ライフサイエンスコーパス: need

1 ereby addressing an important unmet clinical need.

2 ors without substantial differences in unmet need.

3 nxiety disorders represents a critical unmet need.

4 (LID) in Parkinson disease (PD) is an unmet need.

5 ficantly less on the aquifer (30%) for water needs.

6 omal system to meet their unique and complex needs.

7 enomes varies depending on the cell's energy needs.

8 and reposition drugs for diseases with unmet needs.

9 ount for multiple sources of uncertainty are needed.

10 for the pancreatic neuroendocrine tumors are needed.

11 at target receptor-receptor interactions are needed.

12 visualizing, and interpreting the results is needed.

13 d easy-to-use on-site analytical methods are needed.

14 , respectively, for which new treatments are needed.

15 of iron-containing supplements and MNPs are needed.

16 protection against dengue virus infection is needed.

17 additional, auxin-independent regulation is needed.

18 ble oats sourced from different regions, are needed.

19 lowering therapy in individuals with CKD are needed.

20 understanding of this mechanism of action is needed.

21 schools, childcare facilities, and homes is needed.

22 A randomized trial is needed.

23 logical interventions to manage delirium are needed.

24 ent in early-stage psychosis populations are needed.

25 ment levels significantly above 90 mm Hg are needed.

26 ood, more complex biomarker models of AD are needed.

27 uantities of mitochondrial calcium stores is needed.

28 ending on the type of prosthetic restoration needed: 1) single unit porcelain-fused-to-metal (PFM) cr

29 restrictions of China in distillates import need a quick and sensitive method for their quantificati

30 STR and SNP datasets in any species without needing a reference genome, and can be used even with su

31 elopment of EVs isolation protocols urgently needs a quantitative method of EVs purity assessment.

32 tate development of topical therapeutics, we need an efficient model for assessing different formulat

33 fellows' perceptions of current educational needs and interest in novel modalities that may improve

34 behavioral priorities according to momentary needs and prior experience.

35 rs and women 3.0 years with substantial care needs, and most will live in the community.

36 s needed laser goniopuncture and 25 patients needed antiglaucoma drops.

37 It does not need any scanning in the spectral, spatial or polarizati

38 ist technical, clinical and regulatory unmet needs as well as the prerequisites for clinical validati

39 Asian ethnicity (OR = 0.51; CI, 0.39-0.65), needing assistance for at least 3 months (OR = 0.79; CI,

40 This need associated with serum levels of IS independent of r

41 om randomized controlled trials are urgently needed because lepirudin was recalled from the market; d

42 gher, and vigilant and extended follow-up is needed because retinal vascularization is usually incomp

43 ing since between 3 and 17 grab samples were needed before grab sampling results had less uncertainty

44 nt outcomes in trained vs untrained PCPs are needed before screening is widely implemented in large h

45 We need better methods to assess viability of kidneys with

46 try shows great potential for providing much-needed biological markers for diagnosing, tracking, and

47 rovides a framework to the discovery of much needed drugs that selectively target the distinct member

48 high doses of ionizing radiations are often needed during RT, leading to severe damages to normal ti

49 INTERPRETATION: Increased efforts are needed, especially in developing countries, to ensure ac

50 A pressing clinical need exists for 63% to 65% of combat-wounded service mem

51 An urgent need exists for adjuvant treatments that can enhance or

52 h meningococcal serogroup B vaccines and the need for a booster dose to sustain individual protection

53 smaller computational footprint, we saw the need for a fast and simple tool for data pre-processing

54 group, providing a rational for the observed need for a general base in the E3 ligase HOIP, which syn

55 on against dengue virus have highlighted the need for a human DENV challenge model to better evaluate

56 that there was substantial agreement on the need for a mixture of push and pull incentives and parti

57 There is a need for a more refined, molecularly based classificatio

58 l history of perishable products without the need for a read-out device.

59 The need for a strong foundation of high-quality genomes is

60 There is a significant unmet need for a treatment option that does not disrupt treatm

61 alysis software designed to meet the growing need for a user-friendly, extensible, open-source soluti

62 abilizes water-in-oil emulsions, without the need for added surfactants or chemical modification of t

63 e was no difference between groups regarding need for additional eyelid surgery (P = 0.30).

64 ol developed to anticipate future supply and need for all physician specialties.

