ライフサイエンスコーパス: neurofilament protein

1 hemical profiles are similar with respect to neurofilament protein.

2 m and heavy molecular weight subunits of the neurofilament protein.

3 e flank of tadpoles expressing the truncated neurofilament protein.

4 histochemistry using antibodies specific for neurofilament protein.

5 hybrid cells were shown to synthesize human neurofilament protein.

6 muscle myosin heavy chains, connexin-42, and neurofilament protein.

7 arkers including neuron-specific enolase and neurofilament protein.

8 o histamine or an antibody to phosphorylated neurofilament protein.

9 g immunohistochemistry for nonphosphorylated neurofilament protein.

10 P, neuropeptide-Y, tyrosine hydroxylase, and neurofilament protein.

11 for immunohistochemistry with an antibody to neurofilament protein.

12 mmunoreactive to a neuron-specific probe for neurofilament protein.

13 ellular Ca signaling as well as two forms of neurofilament protein.

14 31) and nonphosphorylated (SMI 32) forms of neurofilament protein.

15 de Y (NPY), tyrosine hydroxylase (TH), and a neurofilament protein.

16 d precursor protein, and hyperphosphorylated neurofilament proteins.

17 ontained the middle and low molecular weight neurofilament proteins.

18 al caliber through phosphorylation of axonal neurofilament proteins.

19 l perikaryal accumulations of phosphorylated neurofilament proteins.

20 haracterized pathologically by deposition of neurofilament proteins.

21 enous Nes-S co-assembles with peripherin and neurofilament proteins.

22 ding glutamate receptors, cell adhesion, and neurofilament proteins.

23 Neurofilament protein accumulation was dependent on the

24 There was a selective loss of neurofilament proteins after exposure to 5 or 10 mM asco

25 lores the formation of intraneuronal tau and neurofilament protein aggregates using intracisternal ad

26 he major component of these lesions although neurofilament proteins also are present.

27 the two sets of projection neurons contained neurofilament protein, although the density and distribu

28 Degradation of the 68-kD neurofilament protein and internucleosomal DNA fragmenta

29 ers of neurons, as assessed by expression of neurofilament protein and of total cells, are present in

30 F-L 3'UTR, colocalizes with endogenous heavy neurofilament protein and, at high-level expression, lea

31 ow transport rates overlapping with those of neurofilament proteins and actin, both of which coimmuno

32 tes neuronal cytoskeletal proteins including neurofilament proteins and microtubule-associated protei

33 obleaching studies to reveal the movement of neurofilament proteins and other cytoskeletal proteins i

34 arge myelinated (by using antibodies against neurofilament protein) and small unmyelinated (by using

35 In the present study, neurofilament protein, and the calcium-binding proteins

36 ed by significant reduction in the levels of neurofilament proteins, and alterations in axonal fiber

37 mistry to detect APPs, beta-amyloid (Abeta), neurofilament proteins, and glial fibrillary acidic prot

38 ecific nuclear binding protein, intermediate neurofilament proteins, and parvalbumin.

39 xide synthase, nNOS) and a nonphosphorylated neurofilament protein (antibody SMI-32).

40 Our data show that alpha-internexin and the neurofilament proteins are functionally interdependent.

41 These data show that peripherin and the neurofilament proteins are functionally interdependent.

42 Neurofilament proteins are known to be transported along

43 Increases in non-phosphorylated neurofilament proteins are observed first, with phosphor

44 zed (NF-M) and heavy (NF-H) molecular weight neurofilament proteins, are highly phosphorylated in axo

45 Neurofilament proteins begin to aggregate by day 1 follo

46 analysis revealed significant inhibition of neurofilament protein breakdown by MP and other corticos

47 B(1) receptor and choline acetyltransferase, neurofilament proteins, calbindin, calretinin, synapsin

48 The expression of neurofilament protein, calretinin, and calbindin follows

49 tereologic estimates of the total numbers of neurofilament protein-containing layer IVB cells and Mey

50 V3 exhibited a more consistent proportion of neurofilament protein-containing neurons (70-80%), regar

51 ate cortex were marked by a lower density of neurofilament protein-containing neurons, which were vir

52 Long neurofilament protein-containing processes extended from

53 erved between somatodendritic morphology and neurofilament protein content.

54 loss of long cross-bridges with no change in neurofilament protein content.

55 Neurofilament protein distribution was a reliable tool f

56 and distribution of the total population of neurofilament protein-enriched neurons was very differen

57 ical features, including the distribution of neurofilament protein-enriched pyramidal neurons.

58 he monoclonal antibody SMI32, which labels a neurofilament protein found in pyramidal cells, is reduc

59 ry acidic protein (GFAP), keratocan, nestin, neurofilaments, protein gene product 9.5, tyrosine hydro

60 ) is involved in neurite outgrowth and human neurofilament protein H (hNF-H) Lys-Ser-Pro (KSP) tail d

61 calretinin, calbindin, and parvalbumin), and neurofilament proteins have been explored in the develop

62 HF tau, and high and medium molecular weight neurofilament proteins have significantly greater cross-

63 These results suggest that neurofilament protein identifies particular subpopulatio

64 eas V1, V2, V3, and V3A to area MT that were neurofilament protein-immunoreactive (57-100%), than to

65 performed an analysis of the distribution of neurofilament protein in corticocortical projection neur

66 We have investigated the axonal transport of neurofilament protein in cultured neurons by constrictin

67 rst demonstration of the axonal transport of neurofilament protein in cultured neurons.

