ライフサイエンスコーパス: neurogenic

1 he postnatal weeks, which was proposed to be neurogenic.

2 about the mechanism linking inflammation to neurogenic abnormalities.

3 Most of the neurogenic activity induced by PUFAs resulted in increas

4 this process is sustained by the persistent neurogenic activity of individual pallial neural stem ce

5 nt contributions by activating or inhibiting neurogenic activity with veratridine and tetrodotoxin, r

6 's disease patients, also suggests increased neurogenic activity.

7 Analysis of the neurogenic amines in the brains of workers that consumed

8 ETH inhibited Abeta-mediated suppression of neurogenic and Akt/Wnt/beta-catenin pathway gene express

9 letion extends the response and rescues both neurogenic and behavioral deficits in mice lacking TrkB.

10 Results also support both neurogenic and myogenic contributions of polyQ AR to sev

11 ifferentiate into multiple lineages, such as neurogenic and myogenic differentiations; they also disp

12 32 knockout mouse (T32KO) that displays both neurogenic and myopathic features.

13 thoroughly evaluated for their neurotrophic, neurogenic and neuroprotective potential in ex vivo prim

14 ay be eosinophilic and steroid-responsive or neurogenic and non- inflammatory.

15 Such a generator could be targeted to treat neurogenic and non-neurogenic ejaculatory disorders.

16 ear in the cases of the presumptive pigment, neurogenic and skeletogenic cells, all three of which re

17 We demonstrate Dmrt5 to be neurogenic, and reciprocally regulated by Lhx2: loss of

18 Based on these findings, we suggest that the neurogenic areas are in a position to be differentially

19 em cell niche, but whether vascular cells in neurogenic areas are intrinsically different from those

20 ein Sam68 (Khdrbs1) is strongly expressed in neurogenic areas of the neocortex and supports the self-

21 induced reporter expression within the main neurogenic areas, albeit to varying degrees depending on

22 d substantial reporter expression outside of neurogenic areas.

23 premature senescence of adult NSCs into non-neurogenic astrocytes in mice lacking alpha-SYN resemble

24 We hypothesized that in I/R, neurogenic ATP could degranulate juxtaposed MC and that

25 /GSSG) similar to MDs, human myopathies, and neurogenic atrophies.

26 The outlook for patients with neurogenic bladder has been transformed by a combination

27 ment, causing cardiac failure, diplegia, and neurogenic bladder.

28 ular cells from a neurogenic (V-SVZ) and non-neurogenic brain region (cortex) on the V-SVZ stem cell

29 We identified LLC in meningeal, cortical and neurogenic brain regions.

30 Loss of neurogenic capacity in mature MG is accompanied by reduc

31 However, by postnatal day 16, mouse MG lose neurogenic capacity, despite Ascl1 overexpression.

32 Non-neurogenic cell types, such as cortical astroglia and fi

33 opment and in the adult are intrinsic to the neurogenic cells themselves, the role of the microenviro

34 were presumptive pigment cells, presumptive neurogenic cells, presumptive skeletogenic cells, cells

35 ted Wnt signaling accompanying an incomplete neurogenic commitment.

36 enitors and identified RET as a regulator of neurogenic commitment.

37 In contrast, the neurogenic competence of Ink4a/Arf-deficient astroglia i

38 that enable specialized astrocytes to retain neurogenic competence throughout adult life are still po

39 roposed that factors necessary for providing neurogenic competence to Muller glia in fish and birds a

40 sses differentiation without affecting their neurogenic competence.

41 Here, we investigated neurogenic components involved in asthmatic-like attacks

42 inocycline is an effective therapy to modify neurogenic components of hypertension.

43 f NSI-189, a benzylpiperizine-aminiopyridine neurogenic compound for treating major depressive disord

44 f neuronal differentiation and moreover, for neurogenic compound identification and industrial high-c

45 f the neuronal differentiation program under neurogenic cue.

46 enic enhancement that attenuates age-related neurogenic decay has not been described.

47 YN and DA as potential targets to ameliorate neurogenic defects in the aging and diseased brain.SIGNI

48 knock-out mice show reversal of LPS-induced neurogenic deficits and microglial activation in vivo.

