ライフサイエンスコーパス: negative-strand

1 tions in IAV RNA segments (both positive and negative strands).

2 rmutation in the newly synthesized HIV-1 DNA negative strand.

3 rand RNA synthesis but can no longer produce negative strands.

4 eotide during synthesis of both positive and negative strands.

5 rand RNA synthesis but not for production of negative strands.

6 ured stem-loop inserts in either positive or negative strands.

7 an approximately equal ratio of positive and negative strands.

8 s have attributed analogous functions to the negative-strand 3' terminus.

9 s dsDNA, ssDNA, ssRNA positive strand, ssRNA negative strand and retroid and amino acid preference.

10 itive-sense sgRNAs do not have corresponding negative strands and were hypothesized to be produced by

11 cap-snatching mechanisms of other segmented, negative-strand and ambisense RNA viruses.

12 rfering (DI) RNA in the positive but not the negative strand, and (iv) as a higher-order structure in

13 the positive strand and -3.0 kcal/mol in the negative strand, and has associated with it beginning at

14 s from an internal site in the DI RNA to the negative-strand antigenome of the helper virus.

15 switch takes place during the generation of negative-strand antileader-containing templates used sub

16 itro replication reactions, using poliovirus negative-strand cloverleaf RNA, led to a decrease in RNA

17 east in part by deaminating cytidines on the negative strand DNA intermediates.

18 into DNA, removes the tRNA used to initiate negative-strand DNA synthesis, and generates and removes

19 ses, members of the Bunyaviridae family, are negative-stranded emerging RNA viruses and category A pa

20 his study demonstrates that retroviruses use negative-strand-encoded proteins in the establishment of

21 erpart of the matrix proteins found in other negative strand enveloped RNA viruses.

22 lls by divergent and unrelated positive- and negative-strand-enveloped viruses from the Flaviviridae,

23 virus, family Bunyaviridae, has a tripartite negative-strand genome (S, M, and L segments) and is an

24 virus, family Bunyaviridae) has a tripartite negative-strand genome and causes a mosquito-borne disea

25 The negative-strand genome of tupaia rhabdovirus is composed

26 virus, family Bunyaviridae) has a tripartite negative-strand genome, causes a mosquito-borne disease

27 oup of orthobunyaviruses, has a trisegmented negative-stranded genome comprised of large (L), medium

28 hesis of SG RNA is initiated internally on a negative-strand, genome-length template at a site known

29 hat positive-strand influenza virus mRNA and negative-strand genomic RNA (gRNA) accumulated to high l

30 nucleocapsid (N) antigen expression and both negative-strand (genomic) and positive-strand (replicati

31 replication was detected by the presence of negative strand HCV RNA.

32 consistent with the recent demonstration of negative-strand HCV RNA in brain, and suggest that IRES

33 The presence of negative-strand HCV RNA in PBMCs was evaluated by a stra

34 The presence of negative-strand HCV RNA in PBMCs was significantly posit

35 more likely to have detectable positive- and negative-strand HCV RNA in the PBMC compartment than wer

36 urine nucleotides (ATP and GTP), whereas the negative-strand HCV RNA replication is invariably initia

37 Negative-strand HCV RNA was detected in 78 (25%) of 315

38 n CD68-positive cells in eight patients, and negative-strand HCV RNA, which is a viral replicative fo

39 and tested for the presence of positive- and negative-strand HCV RNA.

40 RNase protection assays showed positive- and negative-strand HCV RNA.

41 found to detect up to 10 pg and 10(-5) pg of negative-strand HEV RNA in first- and second-round PCRs,

42 The ratio of positive to negative strand in macrophages was lower than in control

43 7 h postinfection, the ratio of positive to negative strands in individual cells varies from 5:1 to

44 replication-defective RNAs failed to produce negative strands in transfected cells.

45 RNA, or its complement at the 3' end of the negative-strand intermediate, play key roles in the synt

46 plication involves the specific synthesis of negative-strand intermediates followed by an accumulatio

47 mmetric distribution of tags on positive and negative strands is considered.

48 oma and nonhepatoma cells that replicate the negative-strand lymphocytic choriomeningitis virus (LCMV

49 ied by RNA affinity column with biotinylated negative-strand MHV leader RNA and identified by mass sp

50 molecular cloning of the genome of a novel, negative-stranded neurotropic virus, Borna disease virus

51 n RNA polymerase L proteins of non-segmented negative strand (NNS) RNA viruses (e.g. rabies, measles,

52 Gene expression of the nonsegmented negative strand (NNS) RNA viruses is controlled primaril

53 ogenic Ebola virus (EBOV) has a nonsegmented negative-strand (NNS) RNA genome containing seven genes.