68 l subtypes of plaques in Alzheimer brain and neurofilament protein in swollen neurites, like tau prot

69 rated the presence of phosphorylated tau and neurofilament proteins in neurofibrillary degeneration (

70 eight (NF-H) and low molecular weight (NF-L) neurofilament proteins in the 2 M urea extracts of spina

71 ssive degradation of both 68 kDa and 200 kDa neurofilament proteins in the cord lesion at intervals a

72 The extent of degradation of neurofilament proteins in the lesion following trauma wa

73 a-internexin also coassembles with all three neurofilament proteins into a single network of filament

74 the primate cerebral cortex have shown that neurofilament protein is present in pyramidal neuron sub

75 In young embryos (4-5 weeks old), neurofilament protein-labeled fibers run through the sub

76 ed the effects of both NGF and acrylamide on neurofilament protein levels and synthesis indicated tha

77 In PC12 cells, acrylamide increased neurofilament protein levels and synthesis.

78 g the low, middle, and high molecular weight neurofilament proteins, microtubule-associated protein 2

79 found that green fluorescent protein-tagged neurofilament proteins move predominantly in the form of

80 These data indicate that neurofilament protein moves anterogradely in these axons

81 the L5 DRG, identified by their staining for neurofilament protein (N52), did not change after ligati

82 teins such as cytokeratins 8, 13, and 18 and neurofilament proteins NF-L and NF-M.

83 h cytochrome oxidase (CO) histochemistry and neurofilament protein (NF) immunoreactivity and architec

84 Co-localization of the P2X3-ir neurons with neurofilament protein (NF) showed that the majority of t

85 immunocytochemistry using antibodies against neurofilament protein (NF), 5-HT to reveal descending se

86 d with antisera against substance P (SP) and neurofilament protein (NF).

87 Hyperphosphorylated high molecular weight neurofilament protein (NF-H) exhibits extensive phosphor

88 The high molecular weight neurofilament protein (NF-H) is highly phosphorylated in

89 y phosphorylated human high molecular weight neurofilament protein (NF-H) resulted in the identificat

90 f the Xenopus laevis middle-molecular-weight neurofilament protein (NF-M) into embryonic frog blastom

91 The distribution of middle-weight neurofilament protein (NF-M), an intermediate filament o

92 reased expression of middle molecular weight neurofilament protein (NF-M), and decreased expression o

93 compared effects on expression of the medium neurofilament protein (NF-M), the RNA for which binds hn

94 amined this issue with respect to the medium neurofilament protein (NF-M).

95 Neurofilament proteins (NF-Ps), particularly, NF-H, are

96 With the SMI-32 antibody against neurofilament protein (NFP) as a marker of the motion-se

97 ern analysis indicated degradation of 68 kDa neurofilament protein (NFP), a calpain substrate.

98 Qualitatively, there were phosphorylated neurofilament protein (NFP)-immunoreactive inclusions an

99 Neurofilament proteins (NFP) are intermediate filaments

100 uclear binding protein and nonphosphorylated neurofilament proteins (NFP-ir).

101 hanisms that might affect the degradation of neurofilament proteins (NFPs) were examined in the dista

102 Neurofilament proteins (NFPs), the cytoskeletal proteins

103 ic protein, GFAP), neuronal differentiation (neurofilament proteins, NFPs), and/or photoreceptor diff

104 describe the expression of nonphosphorylated neurofilament protein (NPNFP) in the human vestibular br

105 e pattern of expression of nonphosphorylated neurofilament protein (NPNFP) might define additional su

106 next examined the effects of this truncated neurofilament protein on development of the nervous syst

107 Mammalian neurofilament proteins, particularly midsized (NF-M) and

108 fibrillary acidic protein and a decrease in neurofilament protein, proteolipid protein, and several

109 trictions and a more gradual accumulation of neurofilament protein proximal to the constrictions.

110 d), and approximately 90% of the accumulated neurofilament protein remained in the axon after deterge

111 Axons immunolabeled for neurofilament protein show neuritic beading following Pb

112 oreactive to nNOS, and immunoreactivity to a neurofilament protein shows many labeled cells and fiber

113 We also noted that neurofilament protein SMI31 immunoreactivity was increas

114 een fluorescent protein (GFP) with the heavy neurofilament protein subunit (NFH).

115 uction, but completely inhibited NGF-induced neurofilament protein synthesis.

116 These include neurofilament proteins that constitute the stress-respon

117 se in the phosphorylation of NF-M subunit of neurofilament proteins that correlated with an up-regula

118 , a monoclonal antibody to nonphosphorylated neurofilament proteins that labels pyramidal neurons in

119 e are associated with abnormal aggregates of neurofilament protein, the disorganization of the axonal

120 we have measured the level of two mammalian neurofilament proteins, the 68-kDa NF-L and the 66-kDa N

121 Our results strongly suggest that efficient neurofilament protein transport in vivo minimally requir

122 mmunocytochemical staining for S100 protein, neurofilament protein, tyrosine hydroxylase, and protein

123 SMI-32, which recognizes non-phosphorylated neurofilament protein, we distinguished separate caudal,

124 ns of cultured neurons expressing GFP-tagged neurofilament protein were bleached by excitation with t

125 bule-associated protein 5 and phosphorylated neurofilament protein were used.

126 These data suggest that the neurofilament proteins were transported either as assemb

127 entin(+) SW13 cells, and with peripherin and neurofilament proteins when transfected into N2a cells.

128 ter injury there was 20% degradation of both neurofilament proteins while the breakdown of 68 kDa and

129 0 days of darkness also enhanced the loss of neurofilament protein within deprived dLGN layers.

130 ssible that the preferential distribution of neurofilament protein within feedforward connections to

131 e, and also reversed the significant loss of neurofilament protein within originally deprived dLGN la

132 increased neurofilament number and levels of neurofilament proteins without altering axon caliber.