ライフサイエンスコーパス: nestin

1 eries that are often positive for the marker nestin.

2 uding expression of synaptopodin, CD2AP, and nestin.

3 n mouse developing cerebellum that expresses Nestin.

4 s glial fibrillary acidic protein (GFAP) and Nestin.

5 (iv) regulation of molecules such as Osx and nestin.

6 glial- and neuronal cell phenotype (GFAP and Nestin-1 positivity, respectively) in the iERMs, as well

7 expressed Opn1mw, a cone-specific marker and nestin, a marker for neural precursor cells.

8 Colonies were strongly positive for nestin, a marker for neural precursors, and contained Ne

9 myeloid cells expressed detectable levels of nestin, a marker for neural stem and progenitor cells.

10 ses TLX under the control of the promoter of nestin, a neural precursor marker.

11 Nestin, an intermediate filament found in neural progeni

12 Immunohistochemistry staining of nestin and 5-hmC in 53 clinically annotated primary and

13 lands expressed Snai1 and vimentin alongside nestin and alpha smooth muscle actin (another biomarker

14 he dentin, as assessed by immunostaining for nestin and dentin sialoprotein (DSP).

15 1 strongly correlated with that of CD133 and nestin and differentiation status of malignant glioma ce

16 Upon activation, qNSCs upregulate Nestin and EGFR and become highly proliferative.

17 a small subset of CD146(+) cells expressing Nestin and enriched for MSC and HSC niche activities.

18 e expressed in endothelial cells adjacent to NESTIN and NOTCH receptor-positive cancer cells in prima

19 ed within myenteric ganglia and express both Nestin and p75NTR, but not the pan-glial marker Sox10.

20 ural stem cell markers such as CD133, Msi-1, nestin and Sox-2.

21 n non-cancerous neural stem cells, including nestin and Sox2.

22 (MAPK), as well as a significant decrease in nestin and tubulin-alpha2 chain expression in KCKO cells

23 networks with melanoma stem cell-associated nestin and vascular endothelial growth factor receptor-1

24 astroglia, which also express immunoreactive nestin and vimentin, are prominent features of multiple

25 e nuclei, neural stem cell markers (Pax6 and nestin) and the Tbr2-positive intermediate progenitors a

26 cells expressed the neural stem cell marker nestin, and 65% exhibited the more mature neural marker

27 ed the expression of the stem cell biomarker nestin, and decreased the expression of reactive astrocy

28 ex, expresses the stem cell markers Sox2 and Nestin, and lacks markers of glial or neuronal different

29 d the expression of stem cell markers CD133, Nestin, and Nanog.

30 with the other GBM stemness markers, CD133, Nestin, and Sox2.

31 on of the neuroectodermal stem cell antigen, nestin, and up-regulating the glial maturation marker, G

32 ress markers for radial glia like GFAPdelta, nestin, and vimentin.

33 in life and ultimate depletion of the Type 1 nestin- and GFAP-expressing neural stem cells.

34 x1 protein was also expressed in a subset of Nestin- and GFAP-expressing putative neural stem or prog

35 ntin+, CD24+, FoxJ1+, Sox2+, and CD133+, but nestin- and glial fibrillary acidic protein (GFAP)-.

36 n of alpha-smooth muscle (alphaSM)-actin and nestin antigens by pericytes in new vessels, we delivere

37 ressed the nonspecific precursor cell marker Nestin as well as GFAP and Sox2.

38 onance contrast agents (SPION-actin or SPION-nestin at 4 mg Fe/kg) by i.p. injection to C57black6 mic

39 Nestin binding to Gli3 blocked Gli3 phosphorylation and

40 Here, we report that Nestin binds the hedgehog pathway transcription factor G

41 rphology and expressed the progenitor marker Nestin but not Math1, a marker of committed granule neur

42 Therefore, transcriptional repression of Nestin by p53 restricts cellular plasticity and tumorige

43 mia, we observed pericytes (at d 2, using Gd-nestin, by eyedrop solution), significant photoreceptor

44 their osteoblastic differentiation, in vivo nestin(+) cell depletion rapidly reduces HSC content in

45 of lethally irradiated mice, whereas in vivo nestin(+) cell depletion significantly reduces bone marr

46 pe HSPC were located less than 30 mum from a nestin(+) cell.

