ライフサイエンスコーパス: nephrogenic

1 classified as embryonal adenomas and one as nephrogenic adenofibroma.

2 formation in transparent larvae showed that nephrogenic aggregates form by the coalescence of multip

3 6.TC mice produce high titers of antinuclear nephrogenic autoantibodies and a highly penetrant glomer

4 7) show that targeted Pax2 deletion converts nephrogenic cells to the stromogenic path, suggesting th

5 MM cells than in intact mesenchyme, and the nephrogenic competence of transduced drMM progenitor cel

6 termediate mesoderm at the caudal end of the nephrogenic cord.

7 PP2A was found predominately in the nephrogenic cortex and particularly in the developing gl

8 ng kidney development and its mapping to the nephrogenic cortex, developing glomeruli, and tubules su

9 ry, Tie-2 was detected in capillaries of the nephrogenic cortex, glomerular tufts, cortical interstit

10 To reduce lithium-induced nephrogenic diabetes insipidus (lithium-NDI), patients w

11 aquaporin-2 (AQP2) point mutants that cause nephrogenic diabetes insipidus (NDI) are retained in the

12 Congenital nephrogenic diabetes insipidus (NDI) is a rare disease c

13 Nephrogenic diabetes insipidus (NDI) is caused by impair

14 Hereditary non-X-linked nephrogenic diabetes insipidus (NDI) is caused by mutati

15 A Mexican family with partial congenital nephrogenic diabetes insipidus (NDI) that resulted from

16 n-2 (AQP2) mutations that cause non-X-linked nephrogenic diabetes insipidus (NDI) were characterized

17 20% of patients treated with lithium develop nephrogenic diabetes insipidus (NDI), a disorder charact

18 fect in urinary concentrating ability, i.e., nephrogenic diabetes insipidus (NDI), but the molecular

19 ep in generating a transgenic mouse model of nephrogenic diabetes insipidus (NDI), we have analyzed t

20 pressin and defective trafficking results in nephrogenic diabetes insipidus (NDI).

21 r processing can produce autosomal recessive nephrogenic diabetes insipidus (NDI).

22 a nonsense mutation known to cause X-linked nephrogenic diabetes insipidus (XNDI) in humans (Glu242s

23 X-linked nephrogenic diabetes insipidus (XNDI) is a severe kidney

24 MIP underlie an autosomal recessive form of nephrogenic diabetes insipidus and absence of the Colton

25 -of-function mutations in aquaporins include nephrogenic diabetes insipidus and congenital cataracts.

26 cost of severe renal side effects, including nephrogenic diabetes insipidus and rarely, ESRD.

27 these results identify a novel mechanism of nephrogenic diabetes insipidus and uncover a role of SOC

28 Other features included nephrogenic diabetes insipidus in 87% and hypertension i

29 children, and distal tubular toxicity caused nephrogenic diabetes insipidus in one.

30 The most common cause of hereditary nephrogenic diabetes insipidus is a nonfunctional vasopr

31 This nephrogenic diabetes insipidus leads to dehydration and

32 chronic experimental iron overload leads to nephrogenic diabetes insipidus marked by AVP-resistant u

33 Our findings establish a form of nephrogenic diabetes insipidus produced by impaired wate

34 The nephrogenic diabetes insipidus symptoms and the absence

35 ceptors known to be responsible for X-linked nephrogenic diabetes insipidus were used as model system

36 hat Foxa1(-/-) mice represent a new model of nephrogenic diabetes insipidus with unique molecular eti

37 familiar diseases such as Gaucher's disease, nephrogenic diabetes insipidus, and Creutzfeldt-Jakob di

38 e for retinitis pigmentosa, color blindness, nephrogenic diabetes insipidus, familial ACTH resistance

39 hium, a potent inhibitor of GSK3beta, causes nephrogenic diabetes insipidus, GSK3beta may play a cruc

40 ion R137H, which is associated with familial nephrogenic diabetes insipidus, induces constitutive arr

41 have shown that a molecular determinant for nephrogenic diabetes insipidus, the vasopressin receptor

42 were compatible with a diagnosis of partial nephrogenic diabetes insipidus.

43 nt selected alleles responsible for X-linked nephrogenic diabetes insipidus.

44 otypes--ranging from congenital cataracts to nephrogenic diabetes insipidus.

45 deletion in mice produces distinct forms of nephrogenic diabetes insipidus.

46 in renal handling of water in health and in nephrogenic diabetes insipidus.

47 ility; mutations or downregulation can cause nephrogenic diabetes insipidus.

48 and trafficking, the absence of which causes nephrogenic diabetes insipidus.

49 alcitonin has a potential therapeutic use in nephrogenic diabetes insipidus.

