ライフサイエンスコーパス: neuroectodermal

1 cases supports the hypothesis that a primary neuroectodermal abnormality and a secondary mesenchymal

2 erm-derived cell types as well as cells with neuroectodermal and endodermal characteristics, suggesti

3 gest that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions.

4 scaffold and differentiation of neighboring neuroectodermal and mesodermal cells.

5 tation were capable of differentiation along neuroectodermal and mesodermal lineages, whereas cells i

6 by aberrant expression of genes involved in neuroectodermal and myogenic differentiation, closely si

7 induced pluripotent stem cells (hiPSCs) into neuroectodermal and NC cells using either the MS5 cocult

8 sults show that Wg activity in the precursor neuroectodermal and neuroblast levels specify neuronal m

9 These cells expressed neuroectodermal and progenitor markers such as nestin, d

10 lar adhesion molecule and alpha-fetoprotein, neuroectodermal, and endodermal markers, respectively.

11 rential overexpression of several neural- or neuroectodermal-associated genes in synovial sarcomas re

12 response and were rapidly rejected, whereas neuroectodermal astrocytes demonstrated robust survival

13 so-ventral axis and the repositioning of the neuroectodermal borders.

14 es a subset of medulloblastomas, a malignant neuroectodermal brain cancer, and other cancers.

15 e TRAIL death pathway in childhood primitive neuroectodermal brain tumor (PNET), 8 human PNET cell li

16 e poliovirus receptor, Necl-5, in ectodermal/neuroectodermal cancers.

17 elegans Hox gene, egl-5, in a postembryonic neuroectodermal cell lineage.

18 rosophila CNS develops from three columns of neuroectodermal cells along the dorsoventral (DV) axis:

19 ted transgenic mice that overexpress MYCN in neuroectodermal cells and develop neuroblastoma.

20 ergent-extension movements characteristic of neuroectodermal cells and expressing appropriate genes s

21 nregulated in dysbindin/BLOC-1 deficiency in neuroectodermal cells and iPSC-derived human neurons, am

22 sion in distinct but overlapping clusters of neuroectodermal cells and neuroblasts, whereas the nucle

23 protein first detected in small clusters of neuroectodermal cells and then in a subset of neuroblast

24 differentiate into most mesodermal cells and neuroectodermal cells in vitro and into all embryonic li

25 est that oligodendrocytes are generated from neuroectodermal cells positioned throughout the rostroca

26 It is proposed that single-minded commits neuroectodermal cells to a midline fate, followed by a s

27 dose of XBF-1 promotes the proliferation of neuroectodermal cells while a low dose inhibits ectoderm

28 s of ENS progenitors with lineally unrelated neuroectodermal cells, the ordered colonization of the s

29 distinct from the effect of Rb deficiency in neuroectodermal cells.

30 hereas the Wnt(low) hESCs generate primarily neuroectodermal cells.

31 lin (betaT4) and has properties of primitive neuroectodermal cells.

32 ina, brain, and nonretinal tissues with some neuroectodermal components (all P < .01).

33 over-expressed in terminally differentiating neuroectodermal cultures derived from human embryonic st

34 s was strongly upregulated, thus revealing a neuroectodermal default mechanism for differentiation in

35 nti (IP) is an X-linked dominant disorder of neuroectodermal development.

36 S) cells overexpressing mTERT also initiated neuroectodermal differentiation efficiently, acquiring m

37 During onset of neuroectodermal differentiation in P19 embryonal carcino

38 rentiate into neuronal cells when exposed to neuroectodermal differentiation medium.

39 reprogramming process and that CHCHD2 primes neuroectodermal differentiation of hESCs and hiPSCs by b

40 ervous system during mouse embryogenesis and neuroectodermal differentiation of pluripotent P19 embry

41 D2, whose expression seems to correlate with neuroectodermal differentiation potential of pluripotent

42 Here we show that neuroectodermal differentiation stimulated by retinoic a

43 Neuroectodermal differentiation was triggered on stromal

44 SCs are inferior in their ability to undergo neuroectodermal differentiation.

45 Anterior pigmented neuroectodermal disorganization, dysgenesis of angle str

46 These functions separate mesendodermal and neuroectodermal domains by protecting cells against bein

47 e molecular markers that identify particular neuroectodermal domains, all neuroblasts or individual n

48 iver, pancreas, biliary tree, and associated neuroectodermal endocrine cells.

