ライフサイエンスコーパス: needle

1 y despite in-clinic interventions (including needling).

2 plane to create the multi-segmented optical needle.

3 ystalline material within the same aragonite needle.

4 tion phase recessed into the body of a solid needle.

5 elivered in insulin syringes with a 31-gauge needle.

6 ated on the extracellular end of the growing needle.

7 insertion depths of a 30-gauge side-venting needle.

8 ed with needle diameter for 30G, 25G and 18G needles.

9 croL syringes with 5/16-inch, 30-gauge fixed needles.

10 y acupuncture treatment using the nanoporous needles.

11 ro-acupuncture using non-penetrating placebo needles.

12 py, and had similar efficacy to conventional needles.

13 ts, leaving observable, dying trees with red needles.

14 ure with atraumatic needles and conventional needles.

15 y into diseased areas, both of which involve needles.

16 9.2 A), hub (8.5 A), tailspike (10.9 A), and needle (10.5 A).

17 ug in 0.05 mL) was injected using a 32-gauge needle 2.5 mm from the 5 o'clock position of the limbus,

18 ne; 1, less than or equal to 2 cm around the needle; 2, more than 2 cm and sublobar; 3, at least loba

19 or injury (56 [20%] of 282), noncontaminated needle (53 [19%] of 282), too-lengthy reporting process

20 PgUGT5b were higher than those of PgUGT5 in needles across different genotypes of white spruce.

21 eeks of either standardized Chinese medicine needle acupuncture designed to treat kidney yin deficien

22 . 10mg) was sampled directly using a syringe needle and placed in a glass insert for liquid extractio

23 ts were assigned to receive vaccinations via needle and syringe at 0 and 8 weeks, 0 and 12 weeks, 0,

24 nations at 0, 4, and 8 weeks via single-dose needle and syringe injection in one deltoid or split-dos

25 ramuscular or fractional intradermal dose by needle and syringe or disposable-syringe jet injector at

26 ringe injection in one deltoid or split-dose needle and syringe or needle-free injection with the Str

27 Needle and syringe program (NSP) coverage is commonly us

28 l clinics, one homelessness service, and one needle and syringe programme).

29 CV prevention interventions for PWID include needle and syringe programmes (NSP), opioid substitution

30 ated efficacy: opioid agonist therapy (OAT), needle and syringe programs (NSPs), HIV testing and trea

31 id agonist therapy and increased coverage of needle and syringe programs in North America.

32 ubcutaneous injection of antigen using a 27G needle and syringe.

33 The length of each segment in the optical needle and the spacing between adjacent segments are con

34 The arrays (19x19 needles and 500mum height) were mechanically strong and

35 olled trials comparing the use of atraumatic needles and conventional needles for any lumbar puncture

36 tcomes after lumbar puncture with atraumatic needles and conventional needles.

37 herence tomography through miniature imaging needles and developed an algorithm to efficiently recons

38 ives to traditional Bacillus Calmette-Guerin needles and syringes for the administration of fIPV.

39 rm is capable of sensing the T3SS inner rod, needle, and flagellin.

40 We developed a needle- and antibiotic-free model in which we readily in

41 tches provide an alternative to conventional needle-and-syringe immunisation, and potentially offer i

42 luded needle gauge, number of passes, pleura-needle angle, lesion size and morphologic characteristic

43 The termite hunting needle ant Brachyponera chinensis was introduced from Ea

44 IpaD and the needle are implicated in transduction of the host cell-s

45 hanism for how bacteria ensure that the T3SS needles are neither too short nor too long.

46 Here we characterise a novel micro-needle array (MA) delivery system fabricated to deliver

47 ce for the safety and efficacy of atraumatic needles as a superior option for patients who require lu

48 measured in pre- versus post-treatment fine needle aspirates in mice.

49 endoscopic ultrasound was performed and fine-needle aspirates of the pancreas mass were positive for

50 needle biopsy (50% [17/34] P = .04) and fine needle aspiration (0% [0/2]; P = .009).

51 dobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with non-small

52 ivariate analysis, peripheral transbronchial needle aspiration (TBNA), larger lesion size, nonupper l

53 ogy now allow the detection of these in fine needle aspiration biopsies (FNA).