54 omain polymerase protein (L) of nonsegmented negative-strand (NNS) RNA viruses catalyzes transcriptio

55 tis virus (VSV), a prototype of nonsegmented negative-strand (NNS) RNA viruses including rabies, meas

56 Nonsegmented negative-strand (NNS) RNA viruses initiate infection by

57 tomatitis virus, a prototype of nonsegmented negative-strand (NNS) RNA viruses, forms a covalent comp

58 IMPORTANCE mRNAs of nonsegmented negative-strand (NNS) RNA viruses, such as VSV, possess

59 The nucleocapsid (N) protein of nonsegmented negative-strand (NNS) RNA viruses, when expressed in euk

60 ins six domains that are conserved among all negative-stranded nonsegmented RNA viruses.

61 Negative-strand (NS) RNA viruses comprise many pathogens

62 e RNA-dependent RNA polymerase L proteins of negative-strand (NS) RNA viruses.

63 nding is specific for the 3' terminus of the negative strand of the viral genome with a dissociation

64 enomes is transcribed from both positive and negative strands of DNA and thus may generate overlappin

65 urther, but only when the stem-loops were in negative strands of RNA2.

66 required for the elongation of positive- and negative-stranded picornavirus RNA.

67 (dsDNA, ssDNA, ssRNA positive strand, ssRNA negative strand, retroid) using amino acid distribution.

68 The negative-strand ribonucleic acid (RNA) genome of the vir

69 tion for over a decade, with high titers and negative strand RNA in the liver.

70 ody resulted in significant reduction of HCV-negative strand RNA synthesis.

71 by modeling crystal structures of homologous negative strand RNA virus Ns in NC.

72 MuV is a negative strand RNA virus, similar to rabies virus or Eb

73 In a negative strand RNA virus, the genomic RNA is sequestere

74 eplication and transcription of nonsegmented negative strand RNA viruses (or Mononegavirales) are bel

75 element in control of gene expression of the negative strand RNA viruses and a means by which express

76 feron induction in cells infected with these negative strand RNA viruses.

77 erging category A pathogens that carry three negative stranded RNA molecules as their genome.

78 Reverse genetic analyses of negative-strand RNA (NSR) viruses have provided enormous

79 be corresponding to the 5' end of poliovirus negative-strand RNA (the complement of the genomic 3' NC

80 ' gamma-phosphate is a common feature of the negative-strand RNA [(-)RNA] of the packaged dsRNA segme

81 om other viral families, including segmented negative-strand RNA and double-stranded RNA (dsRNA) viru

82 on similar to that of the L domains of other negative-strand RNA and retroviruses.

83 Of these three tissues, the heart retained negative-strand RNA and viral N antigen the most consist

84 VPg-linked poly(U) products at the 5' end of negative-strand RNA during PV RNA replication.

85 e in the balanced synthesis of positive- and negative-strand RNA for robust viral replication.

86 The expression of the nonsegmented negative-strand RNA genome of respiratory syncytial viru

87 ion cycle after primary transcription of the negative-strand RNA genome to mRNA.

88 V) is an enveloped virus with a nonsegmented negative-strand RNA genome whose organization is charact

89 V) is an enveloped virus with a nonsegmented negative-strand RNA genome whose organization is charact

90 ses are enveloped viruses with a bisegmented negative-strand RNA genome whose proteomic capability is

91 MV) is an enveloped virus with a bisegmented negative-strand RNA genome whose proteomic capability is

92 Arenaviruses have a bisegmented negative-strand RNA genome.

93 riomeningitis virus (LCMV) has a bisegmented negative-strand RNA genome.

