ライフサイエンスコーパス: neural crest cell

1 he progression from progenitor to definitive neural crest cell.

2 s does not guarantee eventual migration as a neural crest cell.

3 ubsequently directed its novel expression in neural crest cells.

4 al tube border cells with the cooperation of neural crest cells.

5 nglia--arise from glial cells in nerves, not neural crest cells.

6 nctional association of Aebp2 with migratory neural crest cells.

7 in combination with BMP signaling to induce neural crest cells.

8 (GN) is a rare benign tumor arising from the neural crest cells.

9 sal neural tube cells to generate emigrating neural crest cells.

10 is not due to a direct function of Prdm1 in neural crest cells.

11 s are abundant in the cytoplasm of migratory neural crest cells.

12 umptive cornea despite dynamic ingression of neural crest cells.

13 anchial arches that are populated by cranial neural crest cells.

14 onent and are believed to differentiate from neural crest cells.

15 ally expressed in premigratory and migratory neural crest cells.

16 eved to originate from either mesenchymal or neural crest cells.

17 the growth, survival and differentiation of neural crest cells.

18 rates EMT and chemotaxis during migration of neural crest cells.

19 epressing core apoptotic pathways in cranial neural crest cells.

20 pithelial to mesenchymal transition (EMT) of neural crest cells.

21 cification, migration and differentiation of neural crest cells.

22 ctor expressed in premigratory and migrating neural crest cells.

23 afish embryo, chromatophores derive from the neural crest cells.

24 s required to produce a sufficient number of neural crest cells.

25 d cellular dynamics that affects the NNE and neural crest cells.

26 ted with aberrant differentiation of cranial neural crest cells.

27 ically in endothelial, but not myocardial or neural crest, cells.

28 ermines this differential behavior, we study neural crest cells, a migratory stem cell population who

29 e to pulp cells and odontoblasts derive from neural crest cells after their migration in the early he

30 nts Eed, Ezh2 and Suz12 are expressed in the neural crest cells and are required for neural crest mar

31 Chd7 morphants have impaired migration of neural crest cells and deregulation of sox10 expression

32 essing markers of human sensory neurons from neural crest cells and established a critical role for t

33 findings demonstrate that Wnt1, a marker of neural crest cells and hitherto unknown angiogenic funct

34 am leads and engulfs the later emerging HMP, neural crest cells and hypoglossal nerve.

35 onstrated the migratory pathways followed by neural crest cells and increased knowledge about their d

36 ar3 is localised to the cell-cell contact in neural crest cells and is essential for CIL.

37 reck is expressed in neural crest cells and is required in a cell-autonomous

38 n by both premigratory and migratory cranial neural crest cells and its ability to down-regulate inte

39 e craniofacial skeleton is derived from both neural crest cells and mesodermal cells; however, the ma

40 at in the zebrafish embryo migration of both neural crest cells and motor axons is temporally synchro

41 acterized by reciprocal interactions between neural crest cells and neighboring cell populations of e

42 sightful view of the regulatory landscape of neural crest cells and offer a new perspective on develo

43 expression states of the early E8.5 pioneer neural crest cells and paraxial mesoderm.

44 productively infects stem-cell-derived human neural crest cells and peripheral neurons in vitro, lead

45 arapacial pigmentation as both the migratory neural crest cells and pigment localized only to PNA-fre

46 nose of the zebrafish are derived from both neural crest cells and placode cells.

47 Neural crest cells and repulsive slit1/robo2 signals the

48 CAX is expressed in neural crest cells and required for their migration in v

49 he neural plate border cell fates, including neural crest cells and Rohon-Beard (RB) sensory neurons.

