ライフサイエンスコーパス: neonatal Fc receptor

1 cations of an increase in IgG binding to the neonatal Fc receptor.

2 ntained within the cytoplasmic domain of the neonatal Fc receptor.

3 t on binding to human FcgammaRI, C1q, or the neonatal Fc receptor.

4 ion complexes, which are transcytosed by the neonatal Fc receptor across syncytiotrophoblasts, infect

5 m01s bound to a recombinant soluble human neonatal Fc receptor at pH 6.0 more strongly than CH2.

6 The neonatal Fc receptor FcRn plays a critical role in the t

7 The neonatal Fc receptor FcRn provides IgG molecules with th

8 ctions have recently been identified for the neonatal Fc receptor FcRn.

9 iometry of immunoglobulin G (IgG) binding to neonatal Fc receptor (FcRn) and Fcgamma receptor (Fcgamm

10 ibody fragments lack the ability to bind the neonatal Fc receptor (FcRn) and have reduced half-lives.

11 blood by transcytosis across the BBB via the neonatal Fc receptor (FcRn) and the low-density lipoprot

12 (Fv) of IgG antibodies on the binding to the neonatal Fc receptor (FcRn) as well as on FcRn-dependent

13 A) and IgG, through its Fc part, bind to the neonatal Fc receptor (FcRn) at low pH in the endosome af

14 erved Fc methionine residues and the loss of neonatal Fc receptor (FcRn) binding and complement-depen

15 Functional studies by antigen binding and neonatal Fc receptor (FcRn) binding correlated very well

16 The neonatal Fc receptor (FcRn) binds maternal immunoglobuli

17 The neonatal Fc receptor (FcRn) binds maternal immunoglobuli

18 ort the three-dimensional structure of human neonatal Fc receptor (FcRn) bound concurrently to its tw

19 The widely distributed neonatal Fc receptor (FcRn) contributes to maintaining s

20 The neonatal Fc receptor (FcRn) directs the transfer of mate

21 me MHC class I-related molecules such as the neonatal Fc receptor (FcRn) execute their function witho

22 ansferred across the placenta by binding the neonatal Fc receptor (FcRn) expressed within the endosom

23 The neonatal Fc receptor (FcRn) facilitates the transfer of

24 The neonatal Fc receptor (FcRn) for IgG, an MHC class I-rela

25 The neonatal Fc receptor (FcRn) has been known to modulate I

26 The endothelial cellular neonatal Fc receptor (FcRn) has been suggested to play a

27 (monoFc) maintained the binding affinity for neonatal Fc receptor (FcRn) in a pH-dependent manner.

28 tudy the involvement of immune complexes and neonatal Fc receptor (FcRn) in the emergence of ADAs in

29 Given the role of neonatal Fc receptor (FcRn) in transferring IgG across p

30 In light of the fact that the neonatal Fc receptor (FcRn) is a key regulator of albumi

31 The neonatal Fc receptor (FcRn) is a major histocompatibilit

32 The neonatal Fc receptor (FcRn) is a major regulator of IgG

33 Improved affinity for the neonatal Fc receptor (FcRn) is known to extend antibody

34 nd in vivo analyses, the MHC class I-related neonatal Fc receptor (FcRn) is known to play a central r

35 Neonatal Fc receptor (FcRn) is the homeostatic receptor

36 Here, we find that the human neonatal Fc receptor (FcRn) is the vehicle that transpor

37 We also identify that the neonatal Fc receptor (FcRn) is upregulated in the cornea

38 ects proteins for lysosomal degradation, the neonatal Fc receptor (FcRn) located at the brush border

39 Increasing affinity to neonatal Fc receptor (FcRn) may extend the pharmacokinet

40 The neonatal Fc receptor (FcRn) mediates the transport of Ig

41 We found that PVIgGs associated with neonatal Fc receptor (FcRn) on the cell membrane, and th

42 (PPI-Fc) is delivered to fetuses through the neonatal Fc receptor (FcRn) pathway, which physiological

43 The neonatal Fc receptor (FcRn) performs two distinct but re

44 The interaction of the IgG1 Fc with the neonatal Fc receptor (FcRn) plays a critical role in mai

45 The neonatal Fc receptor (FcRn) plays a critical role in reg

46 The neonatal Fc receptor (FcRn) plays an important role in r

47 -dependent affinity of IgG molecules for the neonatal Fc receptor (FcRn) receptor primarily arises fr

48 ct Fc region is controlled by the protective neonatal Fc receptor (FcRn) receptor.

