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1 hough other constraints such as vaccine supply and delivery need to be accounted for before such insights can be translat
2 d breaks (DSBs) represent highly deleterious DNA damage and need to be accurately repaired.
3                                  Similar mutations probably need to be acquired by emerging influenza A viruses before th
4      The extreme simplicity of assay execution (no reagents need to be added) and flexibility of fabrication of the devic
5 tions of human AML LSCs and discuss critical questions that need to be addressed in future research.
6        Finally, we comment on the critical limitations that need to be addressed to enable their use for single-cell dyna
7                                              These barriers need to be addressed to ensure the continued development of f
8                                     The following questions need to be answered in this regard: are there key advantages
9                            These cell engineering processes need to be carefully controlled and standardized to maximize
10 refore, the risks and benefits of using broad-spectrum LRAs need to be carefully evaluated, particularly in the CNS, wher
11          Even if successful, however, these approaches will need to be combined with additional complementary approaches
12          The findings of a reverse association in Hispanics need to be confirmed and further explained in future studies
13 ce may not equate to real-world performance, and so results need to be considered alongside real-world, long-term safety
14                                           Other factors may need to be considered in deciding the optimal approach.
15 tructural determinants of food and nutrient production that need to be considered in plans to meet social, economic, and
16 his tutorial describes the different important aspects that need to be considered to come up with efficient and oxidative
17 econstruction based on orientation information alone, which need to be considered when interpreting tractography and conn
18 essure; however, the thermal variations are significant and need to be considered when quantifying the concentration of h
19                              Further, epigenetic end points need to be correlated with observable detrimental organism ch
20            These data indicate that one or several peptides need to be degraded for MTM and LTM.
21 rge amount of new information, new rules for crystal growth need to be developed and tested.
22 wever, simpler and more cost-effective purification methods need to be developed compared to chromatography to enhance it
23  resumed in G2-phase, indicating that specific interactions need to be dissolved for replication to proceed.
24           It is not clear why so many extracellular domains need to be evolved through natural selection.
25                                     Vector control programs need to be expanded to curtail new infections.
26 des in a modular architecture, have potential benefits, but need to be explored further.
27                                           Conversely, mQTLs need to be filtered out when searching for non-genetic effect
28             Strategies for management of low-level viraemia need to be incorporated into WHO guidelines to meet UNAIDS-de
29 y, evaluations across the different nutritional gatekeepers need to be integrated.
30                                                     Efforts need to be intensified along the food chain to reduce Campylo
31 ar mechanisms of this regulation in diabetic cataract still need to be investigated.
32 of new therapeutics for depression, and the next steps that need to be made to facilitate this translation of science to
33  amphotericin B, liposomal amphotericin B, and flucytosine, need to be much more widely available.
34 put elimination within reach, but several difficulties will need to be navigated on the path to elimination.
35  have been taken, there are substantial obstacles that will need to be overcome if CRISPR-Cas9 is to be used in the pract
36 ntitumor immunity, but unlike many immunotherapies does not need to be personalized for each patient.
37 of clathrin-mediated endocytosis, and PKD inhibitors do not need to be present during viral uptake.
38 itotic progression is defined by multiple parameters, which need to be quantitatively evaluated.
39 erized methods to be useful as decision support tools, they need to be resilient to data acquired from different sources,
40 d extensively, it remains an open question why microvessels need to be so narrow.
41          The review also discusses current limitations that need to be solved in future developments.
42 immunosuppressive strategies for lung transplant recipients need to be tailored based on the unique immunological propert
43                 It is clear that these millennia of impacts need to be taken into account when studying and conserving tr
44    To properly resolve transmission events, these processes need to be taken into account.
45                             Consequently, molecular motions need to be taken into consideration when interpreting the res
46  the innate and adaptive resistance of RISC cells, and both need to be targeted to prevent glioblastoma recurrence.
47 plate but they are generally considered inaccurate and they need to be tightly regulated.
48 rediction and making a decision, and underlying assumptions need to be understood in order to optimize data-driven decisi
49 ation of imaging modalities, and these recommendations will need to be updated as new imaging technologies become availab
50 e hypoxemia are expected outcomes from RBC transfusion that need to be weighted with its benefits in selected patients.

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