47 nistration doubles the number of bone marrow nestin(+) cells and favours their osteoblastic different

48 These CD31(-)nestin(+) cells are found in the T and B cell zones or i

49 show that during all stages of development, nestin(+) cells are present within lymph nodes of these

50 Overall our data show that nestin(+) cells contribute to all subsets of the complex

51 Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in dire

52 Here, we show that nestin(+) cells direct inflammatory cell migration durin

53 ared with control mice, there were increased nestin(+) cells in airways and higher levels of active T

54 er, postnatal tamoxifen induced targeting of nestin(+) cells in nes-creER mice showed that most endot

55 d excision of Rac1 in Rac3(-/-) mice reduces Nestin(+) cells in the marrow.

56 The PDGFRalpha(+) CD51 (+)subset of Nestin(+) cells is also enriched in major HSC maintenanc

57 In contrast, quiescent neural crest-derived nestin(+) cells preserve MSC activity, but do not genera

58 However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic i

59 oE) knockout mice fed with high-fat diet, BM nestin(+) cells regulate the egress of inflammatory mono

60 Fate mapping of nestin(+) cells unambiguously revealed the contribution

61 regions simultaneously with the presence of nestin(+) cells undergoing apoptosis.

62 We hypothesized that deletion of Rac in the Nestin(+) cells would perturb the perivascular space, al

63 omal cells characterizes a large fraction of Nestin(+) cells, containing most fibroblastic CFUs, mese

64 Mcp1 deletion in nestin(+) cells-but not in endothelial cells only- incre

65 portant to find surface markers specific for Nestin(+) cells.

66 altering the survival of neural progenitor (Nestin(+)) cells.

67 lacking SRF in neural progenitor cells (Srf-Nestin-cKO) exhibit striking deficits in cortical axonal

68 (SRF), in neural precursor cells (NPCs) (Srf-Nestin-cKO) results in nearly 60% loss in astrocytes and

69 Yap (Yap1) knockout, Yap(nestin) conditional knockout and Yap(GFAP) conditional k

70 mined that the intermediate filament protein nestin correlates with tumorigenic and invasive melanoma

71 Unexpectedly, 60% of Nestin(Cre)Bax(fl/fl)Bak(-/-) mice harbored high-grade t

72 Aged Nestin(Cre)Bax(fl/fl)Bak(-/-) mice manifest progressive

73 ns and glia in addition to the motor neuron (Nestin-Cre and ChAT-Cre) resulted in the greatest improv

74 rs and neurons in the developing brain using Nestin-cre and Nex-cre lines, respectively.

75 n dopaminergic neurons, in conditional Zeb2 (Nestin-Cre based) knockout mice.

76 Ablation of Hdac1 or Hdac2 by Nestin-Cre had no obvious consequences on brain developm

77 ption factor Lhx2 in cortical progenitors by Nestin-cre leads to a dramatically smaller cortex.

78 ne or after initial lens formation using the Nestin-Cre line.

79 cerebellar development using Wnt5a(-/-) and Nestin-Cre mediated conditional knockout mouse models.

80 control (PC4(+/+) Nestin-Cre) mice, PC4(f/f) Nestin-Cre mice are smaller with decreased nocturnal act

81 Interestingly, PC4(f/f) Nestin-Cre mice exhibit a severe deficit in spatial memo

82 alysis of the dorsal hippocampus of PC4(f/f) Nestin-Cre mice revealed dysregulated expression of seve

83 C9orf72(fl/fl) mice were crossed with Nestin-Cre mice to selectively remove C9orf72 from neuro

84 Surprisingly, the Nestin-Cre mice used to mediate gene inactivation displa

85 Nestin-Cre mice were crossed with ERalpha(flox) mice to

86 rain GLUT4 (BG4KO) was generated by crossing Nestin-Cre mice with GLUT4-floxed mice.

87 dm16 deletion during fetal development using Nestin-Cre prevented the formation of ependymal cells, d

88 nestin-Cre Tor1a(flox/DeltaE) compared with nestin-Cre Tor1a(flox/-) animals.

