ライフサイエンスコーパス: neural plate

1 promote the transition to a differentiating neural plate.

2 sly proposed role in patterning the anterior neural plate.

3 superficial and deep layers of the anterior neural plate.

4 elated with the BMP activity gradient in the neural plate.

5 n the prospective eye fields in the anterior neural plate.

6 between their homologues in the Xenopus open neural plate.

7 al intercalation in the medial region of the neural plate.

8 cal constriction during morphogenesis of the neural plate.

9 h superficial and deep layers of the Xenopus neural plate.

10 y been implicated in posteriorization of the neural plate.

11 ting to the medial-lateral patterning of the neural plate.

12 n arrest of cell convergence in the anterior neural plate.

13 orsal ectoderm and becomes restricted to the neural plate.

14 acode that arises at the anterior end of the neural plate.

15 is found as a radial gradient in the forming neural plate.

16 icroinjected into the precardiac mesoderm or neural plate.

17 together with the hindbrain, from the caudal neural plate.

18 ical surface of the lulu mutant epiblast and neural plate.

19 ngle eye anlage is specified in the anterior neural plate.

20 s from a single contiguous domain within the neural plate.

21 g of cells between the notoplate and lateral neural plate.

22 ral and definitive endoderm and the cephalic neural plate.

23 l crest induction, and A-P patterning of the neural plate.

24 cing signals, reinforced by factors from the neural plate.

25 se as a result of patterning of the anterior neural plate.

26 itor cells cross the midline in the anterior neural plate.

27 ry of the embryonic epidermis (skin) and the neural plate.

28 tions in the apical and basal domains of the neural plate.

29 ise from a zone of ectoderm that borders the neural plate.

30 artially redundant functions in the anterior neural plate.

31 sis, we examined its function in the Xenopus neural plate.

32 iation and morphogenesis of the mesoderm and neural plate.

33 ral crest and epidermis and expansion of the neural plate.

34 ipheral nervous systems (PNS) arise from the neural plate.

35 ional Wnt/Fgf/RA signals to posteriorize the neural plate.

36 t reduction in tubulin polymerization in the neural plate.

37 s that arise at the border of the vertebrate neural plate.

38 lial character prior to other regions of the neural plate.

39 concomitant lengthening and narrowing of the neural plate, a morphogenetic process defined as converg

40 and LPGDS induction by Zic1 at the anterior neural plate allows for the localized production and tra

41 Dorsolateral bending of the neural plate, an undifferentiated pseudostratified epith

42 the chick, Miz1 is expressed throughout the neural plate and closing neural tube.

43 s, but this reflects posteriorization of the neural plate and consequent expansion of the hindbrain e

44 ntagonists are required for formation of the neural plate and dorsal mesoderm.

45 ral crest cells arise from the border of the neural plate and epidermal ectoderm, migrate extensively

46 It is known the interactions between the neural plate and epidermis generate neural crest (NC), b

47 cells originate along the border between the neural plate and epidermis, migrate extensively and gene

48 stabilization of planar cell packing in the neural plate and for the formation of stable apical-basa

49 for the expression of neural markers in the neural plate and in neuralised animal caps.

50 erfamily, which is expressed in the anterior neural plate and is required for brain morphogenesis.

51 from a common preplacodal domain around the neural plate and its development is directed by signals

52 ole during regionalisation of the vertebrate neural plate and its inhibition in the most anterior neu

53 C were present on the lateral margins of the neural plate and later became localized adjacent to the

54 Lrig3 was expressed in the neural plate and neural crest (NC) at neurula stages, an

55 replacodal gene expression, while repressing neural plate and neural crest fates.

56 xpression of MIM is enriched in the anterior neural plate and neural folds, and depletion of MIM spec

57 t mediate cell adhesion within the embryonic neural plate and neural folds.

