ライフサイエンスコーパス: negative feedback

1 eased LH pulse frequency, indicating loss of negative feedback.

2 rewarded actions and reduced sensitivity to negative feedback.

3 a proton shuttle controlled by pH-dependent negative feedback.

4 d on balancing the strengths of positive and negative feedback.

5 O2 concentrations ([CO2(aq)]) constituting a negative feedback.

6 feedback in the absence of buffering by the negative feedback.

7 roducts to the CSR has been shown to provide negative feedback.

8 inals, ruling out the involvement of Cx50 in negative feedback.

9 g SL biosynthetic genes from an SL-dependent negative feedback.

10 niformly regulates thalamic activity through negative feedback.

11 tially mediate plant species coexistence via negative feedbacks.

12 ng rate and sensitivity to positive, but not negative, feedback.

13 benthos) are the only significant described negative feedbacks acting to counteract the effects of i

14 a stochastic activation model incorporating negative feedback and constitutive activity.

15 receptor recruitment increases expression of negative feedback and feedforward regulators, including

16 he VS lesion monkeys were more influenced by negative feedback and had lower choice consistency than

17 o be involved in circuit homeostasis through negative feedback and psychiatric disorders.

18 is was likely due to the silicate weathering-negative feedback and the expansion of land plants that

19 ian estradiol regulates the pattern of GnRH (negative feedback) and initiates a surge of release that

20 , including advanced puberty onset, abnormal negative feedback, and abolished positive feedback.

21 Sequestration-based regulatory cascades with negative feedback are often found in biology, and thus o

22 We show that subjects treat negative feedback as evidence for a switch but weigh it

23 rolled by the mitotic switch but by a double-negative feedback between Cdk1 and Chk1.

24 feedback in Lsr expression is combined with negative feedback between cells.

25 e fraction of nucleotides on the go and that negative feedback between dATP and ribonucleotide reduct

26 Our results reveal a hitherto unrecognized negative feedback between glaciation and atmospheric CO2

27 teractions for root litter decomposition and negative feedback between plants and soil biota.

28 signaling, effectively uncoupling the normal negative feedback between these two pathways.

29 This implies a strong negative feedback between weathering by non-vascular veg

30 ncrease water use efficiency thus minimizing negative feedbacks between carbon and nutrient balance.

31 ximal at intermediate levels of ERK-mediated negative feedback but is not influenced by receptor dese

32 The circuit also features negative feedback by PDF to truncate the s-LNv Ca(2+) wa

33 Lowering relative strength of GAL80-mediated negative feedback by replacing GAL80 promoter is necessa

34 catalytically inactive ERK2) and increasing negative feedback (by Egr1-driven expression of dual-spe

35 ith this, experiments revealed that reducing negative feedback (by expressing catalytically inactive

36 Our analyses reveal that negative feedback channeled through the Ras1/2 GTPase is

37 This study focuses on the negative feedback circuit that exists between the EnvZ-O

38 These interactions form a negative feedback circuit that limits the magnitude of m

39 elease, CITED2 activates a highly responsive negative feedback circuit that rapidly and efficiently a

40 These results demonstrate a CRY-BIC negative-feedback circuitry that regulates the activity

41 We propose that NANOG acts as a negative feedback component that provides stem cell-spec

42 k, exerting effects on both its positive and negative feedback components.

43 ted with innate immune responses, absence of negative feedback control of gene expression by regulato

44 ction mutation of TTP impairs IL-10-mediated negative feedback control of macrophage function in vitr

45 Diurnal leaf-level measurements revealed a negative feedback control of photosynthesis, resulting i

46 ercoiling-responsivesness is consistent with negative feedback control of topoisomerase I and topoiso

47 regulatory network, whereby DUSP1-dependent negative feedback control reduces feed-forward control b

48 1 substrates in M. marinum are fine-tuned by negative feedback control, linking the expression of the

49 Estradiol-negative feedback decreased glutamatergic transmission t

50 ve feedback loops, such that the effect of a negative feedback depends on its position with respect t

51 key in ERK-mediated resistance towards SHP1 negative feedback, did not affect TCR signalling nor lig

52 ous studies focused on what happens when the negative feedback dominates the dynamics.