89 at conditional deletion of Tor1a in the CNS (nestin-Cre Tor1a(flox/-)) or isolated CNS expression of

90 egeneration that was substantially milder in nestin-Cre Tor1a(flox/DeltaE) compared with nestin-Cre T

91 lated CNS expression of DYT1 mutant torsinA (nestin-Cre Tor1a(flox/DeltaE)) causes striking abnormal

92 brain-wide deletion of ADK by introducing a Nestin-Cre transgene into a line of conditional ADK defi

93 r expression in the nervous system using the Nestin-Cre transgene only partially rescued obesity in c

94 We show that a Nestin-Cre transgene targets perivascular cells (adventi

95 ned with conditional PC4 knock-out (PC4(f/f) Nestin-Cre) mice where PC4 is knocked out specifically i

96 Compared with the control (PC4(+/+) Nestin-Cre) mice, PC4(f/f) Nestin-Cre mice are smaller w

97 eted from haematopoietic cells, osteoblasts, nestin-cre- or nestin-creER-expressing cells.

98 Nestin-Cre-directed excision of Rac1 in Rac3(-/-) mice r

99 Nestin-Cre-driven deletion of podoplanin on neural proge

100 R(T2), GFAP-Cre-ER(T2), FoxJ1-Cre-ER(T2) and Nestin-Cre-ER(T2)) to explore these issues in adult mice

101 etion of Cxcl12 from haematopoietic cells or nestin-cre-expressing cells had little or no effect on H

102 tailed behavioural analysis of the resulting Nestin-Cre-Lpd knockout mouse line revealed a specific b

103 n-deficient mouse lines using CaMKII-Cre and Nestin-Cre.

104 l complexes (AJCs) was responsible for PH in Nestin-Cre/Llgl1(fl/fl) brains.

105 neural stem-cell-specific deletion of Llgl1 (Nestin-Cre/Llgl1(fl/fl)), a mammalian ortholog of the Dr

106 lso highly enriched CFU-Fs, but negative for Nestin-CreER and NG2-CreER, markers which were unlikely

107 Nestin-CreER(T2) and Pdgfra-CreER(T2) transgenic mice we

108 Postnatal Prdm16 deletion using Nestin-CreER(T2) did not cause hydrocephalus or prevent

109 Our findings suggest that each nestin-CreER(T2) line may best serve different experimen

110 Reporter expression in the third nestin-CreER(T2) line was considerably more specific, bu

111 Here we compare three such nestin-CreER(T2) lines to evaluate specificity of expres

112 We found that all three nestin-CreER(T2) strains induced reporter expression wit

113 Using an inducible nestin-CreER(T2)/R26R-yellow fluorescent protein (YFP) m

114 We generated nestin-CreER(T2)/R26R-YFP/Hif1a(fl/fl) triple transgenic

115 We generated nestin-CreER(T2)/R26R-YFP/Notch1(loxP/loxP) [Notch1induc

116 bgranular zone (SGZ) of wild-type (WT) mice (nestin-CreER(T2)/R26R-YFP/Notch1(w/w)) after tamoxifen (

117 ato-expressing cells in the adult cochlea of nestin-CreER(T2)/tdTomato mice remains unclear; however,

118 We used nestin-CreER(T2)/tdTomato-reporter mice to trace the lin

119 Tamoxifen-inducible nestin-creER(tm)4 lineage tracing demonstrated that it i

120 topoietic cells, osteoblasts, nestin-cre- or nestin-creER-expressing cells.

121 and their progeny by giving transgenic mice (nestin-CreERT2/R26R-YFP/CDK5(flox/flox) [iCdk5] and nest

122 CreERT2/R26R-YFP/CDK5(flox/flox) [iCdk5] and nestin-CreERT2/R26R-YFP/CDK5(wt/wt) [WT]) tamoxifen duri

123 Crossing with Nestin-cyclization recombinase (Cre) eliminated EAAT2 fr

124 A nestin-DeltaTK-IRES-GFP (Nes-DeltaTK-GFP) transgene that

125 Blockade of nestin-dependent signaling inhibited ACh-induced Cdk5 ac

126 ence-activated cell sorting, only Prominin-1/Nestin double-positive cells fulfilled the defining stem

127 uroectodermal and progenitor markers such as nestin, doublecortin, GFAP, neurofilament, and vimentin.