49 Serum half-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG

50 t in blood, syncytiotrophoblasts express the neonatal Fc receptor (FcRn) that transports IgG for pass

51 The neonatal Fc receptor (FcRn) transports IgG across epithe

52 The neonatal Fc receptor (FcRn) transports immunoglobulin G

53 The neonatal Fc receptor (FcRn) transports immunoglobulin G

54 The neonatal Fc receptor (FcRn) transports maternal IgG acro

55 The neonatal Fc receptor (FcRn) transports maternal immunogl

56 bodies via pharmacological inhibition of the neonatal Fc receptor (FcRn) using high-dose IgG therapy.

57 In contrast, in mice in which the neonatal Fc receptor (FcRn) was deleted, the half-life o

58 c fragment of immunoglobulin G (IgG) and the neonatal Fc receptor (FcRn) was determined at low resolu

59 eered to enhance interactions with the human neonatal Fc receptor (FcRn) without loss of the oligomer

60 regulated the constitutive expression of the neonatal Fc receptor (FcRn), an MHC class I-related mole

61 pH-dependent interaction between IgG and the neonatal Fc receptor (FcRn), as FcRn is the main homeost

62 expression of the relevant receptor, namely neonatal Fc receptor (FcRn), by Calu-3 cell layers simul

63 roperties, via modified interaction with the neonatal Fc receptor (FcRn), has been achieved.

64 The MHC class I-related receptor, neonatal Fc receptor (FcRn), plays a central role in reg

65 s, facilitated by interaction with the human neonatal Fc receptor (FcRn), that promotes it as a highl

66 gG is transported across the placenta by the neonatal Fc receptor (FcRn), which recognizes the Fc dom

67 Genetic deletion of the neonatal Fc receptor (FcRn), which rescues albumin and I

68 tibodies at these sites is influenced by the neonatal Fc receptor (FcRn), whose role in protecting ag

69 offspring by instructing T reg formation via neonatal Fc receptor (FcRn)-mediated transfer and uptake

70 ch is attributed to its interaction with the neonatal Fc receptor (FcRn).

71 alf-life requires interaction of Fc with the neonatal Fc receptor (FcRn).

72 ting fusion proteins interact with the human neonatal Fc receptor (FcRn).

73 gG by saturation of the MHC-like Fc receptor neonatal Fc receptor (FcRn).

74 rum half-life of IgG Abs is regulated by the neonatal Fc receptor (FcRn).

75 due to its pH-dependent interaction with the neonatal Fc receptor (FcRn).

76 heir ability to interact with the protective neonatal Fc receptor (FcRn, Brambell receptor) present o

77 udy was to determine the contribution of the neonatal Fc-receptor (FcRn) in rat brain efflux employin

78 The neonatal Fc receptor, FcRn mediates an endocytic salvage

79 r histocompatibility complex class I-related neonatal Fc receptor, FcRn, assembles as a heterodimer c

80 The expression of the neonatal Fc receptor, FcRn, in APCs and its localization

81 We demonstrate here that the neonatal Fc receptor, FcRn, is expressed in female genit

82 The neonatal Fc receptor, FcRn, is responsible for the long

83 The neonatal Fc receptor, FcRn, regulates the half-life of I

84 The neonatal Fc receptor, FcRn, transports immunoglobulin G

85 of these proteins, suggesting a lack of the neonatal Fc receptor, FcRn.

86 The neonatal Fc receptor for IgG (FcRn) functions to transpo

87 Immunoglobulin G (IgG) and the neonatal Fc receptor for IgG (FcRn) have an important fu

88 The neonatal Fc receptor for IgG (FcRn) is a distant member

89 The neonatal Fc receptor for IgG (FcRn) plays a major role i

90 ocyte-derived CD8(-)CD11b(+) DCs require the neonatal Fc receptor for IgG (FcRn) to conduct cross-pre

91 The neonatal Fc receptor for IgG (FcRn) transfers maternal I

92 Darby canine kidney cells expressing the rat neonatal Fc receptor for IgG (FcRn), it significantly re

93 The neonatal Fc receptor for immunoglobulin (Ig)G (FcRn) pro

94 The human MHC class I-related neonatal Fc receptor, hFcRn, mediates bidirectional tran

95 ected wild-type, but not Fcgamma-receptor or neonatal Fc-receptor knock-out mice.

96 I but also the related CD1a, CD1b, CD1c, and neonatal Fc receptor molecules were absent from the surf

97 y CD1), transport of immunoglobulins (by the neonatal Fc receptor), regulation of iron metabolism (by

98 Absent neonatal Fc receptor surface expression led to low serum

99 By engaging the neonatal Fc receptor the Fc domain extends the in vivo l

100 mediates transcytosis through binding to the neonatal Fc receptor, the peptidomimetic introduces cros

101 we show that this effect is dependent on the neonatal Fc receptor, which rescues the dissociated anti