ライフサイエンスコーパス: neurogenetic

1 e fundamental question posed by the field of neurogenetics.

2 age range and 102 patients with a variety of neurogenetic abnormalities.

3 ing technologies have begun to revolutionize neurogenetics, allowing the full spectrum of genetic var

4 functionality, providing a new paradigm for neurogenetic analyses of the mammalian retina in health

5 Neurogenetic and lesion studies have identified regions

6 ne of investigation, highly complementary to neurogenetic and molecular strategies, and holds promise

7 ent-of-origin-specific manner, can influence neurogenetic and psychiatric manifestations.

8 The availability of novel tools in molecular neurogenetics and increasingly sophisticated neuroimagin

9 nce, synaptogenesis and function, behavioral neurogenetics, and responses to neuronal injury.

10 yndrome (DS) is the most common example of a neurogenetic aneuploid disorder leading to mental retard

11 e challenges and highlight the benefits of a neurogenetics approach to understanding brain, behavior

12 Using an intermediate phenotypic neurogenetics approach, we assessed how stress and CRHR1

13 Cross-disorder comparison suggests that the neurogenetic architecture of schizophrenia-associated br

14 approaches to dissect conserved fundamental neurogenetic aspects of sleep.

15 ior, with implications for understanding the neurogenetic bases of WS as well as social anxiety.

16 ve useful for exposing and understanding the neurogenetic basis of normal and pathological human cogn

17 le approach that can be used to identify the neurogenetic basis of systems-level phenotypes.

18 Here, we deploy a combination of neurogenetic, behavioral, and physiological approaches t

19 rders, we analyzed patients in our pediatric neurogenetics clinic who underwent WES.

20 edigrees with bipolar disorder: the Clinical Neurogenetics (CNG) pedigrees (in which linkage to illne

21 Neurofibromatosis type 1 (NF1) is a common neurogenetic condition characterized by significant clin

22 Here we examine neurogenetic contributions to individual differences in

23 diagnostic tool as well as a teaching aid at Neurogenetics courses held at several African universiti

24 Thus, common norepinephrine-related neurogenetic differences enhance the subjective vividnes

25 rate allele-specific targeting of a dominant neurogenetic disease gene and suggest the broad therapeu

26 itionally, we investigated mice that mimic a neurogenetic disease known as Angelman syndrome.

27 s are a major clinical feature of the common neurogenetic disease neurofibromatosis type 1 (NF1).

28 dels of Duchenne muscular dystrophy (DMD), a neurogenetic disease typically caused by frame-shifting

29 The effect on global lesions of a neurogenetic disease was tested in the mouse model of MP

30 we begin by selecting fragile X syndrome, a neurogenetic disease with cognitive-behavioral manifesta

31 nd are increasingly implicated as a cause of neurogenetic disease.

32 ould represent an important cause of complex neurogenetic disease.

33 To evaluate FAAH genes as candidates for neurogenetic diseases in humans and mice, we have mapped

34 sive, multifocal, or even global (e.g., many neurogenetic diseases).

35 ion is increasingly recognized as a cause of neurogenetic diseases.

36 nervous system manifestations of a number of neurogenetic diseases.

37 Chromosome 22q11.2 deletion syndrome is a neurogenetic disorder associated with high rates of schi

38 Angelman syndrome (AS) is a neurogenetic disorder caused by deficiency of maternally

39 Lesch-Nyhan disease is a neurogenetic disorder caused by deficiency of the enzyme

40 Angelman syndrome (AS) is a neurogenetic disorder caused by deletion of the maternal

41 Tuberous sclerosis complex (TSC) is a neurogenetic disorder caused by loss-of-function mutatio

42 Fragile X syndrome (FXS) is an X-linked neurogenetic disorder characterized by a cognitive and b

43 ces in individuals with congenital amusia, a neurogenetic disorder characterized by abnormal pitch pe

