ライフサイエンスコーパス: neural cell

1 modating the protracted development of human neural cells.

2 l conditions and determine the fate of other neural cells.

3 in a significant diminution in the number of neural cells.

4 Trx1 are localized mainly in the nucleus of neural cells.

5 orate the surface of distinct populations of neural cells.

6 m mouse pluripotent cells and differentiated neural cells.

7 iferating NSCs can differentiate into mature neural cells.

8 -dense mitochondria in nGD cerebral cortical neural cells.

9 in the absence of the respective paralog in neural cells.

10 y benefit or harm surrounding neural and non-neural cells.

11 directs the growth of neurites in developing neural cells.

12 ne kinase physiologically expressed by fetal neural cells.

13 -) currents and taurine release in human non-neural cells.

14 body plan characterized by a small number of neural cells.

15 re detected in nGD brains and in CBE-treated neural cells.

16 regulated flow of energy equivalents between neural cells.

17 t combinations of Hdac1 and Hdac2 alleles in neural cells.

18 of the first genetic markers of postmitotic neural cells.

19 rfaces to form intertwined associations with neural cells.

20 2 that is synthesized by cyclooxygenase 2 in neural cells.

21 s essential for the survival and function of neural cells.

22 that carry reporter and therapeutic genes to neural cells.

23 ouse embryonic stem cells and differentiated neural cells.

24 2X receptor subtypes expressed on immune and neural cells.

25 cus on the deleterious effects of alcohol on neural cells.

26 tor (P2X7R) triggers sAPPalpha shedding from neural cells.

27 ut necessary for induction of adipocytes and neural cells.

28 3 and Glut6 are expressed in glial cells and neural cells.

29 thereby controls batteries of transcripts in neural cells.

30 -P formed in situ may have direct effects on neural cells.

31 actions on oligodendrocytes (OLGs) and other neural cells.

32 ost potent inducer of GOT gene expression in neural cells.

33 ndiscriminately killed both tumor and normal neural cells.

34 les of the responding resident and recruited neural cells.

35 ticular form of "forefront" signaling in non-neural cells.

36 tion-induced caspase-3 activity in different neural cells.

37 RNA from human pluripotent stem cell-derived neural cells.

38 than in NDEs from cultured rat type-specific neural cells.

39 neural cultures are ubiquitous for studying neural cells, 3D cultures can more accurately replicate

40 populations of progenitor, neuronal, and non-neural cells across our differentiation time course.

41 n a very restricted set of genes involved in neural cell adhesion and synapse function.

42 ted in Gust-BDNF mice, we used antibodies to neural cell adhesion molecule (NCAM) and ATP receptor P2

43 The neural cell adhesion molecule (NCAM) and the receptor ty

44 The function of neural cell adhesion molecule (NCAM) expression in motor

45 sed axon defasciculation, but did not affect Neural Cell Adhesion Molecule (NCAM) expression or Schwa

46 ysialic acid (PSA) is typically added to the neural cell adhesion molecule (NCAM) in the Golgi by PST

47 e TrkB, the prometastatic signaling molecule neural cell adhesion molecule (NCAM) is a downstream tar

48 The neural cell adhesion molecule (NCAM) is the major carrie

49 The neural cell adhesion molecule (NCAM) is the major substr

50 Neural cell adhesion molecule (NCAM) is the predominant

51 Polysialic acid on the neural cell adhesion molecule (NCAM) modulates cell-cell

52 The Neural cell adhesion molecule (NCAM) plays an important

53 ysialic acid is a glycan modification of the neural cell adhesion molecule (NCAM) produced by the pol

54 polybasic region (PBR) that are required for neural cell adhesion molecule (NCAM) recognition and sub

55 egulation of polysialiac acid carried by the neural cell adhesion molecule (NCAM) regulates the timin

56 As a modification of the neural cell adhesion molecule (NCAM), polySia is produce

57 Antibodies to these targets, including CD56/neural cell adhesion molecule (NCAM), promoted phagocyto

58 l modification is predominantly found on the neural cell adhesion molecule (NCAM), where it is synthe

59 etween dynein and the 180-kDa isoform of the neural cell adhesion molecule (NCAM).