94 Arenaviruses have a bisegmented, negative-strand RNA genome.

95 Influenza viruses contain segmented, negative-strand RNA genomes.

96 We report here that the 5' end of poliovirus negative-strand RNA is capable of interacting with endog

97 VPgpUpU(OH) and nascent negative-strand RNA molecules were synthesized coinciden

98 g this difference, the ratio of positive- to negative-strand RNA of 26 was similar to that found with

99 nstrated that poliovirus positive-strand and negative-strand RNA present in cytoplasmic extracts prep

100 [(32)P]UMP incorporated into VPgpUpU(OH) and negative-strand RNA products indicated that 100 to 400 V

101 B3Delta3' lacked the coat protein gene and negative-strand RNA promoter.

102 regulation was correlated with positive- and negative-strand RNA quantitative detection and the relea

103 Vesicular stomatitis virus (VSV), a negative-strand RNA rhabdovirus, preferentially replicat

104 The influenza A virus genome possesses eight negative-strand RNA segments in the form of viral ribonu

105 The CCHFV genome consists of three negative-strand RNA segments, S, M, and L.

106 omes of influenza A viruses consist of eight negative-strand RNA segments.

107 to nsp10/11 functions as a single cistron in negative-strand RNA synthesis and analyze recent complem

108 tion in yeast is severely inhibited prior to negative-strand RNA synthesis by a single-amino-acid sub

109 Detection of increased negative-strand RNA synthesis by real time RT-PCR for th

110 A-cleaved TBSV RNAs served as a template for negative-strand RNA synthesis by the TBSV RNA-dependent

111 ontranslated region mutation which inhibited negative-strand RNA synthesis did not inhibit CRE-depend

112 While the tyrosine hydroxyl of VPg can prime negative-strand RNA synthesis in a CRE- and VPgpUpU(OH)-

113 eotides from the 5' terminus of SIN restored negative-strand RNA synthesis in DI genomes but not thei

114 sRNA replication by accelerating the rate of negative-strand RNA synthesis in vitro.

115 viral RNA showed that VPg uridylylation and negative-strand RNA synthesis occurred normally from mut

116 n, low concentrations of UTP did not support negative-strand RNA synthesis when CRE-disrupting mutati

117 This indicated that VPg was used to initiate negative-strand RNA synthesis, although the cre(2C)-depe

118 VPg inhibited both VPgpUpU(OH) synthesis and negative-strand RNA synthesis, confirming the critical r

119 lication complex and served as templates for negative-strand RNA synthesis, despite lacking the norma

120 UpU(OH) synthesis was required for efficient negative-strand RNA synthesis, especially when UTP conce

121 These and other results show that prior to negative-strand RNA synthesis, multiple domains of mitoc

122 s-acting elements required for initiation of negative-strand RNA synthesis, we deleted the entire 3'

123 VPgpUpU(OH) synthesis and the initiation of negative-strand RNA synthesis.

124 for CRE-dependent VPgpUpU(OH) synthesis and negative-strand RNA synthesis.

125 ependent VPg uridylylation before and during negative-strand RNA synthesis.

126 replication complexes (RCs) that function in negative-strand RNA synthesis.

127 effects on the magnitude of CRE-independent negative-strand RNA synthesis.

128 st a model for the initiation of coronavirus negative-strand RNA synthesis.

129 nome is the minimal signal for initiation of negative-strand RNA synthesis.

130 A interactions required for positive- versus negative-strand RNA synthesis.

131 g frame or the IRES were required in cis for negative-strand RNA synthesis.

132 sis of VPgpUpU(OH), however, did not inhibit negative-strand RNA synthesis.

133 t required in cis or in trans for poliovirus negative-strand RNA synthesis.

134 the viral replicase during an early step in negative-strand RNA synthesis.

135 ine hydroxyl of VPg in VPg uridylylation and negative-strand RNA synthesis.

136 f VPgpUpU was required for positive- but not negative-strand RNA synthesis.

137 uous elongation of nascent transcript during negative-strand RNA synthesis.

138 Negative-strand RNA synthesized in these reactions immun

139 The amount of negative-strand RNA synthesized with P2 and P3 was appro

140 g-linked poly(U) sequences at the 5' ends of negative-strand RNA templates were transcribed into poly

141 in the conserved sequence at the 3' ends of negative-strand RNA templates.

142 een documented previously for a nonsegmented negative-strand RNA virus (mononegavirus).

143 irus, which represent viruses from different negative-strand RNA virus families.

144 The mumps virus is a negative-strand RNA virus in the family Paramyxoviridae.

145 itive-strand RNA virus infections but not in negative-strand RNA virus infections.

146 The nucleocapsid of a negative-strand RNA virus is assembled with a single nuc

147 and reveal the structural organization of a negative-strand RNA virus L protein.

