ライフサイエンスコーパス: neocortical

1 Human neocortical 15-29-Hz beta oscillations are strong predic

2 thology literature, the presence of elevated neocortical (18)F T807 binding particularly in the infer

3 cleus basalis (NB) of Meynert, the source of neocortical acetylcholine [9, 10], provides a potential

4 rocyte differentiation and results in slower neocortical action potential transmission.

5 recent study in macaques showed diffuse fMRI neocortical activation and subcortical deactivation spec

6 h the notion of the hippocampus coordinating neocortical activity by synchronization in the theta ran

7 Changes in neocortical activity can precede SWR events, but whether

8 When retrieving a pairwise association, neocortical activity corresponding to all event elements

9 Neocortical activity is permeated with endogenously gene

10 is that in slow-wave sleep, replay of waking neocortical activity under hippocampal guidance leads to

11 nt with the intrinsic stochastic dynamics of neocortical activity, which is dominated by preferential

12 tive correlations between plasma Abeta42 and neocortical amyloid deposition (measured with PET).

13 n in transgenic mice induces hippocampal and neocortical amyloid-beta accumulation and plaque deposit

14 From AAV injections into 42 neocortical and allocortical areas, we conclude that mos

15 These results reveal that adult neocortical and hippocampal pyramidal neurons have diver

16 actions of GABA on glutamatergic neurons in neocortical and hippocampal slices from neonatal mouse p

17 ility for flortaucipir F 18 was found across neocortical and mesial temporal lobe structures.

18 ic inhibition will be coordinated over large neocortical and striatal areas.

19 recorded respiration along with hippocampal, neocortical, and olfactory bulb (OB) LFPs in rats anesth

20 We show that Lhx2 controls neocortical area patterning by regulating downstream gen

21 cue-evoked reactivation (prediction) within neocortical areas and related these trial-by-trial measu

22 The coordination of activity across neocortical areas is essential for mammalian brain funct

23 In contrast to other neocortical areas, GINs were only found in cortical laye

24 -beta42 tended to accumulate more in several neocortical areas, including frontal cortices.

25 uded limbic structures, thalamus and certain neocortical areas, which is consistent with prior studie

26 t pattern that appears to be repeated across neocortical areas, with area- and species-specific modif

27 mpal networks and in turn projects to medial neocortical areas.

28 ly stable in the anterior hippocampus and in neocortical areas.

29 P) conditional knockout mice displayed fewer neocortical astrocytes and impaired astrocytic prolifera

30 we use in vivo two-photon calcium imaging of neocortical astrocytes while monitoring the activity sta

31 results identify a novel function of YAP in neocortical astrocytic differentiation and proliferation

32 provide evidence for YAP regulation of mouse neocortical astrocytic differentiation and proliferation

33 YAP in NSCs was required for neocortical astrocytic differentiation, with no apparent

34 Neocortical atrophy reduces PET signal intensity, potent

35 Neocortical basal radial glia (bRG) and cerebellar Bergm

36 pathophysiologic processes (accumulation of neocortical beta-amyloid [Abeta] and tau) provides an im

37 that accounts for the origin of spontaneous neocortical beta.

38 Analysis of vasculature in non-neocortical brain regions suggested that RA may have a s

39 into the soma of pyramidal neurons in mouse neocortical brain slices during whole-cell patch clamp r

40 intracellular recordings in rat (both sexes) neocortical brain slices to assess the ionic mechanisms

41 L5 pyramidal neurons are the only neocortical cell type with dendrites reaching all six la

42 rophysiological and molecular profiles of 58 neocortical cells and show that gene expression patterns

43 We demonstrate that, compared with neocortical ChCs (nc-ChCs), h-ChCs cover twice as much a

44 ween hippocampal chandelier cells (ChCs) and neocortical ChCs.

45 Eighty-seven percent of patients with neocortical cholinergic deficits had caudate nucleus dop

46 Similarities in neocortical circuit organization across areas and specie

47 which in turn ensures the correct wiring of neocortical circuitry.