53 hosphorylation of AKT, supporting a model of negative feedback downstream of PREX1 activation.

54 ptin is believed to mediate the positive and negative feedback effects of oestradiol in the hypothala

55 ordant pairs of users is allowed even with a negative feedback, either with the rewiring step (RUCM)

56 omeostat) engages mechanisms that operate as negative feedback elements to keep the biological variab

57 wn how positive feedback generates switches, negative feedback enables gradient detection, and cohere

58 treated with c-SRC inhibitors, suggesting a negative feedback exists between miR-34a and c-SRC.

59 motes tumour growth by inactivating p53 in a negative feedback fashion and suggest PHLDB3 as a potent

60 photosynthesis of land plants-may provide a negative feedback for climate change.

61 cts a weaker response to therapy if there is negative feedback from differentiated tumor cells that i

62 Also, negative feedback from horizontal cells to photoreceptor

63 Previously unobserved negative feedback from JNK also contributes to Wnd repre

64 that T cell-derived CD70 performs a critical negative feedback function to downregulate inflammatory

65 Negative feedback HSP, also known as synaptic scaling, m

66 LH pulse frequency and impaired progesterone negative feedback in adult females, mimicking the neuroe

67 y activated by Hedgehog, providing essential negative feedback in all tissues.

68 l work has established that the LHb mediates negative feedback in response to aversive events.

69 demonstrate a novel mechanism of presynaptic negative feedback in which an anion-selective LGIC acts

70 Apparent negative-feedback inhibition by ferrous ions is document

71 imiting the proinflammatory response through negative-feedback inhibition of cytokine receptors.

72 The models include a negative-feedback interaction of F-actin onto the Arp2/3

73 ow-diffusing membrane components with slower negative feedbacks involving faster diffusing cytoplasmi

74 If this negative feedback is less pronounced, the treatment resp

75 can activate cell invasion, then, due to the negative feedback, it can deprive mTOR and S6K of their

76 nt at short pulses, whereas voltage-mediated negative feedback leads to self-termination of ChR2 curr

77 onger timescales, CO2 release could act as a negative feedback, limiting progress of glaciation, depe

78 Circadian negative feedback loop (CNFL) genes play important roles

79 n still be grouped into two general classes: negative feedback loop (NFBL) and incoherent feed-forwar

80 mediated NMD inhibition, breaking the normal negative feedback loop and allowing the aberrant increas

81 d miR-155 relieves chronic inflammation by a negative feedback loop and plays a protective role durin

82 Additionally, we uncover a negative feedback loop between actin remodeling and flg2

83 Here the authors show a negative feedback loop between C/EBPalpha and miR-182 an

84 regulation of ERK and define a novel double-negative feedback loop between EpCAM and ERK that contri

85 We describe the negative feedback loop between graft mesenchymal and Tef

86 lated by the insulin signaling pathway via a negative feedback loop between miR-34 and DAF-16/FOXO.

87 Our results describe a double-negative feedback loop between MIR100HG and the transcri

88 us transcription factors, including a double-negative feedback loop between the microRNA-200 (miR-200

89 The double-negative feedback loop between the microRNA-200 family a

90 We report a negative feedback loop between the signaling protein pho

91 Interrupting this negative feedback loop by PMEPA1 knockdown increased pro

92 rectly represses the MDFIC gene, revealing a negative feedback loop by which glucocorticoids limit MD

93 gether, these results describe a tri-element negative feedback loop composed of p53, Apela, and hnRNP

94 mness-regulatory mechanism in which a double-negative feedback loop consisting of PRMT7 and miR-24-3p

95 The model also includes a negative feedback loop due to inhibition of calcium infl

96 replication forks, revealing an ATR-mediated negative feedback loop during replication.

97 odels simulations suggest that, although the negative feedback loop formed by cAMP, cAMP-dependent pr

98 A double-negative feedback loop formed by the morning genes CIRCA

99 lations demonstrate that the CSP-1-dependent negative feedback loop functions in glucose compensation

100 This potentially constitutes a negative feedback loop governing this critical checkpoin

101 e Polycomb group protein EZH2 disrupted this negative feedback loop in both CRPC and enzalutamide-res

102 nse signaling molecule salicylic acid form a negative feedback loop in defense and cell death control

103 We uncovered a negative feedback loop in M2 myeloid cells, wherein inte

104 ygenase type 2 (COX-2), which functions in a negative feedback loop in TGFbeta and ERbeta signaling p

105 lly repressed by p53, defining an additional negative feedback loop in the p53 network.