148 The negative-strand RNA virus measles virus (MeV) uses tissu

149 nfluenza virus type 3 (PIV3), a nonsegmented negative-strand RNA virus of the Paramyxoviridae family

150 nt to be a previously unrecognized enveloped negative-strand RNA virus of the Paramyxoviridae family,

151 that both the N- and C-terminal regions of a negative-strand RNA virus P are involved in binding the

152 h has served in the past as a model to study negative-strand RNA virus replication.

153 s instead, suggesting that current segmented negative-strand RNA virus taxonomy may need revision.

154 Borna disease virus (BDV) is a nonsegmented negative-strand RNA virus that replicates and transcribe

155 Vesicular stomatitis virus (VSV) is a negative-strand RNA virus with inherent specificity for

156 Newcastle disease virus (NDV) is a negative-strand RNA virus with oncolytic activity agains

157 is required for the entry of the prototypic negative-strand RNA virus, including influenza A virus a

158 ratory syncytial virus (RSV), a nonsegmented negative-strand RNA virus.

159 For some negative-strand RNA viruses (e.g., vesicular stomatitis

160 The negative-strand RNA viruses (NSRVs) are unique because t

161 What separates negative-strand RNA viruses (NSVs) from the rest of the

162 e viral genome can form during infections of negative-strand RNA viruses and outgrow full-length vira

163 ation strategy should be applicable to other negative-strand RNA viruses and will promote studies int

164 y delineate the evolutionary relationship of negative-strand RNA viruses but also provide insights in

165 that La supports the growth of nonsegmented negative-strand RNA viruses by both IFN suppression and

166 function, against a number of positive- and negative-strand RNA viruses by enhancing type I IFN indu

167 dependent RNA polymerase of the nonsegmented negative-strand RNA viruses carries out two distinct RNA

168 Importance: The paramyxovirus family of negative-strand RNA viruses cause significant disease in

169 mal RNA synthesis machinery of non-segmented negative-strand RNA viruses comprises a genomic RNA enca

170 verse members of the Paramyxovirus family of negative-strand RNA viruses effectively suppress host in

171 Paramyxoviruses and other negative-strand RNA viruses encode matrix proteins that

172 Negative-strand RNA viruses encode their own polymerases

173 The nucleoprotein of negative-strand RNA viruses forms a major component of t

174 w that the mechanism of RNA encapsidation in negative-strand RNA viruses has many common features.

175 (VSV) is the prototype virus for 75 or more negative-strand RNA viruses in the rhabdovirus family.

176 Negative-strand RNA viruses include a diverse set of vir

177 rnalized viral ribonucleoproteins (vRNPs) of negative-strand RNA viruses induce an early IFN response

178 The genome of nonsegmented negative-strand RNA viruses is tightly embedded within a

179 This suggested that negative-strand RNA viruses produce little, if any, dsRN

180 However, the impact of TRIM56 on negative-strand RNA viruses remains unclear.

181 Negative-strand RNA viruses represent a significant clas

182 The nucleoprotein (NP) of segmented negative-strand RNA viruses such as Orthomyxo-, Arena-,

183 Paramyxoviruses are enveloped negative-strand RNA viruses that are significant human a

184 Arenaviruses are negative-strand RNA viruses that cause human diseases su

185 Arenaviruses are enveloped negative-strand RNA viruses that cause significant human

186 es of a number of L proteins of nonsegmented negative-strand RNA viruses, a cluster of high-homology

187 The large (L) proteins of non-segmented, negative-strand RNA viruses, a group that includes Ebola

188 rate vaccine candidates against nonsegmented negative-strand RNA viruses, a large and expanding group

189 ttenuate VSV, and perhaps other nonsegmented negative-strand RNA viruses, for potential application a

190 Negative-strand RNA viruses, including paramyxoviruses,

191 Rabies viruses, negative-strand RNA viruses, infect neurons through axon

192 ing those by ssDNA viruses and positive- and negative-strand RNA viruses, produce dsRNAs detectable b

193 of the RNA than the NP protein of some other negative-strand RNA viruses, reflecting the degree of NP

194 bly diverse family of enveloped nonsegmented negative-strand RNA viruses, some of which are the most

195 Infection of human dendritic cells (DCs) by negative-strand RNA viruses, such as Newcastle disease v

196 The genomic RNA of negative-strand RNA viruses, such as vesicular stomatiti

197 For the nonsegmented negative-strand RNA viruses, the polymerase is comprised

198 virus (VSV), a prototype of the nonsegmented negative-strand RNA viruses, the two methylase activitie

199 In the replication cycle of nonsegmented negative-strand RNA viruses, the viral RNA-dependent RNA

200 Arenaviruses are enveloped, negative-strand RNA viruses.

201 let-shaped rhabdovirus and a model system of negative-strand RNA viruses.

