ライフサイエンスコーパス: neomycin B

1 RNA aptamer complexed to the aminoglycoside neomycin B.

2 the most effective being 5-epi-sisomicin and neomycin B.

3 ues for paromomycin (0.5 +/- 0.2 microM) and neomycin B (0.6 +/- 0.2 microM).

4 lowest pK(a), with this value being 6.92 in neomycin B, 7.07 in paromomycin I, and 7.24 in lividomyc

5 The specificity of neomycin B, a highly potent AMG antibiotic, to the ribos

6 Ribostamycin and neomycin B also had SC200's of 2 microM, implying that t

7 A conformationally constrained neomycin B analogue displays a rather high affinity to t

8 aptamers for streptomycin, chloramphenicol, neomycin B and ATP identifies 37 candidate sequences (in

9 ed hexa-guanidinium and -lysyl conjugates of neomycin B and compared their inhibitory potential.

10 Neomycin B and kanamycin B bind to pre-tRNAAsp with a Kd

11 The specificity of neomycin B and related aminoglycoside antibiotics in the

12 Both neomycin b and RSG1.2 displaced Mn(2+) upon binding the

13 ments with semisynthetic aminoglycosides and neomycin B and tobramycin show binding affinities in the

14 xhibited a significantly higher affinity for neomycin B and tobramycin than for paromomycin (K(d)s =

15 The higher affinity of the E. coli H69 for neomycin B and tobramycin, as compared to paromomycin an

16 ns (K(+) and Mg(2+)), a small molecule drug (neomycin b), and a cationic peptide (RSG1.2).

17 d ternary complexes of APH with kanamycin A, neomycin B, and metal-nucleotide.

18 entified the small molecules pentamidine and neomycin B as compounds that disrupt MBNL1 binding to CU

19 s, with the RNA binding of paromomycin I and neomycin B being linked to the protonation of four and a

20 he internal loops selected to bind 5''-azido-neomycin B bind with an affinity similar to that of the

21 on into an A-form duplex gradually abolishes neomycin B binding in 3-5-fold steps in affinity over a

22 Further analysis of neomycin B binding with three short synthetic RNA hairpi

23 We show that neomycin B competes with metal ions by ion replacement w

24 The aptamer's affinity for cocaine and neomycin-B decreases with the inclusion of physiological

25 amine derivative; and 5'UNNG3' loops for the neomycin B derivative.

26 n potential GA pairs that also recognize the neomycin B derivative.

27 ile synthetic protocol for the production of neomycin B derivatives with various modifications at the

28 icing of 2 pre-mRNAs affected in DM, whereas neomycin B had no effect.

29 e of neomycin B is 500-fold more potent than neomycin B in inhibiting bacterial RNase P, we synthesiz

30 finding that the hexa-arginine derivative of neomycin B is 500-fold more potent than neomycin B in in

31 pH 9.0, the RNA binding of paromomycin I and neomycin B is coupled to the uptake of 3.25 and 3.80 pro

32 The results indicate that neomycin B is not specific for the G-rich bubble region

33 is, and evaluation of derivatives based upon neomycin B, kanamycin A, and tobramycin conjugates of 9-

34 This suggests that neomycin B may generally bind with this affinity to regu

35 icroM RNA, the A-site hairpin bound a single neomycin b molecule.

36 Here, we have used the aminoglycoside neomycin B (NB) to examine which structural features of

37 A internal loops that bind to derivatives of neomycin B, neamine, tobramycin, and kanamycin A.

38 mine the pK(a) values of the amino groups in neomycin B, paromomycin I, and lividomycin A sulfate, wi

39 mycin A, kanamycin B, tobramycin, sisomicin, neomycin B, paromomycin, lividomycin A, and ribostamycin

40 Neomycin B protected GPI-PLC from a reduction in activit

41 samine ring of the aminoglycoside antibiotic neomycin B (ring II) was conjugated to a 16-mer peptide

42 ities for cocaine and analogues, but not for neomycin-B, showing a selective effect of 2AP substituti

43 -, 3-, 2'-, and 2"'-amino groups, while, for neomycin B, the binding-linked protonation reactions inv

44 Compared to neomycin B, the derivatives based upon tobramycin and ka

45 Quantitative studies of the binding of neomycin B to RRE constructs are carried out to determin

46 amycin A and B, tobramycin, paromomycin, and neomycin B to the corresponding fully guanidinylated ana

47 pal mechanism for recognition and binding of neomycin B to the RNA major groove is mediated by hydrog

48 Methanolysis of neomycin B under acidic conditions produced the bicyclic

49 ves of kanamycin A, tobramycin, neamine, and neomycin B via two-dimensional combinatorial screening,