50 as Hertwig's epithelial root sheath, cranial neural crest cells and stem cells residing in developing

51 the ability of neural tube cells to produce neural crest cells and the timing of peripheral neuron d

52 receptor migrated slower than normal cardiac neural crest cells and were prone to remain in the vicin

53 that is enriched for markers of multipotent neural crest cells, and neural crest progenitors from th

54 Neural crest cells are a population of multipotent stem

55 Neural crest cells are a transient stem cell-like popula

56 Neural crest cells are among the most motile cells in th

57 Neural crest cells are an embryonic cell population that

58 Neural crest cells are both highly migratory and signifi

59 Neural crest cells are coattracted via the complement fr

60 Here, we show that neural crest cells are collectively attracted toward the

61 Neural crest cells are crucial for this process: in thei

62 hindbrain of the developing quail, in which neural crest cells are directed in streams to the branch

63 ey initiate migration in vertebrate embryos, neural crest cells are enriched for methylation cycle en

64 However, trunk neural crest cells are generally regarded as nonskeletog

65 Neural crest cells are induced at the neural plate borde

66 During embryonic development, multipotent neural crest cells are specified at the lateral borders

67 Neural crest cells arise from the border of the neural p

68 Neural crest cells arise from the edges of the nascent c

69 During the hypoxic stage, a large number of neural crest cells arise from the head neural tube by ep

70 ed in the posterior hindbrain, where cardiac neural crest cells arise, which pattern the outflow trac

71 atenin regulates the appropriate movement of neural crest cells away from the neural tube into the em

72 At E8.5, as migrating neural crest cells begin to exit the neural fold/epiderm

73 These defects were associated with aberrant neural crest cell behavior.

74 ion factors Snail2 and Sox10 in premigratory neural crest cells, but does not affect accumulation of

75 l crest cell EMT by controlling premigratory neural crest cell cadherin levels.

76 n to the trigeminal ganglia and also changes neural crest cell Cadherin-7 levels and localization.

77 idence that transgenic expression of Bmp4 in neural crest cells causes a series of craniofacial malfo

78 the BMP type IA receptor (BMPR1A) in cranial neural crest cells causes craniosynostosis during postna

79 gehog (Shh)-induced proliferation of cranial neural crest cell (cNCC) mesenchyme is required for uppe

80 Specifically, cranial neural crest cells (CNCC) lead the initiation of tongue

81 lucose levels, which is derived from cranial neural crest cells (CNCC).

82 The cardiac neural crest cells (cNCCs) and the second heart field (S

83 lves reciprocal interactions between cranial neural crest cells (CNCCs) and the surrounding pharyngea

84 Cranial neural crest cells (CNCCs) delaminate from embryonic neu

85 Cell tracing studies have shown that cranial neural crest cells (CNCCs) emerge from the dorsal neural

86 ant stem cell populations, including cranial neural crest cells (CNCCs), have not been assessed.

87 iofacial tissues that originate from cranial neural crest cells (CNCCs).

88 Both vagal and sacral neural crest cells contribute to the enteric nervous sys

89 rigin along the body axis, with only cranial neural crest cells contributing to facial skeleton.

90 Cranial neural crest cells (crNCCs) migrate from the neural tube

91 Local increase in neural crest cell death and impaired neural crest adhesi

92 During vertebrate development, trunk neural crest cells delaminate along the entire length of

93 Trunk neural crest cells delaminate from the dorsal neural tub

94 Neural crest cells deleted for beta1 integrin were able

95 ammals and that it has specific functions in neural crest cell derivatives.

96 Dental follicle cells (DFCs) are neural crest cell-derived cells and the genuine precurso

97 ive tissue of the tongue arises from cranial neural crest cell-derived ectomesenchyme within the mand

98 se embryonic development, a subpopulation of neural crest cell-derived melanocytes migrates and incor

99 These findings demonstrate that trunk neural crest cell development in C. punctatum follows th

100 e lost in evolution, potentially by altering neural crest cell development, and that changes in the l

101 Among the genes that are involved in neural crest cell development, some genes are more sensi

102 rders are typically attributed to defects in neural crest cell development.

103 severe cranial facial defects, arising from neural crest cell differentiation and migration problems

104 lysis revealed that hcfc1b regulates cranial neural crest cell differentiation and proliferation with

105 e tracing, we further demonstrate that trunk neural crest cells do, in fact, give rise to odontoblast

106 in a discrete apical region of premigratory neural crest cells during EMT, and Rho-ROCK signaling is

107 for proper migration and differentiation of neural crest cells during neuritogenesis.

