ライフサイエンスコーパス: negatively modulate

1 e helical association might be positively or negatively modulated.

2 androgens suppress Bcl-2 expression through negatively modulating activities of the E2F site in the

3 ation reduces dendritic excitability and may negatively modulate activity-dependent dendritic synapti

4 ge ectodermal cells from becoming AER cells; negatively modulate AER activity and thus fine-tune the

5 These data indicate that TNF-alpha can negatively modulate airway responsiveness, controlling a

6 ker expression in vitro, while ERK signaling negatively modulates Akt activation and VSMC marker gene

7 d gamma(c) isoforms indicate that the latter negatively modulates alpha isoform activity, possibly by

8 Conversely, overexpressed RACK1 negatively modulates alpha2(I) collagen transcriptional

9 LYPD6B also negatively modulates alpha3beta4 nAChRs that include the

10 te a novel mechanism by which beta1 integrin negatively modulates alphavbeta3 integrin-ligand binding

11 utrophils revealed a unique role for C5L2 in negatively modulating anaphylatoxin receptor mediated ce

12 defective receptor tyrosine kinase (RTK) and negatively modulates angiogenesis by acting as a decoy r

13 These findings demonstrate that PDE4B negatively modulates anti-inflammatory cytokine expressi

14 hat TID1 gene products act to positively and negatively modulate apoptotic signal transduction or eff

15 val of growth-arrested cells, potentially by negatively modulating apoptotic response via signaling p

16 ) signaling, and cyclin D1 has been shown to negatively modulate AR-dependent expression of prostate-

17 RTN) family proteins interact with BACE1 and negatively modulate BACE1 activity through preventing ac

18 ifies a novel cellular pathway by which SNX6 negatively modulates BACE1-mediated cleavage of APP.

19 SAG-CUL5, but not RBX1-CUL1, negatively modulates beta-TrCP1 levels by shortening its

20 dothelial cell-intrinsic decoy receptor that negatively modulates blood vessel morphogenesis.

21 The ability of pneumococci to make PcpA negatively modulated both the infiltration and apoptosis

22 In contrast, age at priming negatively modulated both the magnitude and duration of

23 lts provide a novel mechanism for decorin in negatively modulating both IGF-I and its receptor.

24 Sprouty negatively modulates branching morphogenesis in the Dros

25 enously administered PGD(2), however, can be negatively modulated by a mechanism dependent upon ANG I

26 coa transcription was negatively modulated by agr and occurred mainly during t

27 ulated through beta-adrenergic receptors was negatively modulated by alpha 1-adrenergic activation.

28 ique to this system, the activity of TraR is negatively modulated by an antiactivator called TraM.

29 ToxT activity is negatively modulated by bile and unsaturated fatty acids

30 enhanced current density, both of which were negatively modulated by cAMP.

31 s in which proliferation of arterial SMCs is negatively modulated by cyclic nucleotides.

32 f MSNs from both the cortex and thalamus was negatively modulated by histamine acting at presynaptic

33 inhibitory input to both classes of MSNs was negatively modulated by histamine.

34 The data show that CXCR4 is negatively modulated by long-term morphine treatments bo

35 d protein eukaryotic initiation factor 4G is negatively modulated by Mnk activity.

36 ranscription of the HLgene in HepG2 cells is negatively modulated by multiple cis-acting negative ele

37 microRNAs is positively regulated by p53 and negatively modulated by NF-kB p65.

38 that the activity of ESE-1 is positively and negatively modulated by other interacting proteins inclu

39 The anti-HIV-1 activity of SAMHD1 is negatively modulated by phosphorylation at residue Thr-5

40 PLCbeta1 and PLCbeta3 activities are negatively modulated by phosphorylation.

41 we demonstrate that the activity of Gis1 is negatively modulated by proteasome-mediated limited prot

42 ly through a PTX-sensitive G protein that is negatively modulated by protein kinase C, possibly at th

43 RecA filament stability is negatively modulated by RecX and UvrD.

44 tested the hypothesis that ETS1 activity is negatively modulated by SP100 in endothelial cells.

45 se regions and model-free valuation areas is negatively modulated by the degree of model-based contro

46 sor gene that we have previously shown to be negatively modulated by the MYCN proto-oncogene, but the

47 The activity of TRPM3 in DRG neurons is also negatively modulated by tonic, constitutive GPCR activit

48 ummary, these studies demonstrate that TIP60 negatively modulates c-Myb transcriptional activity by r

49 reports suggest that protein kinase A (PKA) negatively modulates calcineurin-mediated NF-ATc activat

50 e the mechanism by which CB(2) receptors can negatively modulate CB(1) receptor function.

