ライフサイエンスコーパス: neuroectoderm

1 ities of wnt8 in patterning the mesoderm and neuroectoderm.

2 loss of epithelial structure of ectoderm and neuroectoderm.

3 erning of regional fates within the anterior neuroectoderm.

4 nic cardiac and skeletal muscle mesoderm and neuroectoderm.

5 itors (NMPs) into mesoderm at the expense of neuroectoderm.

6 Wnt1 expression by Six3 within the anterior neuroectoderm.

7 ndodermal inductive signals to the overlying neuroectoderm.

8 ptosis occurs in head mesenchyme and ventral neuroectoderm.

9 to regulate absolute cell numbers within the neuroectoderm.

10 ed by the patterning and segmentation of the neuroectoderm.

11 activation of Hh target genes in the ventral neuroectoderm.

12 ulates the anteroposterior patterning of the neuroectoderm.

13 g ectoderm, leading to expression of Ganf in neuroectoderm.

14 late, cardiac mesoderm, endoderm and ventral neuroectoderm.

15 ive to regulate pattern and cell fate in the neuroectoderm.

16 post-transcriptional control in epiblast and neuroectoderm.

17 -localized in a broad anterior region of the neuroectoderm.

18 reduction and subsequent posteriorization of neuroectoderm.

19 tiation and an expansion of undifferentiated neuroectoderm.

20 that specify cell fates in the mesoderm and neuroectoderm.

21 llel to specify dorsal mesoderm and anterior neuroectoderm.

22 r populations within specific regions of the neuroectoderm.

23 hing and sprouting of blood vessels into the neuroectoderm.

24 r, less likely, of the disorganized adjacent neuroectoderm.

25 in dorsoventral patterning in the Drosophila neuroectoderm.

26 g mesoderm as well as originating within the neuroectoderm.

27 aracteristics of the intermediate and dorsal neuroectoderm.

28 d (ptc) during the patterning of the ventral neuroectoderm.

29 nterior axial mesoderm, endoderm and ventral neuroectoderm.

30 centrations it stimulates differentiation to neuroectoderm.

31 fted with XFD-expressing ACs in the place of neuroectoderm.

32 e neural retina arise from a single layer of neuroectoderm.

33 , rather than at restricted locations of the neuroectoderm.

34 uring embryogenesis, in specific foci of the neuroectoderm.

35 o can perform both of these functions in the neuroectoderm.

36 stoderm embryo to oppose Dpp activity in the neuroectoderm.

37 d in a variety of human cancers derived from neuroectoderm.

38 inct from those arising within the segmental neuroectoderm.

39 ling controls self-patterning in ESC-derived neuroectoderm.

40 nomous requirement for Geminin in developing neuroectoderm.

41 trunk expression extending into somites and neuroectoderm.

42 hanism to define the ventral boundary of the neuroectoderm.

43 or binary cell fate decisions in the ventral neuroectoderm.

44 idline but in the median area of the ventral neuroectoderm.

45 rmed along the ventro-lateral surface of the neuroectoderm.

46 in the Drosophila dorsomedial protocerebral neuroectoderm.

47 in triggered differentiation of hESCs toward neuroectoderm.

48 AX6 promoter and improves differentiation to neuroectoderm.

49 ng from the underlying mesoderm and adjacent neuroectoderm.

50 , one of the earliest genes expressed in the neuroectoderm.

51 tional diversity after delamination from the neuroectoderm.

52 expression throughout the entire presumptive neuroectoderm.

53 l expression domains within the plane of the neuroectoderm.

54 ke overexpression of wnt8, posteriorizes the neuroectoderm, (2) sp5-like morpholino-mediated knockdow

55 at embryonic day (E)9.0 in the yolk sac and neuroectoderm; 2) at E10.5, CX3CR1 single-positive micro

56 t Wnt11R, a Wnt protein that is expressed in neuroectoderm adjacent to the NC territory, is required

57 protein, expressed initially in the ventral neuroectoderm adjacent to the ventral midline, in the do

58 Patterning the neuroectoderm along the anterior-posterior (AP) axis is

59 the dorso-ventral axis and patterning of the neuroectoderm along the anterior-posterior axis during g

60 ook also plays a crucial role to pattern the neuroectoderm along the DV axis.

61 oups of neural precursors segregate from the neuroectoderm and directly differentiate into neurons an

62 ells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro.

63 ias arising from the embryonic neural crest, neuroectoderm and endoderm.