49 iR-155 is essential for inflammation-induced neurogenic deficits via microglial activation and induct

50 This finding suggests that neurogenic delay of selected RGCs may be unique to mamma

51 Neurogenic detrusor overactivity (NDO) is a well known c

52 Neurogenic detrusor overactivity (NDO) is among the most

53 numtoxinA have transformed the management of neurogenic detrusor overactivity.

54 sed proneural genes [neurogenin 2 (Ngn2) and neurogenic differentiation 1 (NeuroD1)] and a subset of

55 basic helix-loop-helix transcription factor, Neurogenic Differentiation Factor-6 (NEUROD6).

56 and electromyography, were consistent with a neurogenic disease.

57 outflow obstruction, diabetes mellitus, and neurogenic disturbances.

58 owed normal cell cycle progression, although neurogenic divisions were severely reduced.

59 e found that BC progenitors undergo terminal neurogenic divisions while in markedly disparate stages

60 cover the construction of the zebrafish otic neurogenic domain.

61 d by the G-C model, but may also result from neurogenic dysfunction.

62 ve clinical translation in future studies of neurogenic dysphagia.

63 EGFR is activated in the ventral midline and neurogenic ectoderm by the Spitz ligand, which is proces

64 oundary between the presumptive mesoderm and neurogenic ectoderm of early Drosophila embryos.

65 The sea star embryo initially has a pan-neurogenic ectoderm, but the genetic mechanism that dire

66 Surprisingly, the neurogenic ectoderm, not the ventral midline, was found

67 ing activity from the ventral midline to the neurogenic ectoderm.

68 ibition of GPR40 was capable of reducing the neurogenic effect of a PUFA, while the inhibition of BDN

69 The neurogenic effect of Wnt agonists on ENS progenitors sup

70 This neurogenic effect was more pronounced after high-thoraci

71 thways effectively blocked the mitogenic and neurogenic effects of ETH.

72 nted both anxiolytic/antidepressant-like and neurogenic effects of fluoxetine, indicating that 5-HT(4

73 mg/kg/day) could prevent the behavioral and neurogenic effects of fluoxetine.

74 The neuroprotective and neurogenic effects of NPY-apoB appeared to involve signa

75 can lead to olfactory deficits and that the neurogenic effects of selective serotonin reuptake inhib

76 Microglia have proliferative and neurogenic effects on NSCs, which are significantly alte

77 myloid-beta (Abeta), and proinflammatory and neurogenic effects.

78 SF) was chosen, due to its clinically proven neurogenic effects.

79 ould be targeted to treat neurogenic and non-neurogenic ejaculatory disorders.

80 Neurogenic enhancement by VEGF preconditioning was, in p

81 onditioning might be harnessed for long-term neurogenic enhancement despite continued exposure to an

82 a factor capable of inducing a long-lasting neurogenic enhancement that attenuates age-related neuro

83 igher dose converted most of the embryo to a neurogenic epithelial sphere expressing the Hnf6 ciliary

84 that the dog may be better representative of neurogenic events in humans, compared with rodents.

85 tential therapeutic target for reversing the neurogenic exhaustion characteristic of the aged OE.

86 elial cells, and identify Decorin as a novel neurogenic factor in the central nervous system.

87 strate a novel function of Dmrt5/Dmrta2 as a neurogenic factor in the developing hippocampus.

88 cerebrospinal fluid and endothelial-derived neurogenic factor requiring biallelic expression, with m

89 We show that Dmrt5, as well as known neurogenic factors Neurog2 and Pax6, can each not only m

90 In the absence of neurogenic factors, the effective substrata produce neur

91 he oral apical CB, located within the apical neurogenic field; (2) the animal lateral CB, which bilat

92 ribe potential overlap between myopathic and neurogenic findings in this family.

93 differentiation 1 (NeuroD1)] and a subset of neurogenic genes [e.g., SRY-box 21 (Sox21), brain-derive

94 eneration, axolotl neural stem cells repress neurogenic genes and reactivate a transcriptional progra

95 h factor has opposing effects on established neurogenic genes Neurog2 and Pax6 Dmrt5 is known to supp

96 PCs impaired the activation of proneural and neurogenic genes, resulting in increased neuroblast deat

97 d off were rich in transcription factors and neurogenic genes.

