ライフサイエンスコーパス: neural tube

1 closure, axial turning and patterning of the neural tube.

2 movements underlying the organization of the neural tube.

3 resolution during morphogenesis of the mouse neural tube.

4 for dorsoventral patterning of the overlying neural tube.

5 es, often manifested in the palate, heart or neural tube.

6 icular zone and floor plate of the embryonic neural tube.

7 rom later-differentiating neurons toward the neural tube.

8 planin, which is expressed on the developing neural tube.

9 tinct subpopulations within the chick dorsal neural tube.

10 al folds, which meet and adhere to close the neural tube.

11 ssed throughout the neural plate and closing neural tube.

12 of Sonic hedgehog in the floor plate of the neural tube.

13 sity at both dorsal and ventral poles of the neural tube.

14 aling-dependent tissues such as the limb and neural tube.

15 of neural progenitors in the mouse and chick neural tube.

16 dentity of major neuronal classes within the neural tube.

17 ogenitors while still residing in the dorsal neural tube.

18 l cell types are not specified in the mutant neural tube.

19 r excitatory neuronal lineages in the dorsal neural tube.

20 istinct progenitor domains in the developing neural tube.

21 ar behaviors underlying morphogenesis of the neural tube.

22 the level from which cells emerge along the neural tube.

23 enitors of both the junctional and secondary neural tubes.

24 In the vertebrate neural tube, a morphogen-induced transcriptional network

25 ication of neural progenitors in the ventral neural tube, a process known to require a gradient of Sh

26 an alternate strategy-cells of the zebrafish neural tube actively sort to their correct positions fol

27 es a neural plate that, after rolling into a neural tube, acts as the main source of neural progenito

28 is when gene regulatory networks pattern the neural tube along its anteroposterior and dorsoventral a

29 neural crest cells remained adjacent to the neural tube and aberrantly expressed E-cadherin while la

30 -migrating cells, originating from the trunk neural tube and associated with nerve fibres, differenti

31 Given known protective effects against neural tube and cardiac defects, there is no reason to a

32 results in severe patterning defects in the neural tube and defective Hedgehog signaling.

33 R-BI(-/-) embryos fail to close the anterior neural tube and develop exencephaly, a perinatal lethal

34 CEP120 morphants, cilia are shortened in the neural tube and disorganized in the pronephros.

35 ), which is known to guide axons outside the neural tube and interneurons in the cortex, is expressed

36 he generation of motor neurons in both chick neural tube and mouse embryonic stem cells, suggesting t

37 developing embryo and promote closing of the neural tube and other morphologic processes during devel

38 Ssdp2 (Ssdp1/2) are highly expressed in the neural tube and promote motor neuron differentiation in

39 l canonical WNT signaling mechanisms mediate neural tube and retinal vascularization and maintain the

40 ify the Shh gradient in the developing mouse neural tube and show that while the amplitude of the gra

41 11 are required for proper patterning of the neural tube and somites by regulating notochord formatio

42 epithelial cells, as seen in the vertebrate neural tube and the Drosophila ventral furrow.

43 h temporal and spatial precision in both the neural tube and the embryo's enveloping layer epithelium

44 environmental barrier dorsal and lateral to neural tube and the somites that is normally formed by P

45 signals acting along orthogonal axes of the neural tube and this is used to define spatial and tempo

46 gical progression of MMC involves failure in neural tube and vertebral arch closure at early gestatio

47 est cells undergo EMT, migrate away from the neural tube, and differentiate into diverse cell types d

48 ced the contribution of their progeny to the neural tube, and dramatically expanded the unsegmented m

49 long the dorsoventral axis of the vertebrate neural tube, and each progenitor domain generates partic

50 deletion of Dlgh-1 caused open eyelids, open neural tube, and misorientation of cochlear hair cell st

51 cells as they evaginate from the developing neural tube, and null Mitf mutations result in microphth

52 o an important role for Sulf1 in the ventral neural tube, and suggests a mechanism whereby Sulf1 acti

53 how that GPC5 orthologs are expressed in the neural tube, and that inhibiting their expression in fro

54 asts differentiate in close contact with the neural tube, and they never loose contact with the neura

55 developing tissues in mice such as somites, neural tubes, and limb buds.

