ライフサイエンスコーパス: neurofibrillary tangle

1 f tau oligomers at the expense of increasing neurofibrillary tangles.

2 did not demonstrate amyloid-beta plaques or neurofibrillary tangles.

3 d around the blood vessels, and formation of neurofibrillary tangles.

4 are inversely proportional to the number of neurofibrillary tangles.

5 turb cellular interactions and accumulate in neurofibrillary tangles.

6 aques, cerebral amyloid angiopathy (CAA) and neurofibrillary tangles.

7 n the complete absence of amyloid plaques or neurofibrillary tangles.

8 rized by the formation of senile plaques and neurofibrillary tangles.

9 horylated and aggregates into characteristic neurofibrillary tangles.

10 d yeast prion proteins, and Tau, which forms neurofibrillary tangles.

11 ation of hyperphosphorylated tau proteins in neurofibrillary tangles.

12 erphosphorylation that leads to formation of neurofibrillary tangles.

13 e in the formation of Alzheimer's-associated neurofibrillary tangles.

14 es, loss of neurons, and the accumulation of neurofibrillary tangles.

15 undant neuronal tau inclusions that resemble neurofibrillary tangles.

16 o those formed by tau protein in Alzheimer's neurofibrillary tangles.

17 by accumulation of amyloid beta (Abeta) and neurofibrillary tangles.

18 erphosphorylated tau, the major component of neurofibrillary tangles.

19 f beta-amyloid (Abeta) plaques and tau-laden neurofibrillary tangles.

20 cular pathologies: amyloid abeta1-42 and Tau neurofibrillary tangles.

21 ulation of beta-amyloid (Abeta) peptides and neurofibrillary tangles.

22 associated pathology of amyloid plaques and neurofibrillary tangles.

23 rotubule binding protein tau, a component of neurofibrillary tangles.

24 gical features including amyloid plaques and neurofibrillary tangles.

25 ized by beta-amyloid (Abeta) plaques and tau neurofibrillary tangles.

26 s, where it correlated with the abundance of neurofibrillary tangles.

27 ic neuronal somatic accumulations resembling neurofibrillary tangles.

28 tau) forms intracellular inclusions known as neurofibrillary tangles.

29 active inclusions were usually distinct from neurofibrillary tangles.

30 y pathological features: amyloid plaques and neurofibrillary tangles.

31 cerebral patterns of amyloid plaques and tau neurofibrillary tangles.

32 europathologic markers of senile plaques and neurofibrillary tangles.

33 be associated with increased risk for AD and neurofibrillary tangles.

34 amyloid-beta plaques and tau-immunoreactive neurofibrillary tangles.

35 , but not dementia, AD, neuritic plaques, or neurofibrillary tangles.

36 ion of tau, thus leading to the formation of neurofibrillary tangles.

37 ) peptide and the intracellular formation of neurofibrillary tangles.

38 ological hallmarks: amyloid-beta plaques and neurofibrillary tangles.

39 phorylation of Tau leads to the formation of neurofibrillary tangles, a hallmark of Alzheimer disease

40 ation of paired helical filaments (PHFs) and neurofibrillary tangles, a key neuropathological feature

41 egates of hyperphosphorylated tau protein in neurofibrillary tangles, a process that occurs late in t

42 Neurofibrillary tangles advance from layer II of the ent

43 PIB was also found to label neurofibrillary tangles, although the overall intensity

44 Alzheimer's disease (AD) is characterized by neurofibrillary tangles, amyloid plaques, and neurodegen

45 ium (never vs ever) and pathologic burden of neurofibrillary tangles, amyloid plaques, vascular lesio

46 euritic plaque, paired helical filaments tau neurofibrillary tangle and cerebral amyloid angiopathy r

47 y associated with age, presence of infarcts, neurofibrillary tangle and neuritic plaque scores, APOE

48 Alzheimer's disease (AD) is characterized by neurofibrillary tangle and neuropil thread deposition, w

49 es, which are proposed to contribute to both neurofibrillary tangles and amyloid plaque formation.