65 alth cobenefits of biochar use highlight the need for an improved understanding of biochar's impacts

66 This has raised the need for analytical methods that can both perform rapid

67 The main limitation of the study was the need for assumptions concerning knowledge of HIV status

68 In response to a need for better sepsis diagnostics, several new gene exp

69 ication using an internal standard curve and need for calibrant diluent, and takes into account the i

70 surgery for treating NASH and underscore the need for clinical trials in this area.

71 ransform spectroscopy (ATR-FTIR) without the need for collimated or polarised incident light, as is r

72 cal decision rules can help to determine the need for CT imaging in children with head injuries.

73 The need for dose adjustment and the incidence of torsades d

74 cy, have safety concerns that underscore the need for effective peripherally acting drugs.

75 MRSA and MDR bacterial pathogens dictate the need for effective prevention as important as for therap

76 n acute hospital services, and an increasing need for end-of-life care.

77 current and future climate; we highlight the need for experimental studies to identify the mechanisms

78 for completion of the synthesis without the need for extensive screening.

79 W) laser source to activate, and without the need for external power supply or signal generation, the

80 Significant progress in meeting the need for FP has been achieved in Senegal, but more needs

81 Our findings highlight the need for further analysis of the T cells involved in ins

82 ountered in 31% of patients, emphasizing the need for further evaluation in larger series and close c

83 TBSA and the need for grafting of the arm, head/neck, and trunk were

84 There is a need for hepatitis C virus (HCV) therapies with excellen

85 tudies and cell-surface analysis without the need for labeling processes.

86 ductor industry, but is often limited by the need for lattice matching between the two material syste

87 5% confidence interval, 4.19-8.61; P<0.001), need for left ventricular assist device (odds ratio, 3.4

88 of HTML5 to be fast, portable and avoid the need for local installation.

89 roscopic techniques so far, there is a clear need for local-probe measurements.

90 resistance are concerning and highlight the need for longer-term follow-up studies.

91 Our results highlight the need for more detailed studies of tree physiological and

92 Thus, there is a pressing need for more efficient processes.

93 kappaB signaling pathway and underscores the need for more selective strategies to therapeutically ta

94 This emphasizes the need for much improved implementation of mitigation meas

95 There is a need for new greener materials (than for example polyeth

96 There is a need for novel approaches to classify patients with thes

97 tide to increase urine production and reduce need for parenteral support volume in patients with shor

98 photoactivated depots of insulin without the need for polymers, by linking photolysis to an isoelectr

99 tern of functional connectivity, without the need for pre-existing or hidden pathology.

100 of biomass recalcitrance and therefore, the need for pretreatments.

101 nes under biomimetic conditions, without the need for protecting groups, yielding powerful synthons i

102 nts than in young children, highlighting the need for raising public health awareness about the detri

103 transportation of reagents and mitigates the need for refrigeration of reagents.

104 eripheral biomarkers that will eliminate the need for scalp biopsies.

105 iscovery of such solitons is hindered by the need for spatial imaging of the 3D fields, which is diff

106 As global warming progresses, the need for species to compensate or drift under the influe

107 delay during the study period highlight the need for standardized diagnostic routines and a better f

108 treatment led to a greater reduction in the need for surgery and a greater improvement in symptoms t

109 ctivation of deep-brain circuits without the need for surgical implantation of any device.

110 dict the course of disease and, perhaps, the need for surgical intervention.

111 of protein interactions in vivo, there is a need for techniques that can yield time-resolved informa

112 f food fraud incidents, there is an inherent need for the development and implementation of analytica

113 l was the rate of corneal perforation or the need for therapeutic penetrating keratoplasty.

114 ons with reasonable accuracy and without the need for using multiple markers.

115 Significant preparation will be needed for a thorough, synchronized, and full withdrawal

116 ter assess their potency and composition are needed for adequate studies of their safety and efficacy

117 ace in biological tissues, and are therefore needed for applications such as medical implants, tissue

118 odel to evaluate the correction factor (Phi) needed for chamber SOA mass yields due to losses of vapo

119 can replace several different dye catalysts needed for five different photoredox reactions (beta-alk

120 nts in this field, highlighting the research needed for future focus.

121 esized that selective exclusion of molecules needed for growth may contribute to regeneration decline

122 unotherapies and combinations likely will be needed for most subtypes.

123 Novel therapies are needed for patients with relapsed or refractory multiple

124 nables the prolonged MSC-T cell interactions needed for sufficient suppression of autoreactive T cell

125 nslating mRNPs, and recapping is all that is needed for their return to the translating pool.