56 The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of morphogen-pattern

57 nic hedgehog (Shh) patterning of the ventral neural tube as an example, we show that the framework ca

58 red in the carapacial staging area above the neural tube at G16, and differentiated into pigment-form

59 etween the different posterior tissues (e.g. neural tube, axial and paraxial mesoderm, lateral plate,

60 sis at gastrulation, closure of the anterior neural tube, axial elongation and somitogenesis.

61 ed with a morphological change in the dorsal neural tube between stages mature G15 and G16.

62 ifferentiated peripheral sensory neurons and neural tube border cells with the cooperation of neural

63 d observed expression in the developing eye, neural tube, brain and kidney.

64 ially Sox2+ cells can contribute not only to neural tube but also to neural crest and epidermis.

65 ulation, initially resides within the dorsal neural tube but subsequently undergoes an epithelial-to-

66 er of neural crest cells arise from the head neural tube by epithelial-to-mesenchymal transition (EMT

67 onsible for the loss of competence of dorsal neural tube cells to generate emigrating neural crest ce

68 DNA methylation in regulating the ability of neural tube cells to produce neural crest cells and the

69 athway mediated by folate compromises normal neural tube closure (NTC) and ciliogenesis.

70 to regulate neural progenitor proliferation, neural tube closure and apical constriction.

71 ZIP12 antisense morpholino knockdown impairs neural tube closure and arrests development during neuru

72 role in the convergent extension that drives neural tube closure and body axis elongation.

73 ts were embryonic lethal and showed impaired neural tube closure and CNCC delamination.

74 K-AKT signaling and AJ biology, required for neural tube closure and CNCC delamination.

75 eta-catenin signaling is required for caudal neural tube closure and elongation, acting through the t

76 Mechanisms underlying neural tube closure and NTDs may be informed by experime

77 e of canonical Wnt/beta-catenin signaling in neural tube closure and NTDs remains poorly understood.

78 he organization of the neural epithelium and neural tube closure are affected when actin dynamics are

79 ocked, we examined the cellular basis of the neural tube closure defect in mouse mutants that lack th

80 n the organizer and along the axial midline, neural tube closure defects (NTDs) arose and dorsal exte

81 Folic acid prevents neural tube closure defects (NTDs), but the causal metab

82 w that a decrease in ephrinB2 protein causes neural tube closure defects during Xenopus laevis embryo

83 n lead to human congenital disorders such as neural tube closure defects.

84 lly results in early embryonic lethality and neural tube closure defects.

85 Loss of XTRPM6 produced gastrulation and neural tube closure defects.

86 fects (NTDs), which result from a failure of neural tube closure during embryogenesis.

87 imaging system by following the dynamics of neural tube closure during mouse embryogenesis and revea

88 The sequence of human neural tube closure events remains controversial, but st

89 Neural tube closure has been studied for many decades, a

90 erior across the epidermis, is important for neural tube closure in the invertebrate chordate Ciona i

91 The process of neural tube closure is complex and involves cellular eve

92 Neural tube closure is sensitive to environmental influe

93 Unidirectional zippering is a key step in neural tube closure that remains poorly understood.

94 1 in mouse embryos causes defects in cranial neural tube closure, accompanied by an increase in the p

95 After neural tube closure, amniotic fluid (AF) captured inside

96 in pure AF and nascent CSF, before and after neural tube closure, and to define how the AF and CSF pr

97 mplete key developmental processes including neural tube closure, axial turning and patterning of the

98 lar and biomechanical mechanisms involved in neural tube closure, based on studies of various vertebr

99 Apical F-actin is known to be important for neural tube closure, but the precise roles of actin dyna

100 ny morphogenetic events including vertebrate neural tube closure, however, its spatial regulation is

101 ine the mechanisms by which TRPM6 influences neural tube closure, we functionally characterized the r

102 ivator with ED-rich tail 2) is essential for neural tube closure.