54 ons of human Tg from needle washouts of fine-needle aspiration biopsies of thyroid nodule from differ

55 tection of Tg in the needle washouts of fine-needle aspiration biopsies, at concentrations useful for

56 Fine-needle aspiration biopsy (FNAB) for DNA amplification an

57 Fine-needle aspiration biopsy (FNAB) of tumor for DNA amplifi

58 erform the first in vivo examination of fine needle aspiration biopsy (FNAB) scleral tracts to determ

59 vitrectomy and 25-gauge trans-vitrector port needle aspiration biopsy immediately before brachytherap

60 rectomy followed by transvitrector port fine-needle aspiration biopsy of the tumor immediately before

61 ancer incidence is increasing, and when fine-needle aspiration biopsy results are cytologically indet

62 ray-scale thyroid ultrasonography and a fine-needle aspiration biopsy were performed.

63 cteristics plus follow-up cytology from fine-needle aspiration can identify thyroid cancers, it is un

64 of diagnosis, thus avoiding unnecessary fine needle aspiration cytologies.

65 ules 1 cm or larger with ultrasound and fine-needle aspiration cytology (FNA).

66 Cytological study of EUS-guided fine needle aspiration from the mass was suggestive of squamo

67 2 of 3 on core biopsy, with a positive fine-needle aspiration of a palpable, ipsilateral axillary ly

68 Fine needle aspiration of a right axillary node confirmed met

69 miRNAs in endoscopic ultrasound-guided fine-needle aspiration samples makes them good biomarker cand

70 rms from screening or ultrasound-guided fine-needle aspiration.

71 er reactions, as assessed by lymph node fine needle aspiration.

72 d set 2-95 endoscopic ultrasound-guided fine-needle aspirations (60 PDAC, 9 IPMN, 26 C).

73 sensing by ruler proteins, whereby upon T3SS needle assembly, the ruler protein's N-terminal end is a

74 The treatments involve the insertion of fine needles at acupoints along specific meridians (meridian

75 se was similar to that induced by hypodermic-needle-based delivery of Ova using the clinically-approv

76 mimics human infection by mosquito bite than needle-based inoculations.

77 fit other photoacoustic applications such as needle-based intramuscular imaging.

78 A novel syringe needle-based sampling approach coupled with liquid-phase

79 s) are deadly paediatric brain tumours where needle biopsies help guide diagnosis and targeted therap

80 g nucleic acid yields in CT-guided lung core needle biopsies used for genomic analysis, there should

81 based on histological evaluation of prostate needle biopsies, which have high false negative rates.

82 n-and are therefore suitable for analysis of needle biopsies.

83 stic sampling as an attractive surrogate for needle biopsies.

84 pared with those with ADH diagnosed via core needle biopsy (5%; 95% CI, 2.2%-8.9%).

85 tic yield (71.5% [40/56]) compared with core-needle biopsy (50% [17/34] P = .04) and fine needle aspi

86 operative MR imaging combined with MR-guided needle biopsy and/or MR-guided lesion localization or br

87 Transvitreal and transscleral needle biopsy can result in complications including vitr

88 cheduled for an initial or repeated prostate needle biopsy due to suspicious digital rectal examinati

89 01 patients who underwent transthoracic core needle biopsy for the KEYNOTE-001 (MK-3475) clinical tri

90 e using 25-gauge vitrectomy as an adjunct to needle biopsy immediately before brachytherapy to minimi

91 012, the proportion of ADH diagnosed by core needle biopsy increased from 21% to 77%.

92 Conclusion Image-guided transthoracic core needle biopsy is an effective method for obtaining tissu

93 Diagnosis of ADH on core needle biopsy or excisional biopsy in women undergoing m

94 on was detectable for all genes in malignant needle biopsy samples (AUC: 0.80 to 0.98), confirming pr

95 Overall mean number of core needle biopsy samples obtained was 7.9 samples.

96 gs were compared with histopathology of core needle biopsy samples or with ultrasound follow-up data

97 tion, PDGFRalpha expression in pre-operative needle biopsy specimens predicted poor overall survival

98 t lesions (HRLs) diagnosed with image-guided needle biopsy that require surgical excision to be disti

99 cer associated with ADH diagnosed using core needle biopsy vs excisional biopsy.

100 d approach to tumor sampling, often invasive needle biopsy, is unable to fully capture the spatial st

101 a false-positive screening without and with needle biopsy, respectively.

