ライフサイエンスコーパス: negative charge

1 hen the buttressing alpha-heteroatom bears a negative charge.

2 similar functional effects by introducing a negative charge.

3 llows for the uptake of particles having net negative charge.

4 hr) without compensating for the loss of the negative charge.

5 an enzyme responsible for increasing the LPS negative charge.

6 phosphate leaves, to neutralize the evolving negative charge.

7 culated that the cation binding sites bear a negative charge.

8 n states lead to increased delocalization of negative charge.

9 the leaving group carries a large amount of negative charge.

10 lt in a significant and repulsive buildup of negative charge.

11 tabilization and for neutralization of ATP's negative charge.

12 ite electrostatic repulsion from the growing negative charge.

13 separated from the one containing the excess negative charge.

14 trast to short MWNT-OVA displaying the least negative charge.

15 ns repelled from each other by their overall negative charge.

16 permutation, shorter CDR3 segments, and less negative charges.

17 of positive topological charge and avoiding negative charges.

18 ), or short MWNTs-OVA (~122nm) of increasing negative charges (-23.4, -35.8 or -39mV).

19 perbases (DBN and DBU) to help stabilize the negative charge, a family of discrete supertetrahedral c

20 d patch of positive charges in FtsN(Cyto) to negative charges abolishes the interaction with FtsA.

21 uctance of the sensor due to accumulation of negative charges added by the immobilized probe DNA and

22 Incomplete quenching of negative charges allows stronger oxidants/electrophile (

23 lates at cell tips and defines a gradient of negative charges along the cell surface.

24 h pH plume front, the goethite reversed to a negative charge, along with quartz and kaolinite, then g

25 change in crystal packing originated in the negative charge and 4-5 masculine bend in the reduced is

26 ompanied by a substantial focal reduction in negative charge and available PS in TCR microclusters.

27 e complementary PNA-beads, the beads acquire negative charge and become electrophoretically mobile.

28 of the fulvenyl group in stabilizing nearby negative charge and highlight the ability of fulvene spe

29 Negative charge and moderate lipophilicity correlate wit

30 The released eNT, due to its less negative charge and small size, diffuses easily to the n

31 hat stabilizing interaction between a remote negative charge and stable radicals, occurring in gas ph

32 n its protein environment (modifying the net negative charge and/or substrate accessibility/binding)

33 r to be mediated by the increase in nitrogen negative charge (and consequent increase in hydrogen bon

34 s of Gram-positive bacteria generally have a negative charge, and we noticed a correlation between (p

35 ation to physiological pH restores the fixed negative charges, and yields remodeled cartilage that re

36 Small molecules with positive, neutral, and negative charge are detected by P-EIM.

37 Moreover, substrates with a net negative charge are disfavored by the channel, probably

38 es the generation of precursors in which the negative charges are masked with biolabile groups.

39 ups, whereas basal surfaces have a permanent negative charge arising from isomorphic substitutions.

40 ive charge accelerates the motion, whereas a negative charge arrests it.

41 here proteins were found to carry the lowest negative charge as confirmed by the zeta potential measu

42 double-stranded RNA, which carries the same negative charge as DNA, but assumes a different double h

43 action for physical adsorption resulted from negative charge assisted hydrogen bonding between H atom

44 ution and size of 0.43mum that carried a net negative charge at neutral conditions (pH 7.0).

45 ith a decreased pKa value, to preserve their negative charge at neutral pH, restore the sensitivity t

46 if of DQ2.5 (negative charge at P4) and DQ8 (negative charge at P1).

47 combines the peptide-binding motif of DQ2.5 (negative charge at P4) and DQ8 (negative charge at P1).