106 irst time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced

107 Thus, our results uncover a negative feedback loop in which CREBH regulates NEFA flu

108 us, Treg cell development is controlled by a negative feedback loop in which mature progeny cells ret

109 Our results identified a negative feedback loop in which SET9 controls DNA methyl

110 We further demonstrate that a negative feedback loop involving miR-135a can restore AR

111 how that partial adaptation arises through a negative feedback loop involving the small protein MgrB.

112 induced FBXL5 protein level, demonstrating a negative feedback loop limiting excessive accumulation o

113 paBalpha protein and impaired NF-kappaB self-negative feedback loop mediated less newly synthesis of

114 robe, which upon irradiation strengthens the negative feedback loop of a CRN that produces oscillatio

115 ulation results suggest that, while a single negative feedback loop of either one- or two-gene elemen

116 mor suppressor 1/2) kinases, to constitute a negative feedback loop of the Hippo pathway in both cult

117 This revealed that Ca(2+) entry exerted a negative feedback loop on rituximab-induced apoptosis, s

118 Thus, mGluRs establish a local negative feedback loop positioned to regulate IHC activi

119 to ICAM-1, suggesting that a tension-induced negative feedback loop promotes ICAM-1-mediated neutroph

120 200 family and ZEB1, which exist in a double-negative feedback loop regulated by TGF-beta, serve impo

121 plication stress and is thereby engaged in a negative feedback loop that attenuates oncogene-dependen

122 SUMOylation and degradation, establishing a negative feedback loop that attenuates SnRK1 signaling a

123 fear-induced miRNAs, act as components of a negative feedback loop that blocks neuronal hyperactivit

124 on of SK channels by mGluR1, which removes a negative feedback loop that constitutively regulates NMD

125 like responses to inputs, is nested within a negative feedback loop that encompasses RAS and RAF, MEK

126 These elements typically have one negative feedback loop that generates oscillations, and

127 porulation sigma factor sigma(F) to create a negative feedback loop that inhibits sigma(F) -directed

128 pic glutamate signalling establishes a local negative feedback loop that is positioned to regulate in

129 We show that it is part of a negative feedback loop that limits proinflammatory and p

130 ne that functions as an afferent signal in a negative feedback loop that maintains homeostatic contro

131 ator of TGFbeta signalling, thus mediating a negative feedback loop that may potentially restrain TGF

132 on, epigenetic barrier crossing coupled to a negative feedback loop that mechanistically differs from

133 A negative feedback loop that relies on the coordination-c

134 These results suggest a negative feedback loop that responds to signaling events

135 suppresses AR expression, this results in a negative feedback loop that suppresses AR protein expres

136 n decreased miR863-3p levels, thus forming a negative feedback loop to attenuate immune responses aft

137 CCN3/NOV inhibits AR signaling and acts in a negative feedback loop to block AR function.

138 Our data suggest that miR-323-3p acts in a negative feedback loop to control the production of IL-2

139 data suggest that PIFs and HECs constitute a negative feedback loop to fine-tune photomorphogenesis i

140 ivated protein kinase Snf1 is coupled with a negative feedback loop to generate the characteristic pu

141 e, which is used as a signal in an autocrine negative feedback loop to regulate cell proliferation.

142 S6K in turn acted through a negative feedback loop to restrain Akt3 expression.

143 wo decades ago the WUSCHEL/CLAVATA (WUS/CLV) negative feedback loop was established as being essentia

144 to be decent substrates of OGT, exhibiting a negative feedback loop when phosphorylated at the P-3 si

145 pression is controlled via an autoregulatory negative feedback loop whereby Chtop binds its own mRNA

146 b gene of the M4 module (NaLRRK1) mediates a negative feedback loop with JA signaling.

147 positive feedforward loop with Stat1/2 and a negative feedback loop with Stat3.