50 Early observations of the patterns of neurofibrillary tangles and amyloid plaques in Alzheimer

51 is pathologically characterized by tau-laden neurofibrillary tangles and beta-amyloid deposits.

52 ligomer formation precedes the appearance of neurofibrillary tangles and contributes to neuronal loss

53 oid precursor protein (APP), and presence of neurofibrillary tangles and dystrophic neurites containi

54 AD, p62 immunoreactivity is associated with neurofibrillary tangles and is involved in tau degradati

55 nantly associated with thioflavin-S-positive neurofibrillary tangles and less reactive in neuropil th

56 In Alzheimer disease (AD), deposition of neurofibrillary tangles and loss of synapses in the neoc

57 Tau immune-reactive neurofibrillary tangles and neuritic threads were presen

58 ody), an early precursor to the formation of neurofibrillary tangles and neurodegeneration of the kin

59 uorescent staining) pathological inclusions, neurofibrillary tangles and neuropil threads but only in

60 chemical stainings] pathological inclusions, neurofibrillary tangles and neuropil threads.

61 ntracellular aggregation and accumulation as neurofibrillary tangles and neuropil treads.

62 l pathological Tau inclusions in the form of neurofibrillary tangles and Pick bodies and in some case

63 athology in the form of neuropil threads and neurofibrillary tangles and pre-tangles.

64 esis of the two canonical Alzheimer lesions--neurofibrillary tangles and senile plaques--are present

65 red helical filaments in Alzheimer's disease neurofibrillary tangles and through mutations linking it

66 ce of other hallmarks of the disease such as neurofibrillary tangles and widespread neuronal losses.

67 al cortex (reflecting incidental age-related neurofibrillary tangles) and neuromelanin-containing neu

68 Alzheimer's pathology (neuritic plaques and neurofibrillary tangles) and the interval between time o

69 isease, such as altered Tau phosphorylation, neurofibrillary tangles, and accumulation of insoluble p

70 d estimates of the densities of Lewy bodies, neurofibrillary tangles, and aminergic neurons in the lo

71 ory, even after adjusting for Abeta plaques, neurofibrillary tangles, and APOE epsilon4.

72 including beta-amyloid (Abeta) plaques, tau neurofibrillary tangles, and cognitive deficits, suggest

73 decline, white matter damage, brain atrophy, neurofibrillary tangles, and dementia.

74 mulation of phosphorylated tau, formation of neurofibrillary tangles, and eventual neurodegeneration.

75 , including beta-amyloid senile plaques, tau neurofibrillary tangles, and fused in sarcoma (FUS) and

76 normalities, brain accumulation of Abeta and neurofibrillary tangles, and influence of apolipoprotein

77 ells and patient brains accumulate less tau, neurofibrillary tangles, and neuritic plaques, respectiv

78 opathological features of AD: Abeta plaques, neurofibrillary tangles, and neurodegeneration.

79 y pathologies in the brain: amyloid plaques, neurofibrillary tangles, and neuron loss.

80 of amyloid-beta (Abeta)-containing plaques, neurofibrillary tangles, and neuronal loss in the brain.

81 Besides senile plaques, neurofibrillary tangles, and neuronal loss, Alzheimer's

82 e (AD) include amyloid-beta (Abeta) plaques, neurofibrillary tangles, and reactive gliosis.

83 and progressively develops amyloid plaques, neurofibrillary tangles, and synaptic dysfunction.

84 sease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and widespread cortical neurona

85 Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks

86 Neuritic dystrophy with amyloid burden and neurofibrillary tangles are pathological hallmarks of Al

87 res of TDP-43 pathology, density of neuronal neurofibrillary tangles, area occupied by amyloid-beta p

88 en shown to produce hyperphosphorylated tau, neurofibrillary tangles as well as aberrant amyloid prec

89 nt-insoluble tau, neuronal loss and reverses neurofibrillary tangle-associated brain dysfunction.

90 ase domain-containing 6 expression ceases in neurofibrillary tangle-bearing pyramidal cells.