102 io (HR) of 3.0 (95% CI, 2-4.5) and, via core needle biopsy, with an adjusted HR of 2.2 (95% CI, 1.5-3

103 nucleic acid yields from imaging-guided core needle biopsy.

104 on of (68)Ga-PSMA PET/CT in conjunction with needle biopsy.

105 malignant changes in the vicinity of a core needle biopsy.

106 nhanced resistance of spruce to infection by needle bladder rust are unknown.

107 nder aseptic condition with sterile 21 gauge needle by an ophthalmologist from patients suspected of

108 Although hypodermic needles can be used to effectively deliver siRNA through

109 depth of 2 mm using a simple surgical glass needle (cannula) of diameter 0.22 mm as the primary opti

110 myocardium of 8 swine using MRI-conspicuous needle catheters.

111 er bacterial membranes, and via a protruding needle complex contact host cell membranes and deliver t

112 expresses a type III secretion system (T3SS) needle complex that induces NLRC4 (NOD-like receptor C4)

113 in significant conformational changes in the needle complex to provide the symmetry adaptation requir

114 -protein machine are the envelope-associated needle complex, the inner membrane export apparatus, and

115 idural injections) or without a conventional needle control group were excluded.

116 y lower for women whose ADH was diagnosed by needle core biopsy compared with excisional biopsy.

117 mber of needle passes, and percentage of the needle core.

118 Needles could sustain 0.6N that is enough to pierce stra

119 patients with D2B times >90 min, and door-to-needle (D2N) times </=30 min were associated with 0.55 (

120 8 hectares in the state of Maine, white pine needle damage (WPND) has continued to spread and is now

121 MESSAGE: RNA-seq analysis on whitebark pine needles demonstrated that methyl jasmonate (MeJA)-trigge

122 pin-echo pulse sequences, and MR-conditional needles, diagnostic MR neurography-guided GFN blocks wer

123 t transfer of viable bacteria increased with needle diameter for 30G, 25G and 18G needles.

124 -to-balloon (D2B) time for STEMI and door-to-needle (DTN) time for AIS, with and without controlling

125 improvement initiative to accelerate door-to-needle (DTN) times, was associated with an average 15-mi

126 olecular-based modality in which an array of needle electrodes is inserted into cartilage held under

127 correspondence to the patterns obtained with needle electrodes.

128 AAB dominated the P. flexilis needle endophyte community.

129 he P22-like family encode a specialized tail needle essential for genome stabilization after DNA pack

130 e use of atraumatic needles and conventional needles for any lumbar puncture indication.

131 presence of adjuvant could be an attractive needle-free and self-administered immunotherapy for alle

132 nst a viral antigen when administered with a needle-free device, although not when injected by a need

133 (18 intradermally and 24 intramuscularly) or needle-free devices (46 intradermally and 13 intramuscul

134 muscularly by needle-syringe or one of three needle-free devices.

135 The needle-free immunization technology offers a reliable, s

136 ants who received split-dose vaccinations by needle-free injection had detectable positive antibody r

137 scular DNA delivery by either Biojector 2000 needle-free injection system (Biojector) or CELLECTRA el

138 deltoid or split-dose needle and syringe or needle-free injection with the Stratis device (Pharmajet

139 %) of 14 participants boosted with an 80 mug needle-free intradermal dose of CV7201 achieved titres o

140 mRNA vaccination by needle-free intradermal or intramuscular device injectio

141 ication for the optimization of the emerging needle-free technology for ID immunization.

142 ional RD-Ad vectors and may have utility as "needle-free" mucosal vaccines.

143 , mucosal vaccination is also expected to be needle-free, which can eliminate pain and the fear of va

144 igate the neutral pH structure of three tail needles from bacteriophage P22, HK620, and Sf6.

145 was the predominant PFAS constituent in pine needles from Slovakia (8-93%).

146 An increased mass of peptide formulation per needle, from 0.37mug to 2mug peptide dose, resulted in a

147 icrofiber suspension is injectable through a needle, from which it can be extruded directly as a hydr

148 Surface modification of acupuncture needles further enhances the therapeutic effects of acup

149 the number of needle passes or a decrease in needle gauge (two-way analysis of variance, P < .0001 fo

150 sults were significant after controlling for needle gauge and number of cores (P = .008).

