ライフサイエンスコーパス: negative regulation

1 tic pleiotropy through mutations that affect negative regulation.

2 system decreases its activity through strong negative regulation.

3 ion had no additive effects on LGP2-mediated negative regulation.

4 rcadian expression of Tshb independent of TH negative regulation.

5 perfamily lectin receptors (Siglecs) provide negative regulation.

6 aAcos is unusual because it is refractory to negative regulation.

7 sitive regulation and gave mixed effects for negative regulation.

8 of serine-426 on TRAF4 was required for this negative regulation.

9 ficity to phosphorylate mGluR and to mediate negative regulation.

10 stone genes are subject to both positive and negative regulation.

11 cells are subject to multiple mechanisms of negative regulation.

12 6 on NOX4 was critical for this FYN-mediated negative regulation.

13 ated region of SMOX mRNA contributes to this negative regulation.

14 dentifies novel targets of PU.1 positive and negative regulation affecting progenitor cell signaling

15 family members, with emphasis on pathways of negative regulation and orchestration of innate and adap

16 ction; however, molecular mechanisms for its negative regulation are poorly understood.

17 y responses are subject to complex layers of negative regulation at intestinal mucosal surfaces.

18 more defective for positive regulation than negative regulation at low mRNA expression, but the defe

19 the available evidence that shows reciprocal negative regulation between innate interferons and TH2 m

20 reover, both positive regulation by McaS and negative regulation by ArcZ require the same binding sit

21 IFN-I induction is subject to negative regulation by both viral and cellular factors,

22 Here we investigated the possibility of a negative regulation by CB1 receptors of leptin-mediated

23 Regulation at the CBP60 node involves negative regulation by CBP60a as well as positive regula

24 en positive regulation by cytokinin (CK) and negative regulation by CLAVATA (CLV).

25 e multiple mechanisms whereby VISTA relieves negative regulation by hematopoietic cells and enhances

26 inactivated by multiple mechanisms; however, negative regulation by insulin is not well understood.

27 The negative regulation by Kil significantly reduces the GTP

28 emanating from both forms of FLT3 are under negative regulation by Lnk.

29 reduce their host-defense functions, dynamic negative regulation by miR-34a provides one means of fin

30 r data point to multiple mechanisms of PREX1 negative regulation by PAKs within receptor tyrosine kin

31 ) of a domain previously responsible for its negative regulation by phytochrome.

32 ilin-p53 pro-apoptotic pathway is subject to negative regulation by PLD1 thorough cofilin inactivatio

33 f ABA binding to receptors, which alleviates negative regulation by protein phosphatases 2C (PP2Cs) o

34 P-triggered immunity (PTI) is under constant negative regulation by protein phosphatases but the unde

35 adation of eRNAs at two enhancers subject to negative regulation by Rev-Erbs resulted in reduced expr

36 in1 receptors- DCC and Unc5C is under direct negative regulation by Satb2 and Ctip2, respectively.

37 ved in starch biosynthesis, suggesting their negative regulation by SlARF4.

38 respectively, leading to either positive or negative regulation by T3.

39 its associated proteins (the degradosome) in negative regulation by these sRNAs.

40 en, BMP4 expression was elevated, indicating negative regulation by this hormone.

41 Negative regulation by VEX1 also affected telomeric pol-

42 Negative regulation by yeast extract resulted in signifi

43 We conclude that the dynamics of Smad negative regulation cannot be explained by the negative

44 This negative regulation critically depends on transcriptiona

45 lopmental competence involves the removal of negative regulation exerted by both NsdD and VosA.

46 Several molecular mechanisms of negative regulation have been published, but the relativ

47 HrpS D32, E200 and K233 are not involved in negative regulation imposed by HrpV.

48 ranscription start site acts as a target for negative regulation imposed on the L4P by cellular TFII-

49 VISTA and examine its function in lymphocyte negative regulation in cancer.

50 t PKCbeta is the isoform responsible for Syk negative regulation in human platelets.

51 Our work identifies novel sites of negative regulation in MYC and thus new sites for its th

52 tronic mRNA isoforms may represent a form of negative regulation in plants, providing a conceptual li

53 internal dynamics leads to poorer allosteric negative regulation in V66A/L68V CzrA.