91 -1.34 to -0.04]), less severe and widespread neurofibrillary tangles (beta = -0.77 score units [95% C

92 racellular amyloid plaques and intraneuronal neurofibrillary tangles, both of which comprise highly i

93 of these "Abeta-negative" subjects have low neurofibrillary tangle Braak stages.

94 dance of these UFAs with neuritic plaque and neurofibrillary tangle burden as well as domain-specific

95 t to model the possibility that knowledge of neurofibrillary tangle burden in the presence of moderat

96 Cerebral neurofibrillary tangles burden, in addition to alpha-syn

97 e model that co-develops amyloid plaques and neurofibrillary tangles but also because it enabled us t

98 rotein, the primary constituent of Alzheimer neurofibrillary tangles, can form liquid droplets and th

99 brain volume ratio, and hippocampal volume), neurofibrillary tangles (cerebrospinal fluid phosphoryla

100 Amyloid plaques and neurofibrillary tangles co-occur in Alzheimer disease, b

101 loidosis, familial Danish dementia, in which neurofibrillary tangles coexist with extensive pre-amylo

102 Alzheimer disease (AD) include intraneuronal neurofibrillary tangles composed of abnormally hyperphos

103 ccumulation of amyloid-beta peptide leads to neurofibrillary tangles composed of aggregated hyperphos

104 nset Alzheimer-like dementia associated with neurofibrillary tangles composed of hyperphosphorylated

105 d beta peptide (Abeta) in brain is linked to neurofibrillary tangles composed of hyperphosphorylated

106 ining the amyloid-beta (Abeta) peptides, and neurofibrillary tangles composed of hyperphosphorylated

107 amyloid-beta (Abeta)-containing plaques and neurofibrillary tangles composed of hyperphosphorylated

108 Alzheimer's disease (AD) is the formation of neurofibrillary tangles composed of hyperphosphorylated

109 Neurofibrillary tangles composed of hyperphosphorylated

110 Neurofibrillary tangles, composed of hyperphosphorylated

111 Neurofibrillary tangles, composed of insoluble aggregate

112 yloid (Abeta) core and a neuritic component; neurofibrillary tangles, composed predominantly of hyper

113 zed by the intracellular accumulation of the neurofibrillary tangles comprised mainly of the microtub

114 the post-traumatic brain frequently exhibits neurofibrillary tangles comprised of aggregates of the p

115 many frontotemporal dementias (FTDs) contain neurofibrillary tangles comprised of hyperphosphorylated

116 n of insoluble protein aggregates, including neurofibrillary tangles comprised of tau in Alzheimer's

117 thologically by abundant amyloid plaques and neurofibrillary tangles concurrent with synaptic and neu

118 ic vesicles, hyperphosphorylated tau (pTau), neurofibrillary tangle conformational-epitope (cNFT), am

119 Ultrastructurally, the neurofibrillary tangles consisted of tau-immunoreactive

120 ther, the development of amyloid plaques and neurofibrillary tangles contributes to neuronal loss.

121 predominant, and typical AD--on the basis of neurofibrillary tangle counts in hippocampus and cortex

122 By comparison with typical AD, neurofibrillary tangle counts per 0.125 mm(2) in hippoca

123 Neurofibrillary tangle counts were performed using thiof

124 enuated the effect of the epsilon4 allele on neurofibrillary tangle density (interaction estimate, -0

125 hologically as increased neuritic plaque and neurofibrillary tangle density.

126 In addition to amyloid-beta plaque and tau neurofibrillary tangle deposition, neuroinflammation is

127 's disease via its presence in intraneuronal neurofibrillary tangle deposits, where it takes the form

128 otective mechanisms, such as the presence of neurofibrillary tangles, disconnection, as well as compe

129 Activated PSK is associated with neurofibrillary tangles, dystrophic neurites surrounding

130 (18)F]RO6958948)) with high affinity for tau neurofibrillary tangles, excellent selectivity against A

131 ampal insoluble pathological tau species and neurofibrillary tangles following a single dose of AAV-v

132 f Alzheimer's Disease (AD) in regard to both neurofibrillary tangle formation and neuronal network hy

133 rtantly, oligomer injections induced AD-type neurofibrillary tangle formation in the macaque brain.

