1 Neisserial adhesin A (NadA), a trimeric autotransporter
2 tched reference strain (5/99, which included
neisserial adhesin A), both of which were used in vaccin
3 The functions of type IV pili and other
neisserial adhesins are discussed in the specific contex
4 Thus,
neisserial adhesion via either of at least two different
5 Genome-derived
neisserial Ag (GNA) 1870 is a meningococcal vaccine cand
6 of polysaccharide-specific Ig in response to
neisserial and other gram-negative porin-expressing bact
7 ain engineered to overexpress genome-derived
neisserial antigen (GNA) 1870, a lipoprotein discovered
8 Genome-derived
neisserial antigen 2132 (GNA2132) is a novel vaccine can
9 t activities in DNA repair: one is a typical
Neisserial AP endonuclease (NApe), whereas the other is
10 ly conserved 9-bp core sequence, whereas the
neisserial apparatus binds a 10-bp motif.
11 Genetic recombination impacts on
neisserial biology in two ways: (i) specific loci underg
12 Based on these frequencies, six
Neisserial clinical isolates could be grouped into three
13 tudy, we found that DNA derived from various
neisserial co-colonizers of the human nasopharynx increa
14 in understanding the mechanisms that enable
neisserial colonisation, in terms of the role of type IV
15 microenvironment, and a multistep model for
neisserial colonization of mucosal epithelia is proposed
16 the cell, the earliest demonstrable step in
neisserial competence.
17 fusion proteins, suggesting that additional
neisserial components are involved.
18 ey are a long-standing, integral part of the
neisserial dcw gene cluster.
19 ociated with the development of disseminated
neisserial disease, and did not require opacity outer me
20 ng frequencies, indicating that heterologous
neisserial DNA modulates phase variation in a transforma
21 ermC, the vector contains two copies of the
neisserial DNA uptake sequence to facilitate high-freque
22 ncies were also increased in the presence of
neisserial DNA.
23 other is a specialised 3'-phosphodiesterase
Neisserial exonuclease (NExo).
24 We have identified a
neisserial gene, hemO, that is essential for heme, hemog
25 ith differences in repeat length between the
neisserial genome sequences is further corroborative evi
26 sts it is an essential gene (engA, essential
neisserial GTPase).
27 When the gene encoding the
neisserial heme oxygenase, hemO, was replaced with pigA,
28 The deduced amino acid sequences of these
neisserial hemoglobin receptors were also highly related
29 ntigens (factor H-binding protein [fHbp] and
neisserial heparin-binding antigen).
30 o-glutamine exchange in the active center of
neisserial HtrA.
31 Several lines of evidence indicate that the
neisserial IgA1 protease is directly responsible for thi
32 pe IV pili play an active role in initiating
neisserial infection of the mucosal surface in vivo.
33 t in innate immune defenses against invasive
neisserial infections.
34 s the transcriptional activity of two common
neisserial intergenic components.
35 egy for vaccine development has targeted the
neisserial iron import systems.
36 Evidence for the role of Fur in
neisserial iron regulation has been indirect because of
37 f predominantly "transparent" (Opa-negative)
neisserial isolates from persons with invasive disease,
38 Approximately 95 different
neisserial isolates tested positive by Western blotting
39 eity of this protein, the 2086 genes from 63
neisserial isolates were sequenced.
40 Human IgGs that bind the
neisserial L7 lipooligosaccharide (LOS) are bactericidal
41 Thus, the Opa family of
neisserial ligands may interact with several members of
42 The inner core of
neisserial lipooligosaccharide (LOS) contains heptose re
43 Neisserial lipooligosaccharide (LOS) contains three olig
44 and phosphoethanolaminylation of lipid A on
neisserial lipooligosaccharide (LOS), a major cell-surfa
45 Neisserial lipooligosaccharides (LOSs) are a family of c
46 identification and characterization of nlaB (
neisserial LPA acyltransferase B), the second LPA acyltr
47 d sequence from the previously characterized
neisserial LPA acyltransferase homologue nlaA.
48 risingly, picogram-per-milliliter amounts of
neisserial LPS were also found to be highly synergistic
49 Overexpressing components of the
neisserial mismatch repair system partially alleviated D
50 Neisserial mod alleles also contained a hypervariable re
51 Neisserial Opa proteins function as a family of adhesins
52 receptor-binding function in the majority of
neisserial Opa proteins.
53 The
neisserial opacity (Opa) proteins are a family of antige
54 The
neisserial opacity (Opa) proteins are phase-variable, an
55 Omp31, Agrobacterium tumefaciens Omp25, and
neisserial opacity proteins (Opa).