103 activation of apical actomyosin required for neural tube closure.

104 sac, and embryo proper, as well as abnormal neural tube closure.

105 ion of de novo thymidylate synthesis impairs neural tube closure.

106 lling and undergo almost complete failure of neural tube closure.

107 ng of the neural plate midline and defective neural tube closure.

108 mbryonic neuroepithelium and is required for neural tube closure.

109 crucial in posterior axis elongation and in neural tube closure.

110 ammals, in contrast to its essential role in neural tube closure.

111 ight genetic and epigenetic contributions to neural tube closure.

112 expansion as a result of uncompleted cranial neural tube closure.

113 ate metabolism, has the potential to support neural tube closure.

114 multiple ectodermal lineages until or beyond neural tube closure.

115 but have distinct and essential roles during neural tube closure.

116 ation of septins governs ciliogenesis during neural tube closure.

117 s exhibiting exencephaly, a severe defect in neural tube closure.

118 bryonic vitamin E to the mouse embryo during neural tube closure.

119 in embryonic vitamin E uptake during murine neural tube closure.

120 sensitive metabolic processes at the time of neural tube closure.

121 ace ectoderm, are required for completion of neural tube closure.

122 namely an increase from two to four ectopic neural tubes, corresponding to the switch in NMP niche,

123 Using rat-chick coelomic grafts, neural tube cultures, and gut explants, we show that ENC

124 ms produced offspring at a rate of 11.3% for neural tube defect (NTD) formation, whereas no embryos i

125 SWV mice strain, susceptible to VPA-induced neural tube defect (NTD).

126 ay be risk factors for having a child with a neural tube defect (NTD); however, the data are inconsis

127 aternal periconceptional NSD use between 334 neural tube defect cases and 7,619 nonmalformed controls

128 Caudal regression syndrome is a rare, neural tube defect characterized by an abnormal developm

129 yos, consistent with a proposed mechanism of neural tube defect prevention through stimulation of cel

130 without the potential for childbearing, and neural tube defect recurrence; and studies conducted in

131 Neural tube defect risk was associated with maternal per

132 lted in a high prevalence of severe anterior neural tube defect-associated congenital malformations.

133 nitrogen oxide exposure was associated with neural tube defects (adjusted odds ratio = 1.8, 95% conf

134 udied the association of these patterns with neural tube defects (NTDs) and congenital heart defects

135 Neural tube defects (NTDs) are common birth defects of c

136 Neural tube defects (NTDs) are the most severe congenita

137 Neural tube defects (NTDs) are the second most common bi

138 abetes mellitus in early pregnancy can cause neural tube defects (NTDs) in embryos by perturbing prot

139 rhl2 loss results in fully penetrant cranial neural tube defects (NTDs) in mice.

140 ART has been reported to be associated with neural tube defects (NTDs) in offspring.

141 Mouse models of folate-responsive neural tube defects (NTDs) indicate that impaired de nov

142 ess is susceptible to disruption, leading to neural tube defects (NTDs), a common birth defect.

143 supplementation can reduce the prevalence of neural tube defects (NTDs), although just how folates be

144 Neural tube defects (NTDs), including spina bifida and a

145 he risk in infants of birth defects, such as neural tube defects (NTDs), known as diabetic embryopath

146 letion-induced autophagy deficiency leads to neural tube defects (NTDs), similar to those in diabetic

147 vere anomalies of the nervous system, called neural tube defects (NTDs), which are among the most com

148 Folate supplementation prevents up to 70% of neural tube defects (NTDs), which result from a failure

149 ly pregnancy causes birth defects, including neural tube defects (NTDs).