58 bryos generate the border region between the neural plate and non-neural ectoderm from which multiple

59 ells are generated at the border between the neural plate and nonneural ectoderm, where they initiate

60 C develops only at the lateral border of the neural plate and not in the anterior fold.

61 ibited mainly wild-type cells in the midline neural plate and notochordal plate, consistent with a ce

62 arly expression in the anterior endoderm and neural plate and regulatory elements in the 3' region ar

63 f the regulatory network specifying anterior neural plate and retina.

64 system have different embryonic origins, the neural plate and sensory placodes.

65 jor components of the body plan, such as the neural plate and somites.

66 ogeny from the superficial epithelium of the neural plate and that these deep cells have a correspond

67 eural crest arises at the border between the neural plate and the adjacent non-neural ectoderm.

68 n ectodermal domain adjacent to the anterior neural plate, and a number of genes have been recently i

69 r the neural crest that lies adjacent to the neural plate, and a precursor field for the placodes, ca

70 ly twice as stiff as either the notochord or neural plate, and at least 10-fold stiffer than the endo

71 is expressed in the gastrula marginal zone, neural plate, and cranial and trunk neural crest.

72 forms at the border surrounding the anterior neural plate, and expresses a unique set of evolutionari

73 signals interferes with the induction of the neural plate, and this activity can be separated experim

74 Thus, like in the neural plate antagonistic interaction between Otx2 and G

75 y during gastrulation and well before proper neural plate appearance.

76 efects in both the lulu primitive streak and neural plate are associated with disruption of the norma

77 te as well as apical constriction within the neural plate are perturbed in Xena knockdown embryos.

78 Changes in the shape of the neural plate as well as apical constriction within the n

79 means, dramatically expanded the size of the neural plate, as evidenced by the increased expression o

80 rsely, stimulation of Smad2 signaling in the neural plate at gastrula stages results in inhibition of

81 ctive midbrain-hindbrain border (MHB) in the neural plate at the end of gastrulation.

82 , results in the same phenotype: an expanded neural plate at the expense of epidermis and delayed neu

83 pression of Noelin-4 causes expansion of the neural plate at the expense of neural crest and epidermi

84 Sox8 accumulates at the lateral edges of the neural plate at the mid-gastrula stage; in contrast to i

85 ation of the biomechanical properties of the neural plate at the tissue-level.

86 then turned off in the dorsal ectoderm, the neural plate, at the neurula stage.

87 are specified at the lateral borders of the neural plate before delaminating, migrating and differen

88 erally symmetric distribution in the Xenopus neural plate, being enriched at medial apical cell junct

89 oepithelial cells, and that ultimately drive neural plate bending, whereas in the deep neural cells m

90 mbryonic brain and spinal cord begins as the neural plate bends to form the neural folds, which meet

91 ble to promote the expression of a subset of neural plate border (NPB) makers without the presence of

92 NC cells arise during gastrulation at the neural plate border (NPB), which is later elevated as th

93 central nervous system, a domain called the neural plate border (NPB).

94 NC and placodes form at the neural plate border (NPB).

95 neural crest development takes place at the neural plate border and consists in the induction of Pax

96 nts contain cells fated to contribute to the neural plate border and even to the anterior neural plat

97 animal hemisphere at blastula stages and the neural plate border and neural crest at neurula stages.

98 precursor survival, leading to reduction of neural plate border and neural crest specifier genes Msx

99 The neural plate border and RBs were induced at the transpla

100 Notch in the regulation of cell fate at the neural plate border and that Notch regulates the total n

101 tion of neural crest-specific factors at the neural plate border appears to be a vertebrate novelty.

102 inductive roles of FGF, Wnt, and BMP at the neural plate border are well established, but the signal

103 Arising from the neural plate border at the intersection of Wnt and Bmp s

104 tent precursor cells that are induced at the neural plate border by a series of complex signaling and

105 Neural crest cells are induced at the neural plate border by the combined action of transcript

106 ory state upstream of multiple, pre-existing neural plate border cell differentiation programs.