126 ycations disrupt and cross cell membranes is needed for understanding and controlling polycation-memb

127 identified or suspected special educational needs for whom EAP-ECDS scores for five or more of seven

128 Epidemiological data are needed from southern and east Africa, and from patients

129 ouseholds by sanitation facility (facilities needing FSM, sewered facilities, ecological sanitation/o

130 LT recipients needing full assistance (KPS 10%-40%) vs being independe

131 represents a clinically relevant factor that needs further investigation.

132 rtments among older patients with palliative needs has led to the development of several service-leve

133 overage (UHC) requires that families who get needed health care do not suffer financial hardship as a

134 C) requires inter alia that families who get needed health care do not suffer undue financial hardshi

135 There remains the need, however, for a soluble, versatile, HBC-based platf

136 In particular, there is an unmet need in rapid, reliable detection of short RNA regions w

137 In view of the major unmet need in this population and the importance of maintainin

138 etermining specific management interventions needed in different locations to counter the trend of de

139 New drug delivery systems are highly needed in research and clinical area to effectively trea

140 A need is identified for the concurrent development of neu

141 By year 3, 17 patients needed laser goniopuncture and 25 patients needed antigl

142 validation, and their impacts on disparities need more detailed investigation.

143 policies for improving the food environment need multifaceted strategies to invoke clinically meanin

144 ses with aminoglycoside-treated patients are needed next to evaluate a possible interference of selen

145 iated with obligate phototrophs, the process need not be confined to the photic zones of marine envir

146 This need not be the case, because gestural enrichments are t

147 for the observed pattern and highlights the need of better understanding human mobility and activity

148 ed tumour phylogenetic trees, suggesting the need of denser sampling of tumours at relapse.

149 f 0.84+/-0.28) in inferring proteins without need of peptide detectability on which the most competit

150 w systems of care must continue to serve the needs of children.

151 Further research is needed on procedural and long-term clinical outcomes.

152 bust and efficient workflow, as segmentation need only be performed at one cardiac phase, while wall

153 achieve better outcomes, and explain why we need open and international discussions concerning a tec

154 ion that patients and their families may not need or want palliative care involvement early in the di

155 Check Hep C successfully supported high-need participants through HCV care and treatment, and SV

156 nd the post-incarceration period is urgently needed, particularly studies using rigorous experimental

157 e-2 diabetes, in which the unmet therapeutic need remains substantial.

158 eq applications and their high-computational needs require the development of pipelines orchestrating

159 song, functional models of HVC activity may need revision to account for the parallel input architec

160 technical reports, or the web is a pressing need shared by researchers and patent attorneys from dif

161 ies (70%), and is associated with frequently needing sips of liquids to facilitate swallowing (75%).

162 ioners to identify where governance capacity needs strengthening and jointly consider social and ecol

163 these questions, experimental platforms are needed that can extensively and controllably profile man

164 Although further study is needed, this report shows promising results and raises i

165 The second theme described the need to 'fit in' with organisational culture.

166 equires both careful quality control and the need to account for sparsity due to the heterogeneity in

167 Health policy in Afghanistan will need to address attitudinal, social, and accessibility b

168 The results support an urgent need to address vaccine hesitancy in policy dialogues at

169 However, there remains a need to anticipate supply given the rapid growth of spec

170 straints such as vaccine supply and delivery need to be accounted for before such insights can be tra

171 represent highly deleterious DNA damage and need to be accurately repaired.

172 f successful, however, these approaches will need to be combined with additional complementary approa

173 Other factors may need to be considered in deciding the optimal approach.

174 phase, indicating that specific interactions need to be dissolved for replication to proceed.

175 r architecture, have potential benefits, but need to be explored further.

176 tics for depression, and the next steps that need to be made to facilitate this translation of scienc

177 , liposomal amphotericin B, and flucytosine, need to be much more widely available.

178 n, there are substantial obstacles that will need to be overcome if CRISPR-Cas9 is to be used in the

179 ve strategies for lung transplant recipients need to be tailored based on the unique immunological pr

180 resolve transmission events, these processes need to be taken into account.

181 adaptive resistance of RISC cells, and both need to be targeted to prevent glioblastoma recurrence.

182 are generally considered inaccurate and they need to be tightly regulated.