150 High glucose in vivo and in vitro induces neural tube defects (NTDs).

151 PCP signaling gene mutations cause severe neural tube defects (NTDs).

152 suboptimal RBC folate for protection against neural tube defects (NTDs); among nonconsumers of folic

153 s have also been identified in patients with neural tube defects (NTDs); however, the relationship be

154 The adjusted odds ratio for neural tube defects among those with the highest carbon

155 tural pesticide use has been associated with neural tube defects and autism, but more subtle outcomes

156 similar to the testing/screening method for neural tube defects and common chromosomal anomalies dur

157 Association of folate deficiency with neural tube defects and impact of fortification programs

158 an essential nutrient, increase the risk of neural tube defects and lead to low performance on cogni

159 abnormalities with or without microcephaly, neural tube defects and other early brain malformations,

160 ously reported positive associations between neural tube defects and periconceptional exposure to NSD

161 lly lethal and recapitulates JBTS, including neural tube defects and polydactyly; however, the underl

162 during the periconception period to prevent neural tube defects and to ensure normal brain developme

163 Neural tube defects are among the most common congenital

164 Neural tube defects are among the most common major cong

165 Few genetic risk factors for neural tube defects are known in humans, highlighting th

166 Neural tube defects are severe congenital malformations

167 lation defects, axial patterning defects and neural tube defects complicating an assessment of the ro

168 from Hungary initiated in 1984, incidence of neural tube defects for folic acid supplementation compa

169 al folic acid supplements reduce the risk of neural tube defects in children, but it has not been det

170 en of childbearing age for the prevention of neural tube defects in infants.

171 ant dam's drinking water on the incidence of neural tube defects in some genetic models.

172 sufficiency on the basis of elevated risk of neural tube defects in women 12-49 y old (e.g., RBC fola

173 fold fusion during neurulation leads to open neural tube defects including spina bifida.

174 ontroversial, but studies of mouse models of neural tube defects show that anencephaly, open spina bi

175 ans to prevent a greater proportion of human neural tube defects than can be achieved by folic acid a

176 on folic acid supplementation for preventing neural tube defects to inform the US Preventive Services

177 ew of the severe congenital malformations - 'neural tube defects' - that result when closure fails.

178 a spectrum of birth malformations, including neural tube defects, a shortened and/or curly tail, no g

179 disposition accounts for most of the risk of neural tube defects, and genes that regulate folate one-

180 ngl2 loss is embryonically lethal because of neural tube defects, and mutations in Vangl2 are associa

181 2, which had been previously associated with neural tube defects, and vitamin B-12 status, as well as

182 during the periconceptional period prevents neural tube defects, animal data suggest that higher sup

183 Neural tube defects, harms of treatment (twinning, respi

184 Failure of this process results in neural tube defects, including spina bifida and anenceph

185 Some relate to birth defects other than neural tube defects, neurological functions or varied as

186 death, pneumonia, congenital heart disease, neural tube defects, preterm birth and low birth weight,

187 e 20 individual malformation categories, eg, neural tube defects, transposition of great vessels, ven

188 use model that exhibits folic acid-resistant neural tube defects, we tested the effect of specific co

189 ood fortification are recommended to prevent neural tube defects.

190 s in lamin B1 are susceptibility factors for neural tube defects.

191 genetic basis underlying the pathogenesis of neural tube defects.

192 implications for a population-level risk of neural tube defects.

193 utations in Vangl2 are associated with human neural tube defects.

194 FR) 677C>T polymorphism is a risk factor for neural tube defects.

195 Ozone was associated with decreased odds of neural tube defects.

196 n in the periconceptional period can prevent neural tube defects.

197 sociation of folic acid supplementation with neural tube defects.

198 supplementation provided protection against neural tube defects.

199 in the prevention of many diseases including neural tube defects.

200 Prevention of neural-tube defects can be achieved with preconceptional

201 e we show that the development of the dorsal neural tube-derived melanoblasts in turtle Trachemys scr

202 lized regions of higher expression along the neural tube, developing brain, craniofacial structures,

203 cluding probes annotated to SKI (involved in neural tube development), ZNF544 (previously implicated

204 During zebrafish neural tube development, both knockdown and overexpressi

205 Hhip overexpression has a severe effect on neural tube development, raising the question why normal

206 kinase A activation to Shh signaling during neural tube development.

207 l chemical environments found in vivo during neural tube development.