134 cellular deposition of amyloid-beta (Abeta), neurofibrillary tangle formation, and a microglial-drive

135 in tau cause familial neurodegeneration and neurofibrillary tangle formation.

136 in the neocortex precedes the spread of tau neurofibrillary tangles from the limbic areas to the cor

137 se is characterized by amyloid-beta plaques, neurofibrillary tangles, gliosis, and neuronal loss.

138 k neuropathology of Alzheimer's disease (AD; neurofibrillary tangles) had its first foothold in speci

139 Prion-like seeding of amyloid fibrils and neurofibrillary tangles has been invoked to explain the

140 sitron emission tomography tracers targeting neurofibrillary tangles has enabled the distribution of

141 Recently, PET tracers for tau neurofibrillary tangles have become available and have s

142 comes hyper-phosphorylated and deposits into neurofibrillary tangles in AD.

143 s with the neurotoxicity of Tau, which forms neurofibrillary tangles in AD.

144 associated protein Tau, a major component of neurofibrillary tangles in Alzheimer disease and other t

145 merly (18) F-AV1451 or (18) F-T807) binds to neurofibrillary tangles in Alzheimer disease, but tissue

146 pathology including dystrophic neuritis and neurofibrillary tangles in Alzheimer's disease (AD) brai

147 ncluding Lewy bodies in Parkinson's disease, neurofibrillary tangles in Alzheimer's disease, polyQ in

148 PINK1 was absent in cortical Lewy bodies, in neurofibrillary tangles in Alzheimer's disease, progress

149 hich is associated with the neurotoxicity of neurofibrillary tangles in Alzheimer's disease.

150 ites has been implicated in the formation of neurofibrillary tangles in Alzheimer's disease; however,

151 to reduce the risk of AD and development of neurofibrillary tangles in APOE epsilon4+ individuals.

152 beta-amyloid (Abeta) protein deposits and/or neurofibrillary tangles in association with progressive

153 well as plaques (diffuse and neuritic), and neurofibrillary tangles in autopsy specimens from age-ma

154 which can further condense into higher order neurofibrillary tangles in neurons.

155 nd forms insoluble inclusion bodies known as neurofibrillary tangles in the brain tissue of patients

156 position of amyloid-beta (Abeta) plaques and neurofibrillary tangles in the brain, accompanied by syn

157 gically characterized by amyloid plaques and neurofibrillary tangles in the brain.

158 cally by the abundance of senile plaques and neurofibrillary tangles in the brain.

159 d, leading to the development of filamentous neurofibrillary tangles in the brain.

160 presence of amyloid beta (Abeta) plaques and neurofibrillary tangles in the brain.

161 typical AD, hippocampal-sparing AD has more neurofibrillary tangles in the cortex and fewer in the h

162 verity from focal perivascular epicentres of neurofibrillary tangles in the frontal neocortex to seve

163 reamyloid deposits, severe CAA, and abundant neurofibrillary tangles in the presence of remarkably fe

164 assessed the density and the distribution of neurofibrillary tangles in three cortical regions and tw

165 ptide (amyloid plaques) and the tau protein (neurofibrillary tangles) in the brains of affected indiv

166 and (or) association with senile plaques and neurofibrillary tangles is a major feature of several ne

167 Accumulation of tau into neurofibrillary tangles is a pathological consequence of

168 ntracellular tau to promote the formation of neurofibrillary tangle-like aggregates.

169 logical hallmark of Alzheimer's disease; the neurofibrillary tangle load correlates strongly with cli

170 ar plaques of amyloid-beta and intraneuronal neurofibrillary tangles made from tau are the histopatho

171 eptide forming extracellular senile plaques, neurofibrillary tangles made of hyperphosphorylated tau

172 stmortem studies have long demonstrated that neurofibrillary tangles made of hyperphosphorylated tau

173 ved from amyloid precursor protein (APP) and neurofibrillary tangles made of hyperphosphorylated Tau.