202 antiviral therapeutics against nonsegmented negative-strand RNA viruses.

203 virus (VSV), a prototype of the nonsegmented negative-strand RNA viruses.

204 of the RNA polymerase (L) of non-segmented, negative-strand RNA viruses.

205 unique GDNQ motif normally characteristic of negative-strand RNA viruses.

206 ts in the design of new therapeutics against negative-strand RNA viruses.

207 ire of targets for antiviral therapy against negative-strand RNA viruses.

208 and possibly other families of nonsegmented negative-strand RNA viruses.

209 which are a characteristic hallmark of many negative-strand RNA viruses.

210 , with implications for many other segmented negative-strand RNA viruses.

211 HCV negative-strand RNA was not detected in PBMCs from any o

212 found in astrocytes from three patients, but negative-strand RNA was not detected in these cells.

213 titis E virus (HEV) produces an intermediate negative-strand RNA when it replicates.

214 They continuously produced negative-strand RNA, but its synthesis was blocked by th

215 mplexes formed with the 3' end of poliovirus negative-strand RNA, including one that contains a 36-kD

216 cules were made coincident in time with each negative-strand RNA.

217 patocytes expressed HCV core protein and HCV negative-strand RNA.

218 containing the 3' untranslated region of HCV negative-strand RNA.

219 ally interacts with the 3' end of poliovirus negative-strand RNA.

220 , genus Phlebovirus), which has a tripartite negative-stranded RNA genome (consisting of the S, M, an

221 viridae, genus Phlebovirus) has a tripartite negative-stranded RNA genome (L, M, and S segments).

222 They have a nonsegmented negative-stranded RNA genome and can cause a number of d

223 ses are enveloped viruses with a bisegmented negative-stranded RNA genome.

224 virus, representing viruses of the dsDNA and negative-stranded RNA viral groups, were used to infect

225 Vesicular stomatitis virus (VSV) is a negative-stranded RNA virus normally sensitive to the an

226 Influenza virus, a negative-stranded RNA virus that causes severe illness i

227 Vesicular stomatitis virus is a negative-stranded RNA virus.

228 ses are a large family of membrane-enveloped negative-stranded RNA viruses causing important diseases

229 Rhabdoviruses are negative-stranded RNA viruses of the order Mononegaviral

230 r Mononegavirales (comprised of nonsegmented negative-stranded RNA viruses or NNSVs) contains many im

231 Arenaviruses are enveloped, negative-stranded RNA viruses that belong to the family

232 he largest nucleoprotein of the nonsegmented negative-stranded RNA viruses, and like the NPs of other

233 In contrast to most negative-stranded RNA viruses, hantaviruses and other vi

234 contribute to pathogenicity in a variety of negative-stranded RNA viruses.

235 importance for efficient budding of several negative-stranded RNA viruses.

236 hanism of replication of influenza and other negative-stranded RNA viruses.

237 the closest relatives of NYNV and MIDWV are negative-stranded-RNA viruses in the order Mononegaviral

238 uitment to these mitochondrial membranes for negative-strand RNA1 synthesis.

239 e BMV replication factors 1a and 2a, and use negative-strand RNA3 as a template for genomic RNA3 and

240 ed RNA3 replication at a step or steps after negative-strand RNA3 synthesis, implying competition wit

241 tion with positive-strand RNA3 synthesis for negative-strand RNA3 templates, viral replication factor

242 ces of hepatitis C virus (HCV) positive- and negative-strand RNAs contribute cis-acting functions ess

243 and the higher levels of both positive- and negative-strand RNAs for the chimeras than for the H77 p

244 f HCV proteins as well as both positive- and negative-strand RNAs in the stable Huh7 cell lines.

245 te switch during the synthesis of subgenomic negative-strand RNAs to add a copy of the leader sequenc

246 initiation nucleotides of both positive- and negative-strand RNAs were found to be either an adenylat

247 U) portions of poliovirus (PV) positive- and negative-strand RNAs were used as reciprocal templates d

248 3'-dCTP inhibited the elongation of nascent negative-strand RNAs without affecting CRE-dependent VPg

249 ction of HCV proteins and both positive- and negative-strand RNAs.

