ライフサイエンスコーパス: neural stem cell

1 ng Drosophila melanogaster neuroblasts (NBs; neural stem cells).

2 iate neural progenitors (INPs) from a single neural stem cell.

3 al cortex growth and midbody organization of neural stem cells.

4 ransport media, and substrates for growth of neural stem cells.

5 sly published data from mouse lung cells and neural stem cells.

6 e suggests propensity for infection of adult neural stem cells.

7 w paradigm regulating asymmetric division of neural stem cells.

8 re thought to regulate the activity of adult neural stem cells.

9 sses that involve the neurovascular unit and neural stem cells.

10 cells) that have many properties similar to neural stem cells.

11 phy) on the migration and differentiation of neural stem cells.

12 d by mitigating over-active Wnt signaling in neural stem cells.

13 ll as maintenance of adult hematopoietic and neural stem cells.

14 al cells and for apical nuclear migration in neural stem cells.

15 uRs), mGluR5 is the most highly expressed in neural stem cells.

16 d integrins in multiple cell types including neural stem cells.

17 on and activity in primary glioma-initiating neural stem cells.

18 tory gal-1 was stably overexpressed in NE-4C neural stem cells.

19 genesis by preventing the differentiation of neural stem cells.

20 dynein recruitment and nuclear migration in neural stem cells.

21 ecursors in the postnatal SEZ, which include neural stem cells.

22 ed transcriptional prepatterning in cortical neural stem cells.

23 c protein distribution in mitotic Drosophila neural stem cells.

24 to inhibit Akt-mTOR signaling in human fetal neural stem cells, a key pathway for brain development.

25 Neural stem cells accumulate reactive oxygen species (RO

26 quantitative datasets of cell proliferation, neural stem cell activation and cell influx, to predict

27 Our model shows that while cell influx and neural stem cell activation play a minor role, the accel

28 early stages of Alzheimer's disease impairs neural stem cell activity in the adult brain.

29 ctor-free scaffold to support and accelerate neural stem cell adhesion, proliferation, and differenti

30 tween Delta-like 1 and ephrin-B2 ligands, as neural stem cells adopt the Delta-like 1 phenotype of st

31 In the postnatal forebrain regionalized neural stem cells along the ventricular walls produce ol

32 ndicating that transplantation of cerebellar neural stem cells also triggers important neuroprotectiv

33 rmination of the proliferation of Drosophila neural stem cells, also known as neuroblasts (NBs), requ

34 tion of proliferation and differentiation of neural stem cells and a diverse range of progenitors.

35 m mouse fibroblasts in 2-5 weeks; expandable neural stem cells and definitive endoderm progenitors ca

36 ion cavity and crucially the contribution of neural stem cells and endothelial cells to morphogenesis

37 include proliferation and differentiation of neural stem cells and extensive rewiring of the remainin

38 ster controller for NE dynein recruitment in neural stem cells and HeLa cells.

39 tocols for the generation of cardiomyocytes, neural stem cells and hepatocytes from fibroblasts with

40 n NRF2-dependent transcriptional response in neural stem cells and identified SPP1 up-regulation as a

41 MYT1L, as indicated by our analyses in human neural stem cells and in the human brain.

42 sis of the miR-21-Sox2 relationship in mouse neural stem cells and in the mouse brain at different de

43 -21-Sox2 association was also found in mouse neural stem cells and in the mouse brain at different de

44 Pnky regulates neuronal differentiation from neural stem cells and mediates RNA splicing through inte

45 e transcription factor signatures of defined neural stem cells and neuron populations.

46 Here we show that FTO is expressed in adult neural stem cells and neurons and displays dynamic expre

47 ND surfaces, whereas the viability of mouse neural stem cells and rat neuroblastic cells was improve

48 mbryonic regional specification of postnatal neural stem cells and the lineage relationship between t

49 neration of new neurons from a pool of adult neural stem cells and their integration into functional

50 lted in indelible expression of Tom in adult neural stem cells and their lineage upon tamoxifen induc

51 h the pro-apoptotic gene Bax is deleted from neural stem cells and their progeny in the adult brain,

52 tool for assessing in vivo functionality of neural stem cells and their suitability for neural repai

53 the field toward better understanding adult neural stem cells and ultimately applying these principl

54 )Rs is involved in controlling activation of neural stem cells and water exchange dynamics in the SEZ

55 in cells as diverse as budding yeast, mouse neural stem cells, and the early C. elegans embryo.