48 Neocortical circuits can be altered by sensory and motor

49 spontaneous ictal events in hippocampal and neocortical circuits in experimental models of chronic t

50 Neocortical circuits use a family of homeostatic plastic

51 m to deliver transgenes into specific rodent neocortical circuits, allowing further elucidation of th

52 tribution of local spotlights of activity in neocortical circuits, while preserving the balanced stat

53 or exploring alternative roles for myelin in neocortical circuits.

54 of connectivity is a fundamental feature of neocortical circuits.

55 ce-dependent development of specific sensory neocortical circuits.

56 act to determine the development of specific neocortical circuits.

57 consolidation requires coherent hippocampal-neocortical communication mediated by PV(+) cells.

58 of declarative memories requires hippocampal-neocortical communication.

59 connections and how the plasticity modulates neocortical complex events has not been studied.

60 The VLEs are crucial for generating neocortical complex events, observed as single pyramidal

61 To elucidate the dynamics of hippocampal and neocortical contributions to the early phases of memory

62 irments in neonatal vocalizations as well as neocortical cytoarchitectonic alterations via neuronal p

63 Alteration of neocortical cytoarchitecture, such as disruption of the

64 Neocortical delineations were done for sulci, gyri, and

65 This instability explains the existence of neocortical delta oscillations and the emergence of abse

66 port that calcium activity in populations of neocortical dendrites is increased and synchronised duri

67 pecific expression trajectories across human neocortical development and aging; classes I, II, and IV

68 of the psychiatric risk gene, NRG3, in human neocortical development and expand on previous findings

69 e critical and diverse functions of WDR62 in neocortical development and provide insight into the mec

70 e genes that are important for glutamatergic neocortical development and Wnt-Frizzled signalling in m

71 adial glia progenitors is critical to proper neocortical development but the mechanisms regulating th

72 is model retains essential features of human neocortical development by encompassing a single self-or

73 Embryonic neocortical development depends on balanced production o

74 ssion of molecular and cellular steps during neocortical development determines its structure and fun

75 A feature of early postnatal neocortical development is a transient peak in signaling

76 strate that CLASP2 has distinct roles during neocortical development regulating neuron production and

77 ecular basis for guiding specific aspects of neocortical development remains a challenge because of t

78 During neocortical development, neurons undergo polarization, o

79 During mammalian neocortical development, newborn excitatory and inhibito

80 Zac1 expression has striking consequences on neocortical development, suggesting that misexpression o

81 ing to brain development and, in particular, neocortical development, we generated forebrain-specific

82 o the multistage developmental regulation of neocortical development.

83 a crucial role in neuronal migration during neocortical development.

84 trinsic and global functions for Lgl1 during neocortical development.

85 genes, such as Robo3 and Otx1, important for neocortical development.

86 c spatiotemporal rearrangements during mouse neocortical development.

87 e show here that the IGF-1R is essential for neocortical development.

88 g pathway plays a crucial role in regulating neocortical development.

89 e corelease can have catastrophic effects on neocortical dynamics.

90 ar activating system (ARAS), contributing to neocortical dysfunction and neurocognitive impairments.

91 ergic Ube3a loss causes AS-like increases in neocortical EEG delta power, enhances seizure susceptibi

92 We find that most neocortical enhancers did not originate by en bloc exapt

93 Young neocortical enhancers exhibit smaller H3K27ac footprints

94 a model of the enhancer life cycle in which neocortical enhancers initially emerge from genomic back

95 y constraint in eutherian mammals than older neocortical enhancers.

96 ly through their common regulatory logic, as neocortical enhancers.

97 butes to focal brain injury, at least in the neocortical epilepsies considered here.

98 ons, and from patients with poorly localized neocortical epilepsies.

99 monitoring for surgical evaluation of focal neocortical epilepsies.

100 nt epilepsy and are the most common cause of neocortical epilepsy in children.

101 ial temporal lobe epilepsy and 31 with focal neocortical epilepsy.

102 Neocortical excitatory and inhibitory neurons derive fro

103 unctions of ERK/MAPK signaling in developing neocortical excitatory neurons.

