ライフサイエンスコーパス: neural fold

1 (Xcad-11) as they begin to emigrate from the neural fold.

2 lls to form one layer; and (4) fusion of the neural folds.

3 eural-crest cells migrating from the cranial neural folds.

4 -reaching, rapid separation of the elevating neural folds.

5 tial during neurulation for elevation of the neural folds.

6 (JmjD2A/KDM4A), is expressed in the forming neural folds.

7 h the ligand PDGFD expressed in the midbrain neural folds.

8 t of neurulation through wide spacing of the neural folds.

9 hesion within the embryonic neural plate and neural folds.

10 g of AJ proteins was increased in the mutant neural folds.

11 band of ectoderm contiguous to the midbrain neural folds.

12 y to reduce the distance between the nascent neural folds, allowing them to meet and fuse.

13 is derived from the nonneural ectoderm, the neural folds also contribute cells to the placode at lea

14 stage embryos, and blocking Smurf1 disturbs neural folding and neural, but not mesoderm differentiat

15 in regions of newly formed cranial and trunk neural folds and adjacent neural crest migratory pathway

16 rthermore, the mitotic index was elevated in neural folds and hindgut of treated embryos, consistent

17 rest cells (CNCCs) delaminate from embryonic neural folds and migrate to pharyngeal arches, which giv

18 r Pax7 by stage 4 + and later contributes to neural folds and migrating neural crest.

19 ls in the neural ectoderm shape and form the neural folds and neural tube.

20 or Id2 is expressed in cranial but not trunk neural folds and subsequently in some migrating cranial

21 ain proper cell-cell interactions within the neural folds and suggest that NFPC and TAF1 participate

22 istinct SRF expression was seen later in the neural folds and the somites by HH stage 8.

23 but also for maintenance of integrity of the neural folds and tube, via correct formation of the apic

24 Noggin is expressed dorsally in the closing neural folds and ventrally in the notochord and somites.

25 is enriched in the anterior neural plate and neural folds, and depletion of MIM specifically inhibits

26 Subsequently, gtpbp2 is expressed in the neural folds, and in early tadpoles undergoing organogen

27 TDs), with the NTDs being caused by abnormal neural fold apposition and fusion.

28 e have focused on the final step wherein the neural folds approach one another and seal to form the c

29 ow that the NC cells induced at the anterior neural fold are able to migrate and differentiate as nor

30 emonstrate that: (i) progenitor cells in the neural folds are multipotent, having the ability to form

31 erate neural crest cells when the endogenous neural folds are removed, probably via interaction of th

32 eventing the formation of NC in the anterior neural folds as loss-of-function experiments using a Dkk

33 crest formation, Shh or Noggin were added to neural folds at defined times in culture.

34 lation of stem cells derived from the dorsal neural folds at the border between neural and non-neural

35 urulation is completed when the dorsolateral neural folds bend inwards, their tips make adhesive cont

36 and that the local release of Bmp2 inhibits neural fold bending.

37 Id2 is also expressed in Xenopus neural folds, branchial arches, cardiac outflow tract, i

38 rm and in a restricted group of cells in the neural folds, but was largely absent from the neural pla

39 We suggest that the inherent movement of the neural folds can accomplish only a finite amount of medi

40 d that individual precursor cells within the neural folds can give rise to epidermal, neural crest, a

41 eis1 in several areas, including the lateral neural folds, caudal branchial arch, hindbrain, and opti

42 letion of MIM specifically inhibits anterior neural fold closure without affecting convergent extensi

43 retinoic acid (RA), starting at the time of neural fold closure, blocks expression of myocardial dif

44 nt extension movements, tissue separation or neural fold closure.

45 p antagonist noggin is expressed dorsally in neural folds containing DLHPs, noggin-null embryos show

46 In vivo chromatin immunoprecipitation of neural folds demonstrates that DNMT3A specifically assoc

47 isplays restricted expression to the lateral neural folds, developing lens, retina, limb, and CNS.

48 However, the neural folds do not fuse with one another, and the deep

49 te ribosomal RNA production in the prefusion neural folds during the early stages of embryogenesis.

50 ural crest cells are induced in chick as the neural folds elevate, recent data suggest that they are

51 presumptive cardiac crest at stage 7, as the neural folds elevate, results in reformation of migratin

52 rticularly, we find that MIM is required for neural fold elevation and apical constriction along with

53 show that Xdsh signaling is not required for neural fold elevation, medial movement or fusion.