44 sis type IV (MLIV) is an autosomal recessive neurogenetic disorder characterized by developmental abn

45 Angelman syndrome (AS) is a childhood-onset neurogenetic disorder characterized by functionally seve

46 Turner syndrome (TS) is a neurogenetic disorder characterized by impaired spatial,

47 Angelman syndrome (AS) is a neurogenetic disorder characterized by severe mental ret

48 Alpers' syndrome is a fatal neurogenetic disorder first described more than 70 years

49 Neurofibromatosis type 1 (NF1) is a common neurogenetic disorder in which affected children and adu

50 Fragile X syndrome is a neurogenetic disorder that is the most common known heri

51 study using heterogeneous ataxias as a model neurogenetic disorder to assess the introduction of next

52 CS represents a novel neurogenetic disorder with general relevance to autism,

53 ntington's disease (HD) is a fatal, dominant neurogenetic disorder.

54 = 58), other neurodegenerative, vascular, or neurogenetic disorders (n = 266), and controls with no s

55 More than 12 neurogenetic disorders are caused by unstable expansions

56 an syndrome (AS) are two clinically distinct neurogenetic disorders arising from a loss of expression

57 II subunits or tRNA processing factors cause neurogenetic disorders in humans, such as hypomyelinatin

58 DNA triplet repeat sequences (TRS) found in neurogenetic disorders may be due to abnormal DNA replic

59 a-hydroxybutyric aciduria) is one of the few neurogenetic disorders of GABA metabolism, and one in wh

60 rrier and target brain cells when applied to neurogenetic disorders such as ataxia-telangiecatasia (A

61 g to 128 mostly consanguineous families with neurogenetic disorders that often included brain malform

62 Neurogenetic disorders typically affect cells throughout

63 esis and provides a novel example of allelic neurogenetic disorders with differing gene expression pr

64 araplegia is a highly heterogeneous group of neurogenetic disorders with pure and complicated clinica

65 e of combinatorial ASOs for the treatment of neurogenetic disorders.

66 nervous system and are among the most common neurogenetic disorders.

67 they may contribute to our understanding of neurogenetic disorders.

68 lternative stem cell source for the study of neurogenetic disorders.

69 ntial of (RXRRBR)(2)XB-AMOs in A-T and other neurogenetic disorders.

70 rgic phenotype will contribute to the future neurogenetic dissection of information processing circui

71 tau) locus is one of the most remarkable in neurogenetics due not only to its involvement in multipl

72 ed the remarkable similarities between early neurogenetic events in vertebrates and invertebrates.

73 sent its use in a series of state-of-the-art neurogenetics experiments.

74 ovarian steroids in women, and may provide a neurogenetic framework for understanding neuropsychiatri

75 al to posteromedial gradient [the transverse neurogenetic gradient (TNG)].

76 Advances in human neurogenetics have begun to shed light on the genomic ar

77 Connectomics and neurogenetics have produced a surge in recent progress,

78 Our findings provide a new foundation for neurogenetic inquiries by revealing a robust and previou

79 At any time in the 7 d neurogenetic interval, a given PVE cell must know what c

80 opments in neuroimaging, neuropathology, and neurogenetics, many developmental disorders of the midbr

81 ployed to study the effects of genes and how neurogenetics may affect future radiology research and p

82 tion in linkage disequilibrium may provide a neurogenetic mechanism for BIN1 while further validating

83 across a range of anxiety disorders, but the neurogenetic mechanisms driving interindividual differen

84 We review these neurogenetic mechanisms in representatives of the differ

85 However, the neurogenetic mechanisms of these disorders are not well

86 genetic association but also of the broader neurogenetic mechanisms of variability in socioemotional

87 ts such as human temperament, the underlying neurogenetic mechanisms remain unclear.

88 ASD diagnostic criteria, but the underlying neurogenetic mechanisms remain unknown.

89 Moreover, they uncover neurogenetic mechanisms that bridge different neurodevel

90 ional genomic routes for dissecting critical neurogenetic mechanisms.