56 Unexpectedly, recruitment of this pool of neural stem cells, and their differentiation into oligod

57 to investigate how FXR1P deficiency in adult neural stem cells (aNSCs) affects proliferation and neur

58 SIGNIFICANCE STATEMENT: Adult neural stem cells (aNSCs) in the hippocampus self-renew

59 elevated during the differentiation of adult neural stem cells (aNSCs), and Tet2 is primarily respons

60 herefore suggest that adult as well as fetal neural stem cells are vulnerable to ZIKV neuropathology.

61 This finding identifies endogenous neural stem cells as a potential therapeutic target for

62 In the brain, ZIKV preferentially infected neural stem cells, astrocytes, oligodendrocyte precursor

63 noncanonical signal transduction concepts is neural stem cells because these cells appear to have acq

64 es into molecular signals directly affecting neural stem cell behavior.

65 nges throughout the lifespan, with activated neural stem cells being especially sensitive to age-rela

66 We demonstrate, for the first time, that neural stem cell biological responses to laminin are dep

67 the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, ind

68 opography to the migration and morphology of neural stem cells by mimicking anatomical features of sc

69 enhancer is maintained in a poised state in neural stem cells by the histone deacetylase Hdac1/Rpd3.

70 Thus, endogenous neural stem cells can be mobilized for the repair of dem

71 In a human NTera2 cell model of primitive neural stem cells carrying resting cytomegalovirus genom

72 w that in asymmetrically dividing Drosophila neural stem cells, cell intrinsic polarity cues provide

73 In vitro cultured neural stem cells derived from Cic conditional knockout

74 This enabled us to discover that neural stem cells, derived from the murine spinal cord a

75 2A, and ADAR1 by short hairpin RNAs in human neural stem cell-derived astrocytes, human primary astro

76 cta index in GFP-LC3-transfected hippocampal neural stem cell-derived neurons.

77 We recently demonstrated that the neural stem cell-derived scar component has several bene

78 study developed novel methods to co-culture neural stem cell-derived spiral ganglion-like neurons (S

79 dult Machado-Joseph disease mice, cerebellar neural stem cells differentiate into neurons, astrocytes

80 proteins were expressed during all stages of neural stem cell differentiation in the dentate gyrus, w

81 ASK1 knockdown in C17.2 neural stem cells diminished high glucose- or tunicamyci

82 icrotubule cytoskeleton influences mammalian neural stem cell division.

83 Like mammalian neural stem cells, Drosophila type II neuroblasts utiliz

84 or neurodegenerative disorders and preserve neural stem cells during cytostatic cancer therapies.

85 tral nervous system scaffolds encountered by neural stem cells during development in vitro by constru

86 Identifying factors driving neural stem cell dysfunction in age-related neurodegener

87 at spinal cord 'replacement' with homologous neural stem cells enables robust regeneration of the cor

88 Using a mouse embryonic neural stem cell (eNSC) model to understand early events

89 ll replacement of lost neurons using enteric neural stem cells (ENSC) is a possible therapy for these

90 2 appear to be responsible for the increased neural stem cell exit from the VZ and cortical migration

91 trosomes and the SAC, brain cells, including neural stem cells, experience massive errors in mitosis,

92 ls is undifferentiated and associated with a neural stem cell expression program.

93 hanistic understanding of how MCPH1 controls neural stem cell fate and brain development.

94 atform to study the dynamics of single adult neural stem cell fate decisions in response to competing

95 s epigenetic regulation at key regulators of neural stem cell fate ensuring adequate NSPCs self-renew

96 dentified specific compounds that can direct neural stem cell fate toward a specific lineage in vivo,

97 , we show that ZIKV infection of human fetal neural stem cells (fNSCs) causes inhibition of the Akt-m

98 n effective chemical approach for generating neural stem cells from mouse fibroblasts and reveals mec

99 regulates neurogenesis and represses Reln in neural stem cells from the adult SVZ.

100 In addition, neural stem cells from Upf3b-null mice have impaired abi

101 in the developing embryo harbor the primary neural stem cells from which most neurons and glia deriv

102 ial novel mechanism linking Pb exposure with neural stem cell function and neurodevelopment in childr

103 gulating expression of factors implicated in neural stem cell function.