60 tively charged glycan mainly attached to the neural cell adhesion molecule (NCAM).

61 to be the Aplysia homolog of the vertebrate neural cell adhesion molecule (NCAM); however, whether a

62 (ZO-1 and VE-cadherin) and PVM/M stabilizing neural cell adhesion molecule (NCAM-120).

63 that the neural cell adhesion molecule CD56 [neural cell adhesion molecule (NCAM1)] is specifically o

64 uded known schizophrenia risk genes, such as neural cell adhesion molecule (NRCAM) and calcium channe

65 The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) functions broad

66 s that express high levels of polysialylated neural cell adhesion molecule (PSA-NCAM) in adult spinal

67 The polysialylated form of neural cell adhesion molecule (PSA-NCAM) is expressed by

68 Co-immunoprecipitation of PSA-carrying neural cell adhesion molecule (PSA-NCAM) with MARCKS and

69 f the neuroplasticity-related polysialylated neural cell adhesion molecule (PSA-NCAM).

70 was dependent on Schwann cell expression of neural cell adhesion molecule 1 (NCAM1) and ultimately p

71 We also found that miR-200c and neural cell adhesion molecule 1 (NCAM1) expression were

72 Changes in expression of the neural cell adhesion molecule 2 (NCAM2) have been propos

73 (epithelial cell adhesion molecule [EpCAM], neural cell adhesion molecule [NCAM], epithelial growth

74 We have previously shown that the neural cell adhesion molecule CD56 [neural cell adhesion

75 n a recently identified BACE1 substrate, the neural cell adhesion molecule close homolog of L1 (CHL1)

76 ns potentially relevant to skin homeostasis: neural cell adhesion molecule L1 and dipeptidyl peptidas

77 Two proteins, the neural cell adhesion molecule L1 and dipeptidyl peptidas

78 cid (PSA) and its major protein carrier, the neural cell adhesion molecule NCAM, play important roles

79 NrCAM is a neural cell adhesion molecule of the L1 family that has

80 These results together with those related to neural cell adhesion molecule polysialylation establish

81 ndent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin an

82 molecule Fasciclin 2, the Drosophila N-CAM (neural cell adhesion molecule) homologue.

83 s, it is also a component of normal tissues (neural cell adhesion molecule).

84 ression was up-regulated in cells expressing neural cell adhesion molecule, a marker of muscle regene

85 gin is often coexpressed with polysialylated-neural cell adhesion molecule, beta-III-tubulin, and cal

86 thought to mediate rabies virus endocytosis (neural cell adhesion molecule, nicotinic acetylcholine r

87 t to the dermal lamina dynamically expresses neural cell adhesion molecule, tenascin-C, and other mol

88 Interestingly, besides the neural cell adhesion molecule, the polysialyltransferase

89 iclin II (FasII), the Drosophila ortholog of neural cell adhesion molecule.

90 inhibiting cell adhesion mediated by the L1 neural cell adhesion molecule.

91 e modulation of polysialic acid (polySia) on neural cell adhesion molecules (NCAM).

92 Prominent family members are the neural cell adhesion molecules NCAM and L1, which were t

93 omodulators to the learning rate and linking neural cell adhesion molecules to memory maintenance.

94 ily of glycosylphosphatidylinositol-anchored neural cell adhesion molecules were identified and valid

95 The transmembrane neural cell adhesion receptor L1 is a Wnt/beta-catenin t

96 enes are involved in synapse function and/or neural cell adhesion, with a substantial fraction also i

97 SC multipotency was examined by induction of neural cells, adipocytes, keratocytes, or TM cells.

98 controlling apoptosis in immature noncycling neural cells after DNA damage.