108 tein in facilitating the proper migration of neural crest cells during the development of the vertebr

109 blasts develop from multipotent craniofacial neural crest cells during tooth and jawbone development,

110 il2 plays a critical role in mediating chick neural crest cell EMT and migration due to its expressio

111 ion alpha-catenin protein, regulates cranial neural crest cell EMT by controlling premigratory neural

112 enin down-regulation is critical for initial neural crest cell EMT, a potential role for alphaN-caten

113 ivo, we demonstrate Cad6B proteolysis during neural crest cell EMT, which generates a Cad6B N-termina

114 , along with gamma-secretase, during cranial neural crest cell EMT.

115 ure network directs the migration of enteric neural crest cells (ENCC) along the gut to promote the f

116 e (HSCR) is caused by a reduction of enteric neural crest cells (ENCCs) in the gut and gastrointestin

117 rung disease is caused by failure of enteric neural crest cells (ENCCs) to fully colonize the bowel,

118 omplete colonization of the bowel by enteric neural crest cells (eNCCs), the ENS precursors.

119 tion, directed migration of cells, including neural crest cells, endothelial cells, axonal growth con

120 During development, vagal neural crest cells enter the foregut and migrate in a ro

121 expression of these two SoxE genes in trunk neural crest cells, especially Sox9, matched the Sox10 m

122 Using murine genetics, we show that neural crest cells exhibit a requirement for the class I

123 A previous study suggests that rudimentary neural crest cells existed in ancestral chordates.

124 Our analysis shows that, before neural crest cell exit from the hindbrain, DAN is expres

125 However, all neural crest cells express Sox10 and the mechanisms dire

126 iosensor we show that in the absence of MuSK neural crest cells fail to retract non-productive leadin

127 ll imaging we show that in lh3 null mutants, neural crest cells fail to transition from a sheet to a

128 Interestingly, neural crest cells failed to populate the heart and inst

129 molecular switch, repressing neural to favor neural crest cell fate.

130 ector of the regulatory networks that define neural-crest cell-fate specification and subsequent meso

131 During development, vagal neural crest cells fated to contribute to the enteric ne

132 gs expand the repertoire of vertebrate trunk neural crest cell fates during normal development, highl

133 Sox8 and Sox9 probes demonstrated that trunk neural crest cells follow a pattern similar to the migra

134 Neural crest cells form diverse derivatives that vary ac

135 Cranial neural crest cells form much of the facial skeleton, and

136 Neural crest cells form within the neural tube and then

137 difications regulate the transition of trunk neural crest cells from a non-segmental sheet like migra

138 Neural crest cells generate a range of cells and tissues

139 Neural crest cells generate much of the craniofacial ske

140 Neural crest cells give rise to a diverse array of deriv

141 In the head, cranial neural crest cells give rise to the dentine-producing ce

142 ansformation than it does to modulate normal neural crest cell growth.

143 Because collagenous cellular cartilage and neural crest cells have not been described in invertebra

144 In neural crest cells, HDAC1/2 induced expression of the tr

145 enomic regions that are active in both human neural crest cells (hNCC) and mouse embryonic craniofaci

146 c, lysine-methylated proteins from migratory neural crest cells identified 182 proteins, several of w

147 Moreover, alphaN-catenin perturbation in neural crest cells impacts the placode cell contribution

148 s, a role that was largely subsumed by vagal neural crest cells in early gnathostomes.

149 nt the specification and emigration of trunk neural crest cells in embryos of a cartilaginous fish, t

150 in branchial arch ectoderm and a failure of neural crest cells in the arches to express FGF-responsi

151 he oxygen supply helps to stop emigration of neural crest cells in the head.

