ライフサイエンスコーパス: neuregulin-1

1 phrenia (e.g., catechol-O-methyltransferase, neuregulin-1).

2 ity receptor, primase 1, erythropoietin, and neuregulin 1.

3 genes during nerve repair in animals lacking neuregulin 1.

4 acellular polarity maintenance cues, such as neuregulin-1.

5 ence analysis identified the factor as mouse neuregulin-1.

6 ion were specifically blocked by antibody to neuregulin-1.

7 differentiation factor is an isoform of beta-neuregulin-1.

8 NEDD4 and the interaction was independent of neuregulin-1.

9 ds to reduced expression of the ErbB3 ligand neuregulin-1.

10 effects of TGFbeta1 were potentiated by beta-neuregulin-1, a differentiation factor expressed in preg

11 In this report we show that neuregulin-1, a growth and differentiation factor essent

12 ing monoclonal antibody huHER3-8 can inhibit neuregulin-1 activation of ERBB3 and downstream signalin

13 Neuregulin 1 acts as an axonal signal that regulates mul

14 We proposed that neuregulin-1 affects fetal lung maturation through a sim

15 We determined the expression of neuregulin 1 and ErbB4 receptors in AS mice and wild-typ

16 ors for adult psychiatric illnesses, such as Neuregulin-1 and Disrupted-in-Schizophrenia-1 (DISC1), i

17 Genomic analyses of MPNSTs arising in neuregulin-1 and epidermal growth factor receptor-overex

18 phenotypes are similar to those reported in neuregulin-1 and ErbB mutant mice, and neuregulin effect

19 In cultured cardiomyocytes, combined neuregulin-1 and insulin-like growth factor-I also had a

20 support the concept that the interaction of neuregulin-1 and insulin-like growth factor-I pathways p

21 Combined treatment with neuregulin-1 and insulin-like growth factor-I strongly i

22 In mammals, the growth factor neuregulin-1 and its receptors of the ErbB family play c

23 Although neuregulin-1 and neuregulin-2 are both binding ligands f

24 The effects of neuregulin-1 and of fibroblast-conditioned media on both

25 ulate that neuronally enriched Bace1 cleaves neuregulin-1 and that processed neuregulin-1 regulates m

26 hwann cells to the major axonal mitogen beta-neuregulin-1 and the death response to TGFbeta or serum

27 d in promyelination signaling through axonal neuregulin-1 and the ERBB2 Schwann cell receptor.

28 , we found that expression patterns of NRG1 (neuregulin-1) and its receptor ErbB4, which are essentia

29 wth factor (EGF) family members, Tgf(alpha), Neuregulin 1, and Neuregulin 3, as well as two other sig

30 Cs) express erbB receptors and their ligand, neuregulin-1, and can respond to neuregulin by prolifera

31 role of endothelial-derived growth factors, neuregulin-1, and insulin-like growth factor-I.

32 liary ganglion neurons is an isoform of beta-neuregulin-1, and that this factor acts in concert with

33 These effects of neuregulin-1 appear to involve the activation of focal a

34 th basic fibroblast growth factor (bFGF) and neuregulin-1 beta 1 (NRG1beta1).

35 Thus, neuregulin-1 beta may control fetal lung maturation thro

36 Neuregulin-1 beta was found to be secreted by the fetal

37 Epidermal growth factor (EGF), neuregulin 1-beta (NRG1-beta), betacellulin (BTC), trans

38 metalloproteinase inhibition, inhibition of neuregulin 1-beta binding to HER3, and inhibition of HER

39 rin synthesis, the membrane-bound prohormone neuregulin 1-beta is cleaved and binds to human epiderma

40 e and 6-O-sulfate groups also contributed to neuregulin-1 binding in these two assays.

41 ficantly reduced erbB receptor activation by neuregulin-1 but had no effect on the activity of neureg

42 n BACE1-null mice, the abolished cleavage of neuregulin-1 by BACE1 is speculated to cause reduced mye

43 To demonstrate a direct cleavage of neuregulin-1 by BACE1, we have identified a BACE1 cleava

44 ith iris cells or low concentrations of beta-neuregulin-1 by themselves was insufficient to stimulate

45 myelination appears to stem from the loss of neuregulin-1 cleavage by BACE1.