151 differences in volume yields, the effect of needle gauge was markedly greater than the number of pas

152 gential group (2.6 vs 2.4, P = .001); biopsy needle gauge was not significantly different (P = .076).

153 measured DNA and RNA yields with respect to needle gauge, number of needle passes, and percentage of

154 nique- and lesion-related variables included needle gauge, number of passes, pleura-needle angle, les

155 sex, use of prophylactic intravenous fluid, needle gauge, patient position, indication for lumbar pu

156 of 111 cases (3.6%) were seen in the double-needle group (P = .180).

157 11.0% (95% CI 9.1-13.3) in the conventional needle group to 4.2% (3.3-5.2) in the atraumatic group (

158 In the single-needle group, nine of 100 cases (9%) of postprocedural b

159 did not differ significantly between the two needle groups.

160 Atraumatic needles have been proposed to lower complication rates a

161 with global increased stiffness, act like a "needle in a ball of yarn", enhancing the ability of the

162 nsit, has been described as "searching for a needle in a haystack" because of the inherently low rate

163 Finding the needle in the haystack takes patience, prudence, and dis

164 The results may move the needle in this hard-to-treat malignancy.

165 trials comparing atraumatic and conventional needles in which no dural puncture was done (epidural in

166 e To determine whether the use of one or two needles influences procedure performance and patient out

167 bserved between intradermal jet injected and needle injected animals reflect differences in the volum

168 ction using the jet injector or subcutaneous needle injection exhibited comparable immune responses a

169 We hypothesized that transcatheter needle injection of caustic agents doped with gadolinium

170 ed diagnostic laparoscopy to rule out Veress needle injury to the gall bladder.

171 ogeneity and lower overall diversity than in needle-inoculated animals.

172 te therapies, and vaccines, but they rely on needle inoculation of virus: the effects of mosquito-bor

173 n and dissemination to distant tissues after needle inoculation.

174 ntly reduced infectivity in C3H/HeN mice via needle inoculation.

175 tricle endocardium and 54 6-electrode plunge needles inserted into the left ventricles of 6 dogs.

176 t 90% irrespective of the fluid flow rate or needle insertion depth.

177 by placing a fluid-filled 25 gauge butterfly needle into the Ommaya reservoir.

178 nt of the trigger finger by using a 21-gauge needle is feasible in current practice, with minimal com

179 lations are rare, even though the sharing of needles is common practice for these inoculation routes

180 glomeruli and proximal tubules from 98 human needle kidney biopsy specimens for microRNA expression a

181 of calcific tendinopathy (local anesthesia, needle lavage, intrabursal steroid injection) was perfor

182 = 66%), and relationships for broadleaf and needle-leaf species converged when using the mass-based

183 ad-leaved deciduous, broad-leaved evergreen, needle-leaved deciduous and needle-leaved evergreen.

184 eaved evergreen, needle-leaved deciduous and needle-leaved evergreen.

185 these data suggest a potential mechanism for needle length sensing by ruler proteins, whereby upon T3

186 Atop the needle lies the tip complex (TC), formed by IpaD and Ipa

187 lting in low ion abundances and reduced nESI needle lifetimes.

188 urvature radius r k < 14.4 nm; typical large needle-like arrays having 20 2D layers units correspond

189 etical 1.76 (day 11) and by the formation of needle-like crystals.

190 These needle-like domains are highly labile in the out-of-plan

191 aded PbZr1-xTixO3 heterostructures stabilize needle-like ferroelastic domains that terminate inside t

192 mineral layers, comprising bundles of small needle-like HA crystals, formed on etched surfaces that

193 ely guide the formation of ordered arrays of needle-like hydroxyapatite (HA) crystals in vitro and on

194 ecretion system (T3SS), which functions as a needle-like molecular machine.

195 ructures and does not colocalize with large, needle-like myosin filaments containing MYO-3, a striate

196 ique virulence mechanism whereby they grow a needle-like structure in order to inject bacterial effec

197 Due to their high surface area and unique needle-like structure, CNTs are uniquely equipped to car

198 r biopsies of liver metastases identified by needle localization in a subset of these patients were r

199 igational accuracy and radiation dose during needle localization of targets for augmented reality (AR

200 There were 9 needle-localized core biopsies that corresponded to MRI

201 The Shigella T3SS consists of a hollow needle, made of MxiH and protruding from the bacterial s

202 The multi-segmented optical needle may be employed in applications such as multi-par

203 KEY MESSAGE: Accumulation of phenolic needle metabolites in Norway spruce is regulated by many

204 measurements with both the classical wick-in-needle method (to estimate free-fluid pressure) and a pi

205 ally deposited inside a medical grade spinal needle, minimizing the matrix effect.