99 They also protect neural cells against mitochondrial oxidative stress, sho

100 potent than natural flavonoids at protecting neural cells against oxidative stress and is capable of

101 ifferent in-register repeat mutants in human neural cells, all multimer-abolishing but no multimer-ne

102 lecular component of anandamide transport in neural cells and a potential target for therapeutic drug

103 om proliferating cells versus differentiated neural cells and applied to Illumina Human HT-12 v4 Expr

104 RF, was evaluated here for its expression in neural cells and brain.

105 induced pluripotent stem cell (iPSC)-derived neural cells and have applied the method to measure amyl

106 family genes are expressed abundantly in the neural cells and have been suggested to play important r

107 verexpression of Srxn1 protects dopaminergic neural cells and human-induced pluripotent stem cell (hi

108 tabolism of glutamate was studied in primary neural cells and in stroke-affected C57-BL6 mice using m

109 omerase activity, and can differentiate into neural cells and mesenchymal stem cell-like cells that s

110 ion program regulated by FoxP1 in both human neural cells and patient-relevant heterozygous Foxp1 mou

111 anges at the injury site, including death of neural cells and release of damage-associated molecular

112 ormal asymmetric cell division by developing neural cells and results in a massively enlarged brain c

113 Communication between neural cells and the vasculature is integral to the prop

114 similarities that may exist between in vitro neural cells and their tissue-derived counterparts remai

115 ted their bidirectional chemoattraction with neural cells, and more specifically, impaired unidirecti

116 a molecular complex with Npn-2 in brain and neural cells, and was required for Sema3F-induced growth

117 of alternative splicing of bcl-x may mediate neural cell apoptosis.

118 Although it is well established that neural cells are ectodermal derivatives in bilaterian an

119 h cells, immune cells, endothelial cells and neural cells are important regulatory components that se

120 on the immune system, T-cells, and specific neural cells are involved simultaneously.

121 However, our data also demonstrate that neural cells are much more tolerant of aneuploidy than e

122 ional changes downstream of EPO signaling in neural cells are not well understood.

123 of the intestine, including mesenchymal and neural cells, are discussed.

124 llowed reimplantation of cultured autologous neural cells as a result of unknown trophic factors rele

125 ents within an experience are represented by neural cell assemblies firing at higher frequencies (gam

126 acid (PSA) which modulates NCAM functions of neural cells at the cell surface.

127 al mouse mutants, we show that Ccm3 has both neural cell autonomous and nonautonomous functions.

128 dysfunction, indicating that SCYL1 acts in a neural cell-autonomous manner to prevent LMN degeneratio

129 ition is a consequence of Cdk5 disruption in neural cells because remyelination in slice cultures is

130 ), physiologically expressed only by certain neural cells, becomes highly oncogenic, when aberrantly

131 fferentiation and its elevated expression in neural cells blocks neuronal differentiation.

132 Pelvic ganglia neural cell bodies contained heparanase 1, heparanase 2,

133 so that the virus is impaired for infecting neural cells, but not epithelial cells, in vitro and is

134 now are examined in 2 distinct sets of human neural cells by quantification in astrocyte-derived exos

135 Neural cells can be derived either from pluripotent or a

136 ure nervous system, but its contributions to neural cell circuitry are largely uncharted.

137 eages and functions, including CNS intrinsic neural cells, CNS intrinsic nonneural cells, and CNS ext

138 mmunogenicity, led us to discover subsets of neural cells co-expressing the neural marker SOX2 and MH

139 ances, as influenced by the OPA1 protein, in neural cell connectivity in the mammalian retina.

140 to the brain, and reduced TH availability to neural cells could instead underlie the diseased phenoty

141 lating Alzheimer's disease pathology in a 3D neural cell culture model should also serve to facilitat

142 -beta and tau pathology in a single 3D human neural cell culture system.

143 induced pluripotent stem cell (iPSC)-derived neural cell cultures (i.e. patient-specific neurons and

144 red temporal series of iPSC-derived in vitro neural cell cultures to endogenous brain tissue from the

145 for the generation and analysis of 3D human neural cell cultures, including the production of geneti

146 d by these mutations, and inevitably causing neural cell damage.

147 iary epithelial damage and regeneration, and neural cell damage.

148 Intraventricular hemorrhage (IVH) results in neural cell death and white matter injury in premature i

149 mide) reciprocally altered Bcl-x splicing in neural cells, decreasing Bcl-x(L) while increasing Bcl-x

150 in both human breast cancer and dopaminergic neural cells, demonstrating their potential for use in t

151 The latter work utilized neural cells derived from embryonic stem and embryonal c

152 blasts, aortic artery endothelial cells, and neural cells derived from human embryonic stem cells.