46 hippocampal synaptic dysfunction in a hyper-neuregulin-1 condition and thus provides novel insights

47 tors for schizophrenia, including dysbindin, neuregulin 1, DAOA, COMT, and DISC1, and neurobiological

48 n of muscle spindle differentiation requires neuregulin 1, derived from Ia afferent sensory neurons,

49 Exposure of unloaded cells to neuregulin-1 did not alter neurite density but increased

50 Further, erbB receptor activation by neuregulin-1 enhances cell motility in two-dimensional s

51 his report, we examine the potential for the neuregulin-1/erbB receptor signaling network to contribu

52 ulates prefrontal cortex myelination through neuregulin-1/ErbB3 signaling and that this is essential

53 neocortex, a process apparently mediated by Neuregulin-1/ErbB4 short- and long-range signaling.

54 Low concentrations of beta-neuregulin-1 evoked a robust increase in whole-cell K(Ca

55 wing nerve injury is not dependent on axonal neuregulin 1 expression.

56 Moreover, we show that neuregulin-1 family member neuregulin-3 is also cleavabl

57 One alternatively spliced neuregulin-1 form has a distinct heparin-binding immunog

58 ozyme-based strategy for the perturbation of neuregulin-1 function in developing chick embryos.

59 The products of the neuregulin-1 gene constitute a set of polypeptide growth

60 ed cardiomyocytes from mice heterozygous for neuregulin-1 gene deletion (NRG-1+/-) and examined the e

61 neuregulin1-beta (a.k.a. heregulin1-beta), a neuregulin-1 gene isoform that preferentially binds to a

62 mRNA expression profiling revealed that the neuregulin-1 gene, encoding an established endogenous li

63 press human NRG1-IV, an isoform of the NRG1 (Neuregulin 1) gene that is increased in the brains of pa

64 ates the response of endogenous ErbB2 to the neuregulin-1 growth factor.

65 arly administration of a retrovirus carrying neuregulin-1 hammerhead-type ribozymes to blastoderm-sta

66 or, which we have termed Don-1 (divergent of neuregulin 1), has structural similarity with the neureg

67 amined the structural specificity needed for neuregulin-1-heparin interactions using a gel mobility s

68 stitutively active vector or ligand binding (Neuregulin-1), Her4 was able to stabilize the MDMX-MDM2

69 Neuronal Neuregulin-1, however, is not involved in this refinemen

70 The loss of neuregulin 1 impaired remyelination after nerve crush, b

71 valuate the role of the N-terminal domain of neuregulin 1 in signaling and turnover of ERBB2/ERBB3.

72 nd repair following nerve injury, we ablated neuregulin 1 in the adult nervous system using a tamoxif

73 hour treatment with either TGFbeta1 or beta-neuregulin-1 in ciliary ganglion neurons developing in v

74 At picomolar concentrations, recombinant neuregulin-1 in combination with GDNF effectively stimul

75 Immunostaining showed neuregulin-1 in fetal lung that increased in fibroblasts

76 sgenic mice overexpressing the growth factor neuregulin-1 in Schwann cells (P(0)-GGFbeta3 mice) devel

77 Neuregulin-1-induced cardiac, neuronal, and mammary diff

78 f a neutralizing antiserum specific for beta-neuregulin-1 inhibited the development of K(Ca) channels

79 tol 3-kinase, blocked the effect of combined neuregulin-1/insulin-like growth factor-I treatment.

80 suggest that whereas the EGF-like domain of neuregulin 1 is required and sufficient for the formatio

81 Neuregulin-1 is expressed throughout the immature and ad

82 l-cell communication model, where the ligand neuregulin-1 is produced and secreted by one cell type,

83 NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia

84 Glial growth factor (GGF), a neuregulin-1 isoform, significantly inhibited myelinatio

85 Two neuregulin-1 isoforms highly expressed in the nervous sy

86 of a cluster-of-differentiation-44 or of pro-neuregulin-1 monomers represents an essential pre-condit

87 In the neuregulin 1 mutant mice, remyelination was again impair

88 Although studies with neuregulin-1 mutant mice have demonstrated that these gr

89 ing heart, a faithful phenocopy of the mouse neuregulin-1 mutations.

90 zophrenia-related genes, such as NR2A, NR2B, neuregulin 1, NR1 and GABA alpha1 subunit were absent in

91 Neuregulin 1 (NRG)-1, localized in the floor plate as we

92 Neuregulin 1 (NRG-1) and its receptor ErbB4 have emerged

93 r cell motility, we investigated its role in neuregulin 1 (NRG-1)-induced cell scattering.