107 s an integral role in the development of the neural plate border cell fates, including neural crest c

108 chordates (cephalochordates and tunicates), neural plate border cells express conserved factors such

109 However, invertebrate neural plate border cells have not been shown to generat

110 ar tail neuron precursors derive from caudal neural plate border cells, delaminate and migrate along

111 in the absence of further signals develop as neural plate border derivatives and eventually express l

112 signaling and suggest a later involvement in neural plate border development, likely due to widesprea

113 These cells arise at the neural plate border during a time in development when pr

114 Id3 is localized at the neural plate border during gastrulation and neurulation,

115 evel of BMP4 signaling is required to induce neural plate border fates, we directly tested BMP4's abi

116 that the contribution of dlx3b and dlx4b to neural plate border formation is partially non-cell-auto

117 and NSD3 is necessary for expression of the neural plate border gene Msx1, as well as the key neural

118 evaluated the effects of knocking down known neural plate border genes and early neural crest specifi

119 xogenous BMP affects expression of amphioxus neural plate border genes as in vertebrates, suggesting

120 Furthermore, it physically interacts with neural plate border genes Pax7 and Msx1 in vivo to direc

121 results putatively place Elk3 downstream of neural plate border genes, but upstream of neural crest

122 In Xenopus, the neural plate border gives rise to at least three cell po

123 complex network of genes is activated at the neural plate border in response to neural crest-inducing

124 stem cell-like progenitors that arise at the neural plate border in vertebrates and migrate extensive

125 stem cell-like progenitors that arise at the neural plate border in vertebrates, migrate extensively,

126 e that the control of Sox8 expression at the neural plate border is a key process in initiating neura

127 ith dynamic confocal imaging reveal that the neural plate border is considerably broader and extends

128 t acquisition of AmphiSoxE expression in the neural plate border led to NCC emergence while duplicati

129 ound the neural plate, overriding the normal neural plate border limit of the early neural crest terr

130 BMP antagonists can induce neural plate border markers in both ventral Xenopus epid

131 is of transcription factor expression in the neural plate border of chick embryos.

132 est induction rather than general defects in neural plate border or dorso-ventral patterning.

133 xpression shows that early inducing signals, neural plate border patterning genes, and melanocyte dif

134 ebrate-specific elaborations on an ancestral neural plate border program, through acquisition of migr

135 lamprey AP-2 appears to function early as a neural plate border rather than a neural crest specifier

136 rparts of these genes function downstream of neural plate border specification in the regulatory netw

137 uggesting that conserved signals specify the neural plate border throughout chordates.

138 b transcription factors are expressed at the neural plate border where they play partially redundant

139 The 'neural plate border' of vertebrate embryos contains prec

140 DNMT3A is expressed in the neural plate border, and its knockdown causes ectopic So

141 Neural crest arises at the neural plate border, expresses a core set of regulatory

142 ovel properties upon the evolving vertebrate neural plate border, potentiating the evolution of defin

143 affecting cell death or proliferation at the neural plate border, prdm1a acts explicitly on cell fate

144 es of transcription factors expressed at the neural plate border, Sox proteins have been shown to reg

145 e neural crest migrates from its origin, the neural plate border, to form diverse derivatives.

146 are multipotent progenitors that form at the neural plate border, undergo epithelial-mesenchymal tran

147 To establish regulatory relationships at the neural plate border, we assess relative expression of 6

148 zic2b influences the induction of NC at the neural plate border, while both zic2a and zic2b regulate

149 , suggesting a permissive role for prdm1a in neural plate border-derived cell fates.

150 the earliest genes activated in response to neural plate border-inducing signals.

151 crest induction in neuralized tissues or the neural plate border.

152 ads to loss of NC precursor formation at the neural plate border.

153 the total number of progenitor cells at the neural plate border.

154 within a pre-placodal domain at the cranial neural plate border.

155 anisms regulating cell fate decisions at the neural plate border.

156 ent progenitors that arise at the vertebrate neural plate border.

