ライフサイエンスコーパス: neonicotinoid

1 ion products that include a pyrethroid and a neonicotinoid.

2 th conjugated and hydrophobic regions of the neonicotinoid.

3 because it appears safer for honey bees than neonicotinoids.

4 ributions to the distinctive interactions of neonicotinoids.

5 ammals confer remarkable selectivity for the neonicotinoids.

6 arly vulnerable to the neurotoxic effects of neonicotinoids.

7 nt alkaloid nicotine and cross-resistance to neonicotinoids a class of synthetic insecticides widely

8 ebate about the environmental risks posed by neonicotinoids, a group of widely used, neurotoxic insec

9 ) fed field levels [10 nM, 2.1 ppb (w/w)] of neonicotinoid accumulate between 4 and 10 nM in their br

10 s exposed to different concentrations of the neonicotinoids acetamiprid, clothianidin, imidacloporid,

11 ticides by number and world market value are neonicotinoids acting as nAChR agonists or organophospho

12 Neonicotinoid agonists with a nitroimino or cyanoimino p

13 stration that acute or chronic exposure to a neonicotinoid alone can significantly alter bee flight.

14 BRT) analysis to predict both probability of neonicotinoid analytical detection and concentration.

15 s [i.e., Lymnaea stagnalis (Ls) AChBP of low neonicotinoid and high nicotinoid sensitivities and Aply

16 Both the neonicotinoid and nicotinoid probes labeled Ac-AChBP at

17 a potential route of pollinator exposure to neonicotinoid and other insecticides.

18 ic exposure of bumblebees to two pesticides (neonicotinoid and pyrethroid) at concentrations that cou

19 f differential molecular recognition for the neonicotinoids and classical nicotinoids by estimates of

20 s at environmental realistic levels of three neonicotinoids and nicotine, and compared laboratory stu

21 In the Ac-AChBP, the neonicotinoids and nicotinoids are nestled in similar bo

22 proposed very different interactions of the neonicotinoids and nicotinoids might be examined with a

23 lision-induced dissociation analysis for the neonicotinoids and nicotinoids with similar labeling fre

24 icotinic receptor, is similarly sensitive to neonicotinoids and nicotinoids.

25 gate the real-world links between the use of neonicotinoids and pollinator mortality are lacking.

26 (organophosphates, carbamates, pyrethroids, neonicotinoids, and manganese fungicides) and five indiv

27 ee neurotoxic pesticide groups (pyrethroids, neonicotinoids, and manganese fungicides).

28 ount for the cognitive impairments caused by neonicotinoids, and predict that exposure to multiple pe

29 r: throughout spring and summer, mixtures of neonicotinoids are also found in the pollen and nectar o

30 Neonicotinoids are commonly used seed treatments on Cana

31 Neonicotinoids are implicated in the decline of bee popu

32 Neonicotinoids are increasingly applied on trees as prot

33 Consequently, neonicotinoids are inevitably transferred into aquatic e

34 Although sublethal levels of neonicotinoids are known to disrupt honeybee learning an

35 Neonicotinoids are often applied as systemic seed treatm

36 Neonicotinoids are subjected to vigilance because of env

37 Neonicotinoids are the most widely used class of insecti

38 Neonicotinoids are widely used insecticides, but their u

39 s, does not apply to the anomalous action of neonicotinoids at the insect nicotinic acetylcholine rec

40 dels based on AChBP directly map the elusive neonicotinoid binding site and further describe the mole

41 of the insect and mammalian nAChRs and their neonicotinoid-binding site lays the foundation for conti

42 To develop a neonicotinoid biosensor, these two oligopeptides are syn

43 s on the nicotinic receptor structure in the neonicotinoid-bound state revealed a unique niche of abo

44 Indeed, the large majority (97%) of neonicotinoids brought back in pollen to honey bee hives

45 nated nectar and pollen from treated plants, neonicotinoids can affect foraging, learning, and memory

46 Neonicotinoids can alter bee navigation, but we present

47 This study illuminates effects that neonicotinoids can induce at very low concentrations.

48 nvironmental release of particles containing neonicotinoids can produce high exposure levels for bees

49 These findings point to neonicotinoids causing a reduced capacity of bee species

50 rcially with either seed coatings containing neonicotinoids (clothianidin or thiamethoxam) or no seed

51 Neonicotinoid complex formation is rapid and accompanied

52 Using Arabidopsis thaliana, we show that the neonicotinoid compounds, imidacloprid (IMI) and clothian

53 Neonicotinoid concentration was best explained by shallo

54 vels were generally not well correlated with neonicotinoid concentrations in flowers, pollen, or nect

55 14, respectively, calculated on the basis of neonicotinoid concentrations in preplant soil and seed a

56 The highest neonicotinoid concentrations were found in soil collecte

57 the observed inability of shredders to avoid neonicotinoid-contaminated leaves, our results emphasize

58 gative relationship between honey and pollen neonicotinoid contamination and Apis colony weight gain.