48 ity experiments also show that addition of a negative charge at Ser-175 favors the autoinhibited conf

49 Placement of negative charge at Ser-175, through phosphorylation or m

50 These effects likely create a small negative charge at the air-water interface, generating a

51 e amine transfers a proton to the developing negative charge at the enolate oxygen, while the other a

52 Accumulation of negative charge at the NSO3 moiety in the transition sta

53 ectron deficiency in the carbon skeleton and negative charge at the oxygen end that upon reaction wit

54 analysis indicates that the latter builds up negative charge at the substrate C(alpha) and positive c

55 n of an aromatic ring at the X1 position and negative charge at the X5 and X6 positions significantly

56 e most functional, again indicating that the negative charge at this position is not a determining fa

57 time that M oligomerization, regulated by a negative charge at Thr205, may be critical to production

58 In addition, we show that introduction of negative charge at tyrosine 18 shifts Tau's previously d

59 The ion neutralizes negative charges at the constriction zone, reducing the

60 time-constant features are attributed to the negative charges at the glass-solution interface.

61 is achieved by the insertion of positive or negative charges at the interface, and the resultant dip

62 Increasing the number of negative charges at the N terminus of yeast actin from t

63 Nucleic acids carry a negative charge, attracting salt ions and water.

64 positive-charged state, hence triggering the negative-charged AuNPs to aggregate by the electrostatic

65 with the MP2/aug-cc-pVQZ model show that the negative charge becomes more dispersed in the anions of

66 teraction of these positive charges with the negative charge borne by the initial Fe(0)-CO2 adduct is

67 e four positive charges are replaced by four negative charges borne by sulfonate groups also installe

68 Composed of negative-charged boron-centered tetrahedral linkers, NPF

69 of 2, phosphate residues have just a single negative charge but Asp and Glu are uncharged.

70 sitive not only to lipid composition and net negative charge, but also to the hydrophobic character o

71 single Zn(2+) or Cu(2+) ion reduced the net negative charge by a greater magnitude than predicted (i

72 er hours or days, these OP adducts acquire a negative charge by dealkylation in a process called agin

73 py-driven and unlikely to be affected by the negative charge by K65 acetylation.

74 ic, increasing up to 1.7-fold on addition of negative charges by phosphorylation of grana-hosted prot

75 on by acidic pH, whereas reintroduction of a negative charge (by MTSES modification of Cys) restored

76 ty (log D = -3.7) and presence of additional negative charges (carboxylates) on the chelator, promoti

77 n, a spin-1/2 excitation, is the fundamental negative charge carrier in pi-conjugated organic materia

78 However, removal of surface negative charges caused low subunit solubility and poor

79 f PA because of its accessibility and higher negative charge compared with the diester phosphates of

80 an be increased by dispersing its contiguous negative charge, confirming the importance of this prope

81 alpha-synuclein to lipid vesicles with high negative charge content is essentially unaffected by N-t

82 curvature, but binding to vesicles of lower negative charge content is increased, with stronger bind

83 Its negative charge could trigger conformational changes nec

84 The negative charge creates a region, known as the ion atmos

85 Substitutions that introduce a negative charge (D, E) at position 117 reduce resistance

86 tive charges, short MWNT-OVA with the lowest negative charge demonstrated better cellular uptake and

87 acylcarnitines but not a lysolipid without a negative charge, demonstrating the necessity of a negati

88 in the repulsive forces due to their higher negative charge densities.

89 n is promoted by one or more regions of high negative charge density and aromatic/hydrophobic residue

90 helical membrane protein is modulated by the negative charge density around the protein.

91 patch is open, which explains how it senses negative charge density but lacks stereoselectivity.

92 The elevation of negative charge density caused by the presence of the ri

93 on between the ARMs of the excess CP and the negative charge density of the capsid exterior.

94 ochlorite, which leads to an increase in the negative charge density of the membrane due to the forma

95 on BOD-GO composite having the same moderate negative charge density, but the highest kS of (79.4+/-4

96 Owing to their high negative charge density, PP-InsP(y) will not cross the c

97 bserved on BOD-GO composite having different negative charge density.

98 osomes containing acidic lipids depending on negative charge density.

99 olarizable and exhibit both a positive and a negative charge depending on the pH of the solution.

100 f pneumococcus may assume various degrees of negative charge depending on the polysaccharide capsule,

101 uch as a transition from net-positive to net-negative charge depending on the solution pH.

102 ll-length Lon with residues conferring a net negative charge disrupted binding of Lon to DNA.