98 RATIONALE: Neurogenic hypertension is characterized by an increase

99 esting that enhanced sympathetic activity in neurogenic hypertension is, at least in part, dependent

100 Why sympathetic activity rises in neurogenic hypertension remains unknown.

101 athy induced by carotid body overactivity in neurogenic hypertension that may contribute to sympathet

102 tem have been involved in the development of neurogenic hypertension, the contribution of ADAM17 has

103 system may be beneficial in the treatment of neurogenic hypertension.

104 ovel therapeutic target for the treatment of neurogenic hypertension.

105 m contributing to neurohumoral activation in neurogenic hypertension.

106 rylation level may be effective for treating neurogenic hypertension.

107 h for reducing sympathetic vasomotor tone in neurogenic hypertension.

108 s and elevated sympathetic vasomotor tone in neurogenic hypertension.

109 ratory modulation of sympathetic activity in neurogenic hypertension.

110 egions is a hallmark of neuroinflammation in neurogenic hypertension.

111 l respiratory drive or during development of neurogenic hypertension.

112 halamus and suggests new strategies to treat neurogenic hypertension.

113 ng to a loss in compensatory activity during neurogenic hypertension.

114 hat age-matched fluids promote Sox2-positive neurogenic identity in developing forebrain and olfactor

115 e investigate whether a secondary functional neurogenic immune deficiency (spinal cord injury-induced

116 rom other animal genomes in their content of neurogenic, immune and developmental genes.

117 Continual neurogenic increase over several months was not accompan

118 P) channels of nociceptive neurons to induce neurogenic inflammation and pain.

119 red ligand that excites nociceptors, causing neurogenic inflammation and pain.

120 ential vanilloid 1 (TRPV1) activation causes neurogenic inflammation and plays an important role in a

121 ation elicits robust pain behaviours without neurogenic inflammation and produces profound hypersensi

122 he periphery and these signals can result in neurogenic inflammation in the innervated tissue.

123 f trigeminal pain fibers by capsaicin evokes neurogenic inflammation in the surrounding epithelium.

124 ere, we show that an acupoint is one form of neurogenic inflammation on the skin.

125 conduction of these spikes may contribute to neurogenic inflammation while orthodromic (centripetal)

126 skin (neurogenic spots), caused by cutaneous neurogenic inflammation, in the dermatome that overlaps

127 fense, drug-induced anaphylactoid reactions, neurogenic inflammation, pain, itch, and chronic inflamm

128 n in sensory nerve endings can contribute to neurogenic inflammation.

129 s are important mediators of pain, itch, and neurogenic inflammation.

130 uous airway inflammation, a process known as neurogenic inflammation.

131 RPA1 antagonists hold potential for treating neurogenic inflammatory conditions provoked or exacerbat

132 byproducts produces AIMSS-like behaviors and neurogenic inflammatory responses in mice.

133 ted with internal organs may be identical to neurogenic inflammatory spots on the skin, which are pro

134 us the periphery, and targeted inhibition of neurogenic innervation limits post-stroke infection.

135 enteric glia significantly contribute to the neurogenic ion transport while glial activity does not a

136 an extent equal to the direct activation of neurogenic ion transport with veratridine and glial driv

137 an extent equal to the direct activation of neurogenic ion transport.

138 T2+/-) /Cx43(f/f) mice significantly reduced neurogenic ion transport.

139 suppression was sufficient to rescue poorly neurogenic iPSC lines.

140 We show that the adult hippocampal neurogenic lineage is critically dependent on the mitoch

141 enesis in vivo and the cell types within the neurogenic lineage that might depend on FGFs remain uncl

142 More recently, other substrates, such as neurogenic locus notch homolog (Notch), have been found

143 The neurogenic locus notch homolog protein (Notch)-2 recepto

144 Lower levels of laminin and neurogenic locus notch homolog protein 1 but higher expr

145 No other changes in other neurogenic markers were observed in either of the neurog

146 rive from the neural crest, express numerous neurogenic markers, and mediate neurite outgrowth and ax

147 ibution of erythema and telangiectasia, less neurogenic mast cell activation, and less MMP-mediated m

148 fibers may themselves drive inflammation via neurogenic mechanisms.

149 sion, which appears to rely on sodium-driven neurogenic mechanisms.

150 ed hypoxia within the SGZ contributes to the neurogenic microenvironment and determines the early, ac

151 al differences between the G-C model and the neurogenic model regarding mechanisms regulating sodium

152 ll refer to this computational model as the 'neurogenic model'.

