ライフサイエンスコーパス: neomorphic

1 tion were identified - dominant negative and neomorphic.

2 this normal function but a gain in a new or neomorphic ability to convert alphaKG to the oncometabol

3 proteins have a dominant gain-of-function or neomorphic activity in Xenopus, and that this is respons

4 These mutations confer a neomorphic activity of 2-hydroxyglutarate (2-HG) product

5 The mutant enzymes exhibit neomorphic activity resulting in production of D2-hydrox

6 wild-type activity and confer to the mutant neomorphic activity that produces the oncometabolite 2-h

7 (FSHD) is caused by an unusual deletion with neomorphic activity.

8 protein with potential dominant negative or neomorphic activity.

9 The key distorter locus, Sd, is a dominant neomorphic allele encoding a truncated, but enzymaticall

10 In numerous assays, the neomorphic allele SMAD4(100T) appears to be capable of a

11 In the case of rho, we isolated a dominant neomorphic allele, which interferes with Notch signaling

12 veral genetic criteria that Lyra alleles are neomorphic alleles of senseless that cause ectopic expre

13 cs of the normal (isocitrate to alphaKG) and neomorphic (alphaKG to alphaHG) reactions, as well as th

14 d to the suggestion that truncated APC bears neomorphic and/or dominant-negative function that suppor

15 uggests that Mu suppression affects only the neomorphic aspect of the allele, not the wild-type aspec

16 link the selective pathology of CMT2D to the neomorphic binding activity of GlyRS(CMT2D) that antagon

17 Here we report that GlyRS(CMT2D) acquires a neomorphic binding activity that directly antagonizes an

18 on of TyrRSDeltaE2-4 SV gave an alternative, neomorphic dimer interface 'orthogonal' to that of nativ

19 in IGF-IR-stimulated cells promoted dramatic neomorphic effects characteristic of an epithelial-mesen

20 hydrogenase 1 and 2 (IDH1 and IDH2) confer a neomorphic enzymatic activity: the reduction of alpha-ke

21 emia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarat

22 emia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarat

23 ur in a number of human cancers and confer a neomorphic enzyme activity that catalyzes the conversion

24 drive human gliomagenesis, probably through neomorphic enzyme activity that produces D-2-hydroxyglut

25 First, dog skulls show unique (neomorphic) features already shortly after birth, and th

26 n-transformed cells, we tested the effect of neomorphic IDH mutants on adipocyte differentiation in v

27 Together, these data demonstrate that neomorphic IDH2 mutations can be oncogenic in mesenchyma

28 Thus we have uncovered an unexpected, neomorphic insulin-sensitizing action for exogenous non-

29 ts and the inherently negative regulation of neomorphic liguleless3 and rough sheath1 transcription.

30 Neomorphic missense mutations affecting crucial lysine r

31 ch is made more favorable for alphaKG by the neomorphic mutation at arginine 132.

32 ae that accumulate exogenous sterol due to a neomorphic mutation in the transcription factor, UPC2.

33 This neomorphic mutation subtly alters the DNA-binding prefer

34 The SUM1-1 mutation is a dominant neomorphic mutation that enables the mutant protein to b

35 -base insertion in the marked gene created a neomorphic mutation.

36 nanticipated phenotypic outcomes elicited by neomorphic mutations imply that tumors with the neomorph

37 osis syndromes, resulting from activating or neomorphic mutations in fibroblast growth factor recepto

38 Neomorphic mutations in IDH1 occur frequently in certain

39 mice, implicating both loss of function and neomorphic mutations in its pathogenesis.

40 morphic mutations imply that tumors with the neomorphic mutations may not respond to therapies design

41 These neomorphic mutations, which can be found in both tumor s

42 cause severe neurite growth defects; and 3) neomorphic mutations, which map to the exterior surface,

43 r altered metabolism in oncogenesis, and the neomorphic, oncogenic function of IDH mutations affects

44 bin2 phenotypes were likely caused by either neomorphic or hypermorphic gain-of-function mutations in

45 lt dogs cannot simply be explained as either neomorphic or paedomorphic.

46 These results are consistent with a neomorphic origin of an ancestral A-Myb/c-Myb gene from

47 Such neomorphic p53 proteins are capable of dramatically alte

48 liguleless3 and rough sheath1, which exhibit neomorphic phenotypes in the leaves.

49 terminal and C-terminal GTPase domains cause neomorphic phenotypic effects that are likely unrelated

50 cer Cell, Cheung and colleagues describe two neomorphic PIK3R1 mutants prevalent in endometrial and c

51 h this divergence and found that most of the neomorphic positions in Galpha form a ring of residues c

52 IDH2 R140, have been shown to result in the neomorphic production of 2HG.

53 tic observations led to the discovery of the neomorphic production of the oncometabolite (R)-2-hydrox

54 This process is a neomorphic property of EWS-FLI1 compared to wild-type FL

55 These genes encode neomorphic proteins that produce the presumed oncometabo

56 ions may contribute to cancer through either neomorphic R(-)-2HG production or reduced wild-type enzy

57 analogous experiments studying the reductive neomorphic reaction (alphaKG to 2HG) with the mutant for

58 elandii, which can be shown to gain the same neomorphic reaction when a homologous mutation is introd

59 one mutation can support both the normal and neomorphic reactions.

60 dings indicate that YY1(T372R) mutations are neomorphic, resulting in constitutive activation of cAMP

61 Our findings uncover an unexpected neomorphic role for PIK3R1(R348 *) and neighboring trunc

62 We also obtained dominant-negative and neomorphic Star mutations, which have phenotypes similar

63 ended to GlyRS in metazoans can regulate the neomorphic structural change, and that the gain of funct

64 The identified neomorphic surface is thus a candidate for making CMT-as