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1 tumumab for 6 cycles followed by maintenance necitumumab.
4 and cisplastin chemotherapy with or without necitumumab according to a block randomisation scheme (b
6 pared standard chemotherapy with and without necitumumab as first-line treatment of mSqCLC, to evalua
7 c sensitivity analyses established that when necitumumab cost less than $563 and less than $1309 per
8 for 6 cycles or gemcitabine, cisplatin, and necitumumab for 6 cycles followed by maintenance necitum
10 e reported in 15 (5%) of 304 patients in the necitumumab group versus nine (3%) of 312 patients in th
13 fy potentially useful predictive biomarkers, necitumumab is unlikely to provide benefit in this patie
14 tients and randomly assigned them to receive necitumumab plus gemcitabine and cisplatin (n=545) or ge
15 reported for 66 (12%) of 538 patients in the necitumumab plus gemcitabine and cisplatin group and 57
17 all survival was significantly longer in the necitumumab plus gemcitabine and cisplatin group than in
18 omagnesaemia (47 [9%] of 538 patients in the necitumumab plus gemcitabine and cisplatin group vs six
20 is study, we aimed to compare treatment with necitumumab plus gemcitabine and cisplatin versus gemcit
21 Overall, we found that the safety profile of necitumumab plus gemcitabine and cisplatin was acceptabl
22 omly assigned 633 patients to receive either necitumumab plus pemetrexed and cisplatin (n=315) or pem
24 events, including deaths, was higher in the necitumumab plus pemetrexed and cisplatin group than in
25 se events were likewise more frequent in the necitumumab plus pemetrexed and cisplatin group than in
26 ival of 11.3 months (95% CI 9.5-13.4) in the necitumumab plus pemetrexed and cisplatin group versus 1
28 The SQUIRE trial demonstrated that adding necitumumab to chemotherapy for patients with metastatic
30 no evidence to suggest that the addition of necitumumab to pemetrexed and cisplatin increases surviv
31 In the base case analysis, the addition of necitumumab to the treatment regimen produced an increme
33 was 90% confidence that the ICER for adding necitumumab would be less than $100 000 per QALY and les
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