54 This negative regulation is achieved by the formation of Ure2

55 virus (HCV) core and NS5A proteins, and this negative regulation is apparent in chronically HCV-infec

56 Negative regulation is lost by effector binding to the c

57 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important roles in m

58 However, DCs are built-in with inherent negative regulation mechanisms which attenuate their imm

59 show an unexpected T-helper-17-cell-specific negative regulation mediated by CD70-CD27 interaction.

60 e events to changes in neuronal activity via negative regulation of a newly identified mitogen-associ

61 humans and mice, where it is involved in the negative regulation of Ab production and cellular activa

62 These results also reveal that negative regulation of ACLY and lipid synthesis is a nov

63 Through negative regulation of ACLY, CUL3 inhibits lipid synthes

64 ess whereas cellular component organization, negative regulation of actin filament depolymerization a

65 6a exerts a kidney protective effect through negative regulation of acute inflammatory response by su

66 ings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis un

67 Fpk1-mediated negative regulation of Akl1 enhances endocytosis, becaus

68 Together, the data suggest that negative regulation of Akt signaling via microRNAs might

69 ied as being associated with positive and/or negative regulation of alternative splicing in a positio

70 ion of AMPKalpha at Ser-485, blocks cAMP-PKA negative regulation of AMPK, and improves metformin resi

71 ently exposed a newly identified pathway for negative regulation of AMPs in the skin by the cholinerg

72 reviously unrecognized role for USP21 in the negative regulation of antiviral response through deubiq

73 ever, the molecular mechanism underlying the negative regulation of aPKCs remains largely unknown.

74 wn-regulation of genes strongly enriched for negative regulation of apoptosis, angiogenesis, and meta

75 uency of autophagosome formation through its negative regulation of ATG9.

76 do, suggesting that PSGL-1 has a role in the negative regulation of autoimmunity.

77 ote remodelling indirectly by preventing the negative regulation of AutoN and NegC.

78 play vital roles in auxin signaling via the negative regulation of auxin response factors (ARFs).

79 development processes were up-regulated and negative regulation of axon extension processes were dow

80 The lack of negative regulation of BA synthesis may be accountable f

81 embryo myogenesis and uncover the concerted negative regulation of BAF60a and BAF60b by the muscle-s

82 rogram of gene expression exemplified by its negative regulation of Bcl6.

83 Our results reveal a new mechanism for the negative regulation of BCR signaling and broadly suggest

84 These results reveal a role of CD23 in the negative regulation of BCR signaling in the absence of I

85 This demonstrates that relaxing negative regulation of BCR signaling, rather than enhanc

86 ribution of C5aR and C5L2 indicates that the negative regulation of BDNF secretion by C5L2 correlates

87 APP limits venous thromboembolism through a negative regulation of both fibrin formation and neutrop

88 bioactive state is inhibited by LXR through negative regulation of both pro-caspase 1 expression and

89 of host gene myosin effects with evidence of negative regulation of cAMP-specific 3',5'-cyclic phosph

90 otein phosphatase (PP1), likely resulting in negative regulation of cAMP/calcium response element-bin

91 These data indicate that the negative regulation of cap-dependent translation by mTOR

92 cid signaling cross talk, is involved in the negative regulation of caterpillar resistance and in the

93 CD4+ Th1 differentiation is associated with negative regulation of CD4+ Th2 and Th17 differentiation

94 Skb1 inhibited mitotic entry through negative regulation of Cdr1 and localized to both the cy

95 ypoxia, activation of NF-kappaB pathway, and negative regulation of cell cycle, a gene signature also

96 sigma factor SigT, which is involved in the negative regulation of cell differentiation, was complet

97 ed in cellular amino acid metabolic process, negative regulation of cell proliferation and cell redox

98 ults reveal a novel function of KDM2B in the negative regulation of cell proliferation by assembling

99 ET5 and TET6 in leaf and root growth through negative regulation of cell proliferation.

100 Negative regulation of cells in the mediastinal lymph no

101 fear memory formation, suggesting that this negative regulation of contextual fear memory by AMPK in

102 Taken together, these studies establish negative regulation of CREB activity by endogenous CaMKI

103 the Bn-clg1A-1D mutation causes a pronounced negative regulation of cutin biosynthesis or loading and