49 in mesoderm and neuroectoderm, with highest neuroectodermal expression in the ventral horn of the sp

50 ical development and reveal a novel role for neuroectodermal expression of Psen1 in development of th

51 ed fashion, reproducing part of the anterior neuroectodermal expression pattern of the endogenous Hox

52 was analyzed to distinguish mesodermal from neuroectodermal expression, we found that N-cadherin is

53 arly somite stage prior to the onset of Fgf8 neuroectodermal expression.

54 se embryo and was shown to promote posterior neuroectodermal fate by enhancing Smad2-activated wnt8 e

55 e embryos has the ability to induce anterior neuroectodermal fate in naive epiblast.

56 Directed differentiation toward a neuroectodermal fate revealed an extended progenitor pha

57 ediated burst in Snail1 expression regulates neuroectodermal fate while playing a required role in ep

58 equired to instruct cells to adopt a ventral neuroectodermal fate.

59 One of the functions of Snail is to repress neuroectodermal genes and restrict their expressions to

60 The derepression of the neuroectodermal genes into the ventral region in snail m

61 We found that different neuroectodermal genes respond differently in various sna

62 In V2 embryos, neuroectodermal genes, such as single-minded and rhomboi

63 cell fate requires the proper restriction of neuroectodermal genes, while the ventral cell movement i

64 ial cells even before the genesis of retinal neuroectodermal glia.

65 ntly arise in the brain and show features of neuroectodermal-like and glial-like tumors.

66 ese results suggest that Netrin-1 can induce neuroectodermal-like differentiation of human EC cells b

67 tion of RBP-Jkappa and p53 induces primitive neuroectodermal-like tumors in mice.

68 sducer of IL-17 receptor signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocyt

69 to affect cell survival primarily within the neuroectodermal lineages during somitogenesis, and secon

70 anted neuroectoderm nuclei overexpressed the neuroectodermal marker gene Sox2 to an excessive level i

71 Instead, we describe the neuroectodermal master modulator SOX10 and the oncogene

72 terdependent, sequential genetic programs in neuroectodermal (NE) cells, prior to the formation of ne

73 Ki-ras, an oncogene seldom altered in neuroectodermal neoplasms, is mutated in one third of th

74 and 10 differentiated), and 9 miscellaneous neuroectodermal neoplasms.

75 n, they reflect a primitive undifferentiated neuroectodermal/neural crest phenotype revealing a devel

76 exposed to stress and enhanced in tumors of neuroectodermal origin and in many neurodegenerative dis

77 icate PTPRD in the pathogenesis of tumors of neuroectodermal origin and, when taken together with oth

78 t tissue, small round blue cell neoplasms of neuroectodermal origin defined by the chromosomal aberra

79 he prototype of a family of tumors (ESFT) of neuroectodermal origin formed by small, round cells with

80 potential and induces development of various neuroectodermal origin tumors including medulloblastomas

81 ntly deleted or altered in certain tumors of neuroectodermal origin, it is important to define the sp

82 types as well as in certain neoplasms of non-neuroectodermal origin, such as malignant mesothelioma a

83 ibody scFv-FcC21, which recognized tumors of neuroectodermal origin, various types of carcinomas, mes

84 neural retina is mainly composed of cells of neuroectodermal origin.

85 FF is very effective against tumor cells of neuroectodermal origin.

86 is of several neoplasms, including tumors of neuroectodermal origin.

87 sing the CasBrE envelope protein in cells of neuroectodermal origin.

88 wth of a variety of cells of mesenchymal and neuroectodermal origin.