103 analysis of Arn revealed that its shape and negative charge distribution are similar to dsDNA, sugge

104 ce of Xyn30D-CBM35 shows a unique stretch of negative charge distribution extending from its binding

105 Treating AN69 dialysis membrane, which bears negative charge due to incorporated sulfonate groups, wi

106 specially effective at helping to delocalize negative charge due to some cyclopentadienide character

107 iciently stabilize the resulting build-up of negative charge during Meisenheimer complex formation, l

108 d R1 gating-charge positions and a conserved negative charge (E43) at the extracellular end of the S1

109 A negative-charge-enriched hairpin loop connecting S5 and

110 and positrons in the geomagnetic field and a negative charge excess in the shower front.

111 Overall, a high Cd to Se precursor ratio, negative-charged fatty acid ligands with a long hydrocar

112 beta-pyrrolic position confirmed the largest negative charge for the C12 carbon atom in antipodal pos

113 A variant with negative charges forms 1:2 host/guest complexes with ami

114 Negative charge "freezing" at the boron atom is indeed a

115 pproximately pH 5 to 5.5 and reduced its net negative charge from -30.8 to -27.0 mV.

116 0, and E85), augmented by the elimination of negative charges from Mb or b(5) by neutralization of he

117 lcholine, and with the same overall membrane negative charge, Gag strongly preferred lipids with both

118 taurine-driven E-ring opening and increasing negative charge generally enhanced ROS photogeneration i

119 At elevated temperatures, a negative charge generated on the surface by a vigorous H

120 ffect of the modified chemical bonding, this negative charge gives rise to an additional barrier for

121 attraction toward substrates of concentrated negative charge governs substrate discrimination, which

122 Loss of the negative charge in one of these residues, D39, causes a

123 -state distributions for proteins with a net negative charge in solution do not depend on tip size.

124 ture and that there is a small generation of negative charge in the aryl ring, which is compatible wi

125 emoval of the positive charge at Lys544 or a negative charge in the C-terminal region likely disrupts

126 effect was found, alleviating the excess of negative charge in the guest toward the outer surface of

127 Its negative charge in the open state is decisive for proton

128 and inter-species chimaeras have shown that negative charge in the RACK1 loop dictates ribosome sele

129 first order reaction in hydroxide and a full negative charge in the rate-determining step.

130 mic acid substitution (G84E), resulting in a negative charge in the SUP-1 TMD.

131 es a cation to compensate for the developing negative charge in the transition state in the absence o

132 Increased negative charge in this C-terminal tail balances positiv

133 nt STIM1 and Orai1 that is mutated to remove negative charges in its C-terminal coiled coil, indicati

134 enerate charge and to transport positive and negative charges in spatially separated phases.

135 Enrichment of negative charges in TCR binding loops, particularly the

136 or E2 is explained via the redistribution of negative charges in the electrode double-layer region wh

137 d, low-pH gradients within the tissue: fixed negative charges in the proteoglycan matrix are protonat

138 ents arise from the slow outward movement of negative charges in the unliganded transporter.

139 Constructs lacking negative charges in the unstructured presequence of LF(N

140 The negative charge increased during these experiments due t

141 tage dependence, and the neutralization of a negative charge increased it.

142 itive charge but not for proteins with a net negative charge indicates that the unfolding occurs prio

143 ive charges facilitating oligomerization and negative charges inhibiting it.

144 For this, the negative charge, initially located on position 1, circum

145 midation, like phosphorylation, introduces a negative charge into proteins.

146 olding mutant FiP35 Pin1, which introduces a negative charge into the first turn.

147 The negative charge introduced by phosphorylation of the sub

148 Thus, negative charges introduced by copper-dependent phosphor

149 ing to sensing membrane curvature when lipid negative charge is decreased.

150 Thus, a continuous phosphodiester backbone negative charge is not essential for sliding over nonspe

151 High negative charge is required to overcome the thermodynami

152 ling suggested that eliminating the Glu(317) negative charge is sufficient to induce a conformational

153 the Poisson-Boltzmann equation indicate that negative charge is transferred across the membrane when

154 In completely encapsulated films, negative charging is enhanced leading to uniform optical

155 moiety is not a good electrophile due to the negative charge it carries.