157 ired for the generation of cell fates at the neural plate border.

158 functional, direct targets of Prdm1a at the neural plate border.

159 ork that controls cell fate decisions at the neural plate border.

160 erm are specified in adjacent domains at the neural plate border.

161 l crest specifiers, foxd3 and tfap2a, at the neural plate border.

162 ity evolves into two distinct domains at the neural plate border: one coinciding with the neural cres

163 We propose that the neural plate borders of the chordate ancestor already pr

164 rate embryos within a discrete domain at the neural plate boundary and eventually gives rise to a mig

165 naling promote neural crest formation at the neural plate boundary in vertebrate embryos.

166 During embryogenesis, CNC is induced at the neural plate boundary through the interplay of several m

167 encroaches anteriorly into node ectoderm and neural plate, but its expression in presomitic mesoderm

168 XDmrt4 is induced at the anterior neural plate by a balance of neural inducers and caudali

169 rest is induced at the lateral border of the neural plate by the combined action of signaling molecul

170 ck, however, only cells at the border of the neural plate can be neuralized by BMP inhibition.

171 Tumorhead (TH) regulates neural plate cell proliferation during Xenopus early dev

172 Folr1-deficient neural plate cells fail to constrict, resulting in widen

173 Folr1 knockdown in neural plate cells only is necessary and sufficient to i

174 ing and that Cdkn1c function is required for neural plate cells to stop dividing and differentiate as

175 ith the frimousse mutation, the anteriormost neural plate cells, which are products of an FGF inducti

176 ors to neural progenitors to differentiating neural plate cells.

177 y observed longer range induction in lateral neural plate cells.

178 dynamic in early vertebrate embryos and that neural-plate cells contain less PRC1 than do epidermal c

179 ne (frimousse) with a profound disruption in neural plate development.

180 teral cell intercalation, and bending of the neural plate driven largely by cellular apical constrict

181 SRp38 is expressed in the neural plate during embryogenesis and is transcriptional

182 rc expression is highly enriched in the open neural plate during neurula stages and in the neural tis

183 the complex reorganisation of the forebrain neural plate during neurulation, which must fold a sheet

184 ve eyes and adjacent regions of the anterior neural plate during the early stages of forebrain morpho

185 nchyme determinants, such as Twist, into the neural plate ectoderm was crucial to the emergence of th

186 to the blastopore, which are fated to become neural plate ectoderm, are polarized and have straight b

187 TH gain of function phenotype and results in neural plate expansion and inhibition of neuronal differ

188 neural plate border and even to the anterior neural plate, explaining why they are so easily neuraliz

189 polarity (PCP) signalling, was necessary for neural plate folding and was accompanied by the polariza

190 ling and cytoskeletal dynamics necessary for neural plate folding.

191 tone H2AX (XH2AX) has a role in the anterior neural plate for eye field formation during Xenopus embr

192 pressor that is required within the anterior neural plate for normal forebrain development in mouse a

193 It is also required in the anterior neural plate for the development of the mammalian rostra

194 al plate specifiers Geminin and Sox2 and for neural plate formation.

195 RB sensory neurons, the medial region of the neural plate from donor Xenopus laevis embryos was trans

196 preventing the posterior-most region of the neural plate from following a hindbrain developmental pr

197 Cells at the margin of the neural plate give rise to neural crest cells, which migr

198 The mouse posterior primitive streak at neural plate/headfold stages (NP/HF, ~7.5 dpc-8 dpc) rep

199 proposes that ectodermal cells give rise to neural plate if they receive no signals at all, while BM

200 d to disrupt the development of the anterior neural plate in a similar way to the frimousse mutation.

201 t is transiently expressed in the developing neural plate in a temporal window corresponding to the p

202 tebrate eye formation begins in the anterior neural plate in the eye field.