104 The negative regulation of cyclin B1 by AR is mediated throu

105 D1 promoter, resulted in abolishment of the negative regulation of cyclin D1 by HIF-1alpha, which pr

106 cotine N-demethylation and suggests that the negative regulation of CYP82E4 expression may serve to r

107 utants is consistent with a role for KORs in negative regulation of DA function, whereas the lack of

108 We conclude that the negative regulation of DC priming of CD8 T lymphocyte im

109 Namely, TAM-mediated efferocytosis, negative regulation of dendritic cell activity, and dysr

110 that Tbx3 can activate Zscan4(+)/2C state by negative regulation of DNA methylation at repeated seque

111 ng that p180C and/or p70 are involved in the negative regulation of DNA pol activity.

112 The loss of negative regulation of Dnmt3a by miR-29a is a major cont

113 cal for maintaining HSC function through its negative regulation of Dnmt3a.

114 h signaling to control cell-cell adhesion by negative regulation of E-cadherin expression.

115 ndent tumor suppressor, mediates coordinated negative regulation of efferocytosis by resident murine

116 Finding a role for RpS6 in the negative regulation of efferocytosis provides the opport

117 g Wnt and TGFbeta during early regrowth, and negative regulation of extracellular proteases in late s

118 he modification and its correlation with the negative regulation of FadD32 activity.

119 e that Gal3 is involved in both positive and negative regulation of FcepsilonRI-mediated signaling ev

120 the BBX19-CO interaction and eliminates the negative regulation of flowering time, while the analogo

121 nd human pre-B B-ALL cells that involves the negative regulation of FOXO1 by nuclear factor kappaB (N

122 Ebf1 accomplishes this through both direct negative regulation of Foxo1 expression and direct posit

123 sly described systems mostly on the basis of negative regulation of FtsZ assembly.

124 Biological functions involved in negative regulation of gene expression were enriched in

125 s relies on the balance between positive and negative regulation of gene transcription.

126 Here we show that positive or negative regulation of glial responses to axon injury is

127 e a novel transcriptional repressor-mediated negative regulation of glycolysis.

128 Together, the data suggest non-canonical, negative regulation of growth and reproduction by DPY-21

129 e demonstrates a prominent role for CD148 in negative regulation of growth factor signals, suppressin

130 Furthermore, the dynamics and function of negative regulation of GTP-loaded K-Ras have not been fu

131 We identify negative regulation of GvHD-related neovascularization b

132 stimulated upon overproduction of DsrA, via negative regulation of H-NS, or of GadY, likely by titra

133 -regulated genes that could be involved in a negative regulation of heart morphogenesis.

134 production and became less sensitive to the negative regulation of HGF by TGF-beta3.

135 Negative regulation of HIF1alpha by AMPK1 is bypassed in

136 ion between Plexin-B2 and Plexin-D1 with the negative regulation of IL-12/IL-23p40 in DCs.

137 rstood, and potential mechanisms involved in negative regulation of IL-31Ralpha signaling have so far

138 eventing multiorgan autoimmunity through its negative regulation of Il-6 gene expression in Fo B cell

139 ic effector cells and has been implicated in negative regulation of immediate hypersensitivity respon

140 that complement C5a directly participates in negative regulation of immune responses to bacteria-indu

141 d suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and

142 firmed an important role for B-cell-mediated negative regulation of immunity.

143 L-35-producing B cells as key players in the negative regulation of immunity.

144 Thus, AnxA2 directly exerted negative regulation of inflammatory responses through TL

145 ncreased bacterial burden, inflammation, and negative regulation of innate immune cell recruitment to

146 protein tyrosine phosphatase involved in the negative regulation of insulin and leptin signaling.

147 cular disease have been described, including negative regulation of insulin signaling, a role in myoc

148 ance, cell-intrinsic molecular mechanisms of negative regulation of integrin adhesiveness and neutrop

149 We hypothesized that negative regulation of IRS-2 activity after IL-4 stimula

150 del where BRD4 coordinates both positive and negative regulation of ISG elongation.