94 Neuregulin-1 (NRG-1) and its receptors, ErbBs, are conce

95 Neuregulin-1 (Nrg-1) contains an intracellular domain (N

96 Because neuregulin-1 (NRG-1) dramatically increases extracellula

97 Here, we show that neuregulin-1 (NRG-1) exerts a critical role in the estab

98 The neuregulin-1 (NRG-1) family of growth and differentiatio

99 To test the hypothesis that neuregulin-1 (NRG-1) growth factors promote mitogenesis

100 Neuregulin-1 (NRG-1) has been identified genetically as

101 Neuregulin-1 (NRG-1) is a good candidate for the extrace

102 Neuregulin-1 (NRG-1) is a growth factor with potent neur

103 Neuregulin-1 (NRG-1) is a paracrine factor released by m

104 Neuregulin-1 (NRG-1) is genetically linked with schizoph

105 ing axon-derived trophic molecules, although neuregulin-1 (NRG-1) is the only trophic factor shown to

106 We previously showed that neuregulin-1 (NRG-1) protected neurons from death in viv

107 Neuregulin-1 (NRG-1) regulates numerous aspects of neura

108 Neuregulin-1 (NRG-1) signaling has been implicated in in

109 antagonistic interactions between agrin and neuregulin-1 (Nrg-1) signaling in cultured myotubes and

110 tically modified mice have demonstrated that neuregulin-1 (NRG-1), along with the erythroblastic leuk

111 Transmembrane isoforms of neuregulin-1 (Nrg-1), ligands for erbB receptors, includ

112 ene expression to synapses is not known, but Neuregulin-1 (Nrg-1), primarily based on its presence at

113 id peptide, also cleaves type I and type III neuregulin-1 (Nrg-1).

114 17 (ADAM17)-dependent shedding of the ligand neuregulin-1 (NRG-1).

115 Both the neuregulin 1 (Nrg1) and alpha7 nicotinic acetylcholine r

116 Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopment

117 We show that neuregulin 1 (NRG1) and hepatocyte growth factor (HGF) p

118 articipates in the proteolytic processing of neuregulin 1 (NRG1) and influences the myelination of ce

119 As the interaction between neuregulin 1 (Nrg1) and its ErbB receptors has been impl

120 Neuregulin 1 (NRG1) and its interneuron-specific recepto

121 Genetic variants of Neuregulin 1 (NRG1) and its neuronal tyrosine kinase rec

122 Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathoph

123 Neuregulin 1 (NRG1) and its receptor ErbB4 are both susc

124 Recent genetic evidence indicates that neuregulin 1 (NRG1) and its receptor erbB4 may be suscep

125 We provide evidence that neuregulin 1 (NRG1) and its receptor ErbB4 tyrosine kina

126 Neuregulin 1 (NRG1) and its receptor, erbB4, are genetic

127 , which was rescued by the administration of neuregulin 1 (NRG1) and nerve growth factor (NGF) recomb

128 Neuregulin 1 (NRG1) and the gamma-secretase subunit APH1

129 Our studies revealed that the ErbB3-neuregulin 1 (NRG1) axis is a dominant pathway responsib

130 Some studies suggest that neuregulin 1 (NRG1) could be involved in the regulation

131 B4, which is the only autonomous receptor of neuregulin 1 (NRG1) in the basolateral amygdala (BLA), w

132 nduces expression of ephrin b2a (efnb2a) and neuregulin 1 (nrg1) in the endocardium to promote trabec

133 Neuregulin 1 (NRG1) is a multifunctional neurotrophin th

134 Neuregulin 1 (NRG1) is a secreted trophic factor that ac

135 Neuregulin 1 (Nrg1) is a susceptibility gene of schizoph

136 Neuregulin 1 (NRG1) is a trophic factor that has been im

137 Neuregulin 1 (NRG1) is a trophic factor thought to play

138 Neuregulin 1 (NRG1) is an axon-derived factor that is cr

139 Genetic variation in neuregulin 1 (NRG1) is associated with schizophrenia.

140 Neuregulin 1 (NRG1) is essential for the development and

141 effects of a protective missense variant in neuregulin 1 (NRG1) linked to schizophrenia by meta-anal

142 factors have been identified, high levels of neuregulin 1 (NRG1) mRNA and protein expression in the C

143 Neuregulin 1 (NRG1) plays a critical role in myelination

144 ewal and survival, we obtained evidence that neuregulin 1 (NRG1) produced by TICs promotes their prol

145 The neuregulin 1 (NRG1) receptor, ErbB4, has been identified

146 Neuregulin 1 (NRG1) signaling is critical to various asp

147 Several lines of evidence suggest that neuregulin 1 (NRG1) signaling may influence cognitive fu

148 ate myelination in the absence of functional Neuregulin 1 (Nrg1) signaling.