128 rotein levels of four hallmark NPC proteins (nestin, doublecortin, sex-determining homeobox 2, and gl

129 Conversely, loss of Nestin dramatically inhibited proliferation and promoted

130 Our findings show how Nestin drives hedgehog pathway-driven cancers and uncove

131 and Cre drivers that are activated at early [Nestin; embryonic day 10.5 (E10.5)] and late [human glia

132 amoxifen-inducible cre recombinase driven by nestin enhancer (Nes-creER) in developing bone marrow we

133 trabecular and cortical bone compartments in nestin-ERalpha(-/-) mice compared with controls.

134 We propose that the increased bone mass in nestin-ERalpha(-/-) mice is mediated via decreased centr

135 The high bone mass phenotype in nestin-ERalpha(-/-) mice was mainly caused by increased

136 Femoral bone strength was increased in nestin-ERalpha(-/-) mice, as demonstrated by increased s

137 WAT) and slightly increased amount of WAT in nestin-ERalpha(-/-) mice.

138 a expression specifically in nervous tissue (nestin-ERalpha(-/-)).

139 lar zone (SVZ) of the lateral ventricles and nestin expressing NeuN positive neurons and adenomatous

140 hese data indicate that Sildenafil amplifies nestin expressing neural stem cells and their neuronal a

141 middle-aged mouse with Sildenafil increased nestin expressing neural stem cells, mature neurons, and

142 Nestin-expressing (Nestin(+)) mesenchymal stromal cells

143 R) cells, stem cell factor-expressing cells, nestin-expressing cells and platelet-derived growth fact

144 Therefore, we selectively removed Cdk5 from nestin-expressing cells and their progeny by giving tran

145 When Cdk5 gene deletion was induced in nestin-expressing cells and their progeny during the wav

146 porter mice to trace the lineage of putative nestin-expressing cells and their progeny in the cochlea

147 Thus, glial cells that originate from nestin-expressing cells and their progeny require Cdk5 f

148 Cell-specific loss of Tsc1 within nestin-expressing cells in adult mice leads to the forma

149 In addition, two populations of vimentin/nestin-expressing cells were identified: a dorsal group

150 ream AKT, and in human pancreatic epithelial nestin-expressing cells, activates both the AKT and MAPK

151 is hypothesis by targeting Hand2 deletion in nestin-expressing neural precursor (NEP) cells.

152 maintained a significantly greater number of nestin-expressing neural progenitor cells compared with

153 moxifen-inducible Hif1a gene inactivation in nestin-expressing NSCs within the adult SVZ.

154 zed that Mef2a, -c, and -d deletion in adult nestin-expressing NSPCs and their progeny would result i

155 , -c, and -d were inducibly deleted in adult nestin-expressing NSPCs and their progeny.

156 estin was colocalized in alphaSM- actin- and nestin-expressing pericytes in BCAO-treated C57black6 or

157 nic NSCs led to an increase in the number of Nestin-expressing precursors; mutational analysis of SC1

158 Moreover, Hedgehog signaling in two Nestin-expressing progenitor populations is crucial not

159 d a marker for multipotent stem cells, these Nestin-expressing progenitors (NEPs) are committed to th

160 tnatal ablation of granule cell progenitors, Nestin-expressing progenitors, specified during mid-embr

161 ineage tracing of individual, quiescent, and nestin-expressing radial glia-like (RGL) precursors in t

162 e show that, in the adult mouse hippocampus, nestin-expressing radial glia-like quiescent neural stem

163 ssion of yellow fluorescent protein (YFP) in nestin-expressing Type-1 NSCs and their progeny in the a

164 We examined nestin expression (a marker for MSCs) and TGF-beta1 sign

165 Instead, Nestin expression in astrocytes is transiently increased

166 Therefore, nestin expression marks cells that regulate inflammatory

167 further define the interplay between 5-hmC, nestin expression, and melanoma virulence.

168 enchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche com

169 Many human HCCs and CCs show elevated nestin expression, which correlates with p53 loss of fun

170 grammed senescence, characterized by loss of nestin expression.