50 VP, a vasopressin analog), characteristic of nephrogenic diabetes insipidus.

51 vasopressin 2 receptor and aquaporin 2 cause nephrogenic diabetes insipidus; however, expression of t

52 pressor complexes to antagonize Wnt-directed nephrogenic differentiation.

53 bodies that are cultured in the presence of nephrogenic factors can respond to inductive signals and

54 ding to positional information that controls nephrogenic fate.

55 Nephrogenic fibrosing dermopathy (NFD) is a newly recogn

56 Nephrogenic fibrosing dermopathy (NFD) is a newly recogn

57 Nephrogenic systemic fibrosis, also known as nephrogenic fibrosing dermopathy, was first documented i

58 s possible to begin to understand the normal nephrogenic function of the wild-type proteins and under

59 This study used a combination of nephrogenic growth factors to differentiate ES cells int

60 The nephrogenic mesenchymal lineage in fgfr2(UB-/-) mice dev

61 Although enhancers for pigmented epithelium, nephrogenic mesenchyme and apical ectodermal ridge are d

62 re/+) allele leads to disorganization of the nephrogenic mesenchyme and impairment of mesenchyme indu

63 pulation of cells expressing markers of both nephrogenic mesenchyme and peripheral stroma.

64 data suggest a novel interaction between the nephrogenic mesenchyme and stromal progenitor cell popul

65 n the recruitment and/or organization of the nephrogenic mesenchyme at early time-points of kidney de

66 t are a likely result of progressive loss of nephrogenic mesenchyme by apoptosis.

67 le is known about the mechanism by which the nephrogenic mesenchyme cell population is maintained at

68 ded by two distinct mesenchymal populations: nephrogenic mesenchyme derived from the intermediate mes

69 null mesenchyme cells at E11.5 show that the nephrogenic mesenchyme does not aggregate tightly around

70 on is inappropriately maintained in anterior nephrogenic mesenchyme in these mutants.

71 conclude that the failure of recruitment of nephrogenic mesenchyme leaves a primitive population of

72 show that induction and condensation of the nephrogenic mesenchyme occurs normally in mutant.

73 bservation that the ureteric bud induced the nephrogenic mesenchyme to undergo tubulogenesis.

74 1, Pax2, and Wt1, are all down-regulated and nephrogenic mesenchyme undergoes massive apoptosis, resu

75 By contrast, removal of Smad4 in nephrogenic mesenchyme using the Bmp7(cre/+) allele lead

76 We found that the nephrogenic mesenchyme, which is required for continued

77 ng generated from a stem-cell population-the nephrogenic mesenchyme-in response to signals emanating

78 in response to GDNF secreted by the adjacent nephrogenic mesenchyme.

79 the SLIT2/ROBO2 signal is transduced in the nephrogenic mesenchyme.

80 c lineage mapping of the collecting duct and nephrogenic mesenchyme.

81 ct with Pax2 and Eya1, factors important for nephrogenic mesoderm specification, to directly regulate

82 al Wnt signalling is not active in the early nephrogenic metanephric mesenchyme, but instead provide

83 correlating with disturbed expression of key nephrogenic molecules.

84 o determine whether the DI was of central or nephrogenic origin, we examined the responsiveness of th

85 The nephrogenic pattern of Ang-2 was documented in a mouse s

86 protein-energy malnutrition in sheep blunts nephrogenic potential in the 0.44 gestation (65 days ges

87 enomic stability, molecular homogeneity, and nephrogenic potential in vitro, ex vivo, and in vivo.

88 Elements that direct Pax2 expression to nephrogenic precursor cells must be responding to positi

89 tirety of organogenesis, focusing on two key nephrogenic progenitor populations: the ureteric epithel

90 kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of

91 directs expression of a lacZ reporter to the nephrogenic region and the midbrain-hindbrain junction i

92 nificantly attenuates lacZ expression in the nephrogenic region but not in the midbrain-hindbrain reg

93 y (FH) tumors (100% and 92%), and intralobar nephrogenic rests (ILNR; 77% and 22%) all differed.

94 significantly associated with both perilobar nephrogenic rests and 11p15 imprinting aberrations.

95 Thirty-four Wilms' tumors with nephrogenic rests and/or areas of anaplasia were microdi

96 Intralobar and perilobar nephrogenic rests are known to have different biological

97 Nephrogenic rests are precursor lesions associated with

98 blastoma is believed to arise from embryonic nephrogenic rests of multipotent cells that fail to term

99 Nephrogenic rests show increases in methylation levels r

100 n of abnormally persistent renal stem cells (nephrogenic rests) which retain embryonic differentiatio

101 ncreased risk was observed for patients with nephrogenic rests, bilateral tumors, history of secondar

102 n pathway response and leads to precancerous nephrogenic rests.

103 ve a high prevalence of precursor intralobar nephrogenic rests.

104 analysis of Wilms' tumour precursor lesions, nephrogenic rests.