59 r results suggest that sub-lethal effects of neonicotinoids could scale up to cause losses of bee bio

60 models effectively predicted the deviance in neonicotinoid detection (62.4%) and concentration (74.7%

61 to obtain low-cost and sensitive sensors for neonicotinoids detection.

62 These neonicotinoids effect a similar global transcriptional r

63 The neonicotinoid electronegative pharmacophore is nestled i

64 the potent and selective interaction of the neonicotinoid electronegative pharmacophore with a uniqu

65 This suggests that neonicotinoids enhance the rewarding properties of sucro

66 Neonicotinoid exhaust emission rates were 0.0036 and 0.1

67 A subset of ligands, termed the neonicotinoids, exhibit specificity for insect nicotinic

68 tion, but we present the first evidence that neonicotinoid exposure alone can impair the physical abi

69 l behavioral studies showed the link between neonicotinoid exposure and adverse effects on foraging a

70 This study examines the connection between neonicotinoid exposure and innate immune function in the

71 immune function in bumblebees is affected by neonicotinoid exposure and suggest a physiological mecha

72 -mitigation efforts should focus on reducing neonicotinoid exposure in the early spring when colonies

73 not provide spatial or temporal relief from neonicotinoid exposures in agricultural regions where th

74 Vitellogenin showed a strong increase upon neonicotinoid exposures in the laboratory and field, whi

75 pesticide that is reported to be safer than neonicotinoids for honey bees, thus deserve greater atte

76 Insect-selective neonicotinoids have an electronegative pharmacophore (ti

77 Intriguingly, for the Ls-AChBP, the neonicotinoids have two bound conformations that are inv

78 Organisms either experienced waterborne neonicotinoid (i.e., imidacloprid, thiacloprid, and acet

79 Here we show that sublethal doses of the neonicotinoid imidacloprid impair sexual communication a

80 laboratory to field-realistic levels of the neonicotinoid imidacloprid, then allowed them to develop

81 ly isolated honeybee brain, we show that the neonicotinoids imidacloprid and clothianidin, and the or

82 Comparisons of the neonicotinoids imidacloprid and thiacloprid in the bindi

83 pression is similarly induced by a different neonicotinoid, imidacloprid, but not by the organophosph

84 Neonicotinoids, important insecticides including imidacl

85 Recovery rates of seed-applied neonicotinoids in exhaust were 0.014 and 0.365% in 2013

86 selected organophosphates, pyrethroids, and neonicotinoids in seven Indian field populations of Bemi

87 The increasing use of neonicotinoids in systematic seed treatment to crops is

88 rs in toxicity compared to previously tested neonicotinoids in terms of reproductive effects.

89 , these chloropyridinyl- and chlorothiazolyl-neonicotinoids induce SA responses associated with enhan

90 Nine neonicotinoids inhibited house fly brain nAChR [(3)H]NMI

91 repeated pulses of low concentrations of the neonicotinoid insecticide (thiacloprid) continuously dec

92 Here, we demonstrate that the neonicotinoid insecticide clothianidin negatively modula

93 Imidacloprid (IMD) is the most widely used neonicotinoid insecticide found on environmental surface

94 re assessed for their sensitivity toward the neonicotinoid insecticide thiacloprid using their feedin

95 a, we show that (i) eight metabolites of the neonicotinoid insecticide, imidacloprid, can be detected

96 o field-realistic levels of a widely applied neonicotinoid insecticide, thiamethoxam, on bumblebee od

97 Most studies have focused on three neonicotinoid insecticides (clothianidin, imidacloprid,

98 The contribution of the neonicotinoid insecticides (e.g., clothianidin and imida

99 black alder trees treated with one of three neonicotinoid insecticides (imidacloprid, thiacloprid, o

100 Neonicotinoid insecticides are commonly used in managing

101 Systemic neonicotinoid insecticides are increasingly used as a cr

102 Several pyrethroid and neonicotinoid insecticides are most effective for contro

103 were achieved rivaling those of the current neonicotinoid insecticides as illustrated here by 3-(6-c

104 n Commission has restricted the use of three neonicotinoid insecticides as seed dressings on bee-attr

105 There is increasing evidence that neonicotinoid insecticides at sublethal concentrations h

106 Neonicotinoid insecticides control crop pests based on t

107 Chronic exposure to neonicotinoid insecticides has been linked to reduced su

108 impact of pathogens in honey bees exposed to neonicotinoid insecticides has been reported, but the ca

109 Neonicotinoid insecticides have been implicated in these

110 Average levels of neonicotinoid insecticides in corn pollen ranged from le

111 neous detection and quantification of (five) neonicotinoid insecticides in sugarcane juice.