206 d no significant correlation existed between needle mycobiome and tree genotype.

207 d Illumina-generated ITS1 sequences from the needle mycobiome of white spruce (Picea glauca) at the n

208 The conformational plasticity of the tail needle N-terminal tip is built in the amino acid sequenc

209 Dagger and needle nematodes included in the family Longidoridae (vi

210 mitochondrial (mt) genomes of the dagger and needle nematodes, Xiphinema rivesi, Xiphinema pachtaicum

211 animals injected either by jet injection or needle, no adverse events were observed in any of the mi

212 patterns of endophytic fungi associated with needles of Pinus taeda trees across regional scales in t

213 nal acupuncture treatment sessions involving needling of predefined acupoints.

214 ues (i.e., roots, trunk/cores, twigs, leaves/needles) of the local plant community were taken, namely

215 patches containing an array of micron-sized needles on an adhesive backing have been developed to be

216 should be a preference for using lower gauge needles over higher gauge needles with more passes.

217 increased with an increase in the number of needle passes or a decrease in needle gauge (two-way ana

218 elds with respect to needle gauge, number of needle passes, and percentage of the needle core.

219 llowed a cortical tangential approach if the needle path was parallel to the renal cortical surface,

220 Twelve (40%) were performed with an anterior needle path, 12 (40%) with a lateral needle path, and si

221 nterior needle path, 12 (40%) with a lateral needle path, and six (20%) with a posterior needle path.

222 needle path, and six (20%) with a posterior needle path.

223 , two in the sham group), and syncope due to needle phobia (n=1; in the sham group).

224 fluoroscopy during image-guided percutaneous needle placement in a pig model.

225 planning and execution of safe and effective needle placement.

226 primary target of the compounds as the T3SS needle pore protein EspD, which is essential for effecto

227 the single probe was assessed in an in vivo needle prick model to mimic sequelae of traumatic brain

228 pulses (50 Hz, 300-600 V) delivered by a two-needle probe with 1-mm inter-electrode distance.

229 We have previously developed miniature needle probes that could enable intraoperative volume im

230 These Photonic Needles probes have sub-10 mum cross-sectional dimension

231 erformed in 100 patients by using the single-needle procedure and in 111 patients by using the double

232 alcifications (P < .001) and with the single-needle procedure in fluid calcifications (P = .024).

233 ocedure duration was shorter with the double-needle procedure in hard calcifications (P < .001) and w

234 fference between using the single- or double-needle procedure when performing US-guided percutaneous

235 dure and in 111 patients by using the double-needle procedure.

236 was not different between single- and double-needle procedures, both overall and when considering cal

237 man NAIP detects both flagellin and the T3SS needle protein and suggested that the ability to detect

238 NAIP1 recognizes the T3SS needle protein, NAIP2 recognizes the T3SS inner rod prot

239 sis were not observed at the wound site, the needle puncture significantly enhanced DNA duplication i

240 pacity and limited immune response caused by needle puncture to the midgut, this approach was success

241 ir of gastrointestinal perforation made by a needle-puncture wound in the silkworm larval midgut.

242 eys indicate that clinical adoption of these needles remains poor.

243 times greater yield for 18- versus 20-gauge needles, respectively.

244 nd 94 ng g(-1) ww in birch leaves and spruce needles, respectively.

245 e 117 and 165 distinct 43% and 31% underwent needling, respectively, and 50% of trabeculectomy eyes u

246 use of an 18-gauge versus a 20-gauge biopsy needle resulted in a 4.8-5.7 times greater yield, wherea

247 The length of each needle segment is approximately equal to the length of t

248 Stimulation of acupoints produces needling sensations caused by the activation of small di

249 ities, nanoparticle deposits, and islands of needle-shaped crystals.

250 icles were aggregated, and some connected to needle-shaped or sheet-like cholesterol crystals.