89 f a small blue cell-like tumor of epithelial/neuroectodermal origin.

90 r phenotype involving RPE and CE, tissues of neuroectodermal origin.

91 tivity typically are cells of mesodermal and neuroectodermal origin; in addition, expression of FGF-1

92 in mesenchymal cells of both mesodermal and neuroectodermal origins undergoing chondrogenesis, sugge

93 inputs is required to establish the precise neuroectodermal pattern of huckebein, which is subsequen

94 specific morpholino oligonucleotides altered neuroectodermal patterning, which could be rescued by ex

95 expression is responsible for the primitive neuroectodermal phenotype of EFT, we established a tetra

96 as the cells differentiate to endodermal or neuroectodermal phenotypes.

97 ic stem cells (hESCs) were differentiated to neuroectodermal precursors (NEP), but not to epidermal (

98 and the cytoskeleton, regulates polarity of neuroectodermal precursors and neurons, helping specify

99 ein that is abundantly expressed in eggs and neuroectodermal precursors during early development.

100 nd hCPe descend from the same pool of dorsal neuroectodermal progenitor cells of the rhombic lip.

101 ogenitor marker Gata4 and a strongly reduced neuroectodermal progenitor compartment.

102 during early gastrulation in the prospective neuroectodermal region of the epiblast and later in deve

103 Neuroectodermal signalling centres induce and pattern ma

104 ., flies and grasshoppers) revealed that the neuroectodermal size is conserved and originates similar

105 erentiation decreasing the expression of the neuroectodermal stem cell antigen, nestin, and up-regula

106 ssion of the intermediate filament nestin, a neuroectodermal stem cell marker, is linked to increased

107 In addition to expressing nestin, the neuroectodermal stem cell marker, retinal progenitors ar

108 os of this class show a reduction of ventral neuroectodermal structures and variable fusion of the ey

109 s, Porcn is required in both extraocular and neuroectodermal tissues to regulate distinct Wnt-depende

110 rmation, but they lack the ability to induce neuroectodermal tissues, a characteristic common to chor

111 s of patients with Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) metastatic to bone/bone

112 foci of yolk sac tumor (n = 21) or primitive neuroectodermal tumor (n = 2), whereas 50 had pure immat

113 pendymoma (n = 8), medulloblastoma/primitive neuroectodermal tumor (n = 4), glioblastoma multiforme (

114 m glioma (n = 7), medulloblastoma/peripheral neuroectodermal tumor (n = 6), ependymoma (n = 3), and p

115 ren treated for medulloblastoma or primitive neuroectodermal tumor (PNET) and document the associated

116 of Ewing's Sarcoma and peripheral Primitive Neuroectodermal Tumor (PNET) are associated with aberran

117 Medulloblastoma (MB) and primitive neuroectodermal tumor (PNET) are histologically similar

118 imaging of brain involvement with primitive neuroectodermal tumor (PNET) demonstrated mild hypometab

119 the Ewing sarcoma (ES)/peripheral primitive neuroectodermal tumor (PNET) family are pediatric cancer

120 with metastatic Ewing's sarcoma or primitive neuroectodermal tumor (PNET) of bone were entered onto a

121 loblastoma, central nervous system primitive neuroectodermal tumor (PNET), and astrocytoma before 6 y

122 medulloblastoma or supratentorial primitive neuroectodermal tumor (PNET).

123 c patients with medulloblastoma or primitive neuroectodermal tumor (PNET).

124 Ten of 20 (50%) patients (primitive neuroectodermal tumor (PNET)/medulloblastoma, three pati

125 genic (OS) and Ewing's (ES) and/or primitive neuroectodermal tumor (PNET)] sarcoma, treated with chem

126 mice to the human medulloblastoma/primitive neuroectodermal tumor (PNETs) in location, histologic ap

127 PR) in one patient with peripheral primitive neuroectodermal tumor (PPNET), and a minimal response (M

128 rentiated sarcoma, and soft tissue primitive neuroectodermal tumor at all sites except paratesticular

129 y SCLC cultures as well as in some primitive neuroectodermal tumor biopsies.