174 gyrus in THY-Tau22 mice, the development of neurofibrillary tangles made of mutant human tau was not

175 ques and markers to assess the burden of tau neurofibrillary tangles, neuritic plaques, alpha-synucle

176 hippocampal) and time interaction terms for neurofibrillary tangles, neuritic plaques, gross infarct

177 Neuropathologic outcomes included neurofibrillary tangles, neuritic plaques, microinfarcts

178 At this age point these mice exhibit neurofibrillary tangles, neurodegeneration and cognitive

179 ascade of events leading to the formation of neurofibrillary tangles, neurodegeneration, and the symp

180 tween the numbers of neuropil threads and of neurofibrillary tangles: neurofibrillary tangles were sp

181 dementia, characterized by amyloid plaques, neurofibrillary tangles, neuroinflammation, and neuronal

182 aque burden, stereologically-based counts of neurofibrillary tangles, neurons and reactive glia, and

183 measures for certain non-amyloid-plaque, non-neurofibrillary-tangle neuropathologies.

184 ressed human tau protein, the development of neurofibrillary tangles, neuropil threads and ghost tang

185 All had qualitative determination of neurofibrillary tangle (NFT) density.

186 Aberrant tau protein accumulation drives neurofibrillary tangle (NFT) formation in several neurod

187 an trigger increased tau phosphorylation and neurofibrillary tangle (NFT) formation in vivo, the mole

188 and facilitates amyloid plaque deposits and neurofibrillary tangle (NFT) formation, resulting in cog

189 gnaling and its relation to Abeta plaque and neurofibrillary tangle (NFT) pathology during disease on

190 inical diagnoses, apolipoprotein E genotype, neurofibrillary tangle (NFT) pathology, and vascular les

191 The study used Braak neurofibrillary tangle (NFT) stage, frequency of neuriti

192 is independently associated with lower Braak neurofibrillary tangle (NFT) stages and possibly fewer n

193 hallmarks: neurotoxic amyloid-beta (Abeta), neurofibrillary tangles (NFT), and extensive cell death.

194 Abeta-containing plaques and tau-containing neurofibrillary tangles (NFT), has not been thoroughly i

195 Neurofibrillary tangles (NFT), intracellular inclusions

196 k amyloid-beta (Abeta) plaques or tau-filled neurofibrillary tangles (NFT), is considered the most pr

197 e location of fibrillar tau deposits, called neurofibrillary tangles (NFT), matches closely with regi

198 are amyloid beta protein (Abeta) plaques and neurofibrillary tangles (NFT).

199 intracellular aggregation of tau protein in neurofibrillary tangles (NFTs) (1, 2).

200 osis is based on density and distribution of neurofibrillary tangles (NFTs) and amyloid-rich neuritic

201 cterized by brain pathology of intracellular neurofibrillary tangles (NFTs) and extracellular amyloid

202 by the production of amyloidogenic peptides, neurofibrillary tangles (NFTs) and neurodegeneration.

203 surrounding Abeta plaques (NP tau), AD-like neurofibrillary tangles (NFTs) and neuropil threads (NTs

204 Neurofibrillary tangles (NFTs) are a pathological hallma

205 Neurofibrillary tangles (NFTs) are a pathological hallma

206 Neurofibrillary tangles (NFTs) are one of the pathologic

207 Neurofibrillary tangles (NFTs) are the pathological hall

208 lzheimer's disease (AD) is very distinctive: neurofibrillary tangles (NFTs) composed of hyperphosphor

209 neurodegenerative diseases characterized by neurofibrillary tangles (NFTs) comprising filamentous ta

210 mer's disease (AD), cortical neurons develop neurofibrillary tangles (NFTs) consisting of hyperphosph

211 plaques containing beta-amyloid (Abeta) and neurofibrillary tangles (NFTs) consisting of modified ta

212 n (CBF) nucleus basalis (NB) neurons display neurofibrillary tangles (NFTs) during Alzheimer's diseas

213 formed by beta-amyloid peptides (Abeta) and neurofibrillary tangles (NFTs) formed by hyperphosphoryl

214 dicated the nApoE4CF Ab specifically labeled neurofibrillary tangles (NFTs) in AD frontal cortex sect