148 ogy of highly druggable motifs consists of a negative feedback loop without any positive feedback loo

149 h CAL-101 [idelalisib]), interrupts a double-negative feedback loop, enhancing GC-regulated transcrip

150 ent cullin and proteasome activity provide a negative feedback loop, ensuring that adhesion assembly

151 Here we describe evidence of a negative feedback loop, in which PGE2 augments the expre

152 We propose a negative feedback loop, in which sphingosine inhibits GB

153 n summary, pneumococci recognition induces a negative feedback loop, preventing excessive inflammatio

154 f the chemicals is regulated by a biomimetic negative feedback loop, the "repressilator" network.

155 downmodulation of a phosphatase-mediated MET-negative feedback loop, which accompanies receptor inter

156 e the integrity of adherens junctions, and a negative feedback loop, which is used to limit beta-cate

157 and impaired dPER function in the circadian negative feedback loop, which manifests into changes in

158 maB network to function as an ultrasensitive negative feedback loop.

159 scade reactions "OFF", thus establishing the negative feedback loop.

160 (IFNs) and limits their production through a negative feedback loop.

161 with the growth regulator melted in a double-negative feedback loop.

162 R-200, independent of Zeb1, to form a double-negative feedback loop.

163 rwhelming immune reaction by engagement of a negative feedback loop.

164 it bone resorption by osteoclasts, forming a negative feedback loop.

165 egrin receptors at the RPE cell surface as a negative feedback loop.

166 ed mobilization of IRF3, thus constituting a negative feedback loop.

167 By contrast, Ripply1 induces a negative-feedback loop by promoting Tbx6 protein degrada

168 critical involvement of Dok-1 and Dok-2 in a negative-feedback loop that prevents overactivation of C

169 The resulting bioelectronic and microfluidic negative-feedback loop then serves to regulate the conce

170 on in mammary adipose tissue through a novel negative-feedback loop.

171 Only two circuit motifs generate adaptation: negative feedback loops (NFLs) and incoherent feed-forwa

172 The regulatory core is controlled by two negative feedback loops (regulated by Mdm2 and Wip1) res

173 dic dynamics, the elements with two positive/negative feedback loops are the minimalist elements to h

174 PKC activation amplifies negative feedback loops at the level of G protein-couple

175 Our data point to the existence of negative feedback loops between these two regulatory pro

176 tructure unbiasedly reveals four interlocked negative feedback loops contributing to circadian rhythm

177 to investigate how interlinked positive and negative feedback loops process EGF signals into ERK pul

178 of ancestral RNAi by, for example, employing negative feedback loops to reset the transmission of epi

179 nterplay between fast (min) and slow (min-h) negative feedback loops with maximal information transfe

180 Two negative feedback loops with Notch and Pros allow Kon to

181 Two auxiliary negative feedback loops, from ERK to MEK and RAF, placed

182 sitive feedback introduces a hierarchy among negative feedback loops, such that the effect of a negat

183 e analyzed dynamics-determining positive and negative feedback loops, thereby elucidating the attract

184 effect driven by the partial preservation of negative feedback loops.

185 teoclast signaling intermediaries or through negative feedback loops.

186 n-generating/consuming enzymes with pairs of negative-feedback loops for pH homeostasis.

187 s and type I interferon gene expression in a negative-feedback manner, thus promoting HHV-8 productiv

188 race of the fractional derivative provides a negative feedback mechanism between the voltage trace an

189 tivation of RasGAP, and that preventing this negative feedback mechanism by inhibiting Abl family kin

190 ownregulation of TCR expression represents a negative feedback mechanism for constraining T cell effe

191 Decreased wetland CH4 emissions can act as a negative feedback mechanism for future climate warming a

192 can mediate repression of ainS, providing a negative feedback mechanism in the Ain/Lux signaling cas

193 Our results identify a new negative feedback mechanism involving the miR-146a/b-TRA

194 dephosphorylation, thus constituting a novel negative feedback mechanism regulating eNOS activity not

195 om activity generates an error signal in the negative feedback mechanism that controls firing rates.