64 roviding an instructive signal for posterior neuroectoderm and foregut endoderm and a permissive sign

65 embryos have increased cell death in ventral neuroectoderm and foregut endoderm, but normal cranial n

66 with reduced cell proliferation in forebrain neuroectoderm and frontonasal mesenchyme.

67 e earliest markers specific for the anterior neuroectoderm and it may play a role in forebrain develo

68 o-/- embryos that mostly consist of anterior neuroectoderm and lack posterior structures, thus resemb

69 the inductive interaction with the anterior neuroectoderm and LHX1 also regulates the expression of

70 Instead, Delta is required for neuroectoderm and mesectoderm formation; embryos missing

71 his negative-feedback loop imposes stasis in neuroectoderm and mesendoderm differentiation, thereby m

72 Cell lineage analyses showed that neuroectoderm and mesoderm along the secondary axis were

73 tion and prevents premature specification of neuroectoderm and mesoderm.

74 yos, Amer2 is expressed mainly in the dorsal neuroectoderm and neural tissues.

75 ish ventral, intermediate, and dorsal column neuroectoderm and neuroblasts, and a cell lineage marker

76 Vnd protein is restricted to ventral column neuroectoderm and neuroblasts; later it is detected in a

77 confocal and two-photon images of zebrafish neuroectoderm and paraxial mesoderm by comparing its res

78 een sog and dpp determines the extent of the neuroectoderm and subdivides the dorsal ectoderm into tw

79 ast, a tissue normally fated to give rise to neuroectoderm and surface ectoderm, in a serum-free, che

80 mitive streak act on the rostral prospective neuroectoderm and the latter gains potency (i.e., is spe

81 e the embryonic neural fields - the anterior neuroectoderm and the more posterior ciliary band neuroe

82 dline, in the dorsoventral patterning of the neuroectoderm and the neuroblasts.

83 ng neurulation to induce and regionalize the neuroectoderm and to produce the morphogenetic forces th

84 no additional signaling between NBs and the neuroectoderm and/or mesoderm is required to trigger the

85 at the early head-fold stage in the midline neuroectoderm, and consequently is an early marker for t

86 of precellular Drosophila embryos: mesoderm, neuroectoderm, and dorsal ectoderm.

87 ereby establishing the presumptive mesoderm, neuroectoderm, and dorsal ectoderm.

88 t that initiates separation of the mesoderm, neuroectoderm, and ectoderm.

89 ant regulator of dorsoventral pattern in the neuroectoderm, and indicate that Dichaete acts in concer

90 ponding intermediate region of the embryonic neuroectoderm, and is essential for the correct specific

91 n the medial and intermediate columns of the neuroectoderm, and mutant analysis indicates that Dichae

92 not Twist1, preferentially expressed in the neuroectoderm, and regulates beta-catenin-mediated gene

93 tterns in the ventral proneural clusters and neuroectoderm, and that its action in neuroblast formati

94 tor (bFGF) is an important growth factor for neuroectoderm- and mesoderm-derived cells.

95 help specify and pattern the early anterior neuroectoderm (ANE) in many deuterostomes.

96 Remarkably, the anterior neuroectoderm (ANE) of the deuterostome sea urchin embry

97 anterior definitive endoderm (ADE), anterior neuroectoderm (ANE), anterior mesendoderm (AME), headfol

98 late the specification and patterning of the neuroectoderm are incompletely understood.

99 s absence led to massive apoptosis in dorsal neuroectoderm around the FB-MB boundary and in a restric

100 igodendrocytes are widespread throughout the neuroectoderm as early as E10.5.

101 s also associated with limited growth of the neuroectoderm, as revealed by morphological observation,

102 d expression of mesoderm-associated, but not neuroectoderm-associated, genes.

103 PV.1 is expressed in the prospective neuroectoderm at the time of ectodermal fate determinati

104 Furthermore, in the embryonic neuroectoderm, Barbu expression is inducible by activate

105 am of wnt8 in patterning of the mesoderm and neuroectoderm because (1) overexpression of sp5-like, li

106 for the establishment of the sharp mesoderm/neuroectoderm boundary in the early embryo.

107 on and for the establishment of the mesoderm/neuroectoderm boundary, respectively.

108 the epiblast, axial mesendoderm and anterior neuroectoderm but not in the visceral endoderm.

109 able at the anterior edge of the presumptive neuroectoderm by 70% epiboly.

110 ose that boz specifies formation of anterior neuroectoderm by regulating BMP and Wnt pathways in a fa

111 le by molecular markers, is conferred on the neuroectoderm by signals from the endomesoderm that are

112 Here we investigate the subdivision of the neuroectoderm by three conserved homeobox genes, ventral

113 k stage (i.e., stage 3c/3+), the prospective neuroectoderm cannot self-differentiate (i.e. , express

114 rm cells examined, but not in any of the 165 neuroectoderm cells.