51 ne or more allosteric cembranoid sites which negatively modulate cembranoid affinity for the inhibito

52 identified Spt4 as a factor that appears to negatively modulate Chd1 binding to chromatin.

53 echanism by which the cannabinoid system can negatively modulate CXCR4 receptor function and perhaps

54 RGS9-2 is a striatum-enriched protein that negatively modulates dopamine and opioid receptor signal

55 tionally, the connection from FEF to TPJ was negatively modulated during target-similar trials, consi

56 CLN3 negatively modulates endogenous ceramide levels in NT2 c

57 Hence, Lnk, through its SH2 domain, negatively modulates EpoR signaling by attenuating JAK2

58 S1 is able to act as an adaptor for p97 that negatively modulates ERAD.

59 SP100 negatively modulates ETS1 transcriptional activation of

60 EAPII negatively modulates ETS1 transcriptional activity and a

61 Collectively, these data indicate that SP100 negatively modulates ETS1-dependent downstream biologica

62 YdgG was found to negatively modulate expression of flagellum- and motilit

63 MicroRNAs (miRNAs) negatively modulate expression of genes that are involve

64 danger: the opportunity to seek food reward negatively modulates expression of species-typical defen

65 TNF limits the normal reparative process by negatively modulating factors that regulate bone.

66 suggesting that distinctly from SM1, SM2 may negatively modulate force development during smooth musc

67 This suggests that some TM4SF members may negatively modulate function of c-kit receptor tyrosine

68 RY 008 also failed to negatively modulate GABAergic function at alpha1beta2gam

69 BAG-1 negatively modulates GADD34-bound PP1 activity, and the

70 Neurosteroids positively and negatively modulate gamma-aminobutyric acid (GABA)(A) re

71 nserved RNA molecules of 22 nucleotides that negatively modulate gene expression primarily through ba

72 tant finding is that PGE2, which is known to negatively modulate glucose-induced insulin secretion, h

73 ntestinal microbiota can both positively and negatively modulate gluten-induced immunopathology in mi

74 data indicate that platelet-associated IgAs negatively modulate GPVI signaling and function in WIP K

75 ed these effects in the positively or in the negatively modulated group of neurons, respectively; thi

76 turated fatty acids, such as oleic acid, and negatively modulates HCV replication.

77 recent reports that phosphorylation of NS5A negatively modulates HCV RNA replication.

78 t protein kinase IV (CaM KIV) is required to negatively modulate hematopoietic functions of BMPs down

79 equency of inhibitory neurons, which in turn negatively modulated high-frequency population oscillati

80 Thus, PTP1 over-expression negatively modulated IL-3 signal transduction.

81 hat does not activate these factors, instead negatively modulates immune responses.

82 Hence, overexpression of IFN-gamma negatively modulates immunity, and the presence of Helio

83 Exon 2 negatively modulates in vitro cooperative transformation

84 Caspase-12 has been shown to negatively modulate inflammasome signaling during bacter

85 lation of HO-1 by a specific inducer, hemin, negatively modulates iNOS expression and activity in ant

86 CD45 functions in a manner similar to LAR by negatively modulating insulin receptor signaling in hema

87 ence recognition by SRP but, rather, that it negatively modulates interactions that occur between SRP

88 ed mechanistic studies demonstrated that NMI negatively modulates IRE1alpha-dependent activation of J

89 s a negative regulator, and to contribute to negatively modulate its activity.

90 atory region of the CNKSR3 gene chromatin to negatively modulate its expression.

91 ate a master regulator of apoptosis, p53, to negatively modulate its transcriptional and apoptotic ac

92 or suppressor protein with high affinity and negatively modulates its transcriptional activity and st

93 e previously shown to interact with BACE1 by negatively modulating its secretase activity.

94 DVA both positively and negatively modulates locomotion, providing a unique mech

95 ation unmasks tonic NR1/NR2A activation that negatively modulates LTP.

96 We hypothesized that PKA might negatively modulate m-calpain in an unexpected manner by

97 3 mRNA occurs through TLR4/TRIF/IRF3/PKC, it negatively modulates mA3 mRNA via TLR4/MyD88/MAPK-signal

98 the DNA-binding and transactivation domains negatively modulates Mac1p activity.