105 Amid mounting concerns about nephrogenic sclerosis and gadolinium deposition in the b

106 mouse revealed a transient, mouse-like, pre-nephrogenic, Six1 regulatory pattern.

107 tromogenic stem cells and [Six2(+), Pax2(+)] nephrogenic stem cells.

108 zation of mutant receptors for patients with nephrogenic syndrome of inappropriate antidiuresis becau

109 ding the V2 vasopressin receptor (V2R) cause nephrogenic syndrome of inappropriate antidiuresis.

110 like clinical picture, which we have termed "nephrogenic syndrome of inappropriate antidiuresis."

111 bodies were thought to be pathognomonic for nephrogenic systemic fibrosis (NSF) in the setting of ch

112 Nephrogenic systemic fibrosis (NSF) is a fibrosing skin

113 Nephrogenic systemic fibrosis (NSF) is a rapidly progres

114 Nephrogenic systemic fibrosis (NSF) is a severe fibrosin

115 Nephrogenic systemic fibrosis (NSF) is associated with g

116 m patients with systemic sclerosis (SSc) and nephrogenic systemic fibrosis (NSF) was performed to ide

117 sented as a novel means for the diagnosis of nephrogenic systemic fibrosis (NSF), a rare disease occu

118 disease, have been strongly associated with nephrogenic systemic fibrosis (NSF), a severe systemic f

119 ew data in 13 patients with biopsy-confirmed nephrogenic systemic fibrosis (NSF), assess the associat

120 e a small risk of adverse effects, including nephrogenic systemic fibrosis (NSF), the untreatable con

121 eir product labeling to describe the risk of nephrogenic systemic fibrosis (NSF).

122 connective tissue or skin disease resembling nephrogenic systemic fibrosis (NSF-like) and a broader s

123 imuli may participate in the pathogenesis of nephrogenic systemic fibrosis and of other fibrotic diso

124 Clinical reports support the evidence of nephrogenic systemic fibrosis as a systemic disease and

125 Gd(3+) and potential side effects including nephrogenic systemic fibrosis have led to the search for

126 dolinium-based contrast agents are linked to nephrogenic systemic fibrosis in patients with renal ins

127 lain their causal role in the development of nephrogenic systemic fibrosis in renally impaired patien

128 Nephrogenic systemic fibrosis is a new disorder reported

129 The pathology of nephrogenic systemic fibrosis is characterized by abnorm

130 Clinical awareness of nephrogenic systemic fibrosis is still emerging and futu

131 o uniformly effective interventions to treat nephrogenic systemic fibrosis other than successful rena

132 lls in the fibrotic and calcified tissues of nephrogenic systemic fibrosis patients.

133 While a specific cause of nephrogenic systemic fibrosis remains to be established,

134 pe and function relevant to the pathology of nephrogenic systemic fibrosis using immunofluorescence,

135 ased contrast agents in patients at risk for nephrogenic systemic fibrosis was recently shown to avoi

136 cts) and from lesional skin of patients with nephrogenic systemic fibrosis were exposed to a range of

137 Nephrogenic systemic fibrosis, also known as nephrogenic

138 e recent association of this lanthanide with nephrogenic systemic fibrosis, an untreatable disease, h

139 We also examined tissues from patients with nephrogenic systemic fibrosis, using IHC to identify the

140 g that gadoxetate disodium does not incite a nephrogenic systemic fibrosis-like fibrotic change in th

141 None of the neonates developed nephrogenic systemic fibrosis.

142 ystemic fibrosis and ectopic ossification in nephrogenic systemic fibrosis.

143 ts with severe renal dysfunction at risk for nephrogenic systemic fibrosis.

144 Nephrogenic systemic sibrosis is a progressive disorder

145 In particular, postnatal maturation of the nephrogenic zone (NZ) is defective.

146 tion and increased apoptosis of cells in the nephrogenic zone and a progressive decrease in the numbe

147 -dysplastic kidneys, patchy depletion of the nephrogenic zone and pockets of superficially placed, ec

148 expressed in the developing nephrons in the nephrogenic zone and ureteric bud branches, where the si

149 IF-2alpha mRNAs were highly expressed in the nephrogenic zone of newborn kidney cortex and in the med

150 main protein Cux1 is highly expressed in the nephrogenic zone of the developing kidney where it funct

151 reduced numbers of nephrons and lacking the nephrogenic zone where new nephrons are continuously add

152 apoptosis and decreasing angiogenesis in the nephrogenic zone, effects that were more marked in male

153 esenchyme (MM), particularly in the cortical nephrogenic zone, which provides the progenitors for rec

154 ed regions of mesenchymal condensates in the nephrogenic zone.

155 ing kidney with expression restricted to the nephrogenic zone.

156 to defective UB branching and underdeveloped nephrogenic zone.

157 ed incorporation into blastemal cells of the nephrogenic zone.