104 n brain evolution has focused largely on the neocortical expansion and reorganization undergone by hu

105 mparative evolutionary biology showing rapid neocortical expansion of these regions in humans relativ

106 issencephalic rodents but critical for human neocortical expansion.

107 n network analysis of human laminar-specific neocortical expression data showed that candidate genes

108 Although high neocortical flortaucipir retention was consistently asso

109 fferences in regional or composite posterior neocortical flortaucipir standard uptake value ratio as

110 Neocortical GABAergic interneuron migration and thalamo-

111 behavior after optogenetically manipulating neocortical gamma oscillations.

112 on as enhancers and are adjacent to critical neocortical genes.

113 Accordingly, the myelin observed in neocortical gray matter is thought to mostly ensheath ex

114 may contribute to bRG and IPC expansion and neocortical growth and folding.

115 lly, correlations between DG convolution and neocortical gyrification (or capacity for gyrification)

116 arly human cortical development, inferring a neocortical-hindbrain split in early progenitor cells an

117 n amyotrophic lateral sclerosis (ALS) and to neocortical hyperexcitability, a prominent feature of bo

118 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in

119 control, protein synthesis-independent LTD, neocortical hyperexcitability, audiogenic seizures, and

120 in vitro that members of two non-overlapping neocortical IN populations, expressing somatostatin (SOM

121 Neocortical inhibitory neurons exhibit remarkably divers

122 MPA receptors in two distinct populations of neocortical inhibitory neurons: basket cells and Martino

123 re a major trigger of spontaneous release at neocortical inhibitory synapses but not at excitatory sy

124 uronal circuits, that proposes the principal neocortical input and output cell types are a conserved

125 tate gyrus synaptic and spiking responses to neocortical input rather than directly storing informati

126 Neocortical interactions with the dorsal striatum suppor

127 Here we review our current understanding of neocortical interneuron diversity and the properties tha

128 tricular blood vessels selectively influence neocortical interneuron progenitor behavior and neurogen

129 efferent synaptic connections of developing neocortical interneuron subtypes.

130 t a link between the lineage relationship of neocortical interneurons and their precise functional or

131 nisms that regulate the radial dispersion of neocortical interneurons are incompletely understood.

132 rded from the cell bodies of hippocampal and neocortical interneurons as well as neocortical pyramida

133 Spatially clustered neocortical interneurons originating from low-titre retr

134 tral telencephalon responsible for producing neocortical interneurons progressively grow radial glial

135 that control the functional organization of neocortical interneurons remain largely unknown.

136 ortant for proper production and function of neocortical interneurons.

137 napse formation and microcircuit assembly of neocortical interneurons.

138 nterneuron KCC2 levels, allowing coordinated neocortical invasion of TCAs and interneurons.

139 lesionectomy with tailoring for surrounding neocortical involvement.

140 proaches: hippocampectomy with tailoring for neocortical involvement; lesionectomy of temporal lesion

141 Both hippocampal and neocortical Kv4.3/KChIP1/DPP10(+) inhibitory interneuron

142 structural properties of single demyelinated neocortical L5 axons.

143 leads to increased neuronal excitability of neocortical layer 2/3 (L2/3) pyramidal neurons.

144 olocalization of Kv4.2/Kv4.3/KChIP3/DPP10 in neocortical layer 5 pyramidal neurons and olfactory bulb

145 tic properties of dendritic Ca(2+) spikes in neocortical layer 5 pyramidal neurons.

146 combinase in corticothalamic (CT) neurons in neocortical layer 6.

147 recordings from synaptically connected human neocortical layers 2-3 neurons, we show that VLEs in fas

148 (RGCs) contributing to both lower and upper neocortical layers.

149 In mammals, the neocortical layout consists of few modality-specific pri

150 Diffuse (neocortical) LBD was associated with shorter disease dur

151 ly calculated in 12 brain regions, including neocortical, limbic and subcortical areas from Alzheimer

152 wever, the engrams and circuits that support neocortical memory consolidation have thus far been unkn

153 diating the stabilization of hippocampal and neocortical memory traces.

