwave detectors have been limited by the necessity to apply a magnetic field.

257 key benefits at small scales, indicating the necessity to apply models that include finer-grained ass

258 cidation of the cysteine connectivities is a necessity to avoid disulfide scrambled and incorrectly f

259 of similar discriminations may relate to the necessity to both strengthen rewarded representations an

260 These findings highlight the necessity to consider co-contaminant effects when we eva

261 arion switching in NTHI pathogenesis and the necessity to considered phasevarion regulation when deve

262 Moreover, the necessity to develop common instruments and evaluation p

263 There is therefore a crucial necessity to develop specialized tools for an accurate d

264 tial to improve recovery, and underscore the necessity to distinguish the role of tonic and phasic GA

265 a multidomain protein, achieved without the necessity to express the individual subunits separately.

266 d particles with spherical symmetry, and the necessity to fill space at uniform density within the fr

267 teps of viral replication cycle indicate the necessity to further investigate BBI as an alternative a

268 se techniques have limitations including the necessity to generate separate calibration curves for ea

269 ackground of its polygenic nature there is a necessity to identify how schizophrenia risk genes inter

270 th standard chemotherapy has highlighted the necessity to identify targeted therapies that can improv

271 s of this exciting technology as well as the necessity to identify the mechanisms underlying any obse

272 ver the sensing interface (i.e., without the necessity to implement an additional regeneration step,

273 rawbacks of existing therapies emphasise the necessity to improve therapeutic strategies.

274 This result highlights the basic necessity to include "very polar" compounds in water mon

275 , but this effort is often encumbered by the necessity to initially identify compounds of interest or

276 The package particularly addresses the necessity to integrate multiple omics information arisin

277 r cell-microenvironment interactions and the necessity to interpret experiments taking the context in

278 lex in HCMV vaccine design and emphasize the necessity to monitor the integrity of the pentameric com

279 ssible chemical modifications highlights the necessity to obtain structural information about the bin

280 at laparotomy (aOR 3.1 95% CI 1.05-9.3), and necessity to perform a clip and drop procedure (aOR 30,

281 h raised expectations of next of kin and the necessity to provide early predictions of long-term prog

282 ge of red blood cells (RBCs) is a logistical necessity to provide sufficient blood products.

283 ation studies are challenging because of the necessity to realistically model the underlying allelic

284 The results underscore the necessity to reconsider strategies that utilize attenuat

285 oid these planetary nitrogen burdens and the necessity to remediate this problem, we foresee the abso

286 ns with unsuitable signal levels without the necessity to repeat the analysis.

287 The absolute necessity to resolve every intertwine between the two st

288 composition and fatty acids profile) and the necessity to revalorize and protect its traditional cult

289 derable programmatic implications (e.g., the necessity to screen for iron status before interventions

290 iological mechanisms, but also highlight the necessity to seek optimal regimens of continual oxytocin

291 ct sizes of single genetic variants, and the necessity to statistically correct for testing millions

292 es in continuous flow conditions without the necessity to stop the flow.

293 l imaging and mostly restricted by technical necessity to the attached bottom surface, showed persist

294 les, there are downsides, most obviously the necessity to trade-off reversibility against structural

295 disability disorders, thus highlighting the necessity to understand Las1 regulation and function.

296 echnologies is steadily growing, driving the necessity to understand the interaction of these new mat

297 ften containing similar information, and the necessity to use complicated tools to achieve the desire

298 To validate the map's necessity we tested its redundancy in comparison with ex

299 This is a necessity when analyzing highly complex samples; however

300 distribution is a convenience rather than a necessity, with the actual requirement for the particles