171 mors within the testis, a peripheral site of Nestin expression.

172 ubules; and (5) a dramatic change in Osx and nestin expression.

173 tion, and stem cell marker (BMI1, Nanog, and Nestin) expression, and these effects could be rescued b

174 Nestin fate-mapped astrocytes also flow anteriorly from

175 These nestin fate-mapped corpus callosum astrocytes are unifor

176 TET2 and TET2-mutated constructs, decreased nestin gene and protein expression in vitro.

177 Moreover, knockdown of nestin gene expression impaired laminin expression and n

178 binding in the 3' untranslated region of the nestin gene in melanoma compared to nevi, and 5-hmC bind

179 ls were detected by GFP expression driven by nestin gene regulatory elements to define age-related ch

180 binding at the 3' untranslated region of the nestin gene, providing one potential pathway for underst

181 that Tctex-1:GFP reporter selectively marks nestin(+)/GFAP(+)/Sox2(+) neural stem-like cells in two

182 Nestin-GFP expression typically diminishes in primary cu

183 senchymal stem cells are labeled with GFP in nestin-GFP mice, and we show that during all stages of d

184 We utilized ApoE-deficient mice crossed to a nestin-GFP reporter to demonstrate that dentate gyrus pr

185 l cells and pericyte-like cells) in WAT, and Nestin-GFP specifically labels pericyte-like cells.

186 icroscopy and electron microscopy to examine Nestin-GFP transgenic mice and provide a detailed ultras

187 Isolated Nestin-GFP(+) cells differentiate into adipocytes ex viv

188 ved BM stroma, which have characteristics of Nestin-GFP(+) MSPCs.

189 The neonatal Nestin-GFP(+) Pdgfralpha(-) cell population also contain

190 share a common signature (Pax7(+), Ki67(-), Nestin-GFP(+), Myf5(nLacZ+), MyoD-positive lineage origi

191 We show that within the Hes5-GFP(+)/Nestin-GFP(+)/EGFR(+) cell population, which comprises t

192 ia through proliferation, are recruited to a Nestin-GFP(high) perivascular population, and contribute

193 lls were Scf-GFP(+), Cxcl12-DsRed(high), and Nestin-GFP(low), markers which also highly enriched CFU-

194 negative for the skeletal stem cell markers Nestin-GFP, Leptin receptor and Gremlin1.

195 MSPCs can be labeled in the adult BM by Nestin-GFP, whereas committed osteoblast progenitors are

196 d ultrastructural reconstruction analysis of Nestin-GFP-positive RGL cells of the dentate gyrus.

197 orescent analysis of isolated myofibers from nestin-GFP/Myf5(nLacZ/+) mice reveals a decline with age

198 leptin-receptor-positive stromal cells, and nestin-green fluorescent protein (GFP)-positive mesenchy

199 bolic response to amylin was enhanced in the nestin/hRAMP1 mice whereas the response to CGRP was blun

200 Consistent with this, the nestin/hRAMP1 transgenic mice had elevated BAT mRNA leve

201 Nestin/hRAMP1 transgenic mice have a remarkably decrease

202 say to show that CGRP-sensitized transgenic (nestin/hRAMP1), but not control, mice exhibited light av

203 P receptor hRAMP1 subunit in nervous tissue (nestin/hRAMP1).

204 at the time of injury with ganciclovir in a nestin-HSV-TK transgenic model, we eliminated injury-ind

205 alysis revealed high levels of microvascular nestin immunoreactivity in the same region.

206 Nestin-immunoreactivity delineated a potential macroscop

207 ects of Cdk5 gene inactivation, knockdown of nestin in agrin-deficient mouse embryos substantially re

208 stem and progenitor-cell-associated protein nestin in an Sp1/3 transcription-factor-dependent manner

209 , along with two stem cell markers CD133 and nestin, in multiple glioma patient specimens, glioma pri

210 These results suggest that nestin is required for ACh-induced, Cdk5-dependent dispe

211 anscription-factor-dependent manner and that Nestin is required for tumor initiation in vivo.