154 y consolidation and impoverished hippocampal-neocortical memory transformation.

155 he positive peak of their SPWs have enhanced neocortical metabolic up-regulation.

156 The essential connectivity structure of the neocortical microcircuit could be captured by only a few

157 of stimuli, but it remains an open issue how neocortical microcircuits can reliably encode and replay

158 oth plasticity and information processing in neocortical microcircuits.

159 While proliferation of resident neocortical microglia under homeostatic conditions was l

160 rticographic recordings across a 10-cm-sized neocortical network.

161 Models of neocortical networks are increasingly including the dive

162 All hippocampal and neocortical networks can be driven to seize quite easily

163 presentations of neural codes of hippocampal-neocortical networks during sleep would reveal important

164 formation and are gradually consolidated in neocortical networks for permanent storage.

165 involved in spatial memory and navigation to neocortical networks involved in diverse aspects of sens

166 M2 and thus a bridge between hippocampal and neocortical networks involved in mnemonic and sensorimot

167 layer 1, a key site of input integration for neocortical networks, leading to an excitation/inhibitio

168 ely regulate the activity of hippocampal and neocortical networks.

169 partly, transferred from the hippocampus to neocortical networks.

170 labeling system to track the development of neocortical neural progenitors with targeted mutations i

171 eriventricular neurons independent of normal neocortical neurogenesis and neuronal migration.

172 jury and oxygen/glucose deprivation in mouse neocortical neuron cultures and reduced infarct size, ne

173 g, localize to >20 excitatory and inhibitory neocortical neuron types defined by physiology, morpholo

174 e inhibiting APC expression, thereby driving neocortical neuronal differentiation and suppressing oli

175 Although neocortical neuronal morphology has been documented in t

176 hough they represent a minority of the total neocortical neuronal population, GABAergic interneurons

177 glia progenitors (RGPs) generate nearly all neocortical neurons and certain glia lineages.

178 on sequencing to show that three subtypes of neocortical neurons have highly distinctive epigenomic l

179 quantified the somatodendritic morphology of neocortical neurons in prefrontal, motor, and visual cor

180 d in nuclei and dendrites of hippocampal and neocortical neurons in rodent brain.

181 onstrate depth-dependent activation of mouse neocortical neurons in vivo, offering an inexpensive nov

182 NQ2 channels in regulating the properties of neocortical neurons is largely unexplored.

183 Simultaneous co-activation of neocortical neurons is likely critical for brain computa

184 Here we report that in mouse neocortical neurons, selective and nonselective VACC blo

185 extension of leading processes of migrating neocortical neurons.

186 ic proliferation and, consequently, death of neocortical neurons.

187 1 but not in CA3 hippocampal or layer II/III neocortical neurons.

188 e found a significant age-related deficit in neocortical ODI (most prominently in frontoparietal regi

189 Neocortical ODI outperformed cortical thickness and whit

190 human pluripotent stem cell (hPSC)-based 3D neocortical organoid model.

191 Using hPSC 3D neocortical organoids, we demonstrate that the effects o

192 erience with sequencing relationships affect neocortical oscillations and neuronal responses is poorl

193 ning may occur in PFC, whereas HPC may guide neocortical plasticity by signaling success or failure v

194 The neocortical postsynaptic proteome data resource can be u

195 activating RNAs (saRNAs) upregulating it in neocortical precursors and their derivatives.

196 We found that neocortical prefrontal memory engram cells, which are cr

197 on of reactive oxygen species, inhibition of neocortical progenitor cell proliferation, induction of

198 s, an essential step for understanding human neocortical progenitor development.

199 e various cell cycle phases of the different neocortical progenitor subpopulations.

200 Cell cycle parameters of neocortical progenitors are an important determinant of

201 ephaly underlain by reduced proliferation of neocortical progenitors during late neurogenesis, abnorm

202 Clonal analysis of E10.5 neocortical progenitors suggests that most, if not all,

203 Ferret neocortical progenitors were found to exhibit longer cel

204 derived fibroblasts, which, similar to mouse neocortical progenitors, transiently arrest at prometaph

205 suppress the expression of WNT inhibitors in neocortical progenitors.