104 Adult hippocampal neural stem cells generate newborn neurons throughout li

105 How neural stem cells generate the correct number and type o

106 Transplantation of human neural stem cells has long been proposed as a potential

107 Neural stem cells have been envisioned as a source of do

108 go, investigations of adult neurogenesis and neural stem cells have led to an established and expandi

109 Thus, cerebellar neural stem cells have the potential to be used as a cel

110 delayed transplantation of human CNS-derived neural stem cells (hCNS-SCns) at 9 or 30 d post-SCI (dpi

111 strated the neurocognitive benefits of human neural stem cell (hNSC) grafting in the irradiated brain

112 histone acetylation and methylation in human neural stem cells (hNSC) treated with ascorbic acid phos

113 e immunity alter fate and migration of human neural stem cells (hNSC).

114 icity of human embryonic/fetal brain-derived neural stem cells (hNSCs) and human mesenchymal stem cel

115 raction of nanodiamond monolayers with human Neural Stem Cells (hNSCs) has been investigated.

116 e sensing, contributing to the regulation of neural stem cell homeostasis.

117 bution to remyelination of a subset of adult neural stem cells, identified by their expression of Gli

118 ly linked to master regulators essential for neural stem cell identify.

119 l lineage tracing of active radial glia-like neural stem cells in the adult mouse dentate gyrus and m

120 pal neurogenesis relies on the activation of neural stem cells in the dentate gyrus, their division,

121 eral studies have shown that ZIKV can infect neural stem cells in the developing brain, but infection

122 Ever since the discovery of neural stem cells in the mammalian brain, the possibilit

123 l scar are generated by ependymal cells, the neural stem cells in the spinal cord.

124 eurogenic radial glia-like cells (resembling neural stem cells in the SVZ), (2) neuronal cells, and (

125 Adult neural stem cells in the ventricular-subventricular zone

126 tyrate (PBA), reduces protein aggregation in neural stem cells in vitro and in embryos in vivo.

127 In neural stem cells in vitro, high glucose elevates O-GlcN

128 Neural stem cells in vivo are located in a relative hypo

129 ration and neuronal differentiation of adult neural stem cells in vivo, which leads to impaired learn

130 tal ZIKV infection that are not explained by neural stem cell infection alone, such as calcifications

131 we provide evidence that TD-derived induced neural stem cells (iNSCs) are an efficacious therapeutic

132 Induced pluripotent stem cell-derived neural stem cells (iNSCs) have significant potential as

133 d pluripotent stem cells (iPSCs) and induced neural stem cells (iNSCs) under conditions previously sh

134 For this purpose, we injected cerebellar neural stem cells into the cerebellum of adult Machado-J

135 bioassay for human iPSC-derived neurons and neural stem cells (iPSC-NSCs) cultured on PEG hydrogels

136 Asymmetric division of neural stem cells is a fundamental strategy to balance t

137 p53 genetic inactivation in ETC-impaired neural stem cells is caused by increased reactive oxygen

138 y of human parthenogenetic stem cell derived neural stem cells ISC-hpNSC for treating Parkinson's dis

139 a model based on reactive astrocyte-derived neural stem cells isolated from GFAP-CreER-Notch1 condit

140 ed evidence of ZIKV infection in these adult neural stem cells, leading to cell death and reduced pro

141 rogramming of mouse fibroblasts into induced neural stem cell-like cells (ciNSLCs) using a cocktail o

142 ges of growth and differentiation of a human neural stem cell line were selected for association anal

143 CTX0E03 is an immortalised human neural stem-cell line from which a drug product (CTX-DP)

144 approach: using pharmacogenomics to focus on neural stem cell lineage, they identified specific compo

145 infection in human cervical, placental, and neural stem cell lines, as well as primary human amnion

146 s and oligodendrocytes can be generated from neural stem cells located within the Sub-Ventricular Zon

147 udies show that Prdm16 is required for adult neural stem cell maintenance and neurogenesis as well as

148 e we demonstrate that Prdm16 is required for neural stem cell maintenance and neurogenesis in the adu

149 uggesting that IE2 concurrently dysregulates neural stem cell maintenance in the VZ and neuronal migr

150 nigral afferents in the regulation of adult neural stem cell maintenance, identifying the first syna

151 We find that FGF receptors are required for neural stem-cell maintenance and that an activated recep

152 rosphere formation and for the expression of neural stem cell markers and Notch target genes in prima

153 neurons and reduced the expression levels of neural stem cell markers.