99 talized selectively to fungal phagosomes and negatively modulates macrophage antifungal effector func

100 receptors and NET, indicating that MCH1r may negatively modulate mesolimbic monoamine function.

101 h FGF signaling regulates gene expression by negatively modulating microRNA abundance through both LI

102 MKK-independent p38 kinase activation while negatively modulating MKK-dependent p38 function.

103 Thus, Lnk negatively modulates mpl signaling pathways and is impor

104 Hence, AMY-R signaling negatively modulates mu-OR-mediated appetitive responses

105 decline during myogenesis and that miR-125b negatively modulates myoblast differentiation in culture

106 l muscle myogenesis, which functions through negatively modulating myostatin activity via a mechanism

107 vely modulates GABA(A) receptor function and negatively modulates N-methyl-D-aspartate (NMDA) recepto

108 Transition probability first negatively modulated neural responses, followed by posit

109 t the neonicotinoid insecticide clothianidin negatively modulates NF-kappaB immune signaling in insec

110 mily that has the potential to positively or negatively modulate nuclear NF-kappaB activity in a cont

111 gic local regulator of OCL activity that can negatively modulate OCL formation and activity.

112 Together, these data suggest that RDL negatively modulates olfactory associative learning, pos

113 Here we show that H2 receptor activation negatively modulates outward currents through Kv3.2-cont

114 Furthermore, PLC gamma and RasGAP negatively modulate PDGF-dependent PI3K activation.

115 PKC phosphorylation negatively modulates phospholipase C (PLC)beta, enzymes

116 that inhibit neutrophil oxidative burst and negatively modulate platelet aggregation by a unique sal

117 Light chains negatively modulate polymerization so that intracellular

118 gulate drought, salt, and cold tolerance and negatively modulate PR gene expression and broad-spectru

119 scular injury response, at least in part, by negatively modulating proinflammatory mediator expressio

120 /p44 mitogen-activated protein kinase (MAPK) negatively modulates protein secretion stimulated by cho

121 We showed that CD13 negatively modulates receptor-mediated Ag uptake in dend

122 phila and mammalian sprouty gene families to negatively modulate respiratory organogenesis.

123 teracted with RhoGDI via its RING domain and negatively modulated RhoGDI SUMOylation and HCT116 cance

124 Rph1 is a labile protein, and Rad53 negatively modulates Rph1 protein level.

125 downstream of BPV-1 splicing enhancer 1 and negatively modulates selection of a suboptimal 3' splice

126 lator of G-protein signaling 4 (RGS4), which negatively modulates signal transduction at G-protein-co

127 I occurs in dermal fibroblasts and that CD44 negatively modulates signaling via these receptors.

128 ER signaling upregulates MTA3 levels to negatively modulate Snail-mediated repression of E-cadhe

129 ment of MPM cell lines with mir-145 agonists negatively modulated some protumorigenic properties of M

130 into dendritic spines and that its knockdown negatively modulates spine shape in culture.

131 We demonstrate that PC190723 negatively modulates Staphylococcus aureus FtsZ polymeri

132 Importantly, serine 727 phosphorylation negatively modulates STAT3 tyrosine phosphorylation, whi

133 y the JAK2.prolactin receptor complex, while negatively modulating Stat3 activity before the onset of

134 iquitination activity of PUB1 is required to negatively modulate successive stages of infection and d

135 Finally, Hei10 positively and negatively modulates SUMO localization along SCs by its

136 nse toward enhanced expression of genes that negatively modulate T cell activation and are associated

137 we identify that HIV-1 Vpr (viral protein R) negatively modulates telomerase activity.

138 nce that NMI activates STAT signaling, which negatively modulates TGF-beta/SMAD signaling.

139 These results suggest that heparan sulfate negatively modulates TGF-beta1 responsiveness by decreas

140 from their association with Smad4 and hence negatively modulates TGFbeta-dependent transcriptional r

141 degradation of transcription factor PU.1 to negatively modulate TH9 homeostasis and antitumour immun

142 Fringe proteins can positively and negatively modulate the ability of Notch ligands to acti

143 cesses by its ability to both positively and negatively modulate the activities of Smad-dependent pat

144 expression of Smad8, which then functions to negatively modulate the amplitude or duration of signali

145 mer of a dopamine D2 receptor (D2R) dimer to negatively modulate the binding of dopamine at the other

146 ated receptor-like kinases, CRLK1 and CRLK2, negatively modulate the cold activation of MPK3/6.