130 Using a human peripheral primitive neuroectodermal tumor cell line, SK-N-MC, we demonstrate

131 Neuroectodermal tumor cell lines derived from other site

132 The GD2 ganglioside expressed on neuroectodermal tumor cells has been used as a target fo

133 TF4 mediates ER stress-induced cell death of neuroectodermal tumor cells in response to fenretinide o

134 allmark of the Ewing's sarcoma and primitive neuroectodermal tumor family, encodes a fusion protein w

135 ntaining tumors, brain lymphoma or primitive neuroectodermal tumor make use of systemic administratio

136 ithout a bone sarcoma (ie, neither primitive neuroectodermal tumor nor osteosarcoma) (HR for PFS, 0.3

137 Ewing's sarcoma and primitive neuroectodermal tumor of bone are closely related, highl

138 n patients with Ewing's sarcoma or primitive neuroectodermal tumor of bone who had a relapse after st

139 ith nonmetastatic Ewing's sarcoma, primitive neuroectodermal tumor of bone, or primitive sarcoma of b

140 d or younger with Ewing's sarcoma, primitive neuroectodermal tumor of bone, or primitive sarcoma of b

141 or = 30 years with Ewing sarcoma, primitive neuroectodermal tumor or primitive sarcoma of bone were

142 We have analyzed a primitive neuroectodermal tumor sample exhibiting loss of heterozy

143 and Type II) are differentially expressed in neuroectodermal tumor tissue relative to differentiated

144 al teratoid/rhabdoid tumor and CNS primitive neuroectodermal tumor).

145 Among sarcomas, 21 of 21 Ewing's/primitive neuroectodermal tumor, 28 of 29 rhabdomyosarcomas, 28 of

146 eosarcomas, one Ewing sarcoma, one primitive neuroectodermal tumor, and one desmoplastic small round

147 hed GEM models of medulloblastoma, primitive neuroectodermal tumor, astrocytoma, oligodendroglioma, m

148 or medulloblastoma, supratentorial primitive neuroectodermal tumor, ependymoma, and rhabdoid tumors,

149 uld raise the suspicion of a renal primitive neuroectodermal tumor, in a young adult.

150 gene found in Ewing's sarcoma and primitive neuroectodermal tumor, is able to transform certain cell

151 lly Ewing's sarcoma and peripheral primitive neuroectodermal tumor, share a common class of tumor-spe

152 of the chest wall, and peripheral primitive neuroectodermal tumor.

153 stoma, choroid plexus carcinoma, and primary neuroectodermal tumor.

154 ade glioma, 32 had medulloblastoma/primitive neuroectodermal tumor/embryonal tumor, 17 had malignant

155 Primary renal primitive neuroectodermal tumor/extraskeletal Ewing's sarcoma (PNE

156 Ewings sarcoma and primitive neuroectodermal tumors (ES/PNET) are characterized by th

157 ma and 158 children diagnosed with primitive neuroectodermal tumors (PNET) in the United States and C

158 loped bilateral retinoblastoma and primitive neuroectodermal tumors (PNET) of the midbrain.

159 such as Ewing's sarcoma (EWS) and primitive neuroectodermal tumors (PNET), are highly aggressive mal

160 Primitive neuroectodermal tumors (PNETs) are a family of primary m

161 Primitive neuroectodermal tumors (PNETs) of the central nervous sy

162 Primitive neuroectodermal tumors (PNETs) of the central nervous sy

163 ions in medulloblastomas and other primitive neuroectodermal tumors (PNETs) of the childhood CNS we p

164 (HASH1) in cerebellar and cerebral primitive neuroectodermal tumors (PNETs), gliomas, and cell lines

165 neuroblastoma, pineoblastoma, and primitive neuroectodermal tumors (PNETs).

166 s to the development of cerebellar primitive neuroectodermal tumors (PNETs).