153 on of motor nerves, as a process to mitigate neurogenic muscle atrophy.

154 r's hereditary optic neuropathy (LHOND), and neurogenic muscle weakness, ataxia, and retinitis pigmen

155 f the mouse mutant mdf, which is affected by neurogenic muscular atrophy, progressive gait ataxia wit

156 HPSE2 mutations were absent in 23 non-neurogenic neurogenic bladder probands and, of 439 famil

157 ish a causal role for JNK in the hippocampal neurogenic niche and anxiety behaviour, and advocate tar

158 is functionally relevant for maintaining the neurogenic niche as inducible, NSPC-specific loss of VEG

159 abeled hemocytes, labeled cells populate the neurogenic niche containing the first-generation neurona

160 s that couples dynamic brain activity to the neurogenic niche in controlling NSC quiescence and hippo

161 Moreover, the number of cells composing the neurogenic niche in crayfish is tightly correlated with

162 The neurogenic niche is a melting pot of cells and factors t

163 Increasing evidence indicates that the adult neurogenic niche of the ventricular-subventricular zone

164 ntral nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by

165 Sox2 signaling pathway as a key component of neurogenic niche sensing, contributing to the regulation

166 contacts with the cellular components of the neurogenic niche that may play a crucial role in the reg

167 cumulation of apoptotic newborn cells in the neurogenic niche that was due not to decreased survival

168 in crayfish, hemolymph-derived cells enter a neurogenic niche to replenish neural progenitors.

169 of non-neural cells that participate in the neurogenic niche, highlighting how cells of different em

170 newborn neurons within the adult hippocampal neurogenic niche, respectively.

171 As a neurogenic niche, the hippocampus supports pronounced L1

172 ndings suggest that in the adult hippocampal neurogenic niche, where the excess of newborn cells unde

173 the path followed by newborn neurons in the neurogenic niche.

174 bventricular zone (SVZ), the major postnatal neurogenic niche.

175 (ChAT)(+) neurons residing in the rodent SVZ neurogenic niche.

176 f the amphibian retina, a well-characterised neurogenic niche.

177 Adult neurogenic niches are present in both vertebrates and in

178 Adult neurogenic niches harbor quiescent neural stem cells; ho

179 Differences between neurogenic niches in the phase and degree of S-phase ent

180 enes, suggesting regional differences in the neurogenic niches in the telencephalon.

181 Common to neurogenic niches located in diverse brain regions is da

182 the cell division cycle (CDC) in 5 of the 16 neurogenic niches of adult brain, the dorsal telencephal

183 NCE STATEMENT This study establishes that in neurogenic niches of an adult diurnal vertebrate, the ce

184 We conclude that, in neurogenic niches of an adult diurnal vertebrate, the ci

185 ngly expressed in ependymal cells located in neurogenic niches revealed by the BLBP and PCNA immunost

186 o decreased brain cell proliferation in most neurogenic niches throughout the forebrain and the midbr

187 in the subventricular zone and dentate gyrus neurogenic niches were evaluated using single and double

188 by the lack of dopamine in one of the adult neurogenic niches, the SVZ.

189 echanisms or by modifying the environment of neurogenic niches, with daily variation in growth factor

190 genic markers were observed in either of the neurogenic niches.

191 implicated in the control of gene dosage in neurogenic niches.

192 arly aspects of the disease can be caused by neurogenic or myogenic mechanisms, we made use of the te

193 Consistent with a neurogenic origin of these phenotypes, neuron-specific d

194 rtensive therapy in patients with coexistent neurogenic orthostatic hypotension and supine hypertensi

195 ist for outcomes in patients with coexistent neurogenic orthostatic hypotension and supine hypertensi

196 ndividual risks for patients with coexistent neurogenic orthostatic hypotension and supine hypertensi

197 Neurogenic orthostatic hypotension and supine hypertensi

198 otential immediate benefits of treatment for neurogenic orthostatic hypotension and the long-term ris

199 Whereas neurogenic orthostatic hypotension poses risks for falls

200 e, and therapeutic requirements for managing neurogenic orthostatic hypotension that manifests with f

201 degree of supine hypertension when treating neurogenic orthostatic hypotension; the effectiveness of

202 ad antinociceptive activity in both phase 1 (neurogenic pain) and phase 2 (inflammatory pain) of the

203 lin-induced tonic pain, in capsaicin-induced neurogenic pain, and notably in oxaliplatin-induced neur

204 These results suggests that non-neurogenic, parenchymal structural plasticity might be m

205 els at which this influence occurs and which neurogenic pathways are involved are not well defined.