115 multiple regulatory nodes of hESC identity, neuroectoderm commitment and neurogenesis.

116 specification, and these changes heralded a neuroectoderm decision before any neural precursor marke

117 n achaete expression within the intermediate neuroectoderm demonstrates that each protein also has re

118 s issue of Immunity, Kang et al. report that neuroectoderm-derived astrocytes are the critical cellul

119 FGF-1) is a potent mitogen for mesoderm- and neuroectoderm-derived cell types in vitro.

120 is a mitogen for a variety of mesoderm- and neuroectoderm-derived cells, as well as an angiogenic fa

121 is a mitogen for a variety of mesoderm- and neuroectoderm-derived cells, as well as an angiogenic fa

122 However, targeted Act1 deficiency in neuroectoderm-derived CNS-resident cells resulted in mar

123 with no detectable contribution by migratory neuroectoderm-derived populations.

124 Two isoforms are specifically expressed in neuroectoderm-derived tissues, but not in tumors or canc

125 During vertebrate embryogenesis, the neuroectoderm differentiates into neural tissues and als

126 d endoderm, with a concomitant inhibition of neuroectoderm differentiation by Nodal itself.

127 Nanog in turn prevents neuroectoderm differentiation induced by FGF signalling

128 ishment of this molecular program in nascent neuroectoderm directly links early neural cell fate acqu

129 re among the earliest genes expressed in the neuroectoderm, dividing it into anterior and posterior d

130 transfer experiments using both endoderm and neuroectoderm donor cells, we have observed substantial

131 BMPs initially inhibit the formation of neuroectoderm during gastrulation while, within the neur

132 ectoderm and the more posterior ciliary band neuroectoderm - during development.

133 zygotically for the formation of the ventral neuroectoderm, endoderm, and prechordal plate.

134 In contrast, the rho neuroectoderm enhancer (NEE) does not discriminate betwe

135 In the multilayered neuroectoderm, epidermal precursors, neuroblasts and gan

136 from discrete subdomains of rhombencephalic neuroectoderm expressing Wnt1; that choroid plexus, a se

137 pattern which is rapidly replaced by strong neuroectoderm expression.

138 y for endoderm specification while promoting neuroectoderm factors.

139 neither of which is expressed in the dorsal neuroectoderm, failed to induce neural crest markers.

140 nsformation of intermediate to dorsal column neuroectoderm fate, and only 10% of the intermediate col

141 cerebral organoids (enCORs) display enhanced neuroectoderm formation and improved cortical developmen

142 rosa and dorsal epidermis, and also inhibits neuroectoderm formation.

143 s in endoderm, prechordal plate, and ventral neuroectoderm formation.

144 the mesendodermal lineage at the expense of neuroectoderm formation.

145 We propose that Sog protects the neuroectoderm from an invasive positive feedback loop cr

146 orsally limited by Bozozok, acts on anterior neuroectoderm from the lateral mesoderm to produce the A

147 l precursor groups (NPGs) segregate from the neuroectoderm generating the nervous system, whereas in

148 spatially co-localized with the prospective neuroectoderm immediately rostral to the primitive strea

149 e the earliest known markers for presumptive neuroectoderm in amphioxus.

150 The posteriorization of neuroectoderm in boz was correlated with ectopic dorsal

151 nd for conferring competence to the anterior neuroectoderm in responding to forebrain-, midbrain- and

152 The establishment of mesoderm and neuroectoderm in the early Drosophila embryo relies on i

153 xpression border separating the mesoderm and neuroectoderm in the early Drosophila embryo.

154 m the bilateral median domain of the ventral neuroectoderm in the last common ancestor of Mandibulata

155 zer formation and limits posteriorization of neuroectoderm in the late gastrula.

156 on, a complete failure of evagination of the neuroectoderm in the ventral diencephalon, and defects i

157 bulum, which is formed by evagination of the neuroectoderm in the ventral diencephalon.

158 OTX2 functions to specify the fate of neuroectoderm in various regions of the developing brain

159 hat expression of slp genes is lost from the neuroectoderm in wg mutants and that ectopic expression

160 y transcription factors expressed in nascent neuroectoderm, including Geminin and members of the Zic

161 rmation and the early development of ventral neuroectoderm, including the floor plate.

162 ripotent stem cells (PSCs) resembles in vivo neuroectoderm induction in the temporal course, morphoge

163 patterning genes that subdivide the ventral neuroectoderm into a grid-like structure.