147 K, coding for two aspartyl phosphatases that negatively modulate the flow of phosphoryl groups to Spo

148 on secreted glycoproteins can positively and negatively modulate the immune response.

149 They also negatively modulate the PI 3-kinase catalytic activity b

150 vealed that the Nup205 nucleoporin NPP-3 can negatively modulate the timing of mitotic onset.

151 ific TFZFs that significantly positively and negatively modulate the transcription of the ICAM-1 gene

152 ed that fasting and chronic aerobic training negatively modulated the ACSL6 mRNA and other genes of l

153 Interestingly, pRb2/p130 expression negatively modulated the binding of p27Kip1 to JCV TAg.

154 In addition, HCV negatively modulated the expression of proprotein conver

155 stry, we found that in maize (Zea mays), KN1 negatively modulates the accumulation of gibberellin (GA

156 Our results indicate that Hsc70 not only negatively modulates the activation of HRI in heme-defic

157 ed that the heat shock cognate protein Hsc70 negatively modulates the activation of HRI in RRL in res

158 To determine how the CTD negatively modulates the chaperone activity of HTLV-1 NC

159 iver results in increased ROS production and negatively modulates the control of cell cycle.

160 dent effects but clearly both positively and negatively modulates the effects of VEGFR-2.

161 CO or NO(*) binding at the ferrous heme negatively modulates the enzyme activity.

162 In turn, Roe negatively modulates the expression of target genes of N

163 regulator gene, csrA, encodes a factor which negatively modulates the expression of the glycogen bios

164 We show that calsarcin-1 negatively modulates the functions of calcineurin, such

165 JMJ27 negatively modulates the major flowering regulator CONST

166 n's disease, and PKCdelta, in which alphasyn negatively modulates the p300- and nuclear factor-kappaB

167 nce of cell volume, and that recombinant p38 negatively modulates the set point for volume-sensitive

168 ll cycle-dependent accumulation of cyclin D1 negatively modulates the transcriptional regulation of A

169 Dickkopf-1 (Dkk1) is a secreted protein that negatively modulates the Wnt/beta catenin pathway.

170 fector pathways, and the role of each GAP in negatively modulating the activity of each Ras isoform i

171 alternative splicing by both positively and negatively modulating the activity of other SR proteins

172 alternative splicing by both positively and negatively modulating the activity of other SR proteins

173 into tubular structures while simultaneously negatively modulating the branching effects of HGF.

174 Sprouty2 plays a key role in negatively modulating the fibroblast growth factor signa

175 nuating the stimulus for leukocyte entry and negatively modulating the injury response.

176 acting partner DOT-1.1 have a global role in negatively modulating the level of polymerase II (Pol II

177 t its pleiotropic effects may be mediated by negatively modulating the transcription of downstream ge

178 nimal estrogenicity themselves could reduce (negatively modulate) the effect of a mixture of estrogen

179 cal FQ-resistant S. Typhimurium isolates may negatively modulate their invasiveness but this is strai

180 al levels of type I receptor, whereas Bdelta negatively modulates these pathways by restricting recep

181 the two variable regions of Pi SLF) together negatively modulate this interaction, with a greater eff

182 gene expression, whereas activation of PI3-K negatively modulates this response in Jurkat T cells.

183 /Tolloid, however, Chordin activity would be negatively modulated through proteolytic cleavage, there

184 BRIL promoter activity was also found to be negatively modulated through two different mechanisms.

185 trol reverse cholesterol transport, but also negatively modulate TLR-mediated inflammatory pathways.

186 hibiting caspases, the IKK/NF-kappaB pathway negatively modulates TNF-alpha-mediated JNK activation,

187 normal cellular function for ZFM1 may be to negatively modulate transcription of target genes coordi

188 of proteinuria on the tubulointerstitium by negatively modulating TRPV5.

189 Here we report that PlGF positively and negatively modulate tumor growth, angiogenesis, and vasc

190 findings demonstrate that tumor-derived PlGF negatively modulates tumor angiogenesis and tumor growth

191 Thus, PlGF positively and negatively modulates tumor growth, angiogenesis, and vas

192 ycogen synthase) and glgS was observed to be negatively modulated via csrA.

193 at sensitivity to ethanol's aversive effects negatively modulates voluntary alcohol intake and thus m

194 ponent regulating vascular wall formation by negatively modulating VSMC contractility.

195 that only lateral inhibition between MSNs is negatively modulated, whereas feedforward inhibition fro

196 Further, Rif1 negatively modulates Zscan4 expression by maintaining H3