206 odevelopment, we misexpressed Zac1 in murine neocortical progenitors.

207 , confirming that a restricted subset of all neocortical projection neurons belongs to the Cux2 linea

208 cytoskeleton is crucial for nucleokinesis of neocortical projection neurons during their radial migra

209 rs Tbr1, Fezf2, Satb2, and Ctip2 operates in neocortical projection neurons to specify six layer iden

210 istinct Foxp-characterized subpopulations of neocortical projection neurons.

211 ges, sites of ZIKV replication including the neocortical proliferative zone and radial columns, as we

212 recordings, we measured ongoing activity of neocortical pyramidal cells during various arousal state

213 These oligomers were introduced into neocortical pyramidal cells during whole-cell recording

214 m the soma, proximal and distal dendrites of neocortical pyramidal cells in awake behaving mice.

215 e evidence that input to the apical tufts of neocortical pyramidal cells modulates their response to

216 channels contributes to persistent firing in neocortical pyramidal cells.

217 sms can be induced in tandem in cultured rat neocortical pyramidal neurons by chronic manipulations o

218 ransfer during the illumination and in adult neocortical pyramidal neurons decayed with a time consta

219 equences as a result of KCNQ2 dysfunction in neocortical pyramidal neurons is still unknown.

220 Neocortical pyramidal neurons receive input onto their a

221 Like neocortical pyramidal neurons, neurons in our model rece

222 he most remote area of the dendritic tree of neocortical pyramidal neurons.

223 mpal and neocortical interneurons as well as neocortical pyramidal neurons.

224 which may help to explain the morphology of neocortical pyramidal neurons.

225 ify the heterogeneity within and between the neocortical pyramidal-cell classes in layers 2/3, 4, and

226 tions in Scn8a(N1768D/+) CA1, but not CA3 or neocortical, pyramidal cells was significantly reduced c

227 The rank order of uptake was striatum > neocortical regions > cerebellum.

228 ting in frontotemporal limbic/paralimbic and neocortical regions (phase I).

229 e survivors with aphasia have suggested that neocortical regions adjacent to auditory cortex are prim

230 mposition of postsynaptic proteomes in human neocortical regions and integrate it with genetic, funct

231 ake was highest in the striatum, followed by neocortical regions and white matter, and lowest in the

232 ortex is common by age 60, whereas spread to neocortical regions and worsening of cognition is associ

233 ions of interneuron precursors to restricted neocortical regions belonging to the same functional are

234 ols (p<0.05, paired t-test), particularly to neocortical regions including insular, lateral frontal,

235 increased activation in the hippocampus and neocortical regions related to encoding, and on consiste

236 Neocortical regions show signatures of expression of ind

237 omologous' organization may adapt individual neocortical regions to the type of information each must

238 udied, including the striatum, white matter, neocortical regions, and cerebellum.

239 connected, receiving afferents from multiple neocortical regions, and supports behavioral and cogniti

240 that event elements, represented in distinct neocortical regions, are bound into coherent 'event engr

241 e-infragranular neurons recorded in multiple neocortical regions, as well as deep brain structures su

242 neurons in primate prefrontal and cingulate neocortical regions, but it still is unclear whether neu

243 with increasing gyrification in a network of neocortical regions, including large portions of the pre

244 ects/animals) produce activation in distinct neocortical regions, while hippocampal activity predicts

245 ily to the medial temporal lobe and adjacent neocortical regions.

246 he dynamical activity of cell populations in neocortical regions.

247 mporal limbic/paralimbic regions compared to neocortical regions.

248 a function of the strength of predictions in neocortical regions.

249 no increased standard uptake value ratios in neocortical regions.

250 rocess of hippocampal pattern completion and neocortical reinstatement.

251 local sharp-wave ripples, and the associated neocortical replay tends to occur during local sleep spi

252 ent representational patterns to distributed neocortical representational patterns in the suppression

253 y, presumably in the form of inter-connected neocortical representations.

254 tively transmit information through specific neocortical representations.