183 expected outcomes from RBC transfusion that need to be weighted with its benefits in selected patien

184 y effect migratory behavior, emphasizing the need to better understand the implications of ALAN for m

185 Our results emphasize the need to closely monitor this vulnerable population.

186 verhead of quantum error correction, and the need to compile into discrete gate sets, the necessary c

187 trials that include racial and ethnic groups need to confirm these findings.

188 aling can lead to malignancy illustrates the need to control Notch activity tightly.

189 Therefore, there is an urgent need to develop a high-throughput and efficient strategy

190 There is an urgent need to develop an efficacious and affordable vaccine to

191 kers of allergic sensitization, indicating a need to develop better markers to predict poor response

192 There is a need to develop efficient statistical methods and comput

193 There is a need to develop methods that are robust to platform/batc

194 There is, therefore, an urgent need to develop single-dose and long-lasting rabies vacc

195 There is a need to ensure that the care and welfare for fish mainta

196 There is a significant need to find biomarkers of response to radiotherapy and

197 tigation efforts in the Red Deer region will need to focus on the >90% of methane emissions currently

198 There is a major unmet need to identify high-risk patients in myocarditis.

199 for alcohol use disorder (AUD) emphasize the need to identify novel molecular targets and efficiently

200 As a result, there is a clear need to identify paleoclimate records extending into the

201 existence of resistance mechanisms with the need to identify predictive factors of therapy response.

202 The need to identify promising and scalable approaches to pr

203 iven present expenditure levels, indicates a need to improve efficiency and value for patients.

204 There is a need to increase awareness of the impact of glaucoma amo

205 ducts selectively and efficiency at pH 7, we need to increase the CO concentration by changing the so

206 ate in the development of other systems that need to integrate inputs from multiple sources to genera

207 This prompts an urgent need to investigate the molecular mechanisms underlying

208 levated circulating E2 Collectively, we will need to modify the concept of estrogen's positive feedba

209 thin this context, we discuss the caveats we need to overcome for automated causal discovery to becom

210 ty to reduce imaging time by eliminating the need to perform T1 sequences.

211 that a majority of patients and wards do not need to rely on contact precautions for preventing nosoc

212 When acting upon an object, we need to represent its visual features (e.g. shape, orien

213 Conclusions pointed out an urgent need to review legislative limits in food matrices consu

214 However, there is an urgent need to rigorously estimate actual mortality rates and q

215 l problems faced by animals is balancing the need to seek food and energy against the accompanying da

216 nvolved in sample preparation, including the need to separate the marker from its binding protein.

217 European countries need to set a timeline for implementing lung cancer scre

218 sses the critical question of how many reads need to support a short RNA molecule in a given dataset

219 elderly population worldwide highlights the need to understand how aging promotes CVD in order to de

220 This finding further emphasizes the need to understand how brain reward networks contribute

221 ediated tumour tolerance has highlighted the need to understand the molecular regulation of PD-L1 exp

222 owever, at present additional scaffolding is needed to achieve chromosome-level assemblies.

223 targeting multiple steps in the continuum is needed to achieve the full beneficial impact of HIV trea

224 apacities, and low regeneration energies are needed to achieve these separations efficiently at scale

225 s structure, it is unknown which factors are needed to activate cumulus specific gene expression.

226 New mosquito control strategies are vitally needed to address established arthropod-borne infectious

227 Future studies are needed to address whether similar mechanisms contribute

228 opmental studies have contributed to and are needed to advance clinical goals.

229 Moreover, our data indicate that PI(4)P is needed to anchor Arl8 (Arf-like GTPase 8) and its effect

230 Further research is needed to assess longer-term efficacy and adverse effect

231 Further studies will be needed to assess possible herd immunity effects with men

232 Further study is needed to assess safety and long-term clinical outcome.

233 Longer term follow-up is needed to assess the durability of quality-of-life impro

234 Larger scale clinical trials are needed to assess the efficacy of gammaT supplements as a

235 ely deploy registered nurses in primary care needed to assure efficient, evidence-based, and quality

236 Further studies are needed to better assess its safety and applicability.

237 and tropical diseases in Africa is urgently needed to better describe the distribution of pathogen-b

238 Innovation in education and training is needed to better prepare future nephrologists for the gr

239 ying the role of regional hypermetabolism is needed to better understand its interaction with the mot

240 ide-bandgap (WBG) perovskite solar cells are needed to boost the efficiency of silicon solar cells to

241 he promise that now exists and what is still needed to bring dramatic and tangible change to patients

242 Further studies are needed to confirm and refine these recommendations.

243 Validation of this novel predictive score is needed to confirm clinical utility.

244 Research is needed to confirm possible interactions of arsenic metab

245 s undergoing longer duration of sedation are needed to confirm these observations.