250 We evaluated the HCV negative-strand secondary structure by enzymatic probing

251 Influenza A virus is a negative-strand segmented RNA virus in which antigenical

252 Hantaviruses, similarly to other negative-strand segmented RNA viruses, initiate the synt

253 The objective of this study was to develop a negative-strand-specific reverse transcription-PCR (RT-P

254 In addition to the liver, the negative-strand-specific RT-PCR assay identified replica

255 The standardized negative-strand-specific RT-PCR assay was subsequently u

256 sponse to respiratory syncytial virus (RSV), negative strand ssRNA virus, depends upon the ability to

257 The structured negative-strand stem-loops that were inserted in both RN

258 ] synthesis on an ectopically expressed RNA3 negative strand [(-) strand] and faithfully complete the

259 nal sequences that were highly efficient for negative-strand synthesis and replication.

260 st, the expression of 2A and 2BCP3 supported negative-strand synthesis at the same level observed wit

261 cre(2C) hairpin had no significant effect on negative-strand synthesis but completely inhibited posit

262 nal end of stem a had little or no effect on negative-strand synthesis but dramatically reduced posit

263 indings suggest a replication model in which negative-strand synthesis initiates with VPg uridylylate

264 ting from apparent template switching during negative-strand synthesis of subgenomic RNA 7.

265 Negative-strand synthesis was not observed when the proc

266 replication complexes capable of initiating negative-strand synthesis was observed when either P23 o

267 egion of the gRNA, contains the promoter for negative-strand synthesis, and influences several infect

268 equences were required for RNA1 recruitment, negative-strand synthesis, and subsequent positive-stran

269 Thus, after negative-strand synthesis, the ns proteins appeared to i

270 0/11 ( approximately 150 kDa) is involved in negative-strand synthesis.

271 cteriophage replication, likely by targeting negative-strand synthesis.

272 ng nsp10 as being a cofactor in positive- or negative-strand synthesis.

273 stabilized viral RNA and inhibited efficient negative-strand synthesis.

274 ted from these reactions and used to measure negative-strand synthesis.

275 e likely occurs during positive- rather than negative-strand synthesis.

276 is thought to occur during the synthesis of negative-strand templates for sgmRNA production and to b

277 the 3'AAUUUUGUC5' sequence at the 3' ends of negative-strand templates.

278 t the association of hnRNP C with poliovirus negative-strand termini acts to stabilize or otherwise p

279 p70 was cross-linked to the MHV positive- or negative-strand UTR in vitro and in vivo.

280 cross-linking to bind both the positive- and negative-strand UTRs of MHV RNA specifically.

281 d an occult infection, with the detection of negative strand viral genome, indicating viral replicati

282 ide new evidence that the 3' terminus of the negative-strand viral genome in the double-stranded RNA

283 Thus, the detection of negative-strand viral RNA is indicative of HEV replicati

284 lling template selection for translation and negative-strand viral RNA synthesis, two processes that

285 Encapsidated negative-strand viral RNA was detected using CsCl-purifi

286 A synthetic negative-strand viral RNA was generated from the plasmid

287 Both positive- and negative-strand viral RNA were detected by real-time qua

288 luorescence, and PCR for positive-strand and negative-strand viral RNA.

289 designed to amplify a 232-bp fragment of the negative-strand viral RNA.

290 efficient replication of both positive- and negative-strand viral RNAs as well as enzymes capable of

291 g CsCl-purified CVB3/TD virions, although no negative-strand virion RNA was detected in similarly tre

292 bryonic fibroblasts extremely susceptible to negative-stranded virus infection, including vesicular s

293 r vesicular stomatitis virus (VSV) and other negative-strand viruses is the RNA genome in association

294 Nucleocapsids of nonsegmented negative-strand viruses like VSV are assembled in the cy

295 nfection with HCV; in particular, an HCV RNA-negative strand was detectable almost exclusively in the

296 reaction, and concentration of positive and negative strands was determined by a novel quantitative

297 HCV RNA negative strands were detected in brain tissue in three

298 In one of the latter patients, HCV RNA negative strands were detected in lymph node and, while

299 ss the viral genome on both the positive and negative strands, with clusters of miRNAs at a number of

300 s, wild-type CTV produced more positive than negative strands, with the plus-to-minus ratios of genom