208 ristic hyperpolarization of cells lining the neural tube; disruption of this spatial gradient of the

209 e similar to those present in the developing neural tube, do not support viral replication but instea

210 In the embryonic neural tube, dorsoventral signaling has emerged as a fun

211 Closure of the neural tube during embryogenesis is a crucial step in de

212 erior boundary of Hox gene expression in the neural tube during embryogenesis.

213 ersist in the notochord, which underlies the neural tube during neurogenesis but not gliogenesis.

214 the paraxial mesoderm on either side of the neural tube, eventually differentiating into afferent ne

215 he time and distance to first division after neural tube exit were stochastic.

216 In vitro, Vangl2(Lp/Lp) neural tube explants generated emigrating NC cells, as i

217 isolated from mouse embryonic day 9.5 trunk neural tube explants.

218 he development of many tissues including the neural tube, eye, intestines, and vasculature.

219 ginate during embryonic development when the neural tube fails to close completely.

220 tor 1 (Folr1; also known as FRalpha) impairs neural tube formation and leads to NTDs.

221 ture of the NNE during the dynamic events of neural tube formation by both activating key epithelial

222 including gastrulation in many organisms and neural tube formation in vertebrates.

223 Here we show that during neural tube formation Rab11-positive recycling endosomes

224 ient mouse embryos exhibit severe defects in neural tube formation, somitogenesis and cardiac develop

225 mechanisms involved in folate action during neural tube formation.

226 phogenetic events including gastrulation and neural tube formation.

227 ure, amniotic fluid (AF) captured inside the neural tube forms the nascent cerebrospinal fluid (CSF).

228 Dorsoventral patterning of the embryonic neural tube gives rise to multiple progenitor cell domai

229 egative Ptch1 mutant in the developing chick neural tube had no effect on Shh-mediated patterning, bu

230 lay, and congenital malformations, including neural tube, heart, and placental defects.

231 bryonic mouse tissues (forebrain, hindbrain, neural tube, heart, limb, and face) at mid-gestation (E1

232 In the developing mouse and chick neural tube, hindbrain serotonergic neurons and spinal g

233 the context of the patterning of the ventral neural tube in response to a gradient of the morphogen S

234 in the p1 progenitor domain of the zebrafish neural tube in response to Sonic Hedgehog signaling.

235 The loss of Tsc1 in the mouse neural tube increases the number of the wild-type neuron

236 otor and interneuron types in the vertebrate neural tube indicates conserved combinations, for exampl

237 and found that its expression in the caudal neural tube is dependent on retinoic acid and Pax6, and

238 a model, we show that, at the junction, the neural tube is elaborated by a unique developmental prog

239 Like many developing tissues, the vertebrate neural tube is patterned by antiparallel morphogen gradi

240 model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of sever

241 s, the primordium of the nervous system, the neural tube, is shaped along the rostrocaudal axis throu

242 Global transcriptome analyses on neural tubes isolated from E9.0 EpoR-null and littermate

243 ses affecting multiple organs, including the neural tube, kidney, and brain.

244 example of abnormal patterning of the early neural tube leading to underdevelopment of the cerebellu

245 n6B and FoxD3 expression in the neural folds/neural tube, leading to premature neural crest emigratio

246 The initial rostrocaudal patterning of the neural tube leads to differential expression of Hox gene

247 etry-breaking events that ultimately lead to neural tube-like patterning along the dorsal-ventral (DV

248 elf-organize into primitive patterns such as neural tube-like rosettes in vitro.

249 More recently, biomechanical inputs into neural tube morphogenesis have also been identified.

250 ough ADAM10, and is required for appropriate neural tube morphogenesis in the Xenopus embryo.

251 In mouse neural tube, newly specified oligodendrocyte progenitors

252 Whereas SR-BI(-/-) embryos with closed neural tubes (nSR-BI(-/-)) had high levels of reactive o

253 essential role for Geminin during mammalian neural tube (NT) formation and patterning.