156 Because of its negative charge, it forms complexes with positively char

157 contrast, at pH 10.0, where PE lipids bear a negative charge, K(DApp) decreases with increasing PE co

158 binding equilibria involving anions of high negative charge, like SO(4)(2-), SeO(4)(2-), S(2)O(3)(2-

159 cations and we suggest that the formation of negative charges might create a surface on the helicase

160 For negative charge migration, this class of bifunctional li

161 The mechanistically novel negative-charge migration that comprises the Brook rearr

162 se (M86E DHP) was generated by introducing a negative charge near His89 to enhance the imidazolate ch

163 se results suggest that DNA and consequently negative charge near the electrode possess a larger impa

164 ich includes a chain of alternating positive/negative charges nine atoms long.

165 We conclude that a concentrated region of negative charge, not steric properties, resulting from m

166 y are of negative polarity, transporting net negative charge of 17-23 C to the lower ionosphere.

167 C-terminal transport domain bears an overall negative charge of -1.23.

168 n this paper we show that removing the fixed negative charge of a single acidic amino acid (Glu(51))

169 Mutations that mimic the negative charge of ADP-ribose destabilized substrate bin

170 The net negative charge of apo-SOD1 was similar to predicted val

171 The negative charge of aspartic acid is believed to be able

172 ere used to screen efficiently the intrinsic negative charge of biogenic Se suspensions at circumneut

173 The negative charge of capsular polysaccharides has been pro

174 For alpha-chlorofatty acid, the negative charge of carboxylic acids is exploited to dete

175 estraints, can be introduced by reducing the negative charge of DNA nanotubes using counter ions and

176 The negative charge of NLC was reduced from -17.54 to -8.47

177 arges of heparin, they do not neutralize the negative charge of OSCS.

178 inder actin association, while the increased negative charge of oxidized C147 would lead to electrost

179 The negative charge of phosphatidylserine in lipid bilayers

180 of the skin combined with the large size and negative charge of siRNAs make epidermal delivery of the

181 e third metal is positioned to stabilise the negative charge of the 5'-phosphate, and thus three meta

182 demonstrated that the respective positive or negative charge of the 8 aforementioned residues is requ

183 In addition, we provide evidence that the negative charge of the A2662 phosphate group must be ret

184 alate layer of the structure and offsets the negative charge of the anionic framework.

185 n was correlated with smaller size and lower negative charge of the attached metal chelates.

186 ly through the partial neutralization of the negative charge of the backbone.

187 ne-containing substituents to reduce the net negative charge of the bacterial surface, thereby promot

188 forming 1-diphosphate lipid A increasing the negative charge of the bacterial surface.

189 eaction, thereby potentially dissipating the negative charge of the catalytically active enolate form

190 Importantly, increasing or decreasing the negative charge of the complexin-I accessory helix inhib

191 dent after a significant increase in the net negative charge of the cytoplasmic surface of the N-term

192 effect of the fluorine atoms the role of the negative charge of the dissociated PFAAs is likely insig

193 lt from the differential interactions of the negative charge of the fragment ion with the electron cl

194 gly affected by charge repulsion, due to the negative charge of the hydroxyl functionalized nanoparti

195 te is decreased by positive and increased by negative charge of the lipids, whereas the conductance o

196 ids spontaneously 'overcharge'; that is, the negative charge of the NA exceeds the positive charge on

197 ons, atoms, or molecules compensate the high negative charge of the nucleic acid backbone.

198 A into cells is achieved by neutralizing the negative charge of the phosphate backbone in a reversibl

199 of Ca2+ binding to C2A is to neutralize the negative charge of the pocket, thereby unleashing the fu

200 ally mimicked Ca2+ binding by decreasing the negative charge of the pocket.

201 at inhibited Ca2+ binding but maintained the negative charge of the pocket.