149 Neuregulin 1 (NRG1) type III is involved in myelination

150 We demonstrate that zebrafish Neuregulin 1 (Nrg1) type III, which signals through ErbB

151 Neuregulin 1 (NRG1), a critical developmental neurotroph

152 in cell culture and in animals suggest that neuregulin 1 (NRG1), a probable schizophrenia susceptibi

153 udies suggest that the signalling pathway of neuregulin 1 (NRG1), a protein involved in the regulatio

154 ation in cultured Schwann cells and identify neuregulin 1 (NRG1), specifically the membrane-bound typ

155 However, the source of neuregulin 1 (NRG1), the ligand for ErbB3, is unknown.

156 g is regulated by laminin211- and, possibly, neuregulin 1 (Nrg1)-derived signals.

157 Neuregulin 1 (NRG1)-ErbB signaling mediates, therefore,

158 as Disrupted-in-schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1).

159 ng are those encoding dysbindin (DTNBP1) and neuregulin 1 (NRG1).

160 silencing the expression of the ErbB3 ligand neuregulin 1 (NRG1).

161 r/tyrosine kinase B receptor (BDNF/TrkB) and neuregulin 1 (NRG1)/ErbB2.

162 The Neuregulin 1 (NRG1)/ErbB4 signaling pathway has been gen

163 Accumulating evidence suggests that neuregulin-1 (NRG1) and disrupted-in-schizophrenia-1 (DI

164 Neuregulin-1 (NRG1) and Disrupted-in-Schizophrenia-1 (DI

165 Neuregulin-1 (NRG1) and its ErbB2/B4 receptors are encod

166 and functional studies implicate variants of Neuregulin-1 (NRG1) and its neuronal receptor ErbB4 in s

167 Neuregulin-1 (NRG1) and its receptor ErbB4 influence sev

168 lin thickness is related to the abundance of neuregulin-1 (NRG1) expressed on the axon surface.

169 we show that the neuronally secreted protein Neuregulin-1 (NRG1) fulfills all these criteria in the a

170 Members of the neuregulin-1 (Nrg1) growth factor family play important

171 Recently, the gene that encodes neuregulin-1 (NRG1) has been identified as a potential s

172 on the surface of Schwann cells and neuronal Neuregulin-1 (NRG1) has emerged as the pivotal signal th

173 In vitro assays revealed that neuregulin-1 (NRG1) induces expression of myelin protein

174 Neuregulin-1 (Nrg1) is a pleiotropic signaling molecule

175 Neuregulin-1 (NRG1) is both a candidate oncogene and a c

176 Neuregulin-1 (Nrg1) is encoded by a single gene and exis

177 Neuregulin-1 (NRG1) is one of susceptibility genes for s

178 Neuregulin-1 (NRG1) signaling participates in numerous n

179 phenotype caused by disruption of BMP10 and Neuregulin-1 (NRG1) signaling pathways, two central medi

180 hat treatment of cells with the ErbB3 ligand neuregulin-1 (NRG1) stabilizes the deubiquitinating enzy

181 In the developing PNS, axonal neuregulin-1 (NRG1) type III is the key determinant for

182 We now report that threshold levels of neuregulin-1 (NRG1) type III on axons determine their en

183 Neuregulin-1 (Nrg1), a member of the neuregulin family o

184 Neuregulin-1 (NRG1), a regulator of neural development,

185 Neuregulins (i.e. neuregulin-1 (NRG1), also called neu differentiation fac

186 We discovered that neuregulin-1 (NRG1), either as an isolated EGF-like doma

187 supported schizophrenia susceptibility gene, neuregulin-1 (NRG1).

188 ith autocrine production of the ErbB3 ligand neuregulin-1 (NRG1).