196 on of kinesin-II from IFT trains serves as a negative feedback mechanism that facilitates flagellar l

197 Finally, we propose the existence of a negative feedback mechanism that governs the pore format

198 ay in glomerular stromal cells is a critical negative feedback mechanism that limits inflammatory ren

199 eated with sclerostin antibody, suggesting a negative feedback mechanism that limits Wnt-driven bone

200 e of homeostatic synaptic regulation, a slow negative feedback mechanism that maintains neural activi

201 dulation of synaptic plasticity represents a negative feedback mechanism that may limit runaway enhan

202 n of DLK1 by pancreatic beta-cells acts as a negative feedback mechanism to counteract the stimulator

203 s reduced via self-attenuation, a protective negative feedback mechanism, masking EADs.

204 ophagosome formation is regulated by a novel negative-feedback mechanism on membrane lipids.

205 We describe a negative-feedback mechanism targeting RIG-I activity, wh

206 ption of normal Zap70 autoinhibition engaged negative feedback mechanisms by which negative selection

207 Thus, GATA3-mediated positive and negative feedback mechanisms control human T-cell lineag

208 Whereas negative feedback mechanisms for microtubule length cont

209 orders, and is accomplished through a set of negative feedback mechanisms that sense and compensate f

210 resulting lines expressing crtI has revealed negative feedback mechanisms, acting predominantly at th

211 ts the whole process, probably by triggering negative feedback mechanisms.

212 A gene transcription is tightly regulated by negative feedback mechanisms.

213 The approach curve was recorded in negative feedback mode of SECM and revealed the contact

214 The negative feedback modulation between LncRNA-SARCC/AR com

215 vioral data showed reduced risk taking after negative feedback (money loss) during the BART with real

216 ation, which creates a combined positive and negative feedback network controlling NF-kappaB activity

217 ic-pituitary-adrenal (HPA) axis is closed by negative feedback of cortisol on the hypothalamus and pi

218 in high plasma glucose, which could lead to negative feedback of insulin resistance, including inhib

219 As AtrA is evolutionarily conserved, negative feedback of the type described here may be wide

220 urial that would have acted as an additional negative feedback on atmospheric pCO2 levels.

221 This noisy linear map implements a negative feedback on cell-size control: a cell with a la

222 biological ocean carbon storage and act as a negative feedback on climate change.

223 Our data suggest that UBD provides a negative feedback on cytokine-induced activation of the

224 s, endosomal sorting and autophagy--provides negative feedback on hepatic insulin signalling.

225 the possibility that magmatic flux acts as a negative feedback on ice-sheet size.

226 sol translocation of ZNRF2 and forms a novel negative feedback on mTORC1.

227 hat upregulation of BCA2 provides regulatory negative feedback on NF-kappaB.

228 This effect provides a modest negative feedback on seawater composition and (87)Sr/(86

229 sin modulated neural activity when receiving negative feedback on task performance from a study inves

230 The reason is that negative feedback on the rate of tumor cell division pro

231 nses to climate change can exert positive or negative feedbacks on climate, mediated in part by slow-

232 This negative feedback, operating on a longer time scale, cha

233 ta signaling in retinal explants, which is a negative feedback pathway for amacrine cell production.

234 ing that activating mutations can bypass the negative feedback pathway formed between HIF1 and mTORC1

235 osal free fatty acid receptor 2 to trigger a negative feedback pathway to lower hepatic glucose produ

236 y p70S6K1 attenuate insulin action through a negative feedback pathway.

237 In order to obtain negative feedback positioning control without risking da

238 ane that orchestrates an autophagy-dependent negative-feedback programme to mitigate oxidative stress

239 The negative feedback promotes epileptic oscillations wherea

240 depends on the level of the NF-kappaB system negative feedback protein A20.

241 Our results indicate a strong negative feedback regime when atmospheric oxygen concent

242 cysteine metabolism in cardiomyocytes, and a negative feedback regulation between CBS and CSE in the

243 The lacustrine Si:C atomic ratio is negative feedback regulation by phytoplankton, which may

244 ystem, N. crassa, by removing the endogenous negative feedback regulation by the circadian oscillator

245 We further demonstrate how this negative feedback regulation insulates alternative sigma

246 e reason that the resulting tissue selective negative feedback regulation is essential to establish s

247 nd inflammatory cytokine signaling through a negative feedback regulation loop involving down-regulat

248 Phosphorylation-mediated negative feedback regulation of cAMP levels by phosphodi

249 tes IL-10 and is thought to be important for negative feedback regulation of the Th1 response.

