ライフサイエンスコーパス: nef gene

1 que astrocyte cultures is dependent upon the nef gene.

2 n infectious HIV-1 provirus with a truncated nef gene.

3 than did SHIV(MD1), which contains the HIV-1 nef gene.

4 infectivity as was virus encoding a deleted nef gene.

5 irus (SIV) neurovirulence map to the env and nef genes.

6 ariants containing wild-type (WT) or mutated nef genes.

7 of an integrated provirus but not the env or nef genes.

8 h live attenuated SIV with a deletion in the nef gene and expressing gamma interferon (IFN-gamma) res

9 V/17E-Fr, which contained the entire env and nef genes and the 3' long terminal repeat of SIV/17E-Br

10 Variants of SIV containing a deletion in the nef gene are attenuated in adult macaques, where they pr

11 morphisms or large sequence deletions in the nef gene associated with delayed disease progression wer

12 Thus, changes in the TM and nef genes between SIV/17E-Cl and SIV/17E-Fr account for

13 range mutant (Ad5 h) expressing SIV gag and nef genes but not Retanef or env (1 x MVA/Ad5).

14 virus that had repaired the deletion in the nef gene by a compensatory mutation was found in one ani

15 demonstrated a limited transcription of the nef gene by nonintegrated HIV in infected quiescent T-ce

16 The nef gene contributes to the replication of primate lenti

17 type 1 (HIV-1) virions which have their own nef gene deleted and are trans complemented to contain H

18 combinants encoding SIV env/rev, gag, and/or nef genes, followed by boosting with SIV gp120 or an SIV

19 The relevance of the accessory vpr, vpu, and nef genes for human immunodeficiency virus type 1 (HIV-1

20 he virologic basis of these differences, the nef gene from HIV-2-seropositive persons was analyzed be

21 the HIV-1 nef gene has been replaced by the nef gene from SIV in a multiround infectivity assay usin

22 ociated polymorphisms in HIV-1 gag, pol, and nef genes from a large cohort of South Africans with chr

23 Analysis of nef genes from these viruses revealed patterns of genoty

24 e tested an HIV-1 isolate in which the HIV-1 nef gene has been replaced by the nef gene from SIV in a

25 tenuated vaccines such as SIV with a deleted nef gene have provided the most robust protection agains

26 Deletion of the nef gene impacts both the efficiency of primary infectio

27 chimeric viral construct containing the HIV nef gene in an SIV backbone), but not in animals infecte

28 Restoration of the nef gene in the recombinant HXB/LW genome restored its p

29 his study document the presence of defective nef genes in HIV-2 infections with a prevalence higher t

30 es were substantially more active than early nef genes in stimulating HIV-1 replication in high CD4-p

31 production to those of virus from which the nef gene is deleted.

32 The nef gene is important for the pathogenicity associated w

33 tious than are isogenic viruses in which the nef gene is intact.

34 A nef gene is present in all primate lentiviruses, includi

35 igate evolutionary patterns in the gp120 and nef genes leading to the emergence of host-specific vira

36 ressing the HIV-1 clade C env, gag, pol, and nef genes (NYVAC-C) with single or double deletions of g

37 We have found previously that the nef gene of HIV-1 is responsible for these changes.

38 The nef gene of human and simian immunodeficiency viruses (H

39 The nef gene of human and simian immunodeficiency viruses en

40 The nef gene of human and simian immunodeficiency viruses is

41 The nef gene of primate lentiviruses encodes a myristoylated

42 A truncated version of the nef gene of simian immunodeficiency virus SIVmac239 capa

43 The product of the nef gene of SIV has been shown to be important for virus

44 The nef gene of the human and simian immunodeficiency viruse

45 The nef gene of the human and simian immunodeficiency viruse

46 ral clones containing point mutations in the nef gene of the pathogenic clone SIVmac239 revealed that

47 However, the nef genes of HIV-1 and SIVmac exhibit minimal sequence i

48 The nef genes of human immunodeficiency virus type 1 (HIV-1)

49 nd the virus control did not carry an active nef gene, our results suggest that, in CD4+ T cells infe

50 al activities that have been ascribed to the nef gene product of simian immunodeficiency virus (SIV)

51 imary cells infected with HIV-1 if the viral nef gene product was expressed.

52 blish more clearly whether the SIV and HIV-1 nef gene products are functionally analogous, we compare

53 The nef gene products encoded by human immunodeficiency viru

54 ef+) or do not (SIV delta nef) encode intact nef gene products.

55 Importantly, HIV lacking the nef gene remained unaffected by these manipulations.

56 ccinia viruses expressing gag, env, pol, and nef genes representing the seven most predominant subtyp

57 t 1-3 mo documented heterogeneity of gag and nef gene sequences and mother-to-child transmission of C

58 HIV-1 nef gene sequences from infecting isolates from the chil

59 tion of an SIV vector with a deletion in the nef gene (SIV(delta nef)) and expressing gamma interfero

60 s (SIV) vectors with a deletion in the viral nef gene (SIV(delta nef)) that express gamma interferon

61 We also replaced the gag, pro, and nef genes (SIVmac239 origin) with those of human immunod

62 l repeat regulatory sequences, utilizing the nef gene splice signals.

63 A portion of the nef gene that encompasses a hypervariable region was fus

64 NL4-3 viruses carrying mutations within the nef gene that selectively impair these functions.

65 SIV that can compensate for the loss of the nef gene to partially restore replicative and pathogenic

66 per infected T cell were similar whether the nef gene was present or not.

67 IL-2-stimulated 221 cells whether or not the nef gene was present.

68 (HIV-1) replication, a segment of the HIV-1 nef gene was replaced with human RNase L cDNA.

69 The HIV-1 nef gene was uniformly retained in all SHIVnef-infected

70 ny, whether the progenitor of the p17gag and nef genes was SF2 or LAV-1b could not be determined.

71 DC expressing the nef gene were able to stimulate Nef-specific CTL, with T

72 g this SHIV model had shown that the vpu and nef genes were important in pathogenesis of the infectio

73 otein were observed, although mRNAs for both nef genes were produced at comparable levels.

74 addition to C2-V5env, the entire p17gag and nef genes were sequenced; however, based on nucleotide s

75 e products encoded by the HIV type 1 (HIV-1) nef gene, which is commonly included in candidate vaccin

76 The evolution of the gp120 and nef genes, which encode two key proteins required for th

77 e) gag gene into the Rev-independent (early) nef gene with concomitant mutation of the corresponding