215 Neurofibrillary tangles (NFTs) in Alzheimer disease and

216 Accumulation of neurofibrillary tangles (NFTs) in Alzheimer's disease co

217 a microtubule-associated protein that forms neurofibrillary tangles (NFTs) in the selective vulnerab

218 e accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFTs) is a neuropathological ha

219 Tauopathies, characterized by neurofibrillary tangles (NFTs) of phosphorylated tau pro

220 Neurofibrillary tangles (NFTs) were counted in four brai

221 ion of the density and neocortical spread of neurofibrillary tangles (NFTs) with clinical AD disease

222 Neurofibrillary tangles (NFTs), a marker of neuronal alt

223 uggest that tau oligomers, which form before neurofibrillary tangles (NFTs), are the true neurotoxic

224 er's disease (AD), senile plaques (SPs), and neurofibrillary tangles (NFTs), but the specific contrib

225 Neurofibrillary tangles (NFTs), composed of truncated an

226 Neurofibrillary tangles (NFTs), hippocampal sclerosis, l

227 he hallmark pathology of amyloid plaques and neurofibrillary tangles (NFTs), it has been reported tha

228 functional brain protein that accumulates in neurofibrillary tangles (NFTs), most commonly in Alzheim

229 The formation of neurofibrillary tangles (NFTs), oxidative stress and neu

230 Aggregated tau is the major component of neurofibrillary tangles (NFTs), structures present in th

231 Aggregated tau is the major component of neurofibrillary tangles (NFTs), structures present in th

232 neurodegenerative diseases characterized by neurofibrillary tangles (NFTs), the predominant tau path

233 n tissue over co-existing tau aggregates and neurofibrillary tangles (NFTs), which are associated in

234 cal hallmarks of Alzheimer's disease (AD) is neurofibrillary tangles (NFTs), which are composed of ab

235 eimer's disease pathology is the presence of neurofibrillary tangles (NFTs), which are intracellular

236 ons, are defined by a pathological hallmark: neurofibrillary tangles (NFTs).

237 CMV antibody levels were associated with neurofibrillary tangles (NFTs).

238 her brain weight (BW) and Alzheimer lesions (neurofibrillary tangles [NFTs] or neuritic plaques [NPs]

239 bodies associated with Parkinson disease and neurofibrillary tangles observed in Alzheimer disease.

240 amyloid beta plaques, neuritic plaques, and neurofibrillary tangles observed in cortical biopsies ob

241 helical filaments (PHFs) that constitute the neurofibrillary tangles observed in neuronal cell bodies

242 th protein misfolding and aggregation as the neurofibrillary tangles of Alzheimer's disease, whereas

243 ase (AD) is characterized by the presence of neurofibrillary tangles of hyperphosphorylated, aggregat

244 ques and intracellular inclusions containing neurofibrillary tangles of phospho-Tau and intraneuronal

245 high levels of transition metal ions and the neurofibrillary tangles of Tau protein.

246 loid deposition as plaques and intracellular neurofibrillary tangles of tau protein.

247 Neurofibrillary tangles, one of the hallmarks of Alzheim

248 n Parkinson's disease (PD) and is present in neurofibrillary tangles or Lewy bodies.

249 s showed a lower frequency of Alzheimer-type neurofibrillary tangles (p < 0.05).

250 (p = 4.9 x 10(-4) ), an increased burden of neurofibrillary tangles (p = 9.1 x 10(-3) ), and an incr

251 with neuropathology (NIA ADC, Braak stage of neurofibrillary tangles, p = 3.9 x 10-6, and Consortium

252 sequences of amyloid-beta (Abeta) plaque and neurofibrillary tangle pathologies.

253 s12570088 were significantly associated with neurofibrillary tangle pathology (P = .01352 and .03151,

254 lysis can reliably track the distribution of neurofibrillary tangle pathology and can predict patholo

255 dentate gyrus of patients with AD and severe neurofibrillary tangle pathology and were accompanied by

256 Neurofibrillary tangle pathology in the form of Braak st

257 Calignon et al. recreated an early stage of neurofibrillary tangle pathology to show that tau aggreg

258 te widespread and established Ass plaque and neurofibrillary tangle pathology, hippocampal neural ste

259 ammatory signaling may promote or accelerate neurofibrillary tangle pathology, we explored the effect

260 s of Alzheimer's disease, including distinct neurofibrillary tangle pathology.