151 Further, cDNA PCR array indicated potential negative regulation of Janus kinase/Stat3 pathway in pM-

152 M. tuberculosis in murine models through the negative regulation of key proinflammatory cytokines and

153 Ypk1, among other actions, alleviates negative regulation of L-serine:palmitoyl-CoA acyltransf

154 The negative regulation of leaf senescence by AtPAT14 in Ara

155 By contrast, BiP's negative regulation of leaf senescence may be linked to

156 us suggesting a novel mechanism by which the negative regulation of MAPK signalling is controlled and

157 rocess, which becomes the major mechanism of negative regulation of mature proliferating hematopoieti

158 LGP2's negative regulation of MDA5 and RIG-I remains intact irr

159 and palmitoylated protein kinase involved in negative regulation of membrane fusion at the lysosomal

160 crotubule tip-associated population of MCAK: negative regulation of microtubule length within the ass

161 Hypermethylation of the miR-137 promoter and negative regulation of miR-137 by CAR contribute in part

162 lded, leading to removal of the ECD-mediated negative regulation of MprB and subsequent activation of

163 eron mRNA) regulation of mRNA stability, and negative regulation of mRNA translation (cpa mRNA), to p

164 t and an accumulation of RNA nucleotides and negative regulation of mRNA.

165 In contrast, negative regulation of mTORC1 signaling by DNA damage is

166 ution of endogenous TGF-beta proteins to the negative regulation of muscle mass via their activation

167 zero, was decreased, genes associated with a negative regulation of myelination, including c-Jun, Sox

168 for R-Ras in promoting autoimmunity through negative regulation of natural regulatory T cell numbers

169 Negative regulation of NCX1- mediated renal Ca(2+) absor

170 reviously unrecognized role for USP18 in the negative regulation of NF-kappaB activation by inhibitin

171 EF24 induced cell apoptosis along with negative regulation of NF-kappaB- X-linked inhibitor of

172 trophy/fibrosis through mechanisms involving negative regulation of NFAT activity in cardiomyocytes a

173 of Mfn2 deletion in HSCs, demonstrating that negative regulation of Nfat is the prime downstream mech

174 s unveil lipin-2 as a critical player in the negative regulation of NLRP3 inflammasome.

175 y, both LjEin2a and LjEin2b are required for negative regulation of nodulation and Ljein2a Ljein2b do

176 We further confirmed this negative regulation of Nrf2 by Hrd1 using Hrd1 condition

177 strates a novel signaling action for RGS6 in negative regulation of oncogene-induced transformation a

178 Our results show that negative regulation of OsARF18 expression by OsmiR160 is

179 The negative regulation of OsMADS34, another LOFSEP gene, an

180 in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.

181 erestingly, the PLS is also required for the negative regulation of p190A RhoGAP activity.

182 atase 1 (DUSP-1) is a factor involved in the negative regulation of p38 MAPK.

183 gical signals and the mechanisms involved in negative regulation of P450s.

184 he p53 pathway and impede full-length MDM2's negative regulation of p53.

185 We propose that negative regulation of Par protein expression by miR-219

186 compared to WT mice, which is indicative of negative regulation of peripheral immune responses by ce

187 scriptional changes were consistent with the negative regulation of peroxisome proliferator-activated

188 The negative regulation of pilus expression by FasX reduces

189 A model where H2O2 mediates the negative regulation of plant responses to prolonged stre

190 pendent gene expression, indicating that the negative regulation of plasmid-dependent genes is a comm

191 Thus, negative regulation of postinitiation mRNA biogenesis ca

192 sustain glutamate release at TC synapses via negative regulation of presynaptic adenosine signaling t

193 ation of actin filament depolymerization and negative regulation of protein complex disassembly are i

194 ciates with polysomes and contributes to the negative regulation of protein synthesis.

195 trols actin and microtubule dynamics through negative regulation of Rac.

196 effector Stat5, providing a link between the negative regulation of Rag transcription by IL-7 and a n

197 depend on G-coupled receptor kinase-mediated negative regulation of receptor signaling and contrasted

198 Negative regulation of receptor signaling is essential f

199 At present, the knowledge on the negative regulation of reprogramming process is indeed p

200 d focal adhesion formation that involves the negative regulation of RhoA synthesis and signaling.

