1 everal additional RGD-binding integrins bind
nephronectin.
2 Our results thus place
nephronectin and alpha8beta1 integrin in a pathway that
3 eta-catenin activation upregulates epidermal
nephronectin and dermal alpha8 integrin expression.
4 expression was dramatically reduced in both
nephronectin-
and alpha8 integrin-null mutants specifica
5 t, and its resumption presumably enables the
nephronectin-
deficient ureteric buds to invade the metan
6 Thus, bulge stem cells, via
nephronectin expression, create a smooth muscle cell nic
7 re there is compensatory upregulation of the
nephronectin family member EGFL6.
8 We show that embryos lacking a functional
nephronectin gene frequently display kidney agenesis or
9 A novel alpha8beta1 ligand,
nephronectin,
has now been identified.
10 Nephronectin induces alpha8 integrin-positive mesenchyma
11 We show that stem cells in the bulge deposit
nephronectin into the underlying basement membrane, thus
12 Nephronectin is a new extracellular matrix protein assoc
13 Thus, these results strongly suggest that
nephronectin is a relevant ligand mediating alpha8beta1
14 Nephronectin is a Wnt target; epidermal beta-catenin act
15 idence that the extracellular matrix protein
nephronectin is an essential ligand that engages alpha8b
16 Nephronectin is expressed at numerous sites outside the
17 Nephronectin is localized in the extracellular matrix in
18 This protein, named
nephronectin,
is an extracellular matrix protein with fi
19 In
nephronectin knockout mice, fewer arrector pili muscles
20 Nephronectin mRNA is expressed in the ureteric bud epith
21 x organization in the nascent kidneys of the
nephronectin mutants.
22 The small secreted integrin ligand
nephronectin (
npnt) is necessary for development of the
23 Here, we report that
Nephronectin (
NPNT), a member of the epidermal growth fa
24 adhesion of mesenchymal cells expressing the
nephronectin receptor, alpha8beta1 integrin, to the bulg