153 Furthermore, patient neural cells derived from induced pluripotent stem cells

154 critical in MSC-stimulated recovery in EAE, neural cell development and remyelination.

155 important mechanisms by which HCMV disturbs neural cell development in vitro.

156 rkA is known to induce neurite outgrowth and neural cell differentiation.

157 e transcription and splicing dynamics during neural cell differentiation.

158 e immune signaling has also been observed in neural cells during development and disease, including i

159 culture for 7 weeks to create an autologous neural cell "ecosystem" and reimplanted bilaterally into

160 lso detected in primary cultures of cortical neural cells, especially astrocytes.

161 es.Following spinal injury in zebrafish, non-neural cells establish an extracellular matrix to promot

162 Immature neural cells established circuits that propagated electr

163 CSB-deficient neural cells exhibited increased sensitivity to DNA cros

164 In neural cells, exosome formation can be blocked by inhibi

165 Enteric neural cells expressing the light-sensitive ion channel,

166 Neural cell fate acquisition is mediated by transcriptio

167 n nascent neuroectoderm directly links early neural cell fate acquisition with regulatory control of

168 Geminin's activity contributes to mammalian neural cell fate acquisition.

169 of Tet1/2/3, displayed impaired adoption of neural cell fate and concomitantly skewed toward cardiac

170 Overall, our data suggest that neural cell fate and neuronal maintenance may be perturb

171 at are conserved across metazoans, including neural cell fate determination and migration, axon guida

172 results establish that PBX1 regulates adult neural cell fate determination in a manner beyond that o

173 1 levels will have important implications in neural cell fate development and disease.

174 derived pharyngeal muscles, specification of neural cell fate in the HSN/PHB lineage, and adaptation

175 gnaling thus acts as a rheostat to influence neural cell fate selection in both normal cortical devel

176 r example, the midline cells are involved in neural cell fate specification along the dorso-ventral a

177 Neural cell fate specification is well understood in the

178 fied enrichment of binding sites for several neural cell fate-specifying transcription factors includ

179 g (SHH) and consequently altering SHH-guided neural cell-fate decisions.

180 in histone modifications over the course of neural cell-fate specification.

181 We know that ventral neural cell fates are defined by a specific cohort of tr

182 Our screen revealed molecules that influence neural cell fates, support the formation of a major conn

183 ecapitulated by differentiation of iPSC into neural cells followed by expression profiling and dissec

184 ipotent stem cells to obtain patient-derived neural cells for in vitro studies and as a source of cel

185 inorelbine had been confirmed in assays with neural cells from the central and peripheral nervous sys

186 require immune responses that interfere with neural cell function and communication without affecting

187 rain development and the regulation of adult neural cell functions.

188 mpatibility complex (MHC)-matched allogeneic neural cell grafting in the brain, which is considered a

189 emonstrate the rationale for MHC-matching in neural cell grafting to the brain and its feasibility in

190 eported in some patients following embryonic neural cell grafts.

191 s can, in turn, induce remarkable changes in neural cell identity and cognitive and behavioral phenot

192 propagating wave of strong depolarization of neural cells, implicated in several neuropathological co

193 on of dopaminergic cells from other types of neural cells in a completely nondestructive manner.

194 of human pluripotent stem cell (PSC)-derived neural cells in animal models of neurological disease.

195 l help realize the potential of hPSC-derived neural cells in disease modeling and cell therapy.

196 By adapting optogenetics for use in non-neural cells in embryos, we show that developmentally pa

197 ities regarding molecular characteristics of neural cells in the affected peripheral nerves.

198 subtype-specific neuronal fate of endogenous neural cells in the cerebral cortex as a function of ini

199 MOB, an adeno-associated virus that infects neural cells in the ovine brain was injected into the su

200 Our findings implicate neural cells in the pathogenesis of CCMs, showing the im

201 en the close relationship between HDAC11 and neural cells in vitro, we examined neural tissue in a pr

202 stribution of both L1CAM and TrkA in various neural cells including neurons, their transcellular bind

203 using an interaction proteomics approach in neural cells including neurons, we uncover the brain-enr

204 mosaicism in early embryonic development and neural cells, including post-mitotic neurons.