167 rade glioma and in two of six with primitive neuroectodermal tumors (PNETs)/ medulloblastoma.

168 hereas experimental supratentorial primitive neuroectodermal tumors (sPNET) correspond to atypical te

169 of a panel of human supratentorial primitive neuroectodermal tumors (sPNET) showed low activity of th

170 Ganglioside GD2 is highly expressed on neuroectodermal tumors and an attractive therapeutic tar

171 as found to be overexpressed in a variety of neuroectodermal tumors and described as an essential ang

172 involved in Ewing sarcoma, related primitive neuroectodermal tumors and desmoplastic small round cell

173 se (PR) in two patients with Ewing/primitive neuroectodermal tumors and included one PR and one minor

174 multilayered rosettes (ETMRs) are primitive neuroectodermal tumors arising in infants.

175 as, and cell lines derived from a variety of neuroectodermal tumors by Northern analysis and in situ

176 strates, in contrast to cells from primitive neuroectodermal tumors cells (n=6), which only migrated

177 with pathology consistent with grade III-IV neuroectodermal tumors in mice.

178 evidence for the development of inheritable neuroectodermal tumors induced by the human polyomavirus

179 One hallmark of Ewing's sarcoma/peripheral neuroectodermal tumors is the presence of the Ews/Fli-1

180 The neuroectodermal tumors neuroblastoma and melanoma repres

181 Primitive neuroectodermal tumors of the central nervous system (CN

182 a new approach to the treatment of primitive neuroectodermal tumors we evaluated the effect of the HM

183 ic animals that develop cerebellar primitive neuroectodermal tumors which model human medulloblastoma

184 ansformed with N-Myc, we generated primitive neuroectodermal tumors with divergent differentiation in

185 g of treatment: medulloblastoma or primitive neuroectodermal tumors, 57.8; germ cell tumors, 63.5; ep

186 of gliomas, central nervous system primitive neuroectodermal tumors, and atypical teratoid/rhabdoid-l

187 blastomas (MBs) and supratentorial primitive neuroectodermal tumors, and we report the outcome in the

188 ise Ewing's sarcoma and peripheral primitive neuroectodermal tumors, are highly aggressive and mostly

189 ingle cell type (two patients with primitive neuroectodermal tumors, five with undifferentiated RMS,

190 tem NSCs generated medulloblastoma/primitive neuroectodermal tumors, whereas forebrain NSCs developed

191 nificantly, CD155 is aberrantly expressed in neuroectodermal tumors.

192 g development and the expression of CD155 in neuroectodermal tumors.

193 nt of Ewing's sarcoma and related peripheral neuroectodermal tumors.

194 also thought to be etiological in primitive neuroectodermal tumors.

195 anslocation in Ewing's sarcoma and primitive neuroectodermal tumors.

196 creaticoblastomas and 1 of 10 with primitive neuroectodermal tumors.

197 eleted in neuroblastoma, melanoma, and other neuroectodermal tumors.

198 mmon mechanism in the causation of primitive neuroectodermal tumors.

199 the neuroblastic rosettes in human primitive neuroectodermal tumors.

200 neuroblastomas to Ewing's sarcoma/peripheral neuroectodermal tumors.

201 Since primitive neuroectodermal tumors/medulloblastomas (PNETs/medullobl

202 a) or malignant (rhabdomyosarcoma, melanotic neuroectodermal tumour of infancy).

203 of Rb/p53 or Rb/p53/PTEN generated primitive neuroectodermal tumours (PNET), indicating an important

204 from other brain tumours including primitive neuroectodermal tumours (PNETs), atypical teratoid/rhabd

205 motherapy, while in supratentorial primitive neuroectodermal tumours future treatment will be aimed a

206 In primitive neuroectodermal tumours prognostic biological markers ha

207 ing sarcoma and related peripheral primitive neuroectodermal tumours share recurrent translocations t

208 l phaeochromocytoma with a family history of neuroectodermal tumours.

209 l phaeochromocytoma with a family history of neuroectodermal tumours.