201 ented here suggest a novel role for IFI35 in negative regulation of RIG-I-mediated antiviral signalin

202 complex, but it was involved in positive and negative regulation of RNA granule assembly by being pho

203 These data reveal a newly defined negative regulation of RUNX1/CBFbeta by MLL fusion prote

204 om the SR, and that perturbation of Ca(V)1.1 negative regulation of RyR1 leak identifies a unique mec

205 t is unable to do so in trans Therefore, the negative regulation of seed dormancy by asDOG1 in cis re

206 these results reveal a role for WFS1 in the negative regulation of SERCA and provide further insight

207 dependent under all conditions tested, while negative regulation of sigma(70) is DksA- but not (p)ppG

208 These data suggest a role for LST1/A in negative regulation of signal propagation.

209 ily of adaptors is generally involved in the negative regulation of signaling pathways.

210 cells; however, the mechanism underlying the negative regulation of signaling remains elusive.

211 of the signaling molecules Jak1 and Jak3 and negative regulation of signaling via Jak and the transcr

212 s show that Lyn(+/-) B cells have defects in negative regulation of signaling, whereas Lyn(+/-) mice

213 ription of the mstX-yugO operon is under the negative regulation of SinR, a transcription factor that

214 The lack of a negative regulation of Sox2 and E2F3 by miR-200 in condi

215 tion sites on SPF45 showed both positive and negative regulation of splicing, with a net effect of in

216 onosiga brevicollis Our results suggest that negative regulation of Src by Csk is more ancient than p

217 n GM-CSF stimulation and show that a loss of negative regulation of Src is pivotal in the hyperactiva

218 emically-induced skin carcinogenesis via the negative regulation of STAT3 and AKT signaling.

219 To date, the negative regulation of STAT3 is poorly understood.

220 Our studies implicate myeloid PTP1B in negative regulation of STAT3/IL-10-mediated signaling, h

221 Our data provide a unique mechanism for the negative regulation of STING-mediated DNA sensing.

222 tes this developmental stage by positive and negative regulation of superenhancers with distinct line

223 the paradigm of NCR function to include the negative regulation of symbiotic persistence in host-str

224 Thus, we have defined a novel mechanism of negative regulation of T cell function by endogenous bra

225 mune diseases, the mechanisms underlying the negative regulation of T(FH) cell differentiation are po

226 downregulation of IFN receptor (IFNAR)-2 and negative regulation of T-cell receptor signaling.

227 hus demonstrate a previously uncharacterized negative regulation of TAK1 activity during Th17 differe

228 These findings unveil the negative regulation of TBK1 via tyrosine phosphorylation

229 These data reveal cooperation of negative regulation of TBP with specific chromatin regul

230 These findings therefore show that negative regulation of TCR signaling during NKT developm

231 ultiple influences on T-cell fate, including negative regulation of Tfh cell differentiation.

232 The negative regulation of TG2 by GPR56 associates with the

233 ppressor function of alphaE-catenin involves negative regulation of the beta4 integrin-SRC signaling

234 ffeine decreases miR-301b expression through negative regulation of the cAMP/PKA/NF-kappaB axis.

235 s demonstrate that MARCKS contributes to the negative regulation of the cellular response to LPS.

236 GC-binding interface on RD3 required for the negative regulation of the cyclase localizes to the Lys(

237 ene containing the miR-15a/16-1 loci, and by negative regulation of the Dleu2 promoter, results in re

238 N, consistent with the CEN/SN's hypothesized negative regulation of the DMN.

239 This negative regulation of the Hippo pathway by fibronectin

240 or collectively, to immune homeostasis: the negative regulation of the innate immune response, the p

241 We also explore further the negative regulation of the L4P by its products and show

242 inflammatory signaling, with emphasis on the negative regulation of the NF-kappaB pathway and the NLR

243 is a well known tumor suppressor through the negative regulation of the PI3K signaling pathway.

244 n various non-ribosomal functions, including negative regulation of the pro-apoptotic transcription f

245 Here, we showed the synergistic negative regulation of the pro-inflammatory cytokine int

246 inhibits Rac/STAT-1 activation, leading to a negative regulation of the production of TNF-alpha and N

247 Our findings implicate USP44 in negative regulation of the RNF8/RNF168 pathway and illus

248 d translation/host cell cytotoxicity through negative regulation of the Ser/Arg (SR)-rich protein kin

249 ied as p53-repressed miRNAs by p53-dependent negative regulation of their transcriptional regulators,

250 BR1, suggesting that DydA is involved in the negative regulation of these pathways.

251 These data suggest the existence of a negative regulation of this cross talk between OCN and i

252 f increased Wnt/beta-catenin signalling, and negative regulation of this pathway results in restorati

253 rabidopsis thaliana, where it contributes to negative regulation of this process.