205 nt, and individual RAN proteins are toxic to neural cells independent of RNA effects.

206 port across the blood brain barrier and into neural cells is critical for normal cerebral physiologic

207 ns, as preventing dystroglycan expression in neural cells led to a similar set of BBB abnormalities a

208 mutated PrP(C) proteins were expressed in a neural cell line derived from a PrP(C)-null mouse.

209 city to phosphorylate intracellular Erk in a neural cell line.

210 lity tests were conducted using homogeneous, neural cell lines and heterogeneous, rat brain cells, re

211 We next generated stable neural cell lines expressing human wild-type or Swedish

212 odo-L-thyronine (T3)-responsive genes of two neural cell lines, expressing either TRalpha1 or TRbeta1

213 Using a combination of neural cell lines, skin fibroblasts from AD patients, an

214 ell media routinely used for endothelial and neural cell lines.

215 permissive for HCMV infection, which causes neural cell loss and premature differentiation, thereby

216 There was no significant difference in neural cell mass between the two groups as shown with Ne

217 Rho-associated kinase (ROCK) regulates neural cell migration, proliferation and survival, dendr

218 litate the development of more precise human neural cell models of other neurodegenerative disorders.

219 taneous Ca(2+) dynamics in cardiomyocyte and neural cell models.

220 aration of developmental pathways specifying neural cell morphology and ion channel expression.

221 defects in axonal targeting and reduction in neural cell numbers.

222 dant extrachromosomal DNA in TREX1-deficient neural cells, of which endogenous Long Interspersed Elem

223 AChRs with alpha-BTX reversed the action of neural cells on GDNF secretion by skeletal muscle.

224 ne bound IL-6 receptor alpha (IL-6Ralpha) on neural cells, on peripheral nerves, on fine sensory affe

225 tional networks to regulate the diversity of neural cells originating from the SVZ.

226 ional progression of in vitro-differentiated neural cells (over a timecourse of 0, 35, 70, 105 and 14

227 We show that IL-6Ralpha on neural cells, peripheral nerves, and fine sensory affere

228 lowed independent activation of two distinct neural cell populations at 560 and 405 nm.

229 nding/translocation domain was retargeted to neural cell populations by deleting its non-specific bin

230 thologies require the production of distinct neural cell populations from endogenous progenitor cells

231 change in progressively more differentiated neural cell populations in vivo.

232 The neural cells produced by NMPs have spinal cord but not a

233 ein called Trithorax increases the number of neural cells produced from a single stem cell, in part b

234 fine an important role for Cic in regulating neural cell proliferation and lineage specification, and

235 functional and histochemical measurements of neural cell proliferation and synaptogenesis in the ICH

236 ls outside the brain induces upregulation of neural cell proliferation at long range.

237 neurons generated from transplanted enteric neural cells provide a functional innervation of bowel s

238 , how the growth cone differs from other non-neural cells remains unclear.

239 the physiological function of Reg-1alpha in neural cells remains unknown.

240 toring clec-41 expression in adr-2 deficient neural cells rescued the chemotaxis defect, providing th

241 tor cells are subsequently differentiated in neural cells, resulting in a 3D neuronal construct with

242 Analysis of potential Sna1 targets in neural cells revealed a novel Sna1 target, N-Myc, a tran

243 mpared the chromosomal stability of over 500 neural cell samples from human and mouse with virtual ka

244 ulin-like domains 2, a protein implicated in neural cell signaling and tumorigenesis.

245 hy mutations in its transporters result in a neural cell-specific disorder remains unclear.

246 iscuss the challenges of generating specific neural cell subtypes from pluripotent stem cells, the us

247 tly drive the expression in nonneural and in neural cells, such that the emission and perception of s

248 uivalence of distinguishable aneuploidies on neural cell survival, providing evidence that somaticall

249 nome, is highly expressed on the specialized neural cells that are uniquely found in adult sex segmen

250 has encountered unusual selective forces in neural cells that have driven them to acquire unique pos

251 , even when expressed far from the muscle or neural cells that mispattern.