202 utase (SOD1) by increasing the intrinsic net negative charge of the polypeptide, i.e., by acetylation

203 The hydrophilicity and negative charge of the pore surface gradually increase a

204 the O-antigen causing an increase in overall negative charge of the remaining LPS inner section.

205 Given the large size and the negative charge of these macromolecules, their delivery

206 The negative charge of two aspartate residues within this st

207 ile Ca(2+) ions can efficiently suppress the negative charges of heparin, they do not neutralize the

208 Using the negative charges of nucleic acid tags, we develop a vers

209 Ca(2+) neutralizes the negative charges of the Ca(2+)-binding sites, resulting

210 An AALSAAA mutant in which all negative charges of the DELSEED motif were removed showe

211 f nucleosome survival correlate with the net negative charges of the histone-interacting surfaces.

212 cal function of FH because by binding to the negative charges of the modified target, FH could preven

213 nding of CL, whose specific features combine negative charges of the two phosphate groups with four h

214 function of the dualism between positive and negative charged off-stoichiometric sites (i.e., N-vacan

215 We suggest the adenosine neutralizes the negative charge on a nonbridging phosphate oxygen atom a

216 glycans was to quantitatively neutralize the negative charge on both alpha2,3- and alpha2,6-linked si

217 ular orbital, denoted Phi(2)(1), and a small negative charge on Ca and (ii) an open-shell singlet (bi

218 resent on both C2 epitopes and complementary negative charge on each antibody.

219 th the predicted repulsive effect of the net negative charge on GlyH-101.

220 on and electrostatic potential analyses, the negative charge on Pz(-) is diluted due to the XB.

221 iO2 and to supported Au particles produces a negative charge on the Au, whereas the transfer from the

222 sting of the stabilization of the developing negative charge on the beta-phosphate by the hydrogen of

223 llenge, likely due to the rapidly increasing negative charge on the cluster as the size goes up.

224 His-160 in which an electrophile accepts the negative charge on the developing carbanion.

225 has been proposed to stabilize a developing negative charge on the ether oxygen in the migration of

226 ith positive charge on the beta-nitrogen and negative charge on the gamma-nitrogen.

227 A binding, which is due to the effect of its negative charge on the iron-sulfur bonds.

228 to PS, Cu(2+) binding does not alter the net negative charge on the membrane as the Cu(PS)2 complex f

229 Here, we exploit the single negative charge on the monosialoganglioside GM1, commonl

230 zes the transition state by neutralizing the negative charge on the nonbridging phosphoryl oxygens.

231 s affected by the presence of the additional negative charge on the OEC of the mutant.

232 In contrast, reducing negative charge on the opposing convex face produces a p

233 addition to stabilization of the developing negative charge on the oxallyl fragment of the rearrange

234 d to an appreciable increase in the size and negative charge on the particles in the system.

235 It is seen forming a salt bridge with the negative charge on the phosphate headgroup.

236 organophosphide ligands (PR2(-)) bearing one negative charge on the phosphorus atom; (2) the dianioni

237 and two lysines (K215 and K217) mitigate the negative charge on the siroheme macrocycle.

238 the terminal sialic acid residues creating a negative charge on the surface of prion particles.

239 i) binding presumably because the additional negative charge on the trianionic P(i) allows stronger e

240 ellular Cl(-) and the concentration of fixed negative charges on macromolecules.

241 d chromatin leading to neutralization of the negative charges on polyanionic DNA and modification of

242 t both peptides accumulate at and neutralize negative charges on the bacterial surface.

243 We thus suggest that the two negative charges on the C-terminus of the obliquely tilt

244 Increasingly negative charges on the complexes lowered the activation

245 lt of the repulsive interactions between the negative charges on the DNA helices.