112 We detected neonicotinoid insecticides in the soil of production fie

113 The widespread and intensive use of neonicotinoid insecticides induces negative cascading ef

114 the negatively charged (delta(-)) tip of the neonicotinoid insecticides interacts with a putative cat

115 Neonicotinoid insecticides specifically have been detect

116 The higher toxicity of neonicotinoid insecticides such as N-(6-chloropyridin-3-

117 Neonicotinoid insecticides target nicotinic acetylcholin

118 As a consequence, seed-coating neonicotinoid insecticides that are used worldwide on co

119 cent efforts to evaluate the contribution of neonicotinoid insecticides to worldwide pollinator decli

120 ate the potential exposure of pollinators to neonicotinoid insecticides used as seed treatments on co

121 Since seed coating with neonicotinoid insecticides was introduced in the late 19

122 Neonicotinoid insecticides were detected at a level of 1

123 s and also toxicants such as epibatidine and neonicotinoid insecticides with a chloropyridinyl substi

124 ney bees tested positive for the presence of neonicotinoid insecticides, and there was only one trace

125 posure of honeybees to and intoxication with neonicotinoid insecticides, namely, the atmospheric emis

126 y nicotine and has preadapted them to resist neonicotinoid insecticides.

127 eams, with the highest exceedances found for neonicotinoid insecticides.

128 the tested organophosphate, pyrethroid, and neonicotinoid insecticides.

129 alth including the pervasive use of systemic neonicotinoid insecticides.

130 d bee declines have been ascribed in part to neonicotinoid insecticides.

131 e negatively tipped ("magic" nitro or cyano) neonicotinoids interact with a proposed unique subsite c

132 h the consumption of contaminated leaves and neonicotinoids leaching from leaves into water.

133 nicotine acts at the same target without the neonicotinoid level of effectiveness or safety.

134 a distinctive pattern of selectivity for the neonicotinoid ligands.

135 overlapped with those related to exposure to neonicotinoids, like the polyamine metabolism involved i

136 sents a rarely studied pathway through which neonicotinoids may enter nontarget environments, e.g., s

137 d suggest a physiological mechanism by which neonicotinoids may impact the innate immune function of

138 havior and improves our understanding of how neonicotinoids may impair short-term colony functioning.

139 Hence, sublethal doses of neonicotinoids might compromise the function of parasito

140 iral proliferation suggests that the studied neonicotinoids might have a negative effect at the field

141 and selectivity are retained when the usual neonicotinoid N-nitroimine (=NNO(2)) electronegative tip

142 studies have identified detectable levels of neonicotinoids (neonics) in the environment, adverse eff

143 idely used classes of cholinergic pesticide: neonicotinoids (nicotinic receptor agonists) and organop

144 idine (1), were used to probe the Drosophila neonicotinoid-nicotinic acetylcholine receptor interacti

145 The neonicotinoid nitro oxygen and cyano nitrogen contact lo

146 us, sublethal cognitive deficits elicited by neonicotinoids on a broad range of native bee species de

147 ng-term exposure and suggest that impacts of neonicotinoids on olfaction are greater than their effec

148 Little is known about the effect of neonicotinoids on other beneficial insects such as paras

149 ss well studied are the potential effects of neonicotinoids on queen bees, which may be exposed indir

150 However, the sublethal effect of neonicotinoids on S. invicta has never been investigated

151 impacts of pesticides, and in particular of neonicotinoids, on bee health remain much debated.

152 es validate the nAChR in vivo target for the neonicotinoids, OPs and MCs.

153 Effects of neonicotinoid pesticide exposure on human health: a syst

154 One of the most concerning chemicals is the neonicotinoid pesticide imidacloprid.

155 the impacts of field-realistic exposure to a neonicotinoid pesticide may seriously compromise this im

156 Bumblebee colonies exposed to a neonicotinoid pesticide provided lower visitation rates

157 Thiamethoxam (TMX) is a common neonicotinoid pesticide that bees can consume in nectar

158 Xenobiotics such as the neonicotinoid pesticide, imidacloprid, are used globally

159 s can pose environmental risks, and a common neonicotinoid pesticide, thiamethoxam, decreases homing

160 bumblebee colonies to sublethal levels of a neonicotinoid pesticide.

161 Neonicotinoid pesticides are used in agriculture to redu

162 Neonicotinoid pesticides have been linked to global decl

163 tions containing field-relevant doses of the neonicotinoid pesticides, imidacloprid (IMD) and thiamet

164 position is a key indicator and/or driver of neonicotinoid presence and concentration in Prairie wetl

165 biotic wetland characteristics likely affect neonicotinoid presence and environmental persistence, bu

166 -substituted guanidine/amidine planes of the neonicotinoids provide a unique electronic conjugation s

167 selected strains, but susceptibility to the neonicotinoid remained unchanged.