154 displaying traits of juvenile astroglia and neural stem cell markers.

155 This study demonstrates that neural stem cells may offer significant therapeutic bene

156 2016) and Nowakowski et al. (2016) use human neural stem cell models and single-cell RNA sequencing t

157 e resulting ciNSLCs closely resemble primary neural stem cells molecularly and functionally.

158 on, genes regulating growth and migration of neural stem cells need to be well characterized.

159 without affecting cell-fate specification of neural stem cells/neural progenitor cells (NSCs/NPCs).

160 in Drosophila as a tumor suppressor in both neural stem cells (neuroblasts) and epithelia.

161 Drosophila neural stem cells (neuroblasts) are a powerful model sys

162 e a niche that sustains the proliferation of neural stem cells (neuroblasts) during starvation.

163 into migratory progenitors that matured into neural stem cells (neuroblasts) in a second domain.

164 During Drosophila embryonic development, neural stem cells (neuroblasts) sequentially express tra

165 erality within a subpopulation of Drosophila neural stem cells (neuroblasts).

166 (INPs) generated by asymmetrically dividing neural stem cells (neuroblasts).

167 reover, the contribution of pericytes to the neural stem cell niche has not been defined.

168 ature is an important component of the adult neural stem cell niche, but whether vascular cells in ne

169 ng both the assembly and function of the SVZ neural stem cell niche.

170 , Liu et al. (2017) demonstrate that in some neural stem cells, Notch activity is asymmetrically ampl

171 gene regulatory network (GRN) that supports neural stem cell (NS cell) self-renewal has so far been

172 ve been identified, few lncRNAs that control neural stem cell (NSC) behavior are known.

173 al transport machinery, regulates Drosophila neural stem cell (NSC) development through Ca(2)(+) mito

174 brin-Matrigel mixed gel was found to promote neural stem cell (NSC) differentiation into neurons and

175 HA contributes to age-related reductions in neural stem cell (NSC) expansion and differentiation in

176 Mammalian neural stem cell (NSC) lines provide a tractable model f

177 nitors, together recapitulating hallmarks of neural stem cell (NSC) ontogeny.

178 t that neurofibromin differentially controls neural stem cell (NSC) proliferation and multilineage di

179 gh finely tuned multistep processes, such as neural stem cell (NSC) proliferation, migration, differe

180 n shown that vascular niche signals regulate neural stem cell (NSC) quiescence and growth.

181 Notch signaling is crucial for maintaining neural stem cell (NSC) self-renewal and heterogeneity; h

182 e, through OPA1 or MFN1/2 deletion, impaired neural stem cell (NSC) self-renewal, with consequent age

183 Genetically engineered neural stem cell (NSC) transplant populations offer key

184 Both neurotrophin-based therapy and neural stem cell (NSC)-based strategies have progressed

185 Transplanted neural stem cells (NSC) interact with the host brain mic

186 two different cells of origin reminiscent of neural stem cells (NSC) or oligodendrocyte precursor cel

187 ogenesis, the generation of new neurons from neural stem cells (NSC), in offspring.

188 ble in neurons, but selectively expressed in neural stem cells (NSCs) and astrocytes.

189 hereby promoting neuronal differentiation of neural stem cells (NSCs) and dendritic branching of diff

190 LX or tailless) controls the self-renewal of neural stem cells (NSCs) and has been implied as an onco

191 However, its role in normal mammalian neural stem cells (NSCs) and in SCZ pathogenesis remains

192 oal, we determined the number of hippocampal neural stem cells (NSCs) and investigated the expression

193 uring neuronal differentiation are silent in neural stem cells (NSCs) and occupy black chromatin and

194 teral SVZ in early postnatal mice, including neural stem cells (NSCs) and their immediate progenies,

195 Neural stem cells (NSCs) are a heterogeneous population

196 Neural stem cells (NSCs) are defined by their ability to

197 Adult neural stem cells (NSCs) are defined by their inherent c

198 The mechanism by which adult neural stem cells (NSCs) are established during developm

199 Neural stem cells (NSCs) are progenitor cells for brain

200 Drosophila neural stem cells (NSCs) are quiescent at early larval s

201 There is strong clinical interest in using neural stem cells (NSCs) as carriers for targeted delive

202 Neural stem cells (NSCs) differentiate into both neurons

203 During Drosophila development, neural stem cells (NSCs) divide asymmetrically and gener

204 dies that address a central question: How do neural stem cells (NSCs) divide in different ways to pro

205 nt neurogenic activity of individual pallial neural stem cells (NSCs) from embryo to adult.