54 grating neural crest cells begin to exit the neural fold/epidermal ectoderm boundary, we examined the

55 Conversely, neural folds exposed to laminin alpha5 in vitro show a r

56 Cells from the juxtaposed neural folds extend long and short flexible extensions a

57 regeneration by NC precursors, we find that neural fold extirpation results in a loss of NC precurso

58 A neural trough forms, and neural folds form and approach one another.

59 Although bilateral neural folds form, they are abnormally far apart and can

60 reduction in the number of somites, abnormal neural fold formation and a greatly increased degree of

61 arly intense expression at the apices of the neural folds from which the neural crest arises.

62 movements and prospective cell identities as neural folds fuse during neural tube formation in Xenopu

63 racterized GPCR-ligand pathway necessary for neural fold fusion and lens development, providing insig

64 n of medially directed cell migration during neural fold fusion and re-establishment of the neural tu

65 expressed far lateral to the medial site of neural fold fusion and that expression moves medially af

66 For example, failure of neural fold fusion during neurulation leads to open neur

67 After neural fold fusion, lateral deep neural cells move media

68 ression of these deep cell behaviors and for neural fold fusion.

69 tebrate neural crest cells, derived from the neural folds, generate a variety of tissues, such as car

70 tage 11.5 induces the endogenous eIF4AII and neural fold genes within 40 minutes.

71 we demonstrate that the Retina and anterior neural fold homeobox (Rax) gene plays a key role in esta

72 We observed that the retina and anterior neural fold homeobox transcription factor (Rax) is selec

73 ovel homeobox gene, rax (retina and anterior neural fold homeobox), whose expression pattern suggests

74 ing embryo were observed at the edges of the neural folds immediately prior to fusion, and also in th

75 expressed in the dorsal neural ectoderm and neural folds in the region where primary sensory neurons

76 use embryo, rax is expressed in the anterior neural fold, including areas that will give rise to the

77 ely large region of ectoderm adjacent to the neural folds, intermingled both with each other and with

78 k1-null mouse embryos transform the anterior neural fold into NC.

79 port the notion that posteriorization of the neural folds is an essential step in NC specification.

80 a concomitant increase of E-cadherin in the neural folds, likely leading to delayed and decreased ne

81 oper organization of the cells in the dorsal neural folds, manifested by a loss in the columnar epith

82 mation of border-like cells that express the neural fold markers MSX1 and BMP4 and the preplacodal re

83 ses loss of animal cell adhesion or delay in neural fold morphogenesis, respectively, without signifi

84 tion is designated shroom (shrm) because the neural folds "mushroom" outward and do not converge at t

85 on of cadherin6B and FoxD3 expression in the neural folds/neural tube, leading to premature neural cr

86 border (NPB), which is later elevated as the neural folds (NFs) form and fuse in the dorsal region of

87 cted as a dorsal stripe of expression in the neural folds of embryos at day 8.5 postcoitum (p.c.).

88 gene targeting of beta-catenin in the dorsal neural folds of mouse embryos represses the expression o

89 Here we unveil a new role for this gene in neural fold patterning.

90 Initially localized to the dorsal neural folds, premigratory neural crest cells undergo an

91 neural crest cells for a limited time after neural fold removal.

92 ral-tube closure defect with ruffling of the neural fold ridges, a yolk sac erythropoietic failure, a

93 of this new closure initiation point causes neural fold separation, demonstrating its biomechanical

94 -actin or laser ablation of the cable causes neural fold separation.

95 we demonstrate that Gbx2 is upstream of the neural fold specifiers Pax3 and Msx1.

96 luding the notochord and is specified during neural fold stages in Xenopus laevis.

97 ons of Cnbp(-/-) embryos at gastrulation and neural-fold stages.

98 down the elongating spinal axis, uniting the neural fold tips in the dorsal midline.

99 cell protrusions emanating from the apposed neural fold tips, at the interface between the neuroepit

100 ch includes an actin cable running along the neural fold tips.

101 y contributes to an inability of the cranial neural folds to move toward the midline and results in N

102 , driving the zipper forward and drawing the neural folds together.

103 ural ectoderm cells on opposing sides of the neural folds undergo a dramatic change in shape to protr

104 Proliferation in cranial neural folds was reduced in homozygous Lrp6(-/-) mutants

105 from different axial levels to the anterior neural fold, we found that competence is initially broad

106 airs signaling, neural crest development and neural folding, whereas TRAF4 overexpression boosts sign

107 crest, including an "intermediate region" of neural folds which has never previously been tested for

108 in the levels of apoptosis in the prefusion neural folds, which are the site of the highest levels o

109 begins as the neural plate bends to form the neural folds, which meet and adhere to close the neural

110 ranial neural tissue that are independent of neural fold zipping.