250 These data implicate calpain/PTP1B negative feedback regulation of VEGFR2, in addition to t

251 NF-kappaB activation is controlled by a negative feedback regulation through the ubiquitin editi

252 of photoreceptor-mediated signaling and its negative feedback regulation.

253 rved LP(Q/E)L sequence that is essential for negative feedback regulation.

254 ity can evolve by optimizing the strength of negative-feedback regulation.

255 key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal biogenesis and

256 ctivated by oxidative stress and serves as a negative feedback regulator of NOX4 in CMs during cardia

257 l postulates that Tre6P is both a signal and negative feedback regulator of Suc levels, forming part

258 his is consistent with the role of CCN1 as a negative feedback regulator of vascular endothelial grow

259 of DDB2 was required for RNF43 function as a negative feedback regulator of Wnt signaling.

260 One such gene encodes CITED2, a negative feedback regulator that attenuates HIF-1 transc

261 The negative feedback regulator ubiquitin-specific protease

262 elevation of miR-24 and reduction of the key negative-feedback regulator IRAK-M. miR-24 reduces the l

263 abrogates the recruitment of SEC, forming a negative feedback regulatory loop.

264 and activity, confirming the existence of a negative feedback regulatory mechanism.

265 transcription, suggesting the existence of a negative-feedback regulatory loop that may account for s

266 mice to appropriately evaluate positive and negative feedback, respectively.

267 This represents positive and negative feedback, respectively.

268 pated, if firing frequency exhibited classic negative-feedback responses, or paradoxical.

269 We suggest a negative feedback sensor that couples photosynthetic car

270 mutant cell lines by antagonizing release of negative feedback signalling, demonstrating the potentia

271 he retina, where cell number is regulated by negative feedback signals, which arrest differentiation

272 regulatory regime to one where fire-mediated negative feedbacks stabilize high O2 levels.

273 ding and reduced sensitivity to positive and negative feedback, suggestive of a deficit in incorporat

274 at-derived leptin, revealing two independent negative feedback systems for fat mass regulation.

275 ion to appropriate regulatory or positive or negative feedback systems.

276 The Wnt pathway activates several negative feedback targets, including axin2 and Dkk1, tha

277 Although a negative feedback tends to maintain this internal state

278 via the CBM--then triggering HOIL1-dependent negative-feedback termination, preventing reactivation.

279 spective plant inhibit the respective PLA, a negative feedback that prevents continuous overexpressio

280 mulating Axin2 in maturing valves represents negative feedback that restrains tissue overgrowth rathe

281 D was introduced to the cascade via indirect negative feedback, the response time was significantly r

282 caused by perseveration or insensitivity to negative feedback though.

283 lations result from an interplay between the negative feedback through the cortico-subthalamo-nigral

284 Attenuation of synaptic signaling by this negative feedback through the interplay of Glu and GABA

285 While it was not necessary for the negative feedback to be coupled to monetary loss, it had

286 ntal shelves would represent Earth's largest negative feedback to climate change.

287 have operated as both a direct and indirect negative feedback to end the T-OAE.

288 ncentrations from 1999 to 2006, resulting in negative feedback to global warming.

289 due, at least in part, to ineffective use of negative feedback to guide subsequent decisions.

290 adrenergic receptors (ARs) constitutes vital negative feedback to prevent cellular overexcitation.

291 ession on hepatocytes, which may determine a negative feedback to protect the liver against immunolog

292 The add-on provides real-time negative feedback to regulate the laser power delivered

293 s picoplankton community shift may provide a negative feedback to rising atmospheric carbon dioxide c

294 and productivity(3), which would represent a negative feedback to rising CO2 and consequently warming

295 ls, health-maintaining mechanisms, including negative feedback to the drivers, can maintain resilienc

296 ctica mean that significant carbon sinks and negative feedbacks to climate change could also develop

297 ion) by benthos, one of the few demonstrable negative feedbacks to climate change.

298 chemical oscillations emerge due to delayed negative feedback via a Hopf bifurcation, resulting in a

299 cs, arbuscular mycorrhizal trees experienced negative feedback, whereas ectomycorrhizal trees display

300 Negative feedback, whether graded or binary, accelerated