164 tablished independent of the division of the neuroectoderm into an anterior Otx2-positive domain and

165 (en) allow one to subdivide the procephalic neuroectoderm into tritocerebral, deuterocerebral, and p

166 2-4 is inducing, rather than repressing, the neuroectoderm is a surprising difference that may be con

167 DV columnar homeobox gene expression in the neuroectoderm is an early, essential, and evolutionarily

168 ers including itself (autoactivation) in the neuroectoderm is blocked by sog.

169 Patterning of the prospective neuroectoderm is greatly perturbed in the mutant embryos

170 The Drosophila neuroectoderm is initially subdivided into three longitu

171 Msx, Nkx and Gsx families in the Drosophila neuroectoderm is not conserved between their homologues

172 The neuroectoderm is patterned along a rostral-caudal axis i

173 orming placode, a diffusible signal from the neuroectoderm is required for induction and/or maintenan

174 he induction of three intermediate lineages: neuroectoderm, lateral plate mesoderm and paraxial mesod

175 n which hPSCs were initially induced to form neuroectoderm, lateral plate mesoderm or paraxial mesode

176 conditional Porcn depletion in optic vesicle neuroectoderm, lens, and neural crest-derived periocular

177 nt cells are efficiently specified along the neuroectoderm lineage toward p75(+) Hnk1(+) Ap2(+) neura

178 Thus, distinct FSCs exist for the four neuroectoderm lineages, and dermal fibroblasts are not p

179 Posterior neuroectoderm markers are not expressed, presumably beca

180 Anterior neuroectoderm markers are widely expressed, at least in

181 ressing hESCs showed increased expression of neuroectoderm markers Sox1, Sox3, and Nestin.

182 progressively decreased, while expression of neuroectoderm markers was strongly upregulated, thus rev

183 otency marker genes and reduced induction of neuroectoderm markers.

184 ssed in a spatiotemporal specific pattern in neuroectoderm, mesoderm and gut endoderm during developm

185 corepressors and coactivator complexes onto neuroectoderm, mesoderm, and endoderm genes.

186 hat translation of Otx2 mRNA in epiblast and neuroectoderm might require a cell type-specific post-tr

187 was abnormal in embryos deficient in primary neuroectoderm (N lineage).

188 can be directed toward a mesendoderm (ME) or neuroectoderm (NE) fate, the first decision during hESC

189 llel, robust, and reproducible derivation of neuroectoderm, neural crest (NC), cranial placode (CP),

190 d immunostaining characteristics, resembling neuroectoderm, neural crest, ocular-surface ectoderm, or

191 helial cells, macrophages and microglia, and neuroectoderm (neurons, astrocytes, and oligodendrocytes

192 ither mesendoderm underlying the prospective neuroectoderm nor a morphologically normal node to provi

193 lf of the embryos prepared from transplanted neuroectoderm nuclei overexpressed the neuroectodermal m

194 ontrol, but mRNA translation in epiblast and neuroectoderm occurred only in otd(2FL) mutants.

195 development, neuroblasts delaminate from the neuroectoderm of each hemisegment in a stereotypic ortho

196 Notch signalling has diverged in the ventral neuroectoderm of insects and crustaceans accompanied by

197 Cell tracing experiments show that the neuroectoderm of Nodal-deficient embryos undergoes a rap

198 ssed in broad lateral stripes comprising the neuroectoderm of the Drosophila blastoderm embryo.

199 ryogenesis, ASPN is broadly expressed in the neuroectoderm of the embryo.

200 ngle domain protein already expressed in the neuroectoderm of the prevertebrate ancestor.

201 The neuroectoderm of the vertebrate gastrula was proposed by

202 Overexpression of Wnt-1 or Wnt-3a in the neuroectoderm of whole embryos led to a dramatic increas

203 ary neurogenesis, PCD takes place within the neuroectoderm of Xenopus embryos in a reproducible stere

204 huckebein expression in specific regions of neuroectoderm or neuroblasts.

205 nizer and the Notum deacylase in presumptive neuroectoderm orchestrate vertebrate brain development.

206 g the formation of a balanced rostral-caudal neuroectoderm pattern.

207 to provide precise spatiotemporal control of neuroectoderm patterning along its AP axis.

208 nockdown reduces the defects in mesoderm and neuroectoderm patterning caused by wnt8 overexpression,

209 d for proper anteroposterior axis formation, neuroectoderm patterning, and somitogenesis.