212 Although Nestin is widely considered a marker for multipotent ste

213 In this study, the first nestin isoform, Nes-S, was identified in neurons of dors

214 The intermediate filament protein Nestin labels populations of stem/progenitor cells, incl

215 gene (UL123) specifically increased Sox2 and Nestin levels in the IE1-positive tumors, upregulating s

216 In a mouse model system, Nestin levels increased progressively during medulloblas

217 hosphodiesterase type 5 (PDE5) inhibitor, on nestin lineage neural stem cells and their progeny in th

218 showed that focal cerebral ischemia induced nestin lineage neural stem cells in the subventricular z

219 -1 secretion from BM stromal cells including Nestin(+) mesenchymal stem cells via reactive oxygen spe

220 Nestin-expressing (Nestin(+)) mesenchymal stromal cells (MSCs) are importan

221 ate-modified micro-DNA that targets actin or nestin mRNA.

222 Nestin(+) MSCs are spatially associated with HSCs and ad

223 Nestin(+) MSCs contain all the bone-marrow colony-formin

224 Purified HSCs home near nestin(+) MSCs in the bone marrow of lethally irradiated

225 Proliferative mesoderm-derived nestin(-) MSCs participate in fetal skeletogenesis and l

226 ct LGs, MECs expressed the stem cell markers nestin, Musashi 1, ABCG2, Pax6, Chx 10, DeltaN p63, and

227 Isolated immature cells contained Ki-67, nestin, Musashi 1, Pax 6, and CHX 10.

228 As these nestin(+) myeloid cells infected with CVB3 migrated thro

229 VB3 infection may lead to the recruitment of nestin(+) myeloid cells into the CNS which might represe

230 Moreover, qNSCs are Nestin negative, a marker widely used for neural stem ce

231 Strikingly, deletion of Cxcl12 from nestin-negative mesenchymal progenitors using Prx1-cre (

232 lls identified by either their expression of nestin (Nes) or osterix (Osx) have previously been shown

233 pha (Chrna) and epsilon (Chrne) subunits and nestin (Nes).

234 eminate, we overexpressed candidate genes in Nestin(+) neural progenitors in the cerebella of mice by

235 the expression of the neuronal markers NeuN, nestin, neurofilament, and MAP-2 in medulloblastoma cell

236 notype, associated with a loss of periportal Nestin(+)NG2(+) cells and emigration of HSCs away from p

237 Nestin(+)NG2(+) cells and HSCs scale during development

238 We show that Nestin(+)NG2(+) pericytes associate with portal vessels,

239 meostasis, in which MPhi cross talk with the Nestin(+) niche cell promotes retention, and in contrast

240 ve down-regulation of HSC retention genes in Nestin(+) niche cells, and egress of HSCs/progenitors to

241 ML disrupts SNS nerves and the quiescence of Nestin(+) niche cells, leading to an expansion of phenot

242 s derived from NEP cells identified a second nestin non-expressing neural precursor (NNEP) cell in th

243 Production of new astrocytes from nestin(+) NPCs is absent in the normal adult cortex, str

244 of early neural markers - OTX2, PAX6, Sox1, Nestin, NR2F1, NR2F2, and IRX2 - in the onset of rosette

245 ruct specifically targeted expression to the nestin(+)/Pax6(+)/GLAST(+) radial glial cells and Tbr2(+

246 HSPC showed impaired early localization near nestin(+) perivascular mesenchymal stem cells; only 6.25

247 found that the intermediate filament protein nestin physically interacts with Cdk5 and is required fo

248 Nestin-positive (Nes(+)) cells are important hematopoies

249 Both nestin-positive and NG2(+) progenitor cells within neuro

250 ce in which Snf5 was ablated specifically in nestin-positive and/or glial fibrillary acid protein (GF

251 Results show that nestin-positive cells can be isolated from IL-1-injected

252 Snf5 ablation in nestin-positive cells resulted in early lethality that c

253 hout the CNS occurs through proliferation of nestin-positive cells that then differentiate into micro

254 /-) mice with conditional deletion of Bax in Nestin-positive cells.