206 device for biomanufacturing patient specific neural stem cells (NSCs) from iPSCs.

207 genesis from adult subventricular zone (SVZ) neural stem cells (NSCs) in culture.

208 rolling the expansion and differentiation of neural stem cells (NSCs) in development has not been stu

209 Neural stem cells (NSCs) in specialized niches in the ad

210 Endogenous neural stem cells (NSCs) in the adult hippocampus are co

211 al for the normal cycling and maintenance of neural stem cells (NSCs) in the brain subependymal zone

212 m1) and Pum2, severely reduced the number of neural stem cells (NSCs) in the postnatal dentate gyrus

213 Adult neural stem cells (NSCs) in the ventricular-subventricul

214 Hippocampal neural stem cells (NSCs) integrate inputs from multiple

215 evels modulate the differentiation of murine neural stem cells (NSCs) into neurons and astroglial-lik

216 concerted production of neurons and glia by neural stem cells (NSCs) is essential for neural circuit

217 The quiescence of adult neural stem cells (NSCs) is regulated by local parvalbum

218 natal co-deletion of Pten and Trp53 in mouse neural stem cells (NSCs) leads to the expansion of these

219 The neural stem cells (NSCs) located in the largest germinal

220 Neural stem cells (NSCs) play an essential role in shapi

221 Neural stem cells (NSCs) reside in a unique microenviron

222 use epilepsy models to probe how hippocampal neural stem cells (NSCs) respond to graded pathological

223 s acting as an autocrine factor expressed in neural stem cells (NSCs) solely from the paternal allele

224 und preferentially in close proximity to SVZ neural stem cells (NSCs) that produce interleukin-15 and

225 onment regulate the differentiation of adult neural stem cells (NSCs) toward the neuronal lineage.

226 During development, neural stem cells (NSCs) undergo transitions from neuroe

227 In the present study, neural stem cells (NSCs) were derived from the SVZ on po

228 Neural stem cells (NSCs) within the hippocampal niche in

229 leads to neoplastic transformation of human neural stem cells (NSCs), but not mesenchymal stem cells

230 h factor (VEGF) activated CD133(+) ependymal neural stem cells (NSCs), lining not only the lateral bu

231 oglia enhance astrogliogenesis of cocultured neural stem cells (NSCs), whereas blockade of IL6 or gen

232 ration of hippocampal neurons from quiescent neural stem cells (NSCs).

233 or the limited repair capacity of endogenous neural stem cells (NSCs).

234 ressant, on the proliferation of hippocampal neural stem cells (NSCs).

235 orylated neural nitric oxide synthase within neural stem cells (NSCs).

236 fragmentation, and apoptosis in hippocampal neural stem cells (NSCs).

237 were tripotential, suggesting an increase in neural stem cells (NSCs).

238 damage responses between neonatal and adult neural stem cells (NSCs).

239 trauma stimulate proliferation of endogenous neural stem cells (NSCs); however, the survival of young

240 ic NanoScript to knockdown GFP expression in neural stem cells (NSCs-GFP).

241 ctions in inflammation/gliosis and increased neural stem cell numbers in areas of tissue injury.

242 t majority of reprogrammed cardiomyocytes or neural stem cells obtained from mouse fibroblasts by OSK

243 Radial glia, the neural stem cells of the neocortex, are located in two n

244 Neural stem cells or neuroblasts in the Drosophila melan

245 pendyma are not a major source of endogenous neural stem cells or neuroprotective astrocytes after SC

246 hus exhibit several key characteristics of a neural stem cell population, and our data support the id

247 hysiological stimuli are relayed to resident neural stem cell populations to control the transcriptio

248 osure to methylmercury was shown to decrease neural stem cell populations, whereas aerobic fitness ha

249 In select areas of the brain, neural stem cells produce new neurons throughout life.

250 Adult neural stem cells/progenitor cells residing in the basal

251 are sufficient to determine the fate of the neural stem cell progeny in mammals.