210 m, which become corneal epithelium and lens, neuroectoderm (posterior iris and ciliary body) and cran

211 In contrast, the regionalized neuroectoderm posterioriorization phenotype is selective

212 e G1, resulting in a switch from endoderm to neuroectoderm potential in pluripotent stem cells.

213 , single neural precursors are formed in the neuroectoderm, potentially supporting the Myriochelata h

214 neuroblast identities takes place within the neuroectoderm, prior to neuroblast delamination.

215 The Drosophila ventral neuroectoderm produces a stereotyped array of central ne

216 olates containing non-specified, prospective neuroectoderm provide an improved model system for analy

217 e report that Lhx5, expressed in the rostral neuroectoderm, regulates the local inhibition of Wnts.

218 ern neural and non-neural tissues within the neuroectoderm remain unknown.

219 neurogenic genes in the mesoderm and ventral neuroectoderm, respectively.

220 ventral, intermediate, and dorsal columns of neuroectoderm, respectively.

221 triking regional posteriorization within the neuroectoderm, resulting in a reduction in anterior fate

222 s of defined target genes in the presumptive neuroectoderm, resulting in their histone acetylation an

223 nts from the embryonic lateral telencephalic neuroectoderm reveal that exogenous BMP proteins (BMP4 a

224 with organizing activity and the prospective neuroectoderm rostral to the streak separate.

225 stem cell (ESC), we report that ESC-derived neuroectoderm self-generates a Six3(+) rostral and a Irx

226 ) are severely reduced, correlating with the neuroectoderm-specific expression phase of pou2.

227 fferentiation of hESCs to neuroepithelium, a neuroectoderm-specific subset of poised enhancers acquir

228 at overexpression of PV.1 in the prospective neuroectoderm specifically blocks neurogenesis in intact

229 The role of miRNAs in neuroectoderm specification is largely unknown.

230 ival of neural crest cells that arise at the neuroectoderm/surface ectoderm border, but not for their

231 toderm culminating in a lateral shift of the neuroectoderm/surface ectoderm border.

232 esult of reciprocal interactions between the neuroectoderm that forms the retina and surface ectoderm

233 ited Sonic hedgehog (Shh) signaling from the neuroectoderm then examined the molecular changes and th

234 neurogenesis: within distinct regions of the neuroectoderm, they are required both for neuroblast for

235 , immature neurons migrate radially from the neuroectoderm to defined locations, giving rise to chara

236 xperiments, we propose that Six3 acts in the neuroectoderm to establish a prepattern of bilateral rep

237 The competence of neuroectoderm to respond to anteriorizing signals declin

238 th posteriorizing signals and the ability of neuroectoderm to respond to them persist after this stag

239 ental events: migration from the rhombomeric neuroectoderm to the pharyngeal arches, proliferation as

240 t to define the specific contribution of the neuroectoderm to this inductive process in Xenopus.

241 These results suggest the use of a neuroectoderm-to-mesoderm signaling pathway in the speci

242 Importantly, epiblast and neuroectoderm translation of otd(2FL) mRNA rescued maint

243 he expression of three homeobox genes in the neuroectoderm-ventral nervous system defective (vnd), in

244 The retina, for example, develops from neuroectoderm via the optic vesicle, the corneal epithel

245 planar polarity of endogenous Vangl2 in the neuroectoderm was similarly redirected by an ectopic Wnt

246 chanisms for establishing and patterning the neuroectoderm, we cloned and determined the embryonic ex

247 In addition to changes in the forebrain neuroectoderm, we observed altered gene expression patte

248 TFAP2B, a transcription factor expressed in neuroectoderm, we studied eight patients with Char syndr

249 Markers of neuroectoderm were not upregulated during development of

250 that Sog diffuses dorsally from the lateral neuroectoderm where it is produced, and is cleaved and d

251 hord, in contrast to its effects on adjacent neuroectoderm where SHH expression is induced, represses

252 n within a zone of the mesoderm abutting the neuroectoderm, where Sna levels are graded.

253 NS development in DROSOPHILA: In the lateral neuroectoderm, where SoxNeuro is uniquely expressed, Sox

254 By contrast, in the medial neuroectoderm, where the expression of SoxNeuro and Dich

255 originate as neighboring cells from anterior neuroectoderm, which expresses genes orthologous to thos

256 n in hESCs begins by initiation of primitive neuroectoderm, which is manifested by rosette formation,

257 step, the Spemann gastrula organizer induces neuroectoderm with anterior character, followed by poste

258 nk reveals RALDH-2 mRNA both in mesoderm and neuroectoderm, with highest neuroectodermal expression i