251 Scanning electron microscopy revealed hollow needle-shaped particle ultrastructure, with a zeta poten

252 avoidance traits (branch conductivity, leaf/needle size, tree height, leaf area-to-sapwood area rati

253 The device is a needle-sized porous container capable of encasing therap

254 r) support, problems with workload planning, needle stick injuries and physical workload (moving and

255 eal dysplasia, Otopalatodigital, and Melnick-Needles syndrome, with X-linked periventricular nodular

256 pants with 306 doses of mRNA (80-640 mug) by needle-syringe (18 intradermally and 24 intramuscularly)

257 Conversely, intradermal or intramuscular needle-syringe injection was ineffective, with only one

258 f CV7201 intradermally or intramuscularly by needle-syringe or one of three needle-free devices.

259 free device, although not when injected by a needle-syringe.

260 can be injected in vivo through conventional needled syringes.

261 with high coverage of both NSP and OST (>200 needle-syringes distributed per PWID and >40 OST recipie

262 often low according to WHO indicators (<100 needle-syringes distributed per PWID per year; <20 OST r

263 ere are 33 (uncertainty interval [UI] 21-50) needle-syringes distributed via NSP per PWID annually, a

264 air and imaged radioisotope distribution in needles, the first experiment of its kind using (13) N.

265 Door-to-needle time (DNT) is a key performance indicator for eff

266 ge therapist), an off-hours pattern (door-to-needle time for thrombolysis), and a flow pattern whereb

267 longer in the drip-and-ship group (onset-to-needle time, 150 vs 135 minutes; onset-to-puncture time,

268 cific systems changes to reduce DTN (door-to-needle) time has not been fully evaluated.

269 Target depth, accuracy (distance between needle tip and target), and radiation dose (dose-area pr

270 flow rate is sufficiently high and when the needle tip is close to the apical terminus.

271 e processed to obtain tracking images of the needle tip.

272 tip protein, p40, reveal similarities to the needle-tip invasin proteins SipD and IpaD of Gram-negati

273 t twofold change (FDR corrected p < 0.05) in needle tissues in response to MeJA application.

274 d a protein complex that acts like a compass needle to guide magnetic orientation in animals.

275 Reduction in the dimensions of hypodermic needle to micron-scale size has gained tremendous intere

276 ult, these devices often require a sheathing needle to prepuncture robust sample matrixes and protect

277 fibre-optic hydrophone was integrated into a needle to receive Golay-coded transmissions from the pro

278 complex' translocator that connects the T3SS needle to the translocon pore.

279 We show the Photonic Needles to be mechanically robust when inserted into 2%

280 B-mode ultrasound imaging and 3D ultrasonic needle tracking.

281 and damage to major blood vessels; however, needle tract seeding is observed in 26% of treated tumor

282 00), tumor growth was observed alongside the needle tract.

283 his study reports profiles of whitebark pine needle transcriptomes, following methyl jasmonate (MeJA)

284 re headache revealed no interactions between needle type and patient age, sex, use of prophylactic in

285 urfaces of FDA-approved human commercial CGM needle-type implanted sensors in a rodent subcutaneous t

286 Although the length and composition of tail needles vary significantly in Podoviridae, unexpectedly,

287 ariate analysis, the use of a 9- or 10-gauge needle versus a 7- or 8-gauge needle was also an indepen

288 9- or 10-gauge needle versus a 7- or 8-gauge needle was also an independently associated with underes

289 A needle was used to create a small cavity in the upper ep

290 of sub ng/ml concentrations of human Tg from needle washouts of fine-needle aspiration biopsies of th

291 llowed the label-free detection of Tg in the needle washouts of fine-needle aspiration biopsies, at c

292 patients who had lumbar puncture, atraumatic needles were associated with a decrease in the incidence

293 Twenty-five- or 27-gauge needles were used for FNAB under direct visualization.

294 , reliant on administration using hypodermic needles, which can be associated with patient compliance

295 method to generate a multi-segmented optical needle with a strong longitudinally polarized field, uni

296 e important T3SS feature is an extracellular needle with an associated tip complex responsible for as

297 ted a nanoporous stainless steel acupuncture needle with enhanced therapeutic properties, evaluated b

298 s demonstrate that a multi-segmented optical needle with variable focal depth, adjustable interval, n

299 using lower gauge needles over higher gauge needles with more passes.

300 AEs were mild/moderate; common AEs included needling (without sight-threatening complications), nonp