255 entrations of TGF-beta1 induced formation of nestin-positive mesenchymal stem cell (MSC) clusters, le

256 the TGF-beta type II receptor (TbetaRII) in nestin-positive MSCs led to less development of osteoart

257 transgenic elevated expression of miR-155 in nestin-positive neural and hematopoietic stem cells, inc

258 is is consistent with expression of EphB2 in nestin-positive neural progenitor cells that migrate med

259 tes genome wide, and decreases the number of nestin-positive neural progenitors in the subventricular

260 or the CSF-1R, ablation of the Csf1r gene in Nestin-positive neural progenitors led to a smaller brai

261 noticeably after retinoic acid induction to nestin-positive neural stem cells.

262 responses evoked by LPA in acutely cultured nestin-positive NPCs from the developing mouse cerebral

263 e role of BAX/BAK in long-term regulation of Nestin-positive progenitor cell pools, with loss of func

264 e role of BAX/BAK in long-term regulation of Nestin-positive progenitor cell pools, with loss of func

265 dedifferentiation of mature hepatocytes into nestin-positive progenitor-like cells, which are poised

266 show that the proliferative effect of NPY on nestin(+) precursor cells is NO-dependent.

267 s unambiguously revealed the contribution of nestin(+) precursor cells to the mesenchymal as well as

268 However, the intracellular location of Nestin prevents its use for prospective live cell isolat

269 e line expressing Cre under the CNS specific Nestin promoter to restrict the genetic ablation of Lpd

270 Upon activation of the nestin promoter, tdTomato was observed just below and me

271 ing Cre recombinase under the control of the nestin promoter.

272 g mice expressing GFP under the direction of nestin promoter/enhancer (Nes-GFP) revealed distinct end

273 ransgenic lines have been designed using the nestin promoter; however, only a subset are capable of e

274 r origin of hypertrophic GFAP(+)/vimentin(+)/nestin(+) "reactive" astroglia and also the plasticities

275 Instead, the hypertrophic, vimentin(+)/nestin(+), reactive astroglia that accumulated in spinal

276 ur findings provide evidence suggesting that nestin regulation is negatively controlled epigeneticall

277 loss in neural progenitor cells in Tsc1(cc) Nestin-rtTA(+) TetOp-cre(+) embryos by doxycycline leads

278 The intermediate filament protein Nestin serves as a biomarker for stem cells and has been

279 /precursor cell markers, including vimentin, nestin, Sox2, Sox9, and GLAST, but not others such as CD

280 In the aorta, nestin(+) stromal cells increase approximately 30 times

281 m astrocytes are continuously generated from nestin(+) subventricular zone (SVZ) neural progenitor ce

282 panded stromal cells, including perivascular Nestin(+) supportive stromal cells, which may facilitate

283 es were examined using the progenitor marker nestin, the radial glial marker, brain lipid binding pro

284 However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood.

285 c-E4G10 radioimmunoconstruct in a transgenic Nestin-tumor virus A (Ntva) mouse model of high-grade gl

286 ng PDGF-B in the posterior fossa of neonatal nestin tv-a mice.

287 s were developed from RCAS-PDGF infection of nestin-tv-a brain progenitor cells in culture.

288 examined this hypothesis in the RCAS-PDGF-HA/nestin-TvA proneural glioma mouse model, in which p21 fa

289 lls were stained for the stem cells markers, nestin, vimentin, ABCG2, and Sca-1.

290 re stained positive for Cytokeratin 7, SOX2, Nestin, Vimentin, and CD44.

291 We also found that SPION-nestin was colocalized in alphaSM- actin- and nestin-exp

292 cells expressing the progenitor cell marker nestin was increased at 1 and 3 days following capsaicin

293 Nestin was upregulated by 3 DPI and declined between 7 a

294 mentin, glial fibrillary acidic protein, and nestin, we show that the distribution of cytoplasmic IFs

295 revealed that the tumor-promoting effects of Nestin were mediated by binding to Gli3, a zinc finger t

296 (fMRI), and neuronal precursor cells (BrdU+/Nestin+) were detected by immunofluorescence.

297 ial fibrillary acidic protein, vimentin, and nestin, which are essential for migration.

298 e cancer stem cell markers c-Myc, CD133, and nestin, which could contribute to the efficacy of the tr

299 ed the type VI intermediate filament protein nestin whose expression was upregulated during the repai

300 he cytoplasmic intermediate filament protein nestin with high affinity.