246 Prospective studies are needed to define the impact of pretransplant sensitizati

247 samples may help to identify the biomarkers needed to detect nonsymptomatic, preclinical phases of t

248 More reliable methods are needed to determine MGMT activity as DNA methylation, th

249 Further work is needed to determine the implications of increased thalam

250 Further studies are needed to determine the life course progression of these

251 Studies are needed to determine whether these features of PDACs with

252 Research is needed to develop safe and effective treatments, a preve

253 irections of research and reporting that are needed to diminish it.

254 Further studies are needed to elucidate the source and epidemiology of PCR r

255 Novel strategies are needed to enhance muscle repair and function and to slow

256 Customised service delivery is needed to ensure parity for different geographic and sec

257 in on neural circuits in the hypothalamus is needed to establish the utility of targeting oxytocin si

258 However, further studies are needed to evaluate whether the control of metabolic para

259 months (OR = 0.79; CI, 0.62-1.00), and proxy needed to fill out the survey (OR = 0.72; CI, 0.61-0.85)

260 potential studies and surveillance platforms needed to fill these gaps, and prioritizing efforts.

261 nd defined mechanisms of inhibition are thus needed to functionally characterize V-ATPase and to full

262 ector attitudes, although larger studies are needed to further define program factors affecting attri

263 onal high-quality interventional studies are needed to further evaluate the effectiveness of patient-

264 Better tools are needed to identify patients at high risk of developing H

265 hree anaesthetic-sensitive rho1 subunits are needed to impart full efficacy to the partial GABA agoni

266 f biliary complications, especially ITBL, is needed to improve the outcomes for DCD grafts.

267 clinical subtypes, and further refinement is needed to improve treatment outcomes.

268 ries worldwide and innovative drugs is still needed to improve TTP management.

269 Interventions are needed to increase high-intensity statin use and adheren

270 Research is needed to inform firm recommendations on how to protect

271 More research is needed to inform our knowledge of the role of insurance

272 Further research is needed to investigate the association between these stru

273 More studies are needed to investigate the use of bone turnover markers f

274 More work is needed to optimize its dosing to minimize adverse events

275 dlPFC, which mediates the cognitive control needed to overcome anxiety and differentiate between old

276 r the minimum number of communication rounds needed to perform the locality-constrained tasks of enta

277 a (called 'IL-6 cluster signaling' here) was needed to prevent premature induction of interferon-gamm

278 The strategies needed to promote equity in the cardiovascular health of

279 Therefore, highly sensitive methods are needed to quantify BPA in various matrices including wat

280 Interventions are urgently needed to significantly reduce both mortality and the he

281 rement, and confirm that lambda < 1/(n-1) is needed to sufficiently suppress multispin effects (with

282 Shared decision making is needed to support decisions about breast reconstruction.

283 But, synthesis of long-chain macromolecules needed to support higher-order functions in living syste

284 itable, and novel therapeutic approaches are needed to target dormant tumors.

285 h with a robust dietary intake assessment is needed to test this hypothesis.

286 Further research is needed to understand how these noncardiac complications

287 More research is needed to understand the effectiveness of screening and

288 the effect seen might be sustained, but this needs to be confirmed at the 18 month follow-up.

289 s with disease risk, therefore, their origin needs to be determined to understanding their role in th

290 or FP has been achieved in Senegal, but more needs to be done particularly to improve acceptability o

291 The relationship to histologic tumor extent needs to be further analyzed.

292 parsimonious approach to quality assessment needs to be maintained to allow the nephrology community

293 Sb(V) forms a precipitate, whereas Sb(III) needs to be oxidized to Sb(V) before being incorporated

294 This i-As content needs to be reduced to make rice bran a useful food ingr

295 lion density reflect the specific ecological needs to detect food/predators and the structural comple

296 gies and algorithms for matching nutritional needs to individual biomedical profiles and the issues s

297 The brain needs to predict how the body reacts to motor commands,

298 ation of the FutureDocs physician supply and need tool developed to anticipate future supply and need

299 These differences need validation, and their impacts on disparities need m

300 4 or 3 revealed periodontal access surgical needs when Class II or III furcation involvements and/or