261 E genotype on incident AD and development of neurofibrillary tangle pathology.

262 nic AD mice exacerbates hallmark amyloid and neurofibrillary tangle pathology.

263 didate variants included neuritic plaque and neurofibrillary tangle pathology; longitudinal Alzheimer

264 During the development of AD, neurofibrillary tangles progress in a fixed pattern, sta

265 characterize the disease-senile plaques and neurofibrillary tangles-ramify systematically through th

266 with AD, including measures of amyloid load, neurofibrillary tangles, reactive astrocytes, and activa

267 ults in tau phosphorylation and formation of neurofibrillary tangles, requires the recruitment of the

268 , which aggregate to form senile plaques and neurofibrillary tangles, respectively, are induced to mi

269 e tau pathway-leading to amyloid plaques and neurofibrillary tangles, respectively, which are histopa

270 Disease neuritic plaque score and the Braak neurofibrillary tangle score, remained significant predi

271 endent negative associations of cerebral tau neurofibrillary tangles score with the interval between

272 re Sarkosyl-insoluble and associate with Tau neurofibrillary tangles selectively in Alzheimer disease

273 nd semiquantitative scores for the burden of neurofibrillary tangles, senile plaques, Lewy bodies (LB

274 Amyloid plaques and neurofibrillary tangles simultaneously accumulate in Alz

275 Each individual was also assigned a neurofibrillary tangle stage (B1-B3), relating to the li

276 ectroscopy metabolite measurements and Braak neurofibrillary tangle stage (Braak stage), neuritic pla

277 ow likelihood of having Alzheimer's disease (neurofibrillary tangle stage B1; n=37).

278 te likelihood of having Alzheimer's disease (neurofibrillary tangle stage B2; n=56), those with hippo

279 gh likelihood of having Alzheimer's disease (neurofibrillary tangle stage B3; n=205), those with hipp

280 AD cases with a Braak neurofibrillary tangle stage of more than IV were identi

281 We found that knowledge of neurofibrillary tangle stage, modeled as the sort of inf

282 psy data to evaluate the effect of different neurofibrillary tangle stages on the rates of progressio

283 by accumulation of amyloid-beta plaques and neurofibrillary tangles, synaptic and neuronal loss, and

284 sclerosis can cause the neuritic plaques and neurofibrillary tangles that define Alzheimer neuropatho

285 and tauopathies, tau protein aggregates into neurofibrillary tangles that progressively spread to syn

286 re the main components of senile plaques and neurofibrillary tangles, the two histopathological hallm

287 r disease (AD) and abnormally accumulates as neurofibrillary tangles; therefore, the pathways by whic

288 Further, the march of neurofibrillary tangles through brain circuits appears t

289 Despite the increase in neurofibrillary tangles, TIA1 reduction increased neuron

290 relative contribution of amyloid plaques and neurofibrillary tangles to brain dysfunction in Alzheime

291 Neurofibrillary tangles, tufted astrocytes, coiled bodie

292 defined on the basis of the distribution of neurofibrillary tangles: typical AD, hippocampal-sparing

293 visualized on coronal slabs, and plaques and neurofibrillary tangles were counted and standardized to

294 pants who died, and beta-amyloid (Abeta) and neurofibrillary tangles were identified by immunohistoch

295 opil threads and of neurofibrillary tangles: neurofibrillary tangles were sparse in brains that had n

296 in vivo imaging of beta-amyloid plaques and neurofibrillary tangles, were obtained from 12 AD patien

297 t bind to Abeta in both neuritic plaques and neurofibrillary tangles, whereas antibodies to material

298 eimer's disease are amyloid-beta plaques and neurofibrillary tangles, which are primarily composed of

299 ) is associated with the accumulation of tau neurofibrillary tangles, which may spread throughout the

300 in brains of Alzheimer's disease and diffuse neurofibrillary tangles with calcification, characterize