254 Neural tube (NT) formation in the spinal region of the m

255 When transplanted into the neural tube of developing chick embryos, iPSCMNs selecti

256 tioned both in cell lines and in vivo in the neural tube of the chick embryo including developing mot

257 l morphogens can be maintained, resulting in neural tube patterning analogous to that observed in viv

258 2 protein expression is downregulated during neural tube patterning and adaptation continues when the

259 . (2016) tackle this issue in the context of neural tube patterning, discovering that differential se

260 in), similar to that operating in vertebrate neural tube patterning, functions to distinguish cell fa

261 ecies that differ in size during the time of neural tube patterning.

262 three key ventral determinants in mammalian neural tube patterning: Nkx2.2, Nkx6.1 and Olig2.

263 ; it is clearly distinct from the restricted neural tube phenotype of Sec24b null embryos and the mil

264 r, Wnt1(Cre2SOR) mutants had an open cranial neural tube phenotype that was not evident in Wnt1(Cre)

265 s per multiciliated cell, and the numbers of neural tube primary cilia; it also led to abnormal devel

266 inactivated Smo, the common Hh receptor, in neural tube progenitors.

267 ication of ventral cell fates throughout the neural tube, reflecting constitutive HH pathway activati

268 echanisms that position motor neurons in the neural tube remain poorly understood.

269 Formation of the vertebrate neural tube represents one of the premier examples of mo

270 erning the ventral and dorsal regions of the neural tube, respectively.

271 iched in Ptf1a-bound regions in pancreas and neural tube, respectively.

272 Failure to close the neural tube results in birth defects, with severity rang

273 -of-function studies in mouse NPCs and chick neural tube show that Prox1 is sufficient and necessary

274 in immunoprecipitation analysis in the mouse neural tube showed that endogenous Prox1 directly binds

275 In the ventral neural tube, sonic hedgehog (Shh) signaling, together wi

276 ly, PRDM13 also ensures a battery of ventral neural tube specification genes such as Olig1, Olig2 and

277 ory along the anterior-posterior axis of the neural tube, the mechanisms establishing the cerebellar

278 In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establis

279 cts are those affecting the formation of the neural tube, the precursor to the central nervous system

280 embryos, these cells emerge from the dorsal neural tube then migrate long distances to different reg

281 crest (NC) arise at the dorsal aspect of the neural tube, then migrate throughout the developing embr

282 After closure of the neural tube, these cells undergo an epithelial-to-mesenc

283 ry showed strong expression of hFOXA2 in the neural tube, third ventricle, diencephalon and pancreas.

284 wo mechanisms are combined in the vertebrate neural tube to increase the range of cell types and deli

285 NC) cells, which migrate from the developing neural tube to populate vertebrate craniofacial structur

286 ral crest cells (NCCs) that migrate from the neural tube to target tissue destinations.

287 neural crest cells (crNCCs) migrate from the neural tube to the pharyngeal arches (PAs) of the develo

288 rvous system migrate ventrally away from the neural tube toward and along the primitive gut.

289 l targets genome-wide in the embryonic mouse neural tube using ChIP-Seq and RNA-Seq.

290 abnormal bulbous cilia associated with mild neural tube ventralization.

291 of Sox2 or Pax7 alters the apportionment of neural tube versus neural crest fates.

292 Using in toto imaging of the zebrafish neural tube, we analyzed specification patterns and move

293 By measuring cell polarity in the neural tube, we find that bbs7 activity is not required

294 g high-resolution live-cell imaging in chick neural tube, we uncover a form of cell subdivision that

295 sonic hedgehog, and Notch) that pattern the neural tube were sequentially perturbed to identify an o

296 to anteriorize 5 Hoxa gene expression in the neural tube when inserted into a HoxA BAC reporter.

297 is localized to the embryonic ventrolateral neural tube where motor neurons arise.

298 Cardiac NCs derive from the vagal neural tube, which also gives rise to enteric NCs that c

299 of the neural plate invaginates to form the neural tube, which expands to form the brain and spinal

300 continuity between the primary and secondary neural tubes while supplying all neural progenitors of b