203 demonstrate that neurogenesis in the Xenopus neural plate in vivo and mammalian neural progenitors in

204 calcium transients throughout the developing neural plate in wild-type embryos, but not in mutant emb

205 Notum is expressed in naive ectoderm and neural plate in Xenopus and is required for neural and h

206 ntercalation and convergent extension of the neural plate in Xenopus.

207 sistance to deformation ("stiffness") in the neural plate, indicating that the cytoskeleton-organizin

208 ox2 promoter and N-1 enhancer at the time of neural plate induction.

209 moter of the Sox2 locus before and after the neural plate induction.

210 ck, misexpression of BMP4 in the prospective neural plate inhibits the expression of definitive neura

211 cell behaviors necessary for converting the neural plate into a neural tube.

212 extensive cell movements transform the flat neural plate into the neural tube.

213 The rest of the neural plate invaginates to form the neural tube, which

214 The mouse neural plate is a cuboidal epithelium that remodels into

215 Contrary to previous reports, the zebrafish neural plate is a multi-layered structure, composed of d

216 The mouse neural plate is a simple epithelium that is transformed

217 cified but does not form a gut tube, and the neural plate is broad and forms ectopic folds rather tha

218 This ensures that the neural plate is flexible enough to be focally bent and s

219 l classes of mesoderm are specified, and the neural plate is formed.

220 During neural induction, the embryonic neural plate is specified and set aside from other parts

221 ption factor Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote pla

222 e embryo and is rapidly downregulated in the neural plate, its role in neural and epidermal gene expr

223 On the basal side of the neural plate, loss of CFL1 has the opposite effect on my

224 enesis as well as expression of intermediate neural plate markers.

225 l to constrict, resulting in widening of the neural plate midline and defective neural tube closure.

226 Extension of the somites and neural plate mirrors that of the notochord in these embr

227 ll shape change and is required for lens and neural plate morphogenesis.

228 e essential for neural crest development and neural plate morphogenesis.

229 reveal a novel role for Smurf1 and Smad1 in neural plate morphogenesis.

230 Ectopic expression of neural plate, neural crest and epidermal genes in the PP

231 rm is patterned into lineage progenitors for neural plate, neural crest, placodes and epidermis.

232 For most of the neural plate-neural tube transition, cells are polarized

233 proximity to each other at the border of the neural plate: neural crest precursors abut the future ce

234 ressed early in a large region of the medial neural plate, Nkx6.1 is restricted to a region overlappi

235 Wnt signals from the neural plate, non-neural ectoderm and paraxial mesoderm

236 esis are the node ectoderm and the posterior neural plate, not the presomitic mesoderm.

237 ry2a and Dlx5, compared to the expression of neural plate (NP) and NC genes.

238 end we tested the ability of segments of the neural plate (NP), isolated from different axial levels,

239 mechanisms: (1) convergent extension in the neural plate (NP); (2) cell wedging along the anterior N

240 a enhancer, which mediates expression in the neural plate of Ciona embryos in response to fibroblast

241 ne DMRT is expressed throughout the anterior neural plate of neurulating embryos.

242 Transcripts for lpar6 are enriched in the neural plate of Xenopus neurulae and loss of function ca

243 ral marker Sox2 or the formation of a mature neural plate or a forebrain, suggesting that the hypobla

244 rm a continuous trail connecting them to the neural plate or its border, suggesting that homeogenetic

245 are co-expressed in lateral ectoderm, medial neural plate or posterior-lateral mesoderm, Pax7 early e

246 direct cells to form central nervous system (neural plate) or sensory placodes.

247 ing the anterior posterior patterning of the neural plate, or placodal specification.

248 o ectopically induce neural crest around the neural plate, overriding the normal neural plate border

249 scription factors that control neurogenesis, neural plate patterning, and neuronal differentiation.

250 neural ectodermal population to a committed neural plate population poised to begin differentiation.

251 ow that FGF/MAPK activity in the prospective neural plate prevents the ectopic expression of lateral

252 In vertebrates, specification of the neural plate requires repression of bone morphogenetic p

253 ormation of mesendodermal precursors and the neural plate, respectively.