152 ebrafish, our experiments suggest that trunk neural crest cells in the last common ancestor of tetrap

153 cy, cell number, and the mitotic activity of neural crest cells in the vicinity of the gut but has no

154 ional, the embryonic head no longer produces neural crest cells in vivo, despite the capability to do

155 vely active form of BmprIb (caBmprIb) in the neural crest cells in which BmprIa was simultaneously in

156 control multiple steps in the development of neural crest cells, including the acquisition of stem ce

157 SAHH is required for emigration of polarized neural crest cells, indicating that methylation is essen

158 s express Sox10 and the mechanisms directing neural crest cells into a specific lineage are poorly un

159 human pluripotent stem cell-derived enteric neural crest cells into developing human intestinal orga

160 t genes, HDAC1/2 direct the specification of neural crest cells into peripheral glia.

161 C1/2) are essential for the specification of neural crest cells into Schwann cell precursors and sate

162 Transplantation of wild-type neural crest cells into smo mutants rescues this defect,

163 of the ENS is controlled by the interplay of neural crest cell-intrinsic factors and instructive cues

164 s one component of EMT and, in chick cranial neural crest cells, involves cadherin-6B (Cad6B) down-re

165 ppearance of cellular cartilage derived from neural crest cells is considered a turning point in vert

166 Migration of neurons and neural crest cells is of central importance to the devel

167 ens junction disassembly within premigratory neural crest cells is one component of EMT and, in chick

168 loss of TGFbeta receptor type II in cranial neural crest cells leads to craniofacial malformations,

169 in vivo genetic deletion of HDAC1/2 in mouse neural crest cells led to strongly decreased Sox10 expre

170 NA methylation plays a role in neural versus neural crest cell lineage decisions.

171 In melanoma, which derives from the neural crest cell lineage, enhanced TWIST1 expression ha

172 l for survival and proper differentiation of neural crest cell lineages, where it plays an important

173 Among these populations, neural crest cells make important contributions to OFT f

174 We propose that these trunk-derived neural crest cells may be homologous to Schwann cell pre

175 We suggest that neural crest cells may have evolved as a consequence of

176 Neural crest cells migrate extensively and contribute to

177 Neural crest cells migrate extensively and give rise to

178 b-iCre transgene to delete Foxd3 after vagal neural crest cells migrate into the midgut, we demonstra

179 Cardiac neural crest cells migrate into the pharyngeal arches wh

180 Neural crest cells migrate throughout the embryo, but ho

181 Cardiac neural crest cells migrated more in response to FGF8.

182 Neural crest cells migrated to an FGF8-soaked bead place

183 l-to-chick neural crest chimeras showed that neural crest cells migrated to and around the ectopic si

184 h muscle during midgestation, despite intact neural crest cell migration and preserved development of

185 tion of newborn GnRH3 neurons by influencing neural crest cell migration and/or differentiation.

186 ingle-cell transcriptome analysis of cranial neural crest cell migration at three progressive stages

187 loss of function of DAN results in enhanced neural crest cell migration by increasing speed and dire

188 ith the notion that Lh3 exerts its effect on neural crest cell migration by regulating post-translati

189 Consistently, Lpd regulates mesenchymal neural crest cell migration cell autonomously in Xenopus

190 Lh3 substrate Collagen18A1 recapitulates the neural crest cell migration defects observed in lh3 muta

191 show that MuSK knockout mice display similar neural crest cell migration defects, suggesting a novel,

192 ring palate morphogenesis, defective cranial neural crest cell migration in capzb(-/-) mutants result

193 However, the signals that regulate neural crest cell migration remain unclear.

194 ve ligand Wnt11r are crucial for restricting neural crest cell migration to the center of each somite

195 a potential role for alphaN-catenin in later neural crest cell migration, and formation of the crania

196 ent aspects of neural development, including neural crest cell migration, axon guidance and cerebella

197 a mutants have cleft palate due to defective neural crest cell migration, whereas pdgfra heterozygote

198 sheet to stream migration restores segmental neural crest cell migration.

199 show that CL-K1 serves as a guidance cue for neural crest cell migration.

200 L1/K1 hetero-oligomer, which impacts cardiac neural crest cell migration.

201 c muscle cells also results in non-segmental neural crest cell migration.

202 promoter of CXCR4, a gene involved in embryo neural crest cell migration.

203 these two cell types might be important for neural crest cell migration.

204 at motor axons are dispensable for segmental neural crest cell migration.

205 eoglycans that are known to be inhibitory to neural crest cell migration.