189 Neuregulin-1 (Nrg1)/erbB signaling regulates neuronal de

190 The growth factor neuregulin-1 (Nrg1, encoded by NRG1) is a key signalling

191 anges that enhance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-growth-factor) or CD44 (re

192 ion during the critical period downregulates neuregulin-1(NRG1)/ErbB4 signaling in PV neurons, causin

193 Accordingly, we have examined the effects of neuregulin-1 on myelination in neuron-Schwann cell cocul

194 ns that overexpress the Schwann cell mitogen neuregulin-1 or overexpress the epidermal growth factor

195 Neuregulin 1 (or NRG1, hereafter referred to as hereguli

196 ndothelial markers von Willebrand factor and neuregulin-1, or phosphorylation of the signal mediators

197 ite that turns out be highly conserved among neuregulin-1 paralogues.

198 Injection of beta-neuregulin-1 peptide into the brains of developing embry

199 BACE1-cleaved extracellular domain of axonal neuregulin-1, perhaps neuregulin-3 as well, binds to Sch

200 Taken together these data suggest that neuregulin-1 plays an important modulatory role in gliom

201 These results suggest that neuregulin-1 promotes both muscle cell differentiation i

202 During development, neuregulin-1 promotes Schwann cell proliferation and sur

203 caused by the conditional elimination of the neuregulin 1 receptor ErbB2 from muscle precursors.

204 toskeleton-associated protein (ARC), and the neuregulin 1 receptor ERBB4.

205 bB2, an integral member of the heterodimeric neuregulin-1 receptor, has been shown to be overexpresse

206 interaction prevents phosphorylation of beta-neuregulin-1 receptors and results in decreased cell pro

207 ace1 cleaves neuregulin-1 and that processed neuregulin-1 regulates myelination by means of phosphory

208 3 heterodimers and metalloprotease-dependent neuregulin 1 release, resulting in the activation of bot

209 Optimal binding to neuregulin-1 required eight or more heparin disaccharide

210 e turnover, but stimulation with full-length neuregulin 1 resulted in receptor degradation at rates t

211 nic mouse heart and show that treatment with neuregulin-1 results in electrophysiological changes in

212 utants precludes an analysis of hypothesized neuregulin-1 roles in later aspects of development.

213 Neuregulin-1 signaling molecules have various roles in t

214 te both the localization and potentiation of neuregulin-1 signaling.

215 Neuregulin 1 signalling is therefore an important factor

216 fetal lung fibroblast-conditioned media and neuregulin-1 stimulated erbB2 receptor phosphorylation i

217 PC3 prostate tumor cells suppresses EGF- and neuregulin-1-stimulated cell cycle progression.

218 gulin-1 but had no effect on the activity of neuregulin-1 that lacks the heparin-binding domain.

219 on is impaired by the prolonged elevation of neuregulin-1, the abnormality of which is a hallmark in

220 ocampal slices were chronically treated with neuregulin-1, the degradation of 2-arachidonoylglycerol

221 In the early phase following injury, axonal neuregulin 1 therefore promotes nerve repair, but at lat

222 Expression of type III neuregulin-1 (TIIINRG1) in induced pluripotent stem cell

223 elates with an enhanced ability of full-size neuregulin 1 to disrupt higher order oligomers of the ER

224 as two disaccharides were still able to bind neuregulin-1 to a lesser extent.

225 Addition of neuregulin-1 to cultures on MSC-1 feeder layers resulted

226 beta-Neuregulin-1 transcripts are expressed in the midbrain p

227 e found to express 100-fold higher levels of neuregulin-1 transcripts than MSC-1 cells.

228 Neuregulin 1 type III (NRG1 type III) is a major physiol

229 Neuregulin 1 type III (Nrg1III) and laminin alpha2beta1g

230 In the peripheral nervous system, axonal neuregulin 1 type III promotes myelination by activating

231 In addition, BACE1 cleaves neuregulin 1 type III, a protein critical for myelinatio

232 ociates with the BRG1 complex in response to neuregulin 1 type III.

233 toward local inhibition by overexpression of neuregulin-1 type 1 results in an absence of early L5b G

234 h length, as well as reports that PNS axonal neuregulin-1 type III regulates the initiation and prope

235 se cerebellar granule neurons the effects of neuregulin-1 (type I) are mediated by a homo-dimeric Erb

236 Full-length neuregulin-1 was increased and its cleavage product was

237 This inductive effect of neuregulin-1 was restricted to a window of sensitivity b

238 diffusible factors into the cardiac chamber, neuregulin-1 was shown to promote trabeculation of the v

239 Using the whole mouse embryo culture system, neuregulin-1 was shown to regulate lacZ expression withi

240 wever, by 3 months post-injury axons lacking neuregulin 1 were effectively remyelinated and virtually