ライフサイエンスコーパス: neonatal lupus

1 y be important in the development of cardiac neonatal lupus.

2 syndrome, systemic lupus erythematosus, and neonatal lupus.

3 rphisms (SNPs) for associations with cardiac neonatal lupus.

4 B developed a transient rash consistent with neonatal lupus.

5 potential therapeutics for diseases such as neonatal lupus.

6 syndrome, systemic lupus erythematosus, and neonatal lupus.

7 ndrome, systemic lupus, dermatomyositis, and neonatal lupus.

8 nd 58 mothers from the Research Registry for Neonatal Lupus.

9 lays a role in the pathogenesis of cutaneous neonatal lupus.

10 of TNFalpha in the pathogenesis of cutaneous neonatal lupus.

11 tal for Joint Diseases Research Registry for Neonatal Lupus.

12 ymptomatic mothers of infants afflicted with neonatal lupus.

13 g information from the Research Registry for Neonatal Lupus.

14 itate the establishment of a murine model of neonatal lupus.

15 ersal finding in mothers whose children have neonatal lupus.

16 were recruited to the Research Registry for Neonatal Lupus.

17 en who had either CHB or no manifestation of neonatal lupus (59% versus 30%; P = 0.02).

18 leted the PRIDE study (22 with no child with neonatal lupus, 7 with a child with CHB, and 3 with a ch

19 ed healthy children and had no children with neonatal lupus (95%) (P not significant for all comparis

20 cutaneous lesions in these patients and with neonatal lupus, a syndrome in which mothers with anti-Ro

21 n ages >or=8 years who had manifestations of neonatal lupus (affected group) and their unaffected sib

22 Neonatal lupus, albeit rare, affords an excellent opport

23 rmine the mortality and morbidity of cardiac neonatal lupus and associated risk factors in a multi-ra

24 Follow-up studies on neonatal lupus and its pathogenesis have progressed, lea

25 proper counseling of mothers of infants with neonatal lupus and of women with positive anti-Ro or ant

26 others enrolled in the Research Registry for Neonatal Lupus and the observational PR Interval and Dex

27 provide evidence of a biologic link between neonatal lupus and the rash of SCLE.

28 returned questionnaires on 49 children with neonatal lupus and their 45 unaffected siblings.

29 scence and young adulthood, individuals with neonatal lupus and their unaffected siblings do not appe

30 living children (50%) were premature, 3 had neonatal lupus, and 1 had pulmonic stenosis.

31 All had neonatal lupus, and their mothers had manifestations of

32 Sixteen children had no manifestations of neonatal lupus at birth.

33 Cardiac manifestations of neonatal lupus (cardiac NL) include congenital heart blo

34 wering the risk of cardiac manifestations of neonatal lupus (cardiac-NL) in pregnancies of anti-SSA/R

35 athogenesis of the cardiac manifestations of neonatal lupus (cardiac-NL) involves maternal autoantibo

36 genetic risk factors preferentially from the neonatal lupus child's grandparents.

37 erational study demonstrates that mothers of neonatal lupus children accumulate genetic risk factors

38 Cardiac manifestations of neonatal lupus, comprising atrioventricular conduction d

39 Neonatal lupus developed in 10 cases; 4 were neonatal lu

40 rly one fifth of fetuses who develop cardiac neonatal lupus die of complications predicted by echocar

41 Mothers of children with neonatal lupus erythematosus (NLE) and heart block, as w

42 h subacute cutaneous lupus erythematosus and neonatal lupus erythematosus and are thought to be patho

43 patocellular carcinoma, and liver disease in neonatal lupus erythematosus.

44 PURPOSE OF REVIEW: Cardiac manifestations of neonatal lupus include anti-SSA/Ro-SSB/La-mediated condu

45 Cardiac manifestations of neonatal lupus include conduction disease and, rarely, a

46 +/- 0.356), and mothers of children without neonatal lupus (mean +/- SD 0.229 +/- 0.315).

47 maternal anti-SSA/Ro antibodies with cardiac neonatal lupus met entry criteria.

48 Children of European ancestry with cardiac neonatal lupus (n = 116) were genotyped using the Illumi

49 uency of recurrent cardiac manifestations of neonatal lupus (NL) in a second child is critical to und

50 Cardiac neonatal lupus (NL) is presumed to arise from maternal a

51 ternal anti-Ro60 Abs with cardiac disease in neonatal lupus (NL) is that these Abs initiate injury by

52 Neonatal lupus (NL) occurs in fetuses exposed to materna

53 However, the impact of this manifestation of neonatal lupus (NL) on the risk of cardiac disease occur

54 oimmunity and organ damage in the context of neonatal lupus (NL).

55 nd 74 mothers from the Research Registry for Neonatal Lupus (NL).

56 anti-Ro autoantibodies and had a child with neonatal lupus (NL); allele frequencies were compared to

57 Neonatal lupus developed in 10 cases; 4 were neonatal lupus rash only.

58 This association with neonatal lupus rash was equivalent to published findings

59 e mother, birth of a previous child with CHB/neonatal lupus rash, current treatment with < or = 20 mg

60 These data suggest that children with neonatal lupus require continued followup, especially pr

61 Cutaneous neonatal lupus resembles subacute cutaneous lupus erythe

62 d clinical-translational research in cardiac neonatal lupus reveal novel insights and targets for the

63 child enrolled in the Research Registry for Neonatal Lupus (RRNL).

64 vestigated the presence of maternal cells in neonatal lupus syndrome (NLS), an autoimmune disease tha

65 ients had serologic findings consistent with neonatal lupus syndrome (NLS).

66 New understandings of the pathogenesis of neonatal lupus syndrome and congenital heart block revea

67 In addition, the neonatal lupus syndrome is discussed in detail, and newe

68 eins and is a permanent manifestation of the neonatal lupus syndromes (NLS).

69 Reassuringly, most children with neonatal lupus syndromes do not develop rheumatic diseas

70 The neonatal lupus syndromes, although quite rare, provide a

71 y in patients with subacute cutaneous lupus, neonatal lupus, systemic lupus erythematosus, and Sjogre

72 rvals (95% CIs) for association with cardiac neonatal lupus were determined.

73 milies enrolled in the Research Registry for Neonatal Lupus were evaluated for rates of recurrence of

74 7 most significant associations with cardiac neonatal lupus were found in the HLA region.

75 al grandfathers in the Research Registry for Neonatal Lupus were interrogated for clinical symptoms b

76 others enrolled in the Research Registry for Neonatal Lupus were reviewed.

77 4 mothers of children with manifestations of neonatal lupus were studied for type I IFN activity, usi