206 with at least 694 common targets in multiple neurogenic pathways.

207 ortical progenitors and in the length of the neurogenic period during development.

208 es here provide mechanistic support that the neurogenic period indeed may be a window of vulnerabilit

209 Upon entry into the neurogenic phase, individual RGPs produce ?8-9 neurons d

210 gh SARA knockdown did not lead to detectable neurogenic phenotypes, SARA-suppressed neurons exhibited

211 CAG expansions and characteristic SBMA-like neurogenic phenotypes.

212 m cell lines exhibited reproducible aberrant neurogenic phenotypes.

213 However, the evolutionary origins of neurogenic placodes have remained obscure owing to a pau

214 he sudden appearance of the neural crest and neurogenic placodes in early branching vertebrates has p

215 ral cranial sensory ganglia originating from neurogenic placodes, such as the nodose ganglion, failed

216 erentiate to form the mammalian brain, while neurogenic placodes, which generate cranial sensory neur

217 ical neurons, but factors that control their neurogenic plasticity remain elusive.

218 tegrity of NSCs, which is critical for their neurogenic potency.

219 , a subset of self-renewing progenitors lack neurogenic potential during the earliest phase of cortic

220 hNSCs) and human mesenchymal stem cells with neurogenic potential from umbilical cord (UC-MSCs) and p

221 equired for stemness and the preservation of neurogenic potential in concert with dopamine.

222 C populations in naive rat revealed a higher neurogenic potential in SVZ-NPCs compared with SC-NPCs.

223 entricular zone (V-SVZ) presents the highest neurogenic potential in the brain of the adult individua

224 The neurogenic potential of adipose tissue - derived human m

225 ne, acts as a niche component to sustain the neurogenic potential of adult NSCs and identify alpha-SY

226 e assay the morphology, cytoarchitecture and neurogenic potential of cV-SVZ.

227 These results suggest that the neurogenic potential of IPs may be boosted in vivo by ma

228 MGPCs, signaling through gp130 inhibits the neurogenic potential of MGPCs and promotes glial differe

229 progenitors (mFPPs) that retain efficient DA neurogenic potential over multiple passages and can be c

230 ture of canine V-SVZ (cV-SVZ), to assess its neurogenic potential, and to compare our results with th

231 genes suggesting regional differences in the neurogenic potential.

232 signalling, both of which normally limit its neurogenic potential.

233 Here we review the neurogenic process and observed alterations found in PD

234 g DG development produces an increase in the neurogenic process, increasing NPCs numbers.

235 aternal inflammation disrupts 5-HT-dependent neurogenic processes during fetal neurodevelopment.

236 ations of crucially important 5-HT-dependent neurogenic processes.

237 ired memory capacity, neural plasticity, and neurogenic processes.

238 es of perinatal mice contain a population of neurogenic progenitors formed during embryonic developme

239 genin 1 (Ngn1), simultaneously activates the neurogenic program and inhibits the alternative astrogli

240 mechanisms that control activation of their neurogenic program remain poorly understood.

241 actory to Neurog2 activation, the underlying neurogenic program remained amenable to reprogramming by

242 tes genes with roles in several steps of the neurogenic program, including Notch signaling, neuronal

243 urogenesis and differentiation could provide neurogenic programs with flexibility, while allowing for

244 Neurog2 and Ascl1 rapidly elicited distinct neurogenic programs with only a small subset of shared t

245 These early-age neurotrophic and neurogenic (proliferative) effects in the Arg-61 mouse m

246 ychiatric disorders wherein neurotrophic and neurogenic properties are affected, two neurotrophically

247 functionally exhibit intrinsic stem-like and neurogenic properties with enhanced rRNA transcription a

248 stabilizer and displays neuroprotective and neurogenic properties.