56 ing infections caused by multidrug-resistant
neisserial or streptococcal strains.
57 The
neisserial outer membrane protein, PorB, is a TLR2 ligan
58 y designated FrpB, an iron-regulated, 76-kDa
neisserial outer membrane protein, shows sequence homolo
59 constitute the vast majority of channels in
neisserial outer membranes and can be subdivided within
60 PorB is required for
neisserial pathogenesis and can elicit a Toll-like recep
61 is the most dissimilar of the three types of
neisserial pilE loci.
62 eat sequence, a feature present in all other
neisserial pilin genes examined to date.
63 th the N-terminal conserved regions of other
neisserial pilin proteins.
64 ivariable and hypervariable regions of other
neisserial pilins and displays a large deletion in a hyp
65 icited when CPS is conjugated to the class 3
neisserial porin (CPS-porin).
66 PorB is a pan-
neisserial porin expressed regardless of organisms' path
67 The
neisserial porin P.I is a GTP binding protein that forms
68 The effect of
neisserial porin PorB on activation-induced cell death w
69 Due to
neisserial porin's ability to activate B cells and poten
70 nificant for elucidating the mechanism(s) of
neisserial porin's immune stimulatory activity.
71 y effect on the B-cell-stimulatory effect of
neisserial porins (essential for the adjuvant activity o
72 Neisserial porins are strong immune adjuvants and B cell
73 The
neisserial porins are the major protein components of th
74 Furthermore,
neisserial porins co-localize with mitochondria of targe
75 The mechanism of the antiapoptotic effect of
neisserial porins could be explained by the protein-prot
76 Neisserial porins have been shown to act as adjuvants in
77 Neisserial porins have been shown to act as B cell mitog
78 Neisserial porins increased the surface expression of th
79 In addition, incubation with the
neisserial porins increased the T lymphocyte costimulato
80 Neisserial porins interact with target cells to localize
81 potent adjuvant activity, the effect of the
neisserial porins on T-B cell interactions and T cell co
82 The effect of
neisserial porins on the immune system also involves int
83 a support the hypothesis that the ability of
neisserial porins to improve the immune response to poor
84 does not significantly affect the ability of
neisserial porins to induce the costimulatory ligand B7-
85 rins (essential for the adjuvant activity of
neisserial porins), B cells from both murine strains wer
86 The immunopotentiating activity of
neisserial porins, the major outer membrane protein of t
87 sm behind the immunopotentiating activity of
neisserial porins.
88 ent reports of the crystal structures of the
neisserial receptor proteins TbpA and TbpB, each solved
89 tified one small RNA, herein named NrrF (for
neisserial regulatory RNA responsive to iron [Fe]), whic
90 The commensal
neisserial species were identified as reservoirs for all
91 GAA) present frequently in the chromosome of
neisserial species.
92 Although FetA is commonly expressed by most
neisserial strains and is a potential vaccine candidate
93 is present in different copy numbers in the
neisserial strains examined.
94 Unexpectedly, none of 10
Neisserial strains tested bound native properdin.
95 of Hb receptors or the general mutability of
Neisserial strains.
96 f a complement down-regulator protein to the
neisserial surface by specific Ab may enhance intrinsic
97 Neisserial surface protein A (NspA) is a highly conserve
98 Neisserial surface protein A (NspA) is currently being i
99 c acid, factor H binding protein (fHbp), and
neisserial surface protein A (NspA) to regulate the alte
100 g expression of capsule (select serogroups),
Neisserial surface protein A (NspA), factor H (fH) bindi
101 rected against the highly conserved protein,
neisserial surface protein A (NspA).
102 ein currently undergoing clinical trials and
Neisserial surface protein A.
103 In contrast to type IV pili, many other
neisserial surface structures are not involved in cortic
104 Little is known about other
neisserial targets for complement proteins C3 and C4, wh
105 Complementation studies indicated that the
neisserial Ton system cannot interact with the E. coli F
106 The
neisserial transferrin binding proteins (Tbps) comprise
107 region with potential cleavage sites for the
neisserial type 1 and type 2 IgA1 proteases.
108 Neisserial type 2 IgA1 protease cleaves purified LAMP1 i
109 to induce cortical plaques, indicating that
neisserial type IV pili are required for cortical plaque
110 was delineated by a 33-bp repeat containing
neisserial uptake sequences located downstream of col.
111 ream of this promoter is an inverted pair of
neisserial uptake signal sequences, which are commonly c
112 the choice of complement sources to evaluate
neisserial vaccine candidates.
113 the choice of complement sources to evaluate
neisserial vaccine candidates.