254 ranscription in the primitive streak and the neural plate, respectively.

255 In the absence of Cdx function, the caudal neural plate retains hindbrain characteristics and remai

256 of a GFP expression vector into the midline neural plate, revealed defective convergent extension in

257 stula and gastrula stages, initially express neural plate-specific genes but fail to maintain the ind

258 lfacilitin is required for expression of the neural plate specifiers Geminin and Sox2 and for neural

259 in the ventral telencephalon from the early neural plate stage and functionally cooperates with FoxG

260 eneral functions for beta-catenin beyond the neural plate stage during brain development and a partic

261 be derived from human and mouse ESCs or from neural plate stage embryos.

262 ntrast, activation of Notch signaling at the neural plate stage produces excess KA' interneurons and

263 Our data reveal that Gli3 is required at the neural plate stage to regulate Wnt expression and Wnt/be

264 Fate mapping at the open neural plate stage was carried out using orthotopic graf

265 tor cells (NPCs) specified as neurons at the neural plate stage, it delays their delamination and dif

266 f gastrulation and peak in number during the neural plate stage.

267 ned by the mid-gastrula stage but are by the neural plate stage.

268 aspect of the central nervous system at open neural plate stages in Xenopus.

269 At neural plate stages most of these genes remain reduced,

270 astomeres suppressed hnRNP K expression from neural plate stages through to at least stage 40.

271 At neural plate stages, future placode cells are confined t

272 ls/activity of each protein at two different neural plate stages.

273 expression at the primitive streak or early neural plate stages.

274 This process is initiated from a neural plate that has a distinct organization compared t

275 lops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates,

276 canonical BMP activity gradient in the chick neural plate that results in low and temporally pulsed B

277 ion of rostroventral markers of the anterior neural plate that will give rise to the basal forebrain.

278 d Wnt8b at the lateral edges of the anterior neural plate that will give rise to the pallium.

279 Second, the axial regionalization of the neural plate that will result in the specification of ne

280 m on the overlying ectoderm that generates a neural plate that, after rolling into a neural tube, act

281 cation in the ectoderm, at the border of the neural plate, the neural crest (NC) population leaves it

282 ll survival and proliferation throughout the neural plate, the neural progenitor marker Sox2 was unaf

283 rom a common precursor field anterior to the neural plate, the pre-placodal region (PPR).

284 vergent extension in the mouse notochord and neural plate, the results indicate that chato regulates

285 ion factors Tfap2a and Tfap2c in the lateral neural plate, thereby specifying neural crest fate.

286 vitro by adding soluble Wnt to intermediate neural plate tissue cultured in collagen, and induced ve

287 Conversely, RBs fail to form when neural plate tissue from embryos with decreased BMP acti

288 conferring resistance to deformation to the neural plate tissue.

289 10 ng/ml were able to induce RBs in cultured neural plate tissue.

290 trict six3b expression, and later within the neural plate to for attenuation of rx3 expression indepe

291 ier genes are not expressed at the amphioxus neural plate/tube border, raising the intriguing possibi

292 tively abolish FGF signaling in the anterior neural plate via deletion of three FGF receptor (FGFR) g

293 stages in an intermediate region of the open neural plate where primary interneurons form.

294 different responses: Hensen's node induces a neural plate whereas the head mesoderm induces placodes.

295 ion from XTRPM7 in the region lateral to the neural plate, whereas XTRPM7 is mainly involved in regul

296 e, we examine the patterning of the anterior neural plate, which produces placodal derivatives such a

297 ganizer and its derivatives have endowed the neural plate with a coarse pattern along its anteroposte

298 prdm1 is expressed at the border of the neural plate within the domain where neural crest cells

299 sufficient to induce posterior fates in the neural plate, yet a mechanistic understanding of the pro

300 issue constriction in the caudal and ventral neural plate zone.