249 servations provide evidence that Ciona has a neurogenic proto-placode, which forms neurons that appea

250 Neurogenic pulmonary edema is an underrecognized and und

251 Neurogenic pulmonary edema occurs as a complication of a

252 ncluded English-language articles concerning neurogenic pulmonary edema using the search terms "neuro

253 eristics, impact on outcome and treatment of neurogenic pulmonary edema, and considerations for organ

254 includes myocardial infarction, myocarditis, neurogenic pulmonary edema, and nonischemic cardiomyopat

255 oedema" or "pulmonary edema," "experimental neurogenic pulmonary edema," "donor brain death," and "d

256 anscriptome signatures characteristic of (1) neurogenic radial glia-like cells (resembling neural ste

257 ons in the adult spinal cord, a noncanonical neurogenic region.

258 We found that Li accumulated in neurogenic regions and investigated the effects on hippo

259 The neurogenic regions express overlapping but distinct sets

260 ism by which NSC number is controlled in the neurogenic regions of the adult brain is not fully under

261 n N-terminal protein kinase activity in both neurogenic regions of the adult mouse brain.

262 umulation of apoptotic cells specifically in neurogenic regions of the CNS, and that microglial phago

263 Indeed, hippocampal neurogenic regions showed increased cell death (+77%) an

264 brain except for ependymal cells and in the neurogenic regions, where SOX9 is also expressed by neur

265 in all major areas of the CNS outside of the neurogenic regions.

266 Brn1/2/4, which function sequentially in the neurogenic regulatory pathway and are also required for

267 eting them may be an innovative strategy for neurogenic resistant hypertension therapy.

268 Moreover, ?1/6 of neurogenic RGPs proceed to produce glia.

269 In addition, the stimulation of neurogenic spots by electrical, mechanical, or chemical

270 nt study provides experimental evidence that neurogenic spots exhibit all the characteristics of the

271 ns produce hypersensitive spots on the skin (neurogenic spots), caused by cutaneous neurogenic inflam

272 ed expression of Ascl1 in mouse MG induces a neurogenic state in vitro and in vivo after NMDA (N-meth

273 f Ascl1 in vitro reprograms Muller glia to a neurogenic state.

274 Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling

275 GNIFICANCE STATEMENT The subventricular zone neurogenic stem cell niche generates highly migratory ne

276 by modulating neuronal recruitment from the neurogenic subventricular zone (SVZ) of the adult mouse

277 Surgical intervention relieved arterial and neurogenic symptoms, and abnormal duplex velocities retu

278 than neurogenic while the other one is more neurogenic than neurotrophic and the former exhibits rem

279 d postmortem studies are consistent with the neurogenic theory, but they are indirect.

280 Patients with neurogenic thoracic outlet syndrome (NTOS) may have sign

281 As a result, the niche shifted from neurogenic to neuro/astrogenic with increased age.

282 sition of rapid cell cycles, the switch from neurogenic to proliferative divisions, and the re-expres

283 l stage when retinal progenitors switch from neurogenic to terminal patterns of cell division.

284 cently showed that MEIS2 cooperates with the neurogenic transcription factor PAX6 in the control of a

285 rived CMs (PSC-CMs) were transduced with the neurogenic transcription factors Brn2, Ascl1, Myt1l and

286 ecific trajectories reveal the expression of neurogenic transcription factors in early radial glia an

287 tulinumtoxin-A (100 IU) in patients with non-neurogenic urge incontinence is 33 and 5%, respectively.

288 the effect of purified vascular cells from a neurogenic (V-SVZ) and non-neurogenic brain region (cort

289 , highlighting the intrinsic capacity of non-neurogenic vasculature to support stem cell behavior.

290 The neurogenic ventricular regions express overlapping but d

291 of these molecules is more neurotrophic than neurogenic while the other one is more neurogenic than n

292 ted BPA/BPS exposure specifically during the neurogenic window caused later hyperactive behaviors in

293 iency delays IPC production and prolongs the neurogenic window, resulting in an increased number of n

294 enic pulmonary edema using the search terms "neurogenic" with "pulmonary oedema" or "pulmonary edema,

295 We were able to confirm its dual role in neurogenic Wnt signaling in vitro for both canonical Wnt

296 er birth, by which time most neurites in the neurogenic zone were eliminated, a compact Golgi apparat

297 dymal (E) cells in the adult mouse forebrain neurogenic zone.

298 at this stage, with several neurites in the neurogenic zone.

299 pression of downstream Smad proteins in this neurogenic zone.

300 capable of eliciting expression within both neurogenic zones of the adult brain.