ライフサイエンスコーパス: neurofibromatosis 1

1 Lack of expression of neurofibromin in neurofibromatosis 1 and its lethal derivative, malignant

2 Neurofibromatosis 1 and neurofibromatosis 2 are autosoma

3 was to determine the diagnostic criteria for neurofibromatosis 1 and neurofibromatosis 2, recommendat

4 inical impact on the neurocutaneous diseases neurofibromatosis 1 and neurofibromatosis 2.

5 ete understanding of the molecular bases for neurofibromatosis 1 and neurofibromatosis 2.

6 diagnosis and treatment of individuals with neurofibromatosis 1 and neurofibromatosis 2.

7 Tuberous sclerosis complex and neurofibromatosis 1 are of special interest to the neuro

8 expression profiles of six sporadic and two neurofibromatosis 1-associated PAs with other tissues an

9 ession was also determined in KIT mutant and neurofibromatosis-1-associated GIST, and complex II acti

10 It is now known that neurofibromatosis-1-associated GISTs are SDHB-positive,

11 ated with neurofibromatosis 1 show a loss of neurofibromatosis 1 expression and high levels of Ras, b

12 n EVH [Ena/Vasp homology] domain 1) and NF1 (neurofibromatosis 1) genes underlie clinically related h

13 New data suggest that individuals with neurofibromatosis 1 have a 10% lifetime risk of developi

14 Neurofibromatosis 1 is a hereditary syndrome characteriz

15 in SDHB (n = 2), SDHD (n = 3), RET (n = 5), neurofibromatosis 1 (n = 1), and myc-associated factor X

16 The genes for neurofibromatosis 1, neurofibromatosis 2, and one of two

17 Neurofibromatosis 1, neurofibromatosis 2, and tuberous s

18 negative Ras-MAPK-ERK regulator linked to a neurofibromatosis 1 (NF-1)-like human syndrome; however,

19 viduals with two inherited cancer syndromes, neurofibromatosis 1 (NF1) and neurofibromatosis 2 (NF2),

20 Patients with neurofibromatosis 1 (NF1) are predisposed to develop mul

21 The tumour-suppressor gene Neurofibromatosis 1 (Nf1) encodes a Ras-specific GTPase

22 We have identified a protein isoform of the neurofibromatosis 1 (NF1) gene (neurofibromin) containin

23 The neurofibromatosis 1 (NF1) gene encodes a cytoplasmic pro

24 The neurofibromatosis 1 (NF1) gene has been implicated in as

25 gested that one of the targets of MMR is the neurofibromatosis 1 (NF1) gene.

26 he phosphatase and tensin homolog (Pten) and neurofibromatosis 1 (Nf1) genes recently were found to b

27 Individuals affected with neurofibromatosis 1 (NF1) harbor increased numbers of GF

28 Historically, neurofibromatosis 1 (NF1) has been inextricably linked w

29 arning to rut mutants, whereas expression of Neurofibromatosis 1 (NF1) in alpha/beta neurons is suffi

30 Whereas biallelic neurofibromatosis 1 (NF1) inactivation is observed in NF

31 of children develop PA in the context of the neurofibromatosis 1 (NF1) inherited tumor predisposition

32 Individuals with the neurofibromatosis 1 (NF1) inherited tumor syndrome devel

33 Neurofibromatosis 1 (NF1) is a common inherited disease

34 Although neurofibromatosis 1 (NF1) is a relatively common autosom

35 Neurofibromatosis 1 (NF1) is an autosomal dominant tumor

36 aches to mutation detection in mRNA from the neurofibromatosis 1 (NF1) locus have required the PCR am

37 >U RNA editing of neurofibromatosis 1 (NF1) mRNA changes an arginine (CGA)

38 Individuals affected with the neurofibromatosis 1 (NF1) tumor predisposition syndrome

39 Individuals with the neurofibromatosis 1 (NF1) tumor predisposition syndrome

40 Neurofibromatosis 1 (NF1), also known as von Recklinghau

41 c nerve gliomas) are closely associated with neurofibromatosis 1 (NF1), and allelic losses of the NF1

42 uals with the tumor predisposition syndrome, neurofibromatosis 1 (NF1), are prone to development of n

43 the inherited tumor predisposition syndrome, neurofibromatosis 1 (NF1), are prone to the development

44 dren with the tumor predisposition syndrome, neurofibromatosis 1 (NF1), develop optic pathway gliomas

45 s using cells derived from a murine model of neurofibromatosis 1 (NF1), Yang et al. dissect the molec

46 Individuals with the neurofibromatosis 1 (NF1)-inherited tumor predisposition

47 Children with neurofibromatosis-1 (NF1) are at risk for developing num

48 In this study, we used neurofibromatosis-1 (NF1) as a model system to elucidate

49 Inactivation of the neurofibromatosis-1 (NF1) gene de-regulates RAS and coop

50 To study the role of the neurofibromatosis-1 (NF1) gene in mammalian brain develo

51 In Drosophila, null mutations of the neurofibromatosis-1 (Nf1) gene produce abnormalities of

52 aracterized by inactivating mutations of the Neurofibromatosis-1 (NF1) gene that predisposes these pa

53 ious studies from our laboratories have used neurofibromatosis-1 (NF1) genetically engineered mouse (

54 We investigated the pathophysiology of neurofibromatosis-1 (NF1) in Drosophila melanogaster by

55 ommon clinical problems in children with the neurofibromatosis-1 (NF1) inherited cancer syndrome.

56 Neurofibromatosis-1 (NF1) is a common tumor predispositi

57 ma resulting from either inactivation of the neurofibromatosis-1 (Nf1) tumor suppressor gene or const

58 In this regard, mutational inactivation of neurofibromatosis-1 (NF1), tuberous sclerosis complex (T

59 somal dominant human disorder that resembles Neurofibromatosis-1 (NF1).

60 ients and are a major contributing factor to neurofibromatosis-1 patient mortality and morbidity.

61 yndrome, tuberous sclerosis complex 1 and 2, neurofibromatosis 1, phosphatase and tensin homolog, and

62 Such tumours associated with neurofibromatosis 1 show a loss of neurofibromatosis 1 e