168 Rates of recovery of seed-applied neonicotinoid residues by exhaust filter bags were 0.015

169 Neonicotinoid residues captured on horizontal and vertic

170 Neonicotinoid residues escaping in vacuum-planter exhaus

171 ecological and agronomic factors underlying neonicotinoid residues is needed to inform evidence-base

172 residues were used to differentiate between neonicotinoid residues originating from seed or from dis

173 To estimate risk posed by this pathway, neonicotinoid residues were analyzed in foliage from bla

174 reproduction was negatively correlated with neonicotinoid residues.

175 en, and cotton nectar contained little or no neonicotinoids resulting from insecticide seed treatment

176 associated with the metabolic resistance to neonicotinoids, results in a significant increase in the

177 Moreover, the impacts of neonicotinoid seed coatings in reducing subsequent appli

178 vide the first evidence that farmers who use neonicotinoid seed coatings reduce the number of subsequ

179 Neonicotinoid seed dressings have caused concern world-w

180 We hypothesize that any sublethal effects of neonicotinoid seed dressings on Bombus colonies are pote

181 d population extinction rates in response to neonicotinoid seed treatment use on oilseed rape.

182 s and Aplysia californica (Ac) AChBP of high neonicotinoid sensitivity] mimicking vertebrate and inse

183 image of thiacloprid as a relatively benign neonicotinoid should now be questioned.

184 take) associated with the systemic nature of neonicotinoids should be accounted for during their regi

185 es RKRIRRMMPRPS and RNRHTHLRTRPR for binding neonicotinoids such as thiacloprid and imidacloprid.

186 As an exception, the remarkably potent OP neonicotinoid synergist, O-propyl O-(2-propynyl) phenylp

187 via spray drift or surface runoff or (due to neonicotinoids' systemic nature) via senescent leaves.

188 imes more negatively affected by exposure to neonicotinoids than non-crop foragers.

189 es, the nicotinic acetylcholine receptor for neonicotinoids, the gamma-aminobutyric acid receptor/chl

190 Neonicotinoids, the most important new class of syntheti

191 at were either untreated or treated with the neonicotinoid thiacloprid as part of normal farming prac

192 s) colonies to field-realistic levels of the neonicotinoid thiamethoxam (2.4ppb & 10ppb) over four we

193 alistic, chronic exposure to the widely-used neonicotinoid thiamethoxam on the development of sonicat

194 at, spiromesifen and spirodiclofen) and five neonicotinoid (thiamethoxam, chlotianidin, imidacloprid,

195 thiacloprid, a widely used cyano-substituted neonicotinoid thought to be less toxic to honey bees and

196 af-shredding invertebrates may be exposed to neonicotinoids through both the water phase and the cons

197 lecular basis of observed adverse effects of neonicotinoids to bees.

198 abolizing P450) at metabolizing nicotine and neonicotinoids to less toxic metabolites in vitro and ge

199 getation be retained or restored to minimize neonicotinoid transport and retention in wetlands, there

200 the poor navigation and foraging observed in neonicotinoid treated bumblebee colonies.

201 ous field studies, leaving the net impact of neonicotinoid treated crops on bees relatively unknown.

202 e field experiments to assess the effects of neonicotinoid-treated crops on three bee species across

203 xperienced when foraging on crops grown from neonicotinoid-treated seeds.

204 Pesticides, including neonicotinoids, typically target pest insects by being n

205 r costs and farming benefits of prophylactic neonicotinoid usage on a mass flowering crop.

206 ny losses and national-scale imidacloprid (a neonicotinoid) usage patterns across England and Wales.

207 y targeted efforts could considerably reduce neonicotinoid use in field crops without yield declines

208 stribution data for 62 species to amounts of neonicotinoid use in oilseed rape.

209 Neonicotinoid use increased rapidly between 2003 and 201

210 Restrictions on neonicotinoid use may reduce population declines.

211 ble data to estimate and interpret trends in neonicotinoid use since their introduction in 1994, with

212 If current trends continue, neonicotinoid use will increase further through applicat

213 tiple agricultural pesticides, including the neonicotinoids used as seed treatments.

214 thereby establishing an atypical concept for neonicotinoid versus nicotinoid selectivity between inse

215 d removal of six high-production high-volume neonicotinoids was investigated in 13 conventional waste

216 NMI) analog of imidacloprid, a highly potent neonicotinoid, was used here as a radioligand, uniquely

217 Given the scale of use of neonicotinoids, we suggest that they may be having a con

218 We propose that neonicotinoids with a protonated N-unsubstituted imine o

219 e been based on the premise that exposure to neonicotinoids would occur only during the blooming peri