255 Under homeostatic conditions, we found that neocortical resident microglia were long-lived, with a m

256 alters the spatiotemporal properties of the neocortical response in a manner that may both refine an

257 s to the slow-oscillation-dominated state, a neocortical rhythm characterized by synchronized neurona

258 in developing neocortex, which we term the "neocortical ribosome signature." Thalamic WNT3 further r

259 Coupling between hippocampal and neocortical ripples was strengthened during sleep follow

260 activity is thought to influence developing neocortical sensory circuits.

261 e symptoms were associated with increases in neocortical SERT binding in the GnRHa group relative to

262 Our results demonstrate a neocortical signature of automatic near-instant access t

263 on the hippocampus are thought to migrate to neocortical sites for more permanent storage, with an em

264 g whole-cell recordings from hippocampal and neocortical slices from postnatal day (P) 2-P15 mice, ph

265 r recordings from layer V pyramidal cells in neocortical slices obtained from IL-6 -: treated mice sh

266 Neocortical slices were exposed to direct current stimul

267 d model of UP/DOWN state generation in mouse neocortical slices whereby the cholinergic tone present

268 netics and 2-photon calcium imaging in mouse neocortical slices.

269 ry synaptic strength in both human and mouse neocortical slices.

270 ilarly, we found that Motifs were coupled to neocortical spindles, down-to-up transitions, theta burs

271 phy positive (Abeta+) subjects, flortaucipir neocortical standard uptake value ratio was significantl

272 r memory to be established in a long-lasting neocortical store, many learning repetitions are conside

273 ment by encompassing a single self-organized neocortical structure, without including an animal-deriv

274 We measured neocortical sub- and suprathreshold dendritic membrane p

275 vessels, and particularly those close to the neocortical surface and in the meninges, were left unaff

276 Here we show that at neocortical synapses in slices from rat visual cortex, a

277 erved expression loci of the hippocampal and neocortical synaptic potentiation studies we examined.

278 suggest that soluble oligomers in surviving neocortical synaptic terminals are associated with demen

279 Proteomics in three independent developing neocortical synaptosomal preparations identified putativ

280 ivision of labor between a hippocampal and a neocortical system, respectively.

281 mic axons are guided internally toward their neocortical target by corridor (Co) neurons that act as

282 ed connectivity in the DMN and salience when neocortical Tau levels are low, whereas abeta(+) individ

283 e metabolism decreased when both amyloid and neocortical tau were high and predicted subsequent memor

284 Neocortical tauopathy was positively associated with met

285 s from neurotypical adult and prenatal human neocortical tissue, and evaluated ASD risk genes for evi

286 reviously established computational model of neocortical tissue, and validate it as an adequate model

287 ntrast, during rapid-eye-movement sleep, the neocortical tone is sustained mainly by acetylcholine.

288 protein L7 in polysomes, thereby regulating neocortical translation machinery specificity.

289 Thalamic WNT3 regulates neocortical translation of two such mRNAs, Foxp2 and Apc

290 l-type-specific neuronal activity in driving neocortical UP states.

291 ampal oscillations: (1) SO, which coupled to neocortical up-and-down transitions; (2) theta, which ph

292 yramidal cells, and 3) in vivo recordings of neocortical V4 neurons.

293 d Cux2-CreERT2 mice we demonstrated that the neocortical ventricular zone (VZ) contains radial glial

294 and fusiform regions, as well as a posterior neocortical VOI composed of average values from parietal

295 rence region was 2.22% for a large posterior neocortical VOI, 1.84% for MUBADA, 1.46% for frontal, 1.

296 An objective anatomical method defines a neocortical volume of 0.29 +/- 0.01 mm(3) containing ~31

297 ) was calculated for a statistically defined neocortical volume of interest.

298 vs 757.31 [38.95] cm3 [P = .02]; normalized neocortical volume, 567.88 [85.55] vs 645.00 [42.84] cm3

299 lines, Guo et al. (2013) concluded that the neocortical VZ does not contain lineage-restricted RGCs.

300 atory projection neurons into the developing neocortical wall.