252 adult mice brains, all compounds stimulated neural stem cell proliferation, migration, and different

253 ey microtubule-mediated processes, including neural stem cell proliferation, radial migration, and gr

254 Hence, the patient-derived iPSCs and neural stem cells provide a system to further unravel th

255 ranscriptomes of adult hippocampal quiescent neural stem cells (qNSCs) and their immediate progeny.

256 cular-subventricular zone (V-SVZ), quiescent neural stem cells (qNSCs) become activated (aNSCs), and

257 racellular matrix (ECM) is known to regulate neural stem cell quiescence in the adult subventricular

258 Brain neural stem cells (radial glial progenitors, RGPs) under

259 naling pathway, playing an important role in neural stem cell regulation during mammalian brain devel

260 key neurodevelopmental processes, including neural stem cell regulation, proper positioning of migra

261 e, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and reactivat

262 Adult neural stem cells reside in specialized niches that main

263 Adult neural stem cells reside in specialized niches.

264 rocyte progenitor cells and endogenous adult neural stem cells resident within the subventricular zon

265 MBD1 is expressed in neural stem cells residing in the dentate gyrus of the a

266 We previously showed that MCPH1 deletion in neural stem cells results in early mitotic entry that di

267 estigated transplantation of gal-1-secreting neural stem cell (s-NSC) into ischemic brains and identi

268 The mechanisms that control adult neural stem cell self-renewal are still largely unknown.

269 The orphan nuclear receptor TLX regulates neural stem cell self-renewal in the adult brain and fun

270 Nin regulates neural stem cell self-renewal, interkinetic nuclear migr

271 Neural stem cells show age-dependent developmental poten

272 Neural stem cells showed differential migratory and morp

273 We report here that mice with embryonic neural stem-cell-specific deletion of Llgl1 (Nestin-Cre/

274 novel REST targets to maintain the quiescent neural stem cell state.

275 kers for GSC are developed from embryonic or neural stem cell systems; however, currently available G

276 developing brain, neurons are produced from neural stem cells termed radial glia [1, 2].

277 ocus on questions related to adult mammalian neural stem cells that also apply to other somatic stem

278 lt frog retina retains a reservoir of active neural stem cells that contribute to continuous eye grow

279 Ependyma have been proposed as adult neural stem cells that provide the majority of newly pro

280 ScNs were obtained from neural stem cells that were derived from transgenic mous

281 persistence of radial glial cells acting as neural stem cells, the brain of the adult zebrafish cons

282 Two areas in the adult mouse brain contain neural stem cells: the subventricular zone of the anteri

283 ed compounds promoted differentiation of rat neural stem cells to a neuronal phenotype in vitro, in s

284 Here we use Drosophila neural stem cells to elucidate the mechanisms involved i

285 The mechanisms instructing neural stem cells to generate the appropriate progeny ar

286 NF-kappaB-mediated signaling that activates neural stem cells to reconstitute the olfactory epitheli

287 Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of t

288 Importantly, cerebellar neural stem cell transplantation mediated a significant

289 and colleagues asked whether the results of neural stem cell transplantation might be improved by ac

290 One example is the neural stem cell tumours that arise from constitutive No

291 to a reduced number of both radial glia-like neural stem cells (type-1 cells) and intermediate progen

292 an injury response, including activation of neural stem cells ultimately leading to neurogenesis.

293 How a neural stem cell under homeostasis converts after injury

294 nfected human NTera2 cell model of primitive neural stem cells, we found that costimulation with vaso

295 In astrocytes and neural stem cells, we identified G-protein-coupled recep

296 lar mechanisms by which REST regulates adult neural stem cells, we perform chromatin immunoprecipitat

297 entiate into paired box 6-positive (PAX6(+)) neural stem cells, which give rise to OLIG2(+) progenito

298 a muted NRF2 activation response in human HD neural stem cells, which was restored by genetic correct

299 been accomplished by treating pluripotent or neural stem cells with growth factors and morphogens tha

300 Here we show that neural stem cells, with absent or reduced DCX protein ex