246 Negative charges on the HBc VLP surface were then reduce

247 protein with enhanced sweetness by removing negative charges on the interacting side of thaumatin wi

248 ter electrostatic forces between the partial negative charges on the iodide and cyanide ions and the

249 Together, these results indicate that negative charges on the modified proteins dominate the i

250 ulfonate) (PSS) layer onto the AuNRs imposed negative charges on the nanorod surface, and the interac

251 he absence of a Mg(2+) ion to neutralize the negative charges on the phosphates explain the weaker af

252 In Cx46, neutralization of negative charges or addition of a positive charge in the

253 a pH higher than 5, phosphopeptides have two negative charges per residue and are well-retained in AE

254 minantly acidic, provide evidence that a net negative charge plays a significant role in driving the

255 Introduction of two negative charges plus a single-residue insertion, to mim

256 by layer-by-layer deposition of positive or negative charged polyelectrolytes.

257 exist to the idea that a higher magnitude of negative charge predicts higher prevalence.

258 Similarly, neutralization of the negative charges present in the cell microenvironment le

259 ics simulations suggest that this additional negative charge prevents the C-terminal tail from intera

260 MB bears an additional carboxylic group, the negative charge provided by this group prevents intimate

261 only the amount but also the position of the negative charges provided by phosphorylation.

262 essential role, in addition to serving as a negative-charge provider, as a critical determinant of t

263 we found that the contact system recognized negative charges rather than specific chemical structure

264 linked mutations to SOD1 will reduce its net negative charge regardless of subcellular localization.

265 However, their negative charge remains a challenge for delivery and tar

266 some alkylammonium-based systems the excess negative charge resided on anions and not on the positiv

267 residues removed was not due to the loss of negative charged residues of the DELSEED motif in these

268 uential blocks having positive, neutral, and negative charges, respectively.

269 that certain configurations of positive and negative charges result in enhanced uptake into a mucin

270 The negative charge results in the generation of C-type glyc

271 Negative charging results in faster radiative decay but

272 to provide a fluorescent label and a triple-negative charge, separated by microchip electrophoresis,

273 ore places Glu-181 well within the region of negative charge shift following excitation.

274 Compared to the short MWNTs-OVA bearing high negative charges, short MWNT-OVA with the lowest negativ

275 at is inserted, in which case a compensating negative charge should be distributed over the carbon ca

276 esulting HCR products with a large number of negative charges significantly enhanced the stability of

277 tudied primarily in their highest accessible negative charge states (3-, 4-, and 5-, respectively), a

278 oxide (GO), such as the high hydrophilicity, negative charge, strong adsorption capability, and large

279 ichannels and Vj gate polarity reversal by a negative charge substitution (N2E) in the amino terminal

280 Conversely, negative charge substitution at these serines (3S>D) ant

281 rotein underwent smaller fluctuations in net negative charge than predicted (i.e., ~3 units, instead

282 t both orients the substrate and offsets the negative charge that builds up during catalysis.

283 constitutively active in the absence of the negative charge that is associated with the common V600E

284 y molecular chaperones possess a substantial negative charge that may allow them to impart solubility

285 The Q875E mutation introduces a negative charge that may modify the local electrical fie

286 mical protecting group, thus eliminating the negative charges that have been shown to have a negative

287 An increase in headgroup negative charge through the addition of phosphatidylglyc

288 positive charges, which we propose chaperone negative charges through the PA channel during DeltapH t

289 By shielding the negative charge, thus increasing the interaction of DNA

290 Phosphorylation adds negative charge to amino acid side chains, and negativel

291 This modification adds a negative charge to residues of the histone tails that in

292 By imparting additional negative charge to these Asp/Glu clusters, such Ser/Thr

293 arge-transfer picture, but instead exhibit a negative charge-transfer energy in line with recent mode

294 ests that a disordered domain with dispersed negative charges underlies PRC1 activity, and is conserv

295 ergy barrier in gas phase increases with the negative charge, varying from 16 kJ mol(-1) for [EDTAH4.

296 tal (NBO) charges show that Cgamma carries a negative charge, while Lu, Hgamma, and Sibeta carry posi

297 phosphatidylinositol 4,5-bisphosphate (PIP2)-negative charges with poly-l-lysine and prevented by int

298 The structures further revealed a ring of negative charge within the central vestibule, poised to

299 One mutation, D51/E52/E55A, targeted negative charges within region II of the primary interfa

300 The ability to incorporate negative charge without sacrificing binding affinity is