252 n this review, we focus on the impact of non-neural cells that participate in the neurogenic niche, h

253 e BBB properties when co-differentiated with neural cells that provide relevant cues, including those

254 m cells (iPSCs), we generated MCT8-deficient neural cells that showed normal TH-dependent neuronal pr

255 In cultured wild-type brain cortical neural cells, the GCase-irreversible inhibitor, condurit

256 ay be possible to convert in vivo endogenous neural cells to a neuronal fate directly, providing an a

257 (APP) can be cleaved by alpha-secretases in neural cells to produce the soluble APP ectodomain (sAPP

258 raveled a remarkable propensity of primitive neural cells to self-organize into primitive patterns su

259 Enteric neural cells transplanted into the bowel give rise to mu

260 These VP1 mutations may alter neural cell tropism or enable escape from neutralizing a

261 se differential miRNA expression to regulate neural cell-type-specific phenotypes, and provides an im

262 Proper developmental, neural cell-type-specific, and activity-dependent regula

263 cells has enabled the production of several neural cell types affected by disease.

264 on constrains the generation of most retinal neural cell types and promotes a Muller glial cell fate

265 expanding protocols for generating different neural cell types and three-dimensional tissues, but the

266 It is unclear which neural cell types are involved in the mechanism of DBS,

267 Several Hh-dependent ventral neural cell types are not specified in the mutant neural

268 s AAV2/9 targets gene expression to specific neural cell types dependent on developmental stage.

269 ystem and target gene expression to specific neural cell types following intravenous injection into f

270 t coordinated interactions between the three neural cell types in branchiomeric nerves differ accordi

271 , large-scale production of disease-relevant neural cell types in formats compatible with high-throug

272 we present tables listing the various human neural cell types that can be generated and the neurolog

273 ual and practical guide to classification of neural cell types using single-cell gene expression prof

274 ChIP-seq to associate specific lncRNAs with neural cell types, developmental processes, and human di

275 is of experimental NMR data on five purified neural cell types, we demonstrate the utility of our met

276 rrect spatiotemporal generation of different neural cell types.

277 is comprised of a vast diversity of distinct neural cell types.

278 erning, specification and differentiation of neural cell types.

279 whether INPs simply expand or also diversify neural cell types.

280 e of critical interactions with glia and non-neural cell types.

281 questions requiring the analysis of defined neural cell types.

282 rain is composed of thousands of interacting neural cell types.

283 eliant on Sox2/Pax6 cooperativity in several neural cell types.

284 ical function and utility for distinguishing neural cell types.

285 Here we show that mouse neural cells undergo mediolaterally biased cell intercal

286 However, in differentiating neural cells we observed decreased expression of schizop

287 Primary rat neural cells were exposed to oxytocin before induction o

288 ith the age of the donors from which enteric neural cells were obtained.

289 aRNA-driven activation (RNAa) was limited to neural cells which normally express Foxg1 and did not hi

290 ulating an IFN-gamma-dependent dialogue with neural cells, which maintains the effector function of t

291 nd survival mediated by Ln gamma1 peptide in neural cells, which may contribute to the pathogenesis o

292 tial to differentiate to unlimited number of neural cells, which provide powerful tools for neural re

293 t, BMP blockade produces partially polarized neural cells, which retain contact with the apical and b

294 the detection of other analytes secreted by neural cells, which would have the potential to open new

295 known to be phosphorylated by Cdk5 in chick neural cells while Grin1 has not been reported to be pho

296 SR100 to potently activate exon inclusion in neural cells while weakening 3' splice site recognition

297 Treatment of HCMV-infected neural cells with trehalose also inhibited production of

298 ombinant human IgMs that bind to epitopes on neural cells, with the aim of treating neurological dise

299 ce for amplification of Fgf10-lineage traced neural cells within the hypothalamic parenchyma itself.

300 specific ablation of immune, epithelial, or neural cells without off-target effects.