91 of autism spectrum disorder and is a unique neurogenetic model for testing theories about the brain

92 and D. melanogaster (a saprophytic fly and a neurogenetic model organism).

93 Zebrafish as a neurogenetic model system depends on the correct neuroan

94 Williams syndrome (WS) is a neurogenetic-neurodevelopmental disorder characterized b

95 songbirds advantageous for investigating the neurogenetics of learned vocal communication--a complex

96 recent progress in studies of the molecular neurogenetics of sexual differentiation and behaviour ha

97 Understanding the neurobiology and neurogenetics of social cognition and behavior has impor

98 Our results reveal a neurogenetic pathway mediating interindividual variabili

99 s in the heterotopia exhibit a "rim-to-core" neurogenetic pattern rather than the characteristic "ins

100 f cell division elapsed during the prolonged neurogenetic period of the monkey cortex, providing a ba

101 ession diminishes at the end of the cortical neurogenetic period, just before birth.

102 To determine whether other neurogenetic populations respond to peripheral bFGF, we

103 l Shh and Wnt expression may distinguish the neurogenetic potential of these structures.

104 lular factors exert proliferative effects on neurogenetic precursors in vivo.

105 An early neurogenetic program allocates the progeny of NSCs eithe

106 rallel or downstream of atonal to modify the neurogenetic program.

107 llenge of clinical relevance, we examine how neurogenetics research can identify novel therapeutic ta

108 ases) and 1,986 unaffected controls from the NeuroGenetics Research Consortium (NGRC).

109 milial PD) and 1544 non-familial PD from the NeuroGenetics Research Consortium (NGRC); an additional

110 for 2000 PD cases and 1986 controls from the NeuroGenetics Research Consortium GWAS and sequenced a s

111 In recent years, neurogenetics research had made some remarkable advances

112 Neurogenetics research has begun to advance our understa

113 Despite these advancements, neurogenetics research is currently confronted by three

114 By addressing these challenges, neurogenetics research is poised to exponentially increa

115 y be applied more broadly within behavioural neurogenetics research.

116 whereas Fgfr1 cKO failed to mount a cortical neurogenetic response.

117 of environmental cues, coordinating diverse neurogenetic signals.

118 high-resolution transcriptional baseline for neurogenetic studies of normal and abnormal human brain

119 s pave the way for anatomical and functional neurogenetic studies of sensory processing in mosquitoes

120 Neurogenetic studies with Drosophila have identified dis

121 an be measured in an assay useful for future neurogenetic studies.

122 Neuroimaging data from the Duke Neurogenetics Study (N=312) provide evidence of this SNP

123 Through an ongoing parent protocol, the Duke Neurogenetics Study, we measured threat-related amygdala

124 9.65+/-1.24 years) participating in the Duke Neurogenetics Study.

125 niversity students participating in the Duke Neurogenetics Study.

126 sortium is examining this highly informative neurogenetic syndrome phenotypically and genomically.

127 Aside from features associated with risk of neurogenetic syndromes in general (e.g., cognitive impai

128 Vestibular schwannomas, neurogenetic syndromes such as schwannomatosis and multi

129 We employed neurogenetic techniques to characterize neurons that inf

130 we define three challenges for the field of neurogenetics that we believe must be addressed to trans

131 Neurogenetic tools of Drosophila research allow unique a

132 Coupled with new and exciting neurogenetic tools, the near future promises an exciting

133 eeded to enable a complete dissection of the neurogenetic underpinnings of this universal fitness tra

134 er Primates evolved through lineage-specific neurogenetic variation.

135 Some individuals have a neurogenetic vulnerability to developing strong facilita

136 Overview of Neuron's special review issue on neurogenetics, we reflect on progress made over the last

137 Functional neuroimaging and behavioral neurogenetics will permit in-vivo correlations and conse