206 form of tumor plasticity with reversion to a neural crest cell migratory phenotype.

207 he molecular diversity and dynamics within a neural crest cell migratory stream that underlie complex

208 he dynamic phases of precursor and migratory neural crest cell movements from the neural keel stage t

209 raniofacial abnormalities to deficiencies in neural crest cell (NCC) craniofacial precursors early in

210 e found to be enriched for genes involved in neural crest cell (NCC) development and vasculogenesis.

211 mouse models, to demonstrate that defective neural crest cell (NCC) development explains RCPS cranio

212 of growth factors, and its functions include neural crest cell (NCC) maintenance, specifically NCC mi

213 Accurate neural crest cell (NCC) migration requires tight control

214 hymal transition, acquisition of avian trunk neural crest cell (NCC) polarity is prerequisite for dir

215 ogenitors that give rise to neurons, and the neural crest cell (NCC) progenitors that give rise to gl

216 for the development of multiple endoderm and neural crest cell (NCC)-derived structures in the pharyn

217 Deleting Bmp4 from both neural crest cells (NCC) and early endoderm-derived epit

218 Neural crest cells (NCC) are a transient, embryonic cell

219 Neural crest cells (NCC) are multi-potent cells of ectod

220 Neural crest cells (NCC) are stem cells that generate di

221 on proper dorsal-ventral (D-V) patterning of neural crest cells (NCC) within the pharyngeal arches.

222 ll enteric neurons and glia are derived from neural crest cells (NCC).

223 The molecular mechanisms that sort migrating neural crest cells (NCCs) along a shared pathway into tw

224 S development by combining human-PSC-derived neural crest cells (NCCs) and developing human intestina

225 Here we show that neural crest cells (NCCs) and their derivatives provide

226 Neural crest cells (NCCs) are a subset of multipotent, m

227 Neural crest cells (NCCs) are highly patterned embryonic

228 Neural crest cells (NCCs) are physically responsible for

229 how that the in vivo collective migration of neural crest cells (NCCs) depends on such confinement.

230 migration and differentiation capacities of neural crest cells (NCCs) have fascinated scientists sin

231 Neural crest cells (NCCs) migrate over incredible distan

232 ng Hand1 phosphoregulation in the developing neural crest cells (NCCs) of mice.

233 ing sensory neuroblasts and emigrant cranial neural crest cells (NCCs) play a role in coordinating th

234 ort the oral cavity are derived from cranial neural crest cells (NCCs) that develop in the maxillary

235 iac outflow tract (OFT) requires multipotent neural crest cells (NCCs) that migrate from the neural t

236 endocardial cushions and repositions cardiac neural crest cells (NCCs) within the OFT, 2 processes th

237 that neuroepithelial cells (NECs), including neural crest cells (NCCs), can contribute directly to th

238 of vertebrate traits, including emergence of neural crest cells (NCCs), in which neofunctionalization

239 studying NBL based on the transformation of neural crest cells (NCCs), the progenitor cells of the S

240 Hoxa1 is expressed in precursors of cardiac neural crest cells (NCCs), which populate the heart.

241 Neural crest cells (NCCs), which undergo EMT during deve

242 system (ENS) and are derived from migratory neural crest cells (NCCs).

243 t in enteric neurons, which are derived from neural crest cells (NCCs).

244 To test this idea, we infected migrating neural crest cells of chicken embryos with replication-c

245 Although cranial neural crest cells of Foxi3 mutants are able to migrate,

246 Introducing components of this circuit into neural crest cells of the trunk alters their identity an

247 d in both premigratory and migrating cranial neural crest cells of Xenopus embryos.

248 ver cranial vessels, MCs derived from either neural crest cells or mesoderm emerged around the prefor

249 p53 expression, and that CHD7 loss in mouse neural crest cells or samples from patients with CHARGE

250 he migration of the lateral line primordium, neural crest cells, or head mesendoderm.

251 Cardiac neural crest cells participate in both remodeling of the

252 tion may also be involved in the survival of neural crest cell population during development.