254 ever, inappropriate stimulation or defective negative regulation of this system can lead to inflammat

255 pathways demonstrate distinct mechanisms of negative regulation of TLR responses, and all impact aut

256 Consistent with restoration of HO-1/CAV-1-negative regulation of TLR4 signaling, genetic or pharma

257 cumulation in rafts, thereby determining the negative regulation of TLR4 signaling.

258 Negative regulation of toll-like receptor signaling, dow

259 l module, which is required for positive and negative regulation of transcription, correct preinitiat

260 We previously established a mechanism of negative regulation of transforming growth factor beta s

261 h OX40L and TSLP have been implicated in the negative regulation of Treg.

262 gs imply an important role of NF-kappaB in a negative regulation of TRPC6 expression at the gene tran

263 s on the emerging mechanisms involved in the negative regulation of type 2 immunity.

264 ting host resistance to tuberculosis through negative regulation of type I IFN production.

265 enetic events linked to a novel mechanism of negative regulation of VDR-mediated transcription.

266 hile PTP1B siRNA increased both, implicating negative regulation of VEGFR2 by PTP1B.

267 in E. amylovora virulence and suggested that negative regulation of virulence by GacS/GacA acts throu

268 o understand the molecular mechanism for the negative regulation of Wg signaling by Sulf1, we studied

269 tructural and functional differentiation via negative regulation of Wg trans-synaptic signaling in th

270 Through negative regulation of Yap-dependent proliferation, the

271 ic map of gene function revealed TRAF2/c-REL negative regulation of YAP1/WWTR1-responsive pathways.

272 f epithelial-mesenchymal transition, and the negative regulation of ZEB1 contributed to the inhibitor

273 The positive and negative regulations of some chromosomal genes by pGP4 a

274 In LC, it exerts an autocrine negative regulation on androgen production induced by go

275 angl2 (Vang-like 2) exerts dual positive and negative regulation on Dvl during CE in both the mouse a

276 Leptin is also known to exert a negative regulation on hypothalamic endocannabinoid leve

277 Our data suggest that IL-21 exerts negative regulation on IRF4 and Treg activity, developin

278 responses are more persistent due to lack of negative regulation on pro-IL-1beta expression.

279 at the dCas9 effectors can exert positive or negative regulation on the expression of developmentally

280 Ca(2+) also exerts negative regulation on the olfactory transduction cascad

281 urthermore, let-7-Fam miRNAs appear to exert negative regulation on the worm's resistance to P. aerug

282 miR-200b exerted a negative regulation on tumor-induced angiogenesis.

283 This negative regulation, on grooved topography, was reversed

284 ctively, our data indicate that CD151 exerts negative regulation over IgE-induced late phase response

285 ontelomeric pol-I-transcribed genes, whereas negative regulation primarily affected VSGs.

286 This novel negative regulation principle might balance TNF-induced

287 r signaling components of efferocytosis, its negative regulation remains incompletely understood and

288 pressed or depleted, indicating positive and negative regulation, respectively.

289 pansion and the action of various sources of negative regulation that hold it in check.

290 ion proceeds firstly via pathways subject to negative regulation, then via promoter mutations and gen

291 Neurogenesis requires negative regulation through differentiation of progenito

292 kinases and its correlation with the enzyme-negative regulation, thus shedding a new horizon on the

293 How plants overcome this negative regulation to mount an effective defense respon

294 nalling is subject to stringent positive and negative regulation to promote proper development and ho

295 Loss of this negative regulation under ER stress increases capacity f

296 This negative regulation was mediated by subacute postseizure

297 more, the model suggests that impairing this negative regulation will drive a bifurcation which may r

298 Such collective negative regulation will help to ensure that recombinati

299 trosome-associated SYS-1 degradation couples negative regulation with cell-division timing to facilit

300 , downregulation of MRTF-A/B alleviates this negative regulation without further translocation of NF-