253 experiments reveal effects on the migratory neural crest cell population that include subsequent def

254 for Leo1 in the development of the heart and neural crest cell populations.

255 depletion of either ADAM within premigratory neural crest cells prematurely reduces or maintains Cad6

256 strate Rdh10 is specifically required in non-neural crest cells prior to E10.5 for proper choanae for

257 Loss of Ift88 also resulted in a decrease in neural crest cell proliferation during early stages of p

258 F9-PITX2 signaling cascade regulates cranial neural crest cell proliferation during palate formation.

259 sence of Foxd3, and therefore the absence of neural crest cells, proliferation of insulin-expressing

260 Neural crest cells purified from embryos using the Sox10

261 As they enter the somites, neural crest cells rearrange into spatially restricted s

262 Chick premigratory cranial neural crest cells reduce Cadherin-6B (Cad6B) levels thr

263 Subsequently, clumps of adherent neural crest cells remained adjacent to the neural tube

264 ferentiation of both myogenic stem cells and neural crest cells requires capzb.

265 Overexpression of Shox2 in all neural crest cells resulted in a small increase in the n

266 gnificantly, ablation of Wnt1-Cre-expressing neural crest cells resulted in fully penetrant persisten

267 we show that loss of Tgfbr2 in mouse cranial neural crest cells results in elevated expression of TGF

268 Neural crest cell specification and differentiation to a

269 These neural crest cell streams join the segmental trajectorie

270 The development of cranial neural crest cell-streams relative to somite formation i

271 l tube closure, and the formation of cranial neural crest cell-streams were detected by light and sca

272 ll subset of somitic cells adjacent to where neural crest cells switch from sheet to stream migration

273 We show that in neural crest cells Tfap2 directly activates expression o

274 ous system (PNS), originate from multipotent neural crest cells that also give rise to other cells, i

275 o neurons, they are derived from pluripotent neural crest cells that differentiate into numerous cell

276 vel function for alphaN-catenin in migratory neural crest cells that form the trigeminal ganglia.

277 studies highlight developmental pathways in neural crest cells that have a direct bearing on melanom

278 e enteric nervous system (ENS) develops from neural crest cells that migrate along the intestine, dif

279 awed vertebrates arises primarily from vagal neural crest cells that migrate to the foregut and subse

280 ystem (ENS) is derived from vagal and sacral neural crest cells that migrate, proliferate, and differ

281 In another example, we follow and analyze neural crest cells that regained sox10 function after de

282 is initiated by migrating Delta1-expressing neural crest cells that trigger NOTCH signaling and myog

283 y, we show for the first time that migratory neural crest cells that will give rise to the cranial tr

284 ther with epidermally-derived placode cells, neural crest cells then form the cranial sensory ganglia

285 an forms a physical boundary that constrains neural crest cells to discrete streams, in turn facilita

286 e morpholino oligonucleotides causes cranial neural crest cells to migrate a significantly shorter di

287 profiling from human and chimpanzee cranial neural crest cells to systematically and quantitatively

288 ail-chick chimeras involving fate mapping of neural crest cells to the ultimobranchial glands that re

289 r-MuSK dependent, PCP-like pathway restricts neural crest cells to their segmental path.

290 1, to provide extrinsic signals critical for neural crest cells to transition from a sheet-like migra

291 EMT, plays a critical role in promoting the neural crest cell transition to a mesenchymal state.

292 zed to the dorsal neural folds, premigratory neural crest cells undergo an epithelial-to-mesenchymal

293 Premigratory neural crest cells undergo EMT, migrate away from the ne

294 ollision outcomes observed experimentally in neural crest cells, we must either carefully tune our pa

295 By comparing pre-migratory and migratory neural crest cells, we show that the switch from E- to N

296 l: the medial portion being derived from the neural crest cells, whereas the lateral portion from the

297 Conditional deletion of Shox2 in neural crest cells (which give rise to all DRG neurons)

298 Neural crest cells, which are specific to vertebrates, a

299 the margin of the neural plate give rise to neural crest cells, which migrate extensively throughout

300 tly expressed in the cytoplasm of condensing neural crest cells within the pharyngeal arches.