ライフサイエンスコーパス: neurogenin

1 eurogenesis by stabilising the bHLH protein, neurogenin.

2 expression during cell-fate specification by neurogenin.

3 riptional regulators of mammalian genes, the neurogenins.

4 The proneural transcription factor neurogenin 1 (neurog1) has been shown to be a key regula

5 Here we show that neurogenin 1 (ngn1), a vertebrate proneural gene related

6 has been postulated that a proneural factor, neurogenin 1 (Ngn1), simultaneously activates the neurog

7 n of the proneural bHLH transcription factor neurogenin 1 (ngn1).

8 Neurogenin 1 and MASH1 activate PK2 transcription by bin

9 ripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1

10 in is directly involved in the regulation of neurogenin 1 and possibly other proneural genes when neu

11 In the zebrafish, the transcription factor neurogenin 1 is essential for the generation of the sens

12 find that inactivation of the gene encoding neurogenin 1 leads to the development of over twice the

13 transcription factor Neurog1 (Ngn1, Neurod3, neurogenin 1) is involved in neuronal differentiation an

14 molog 1a) knockdown or neurons with neurog1 (neurogenin 1) knockdown, we showed that the remaining ce

15 he mouse otocyst epithelium, Tbx1 suppresses neurogenin 1-mediated neural fate determination and is r

16 Neurogenins 1 and 2 appear to control distinct sublineag

17 Proneural genes, including Pax6 and Neurogenin-1 and -2, were higher in preterm rabbit pups

18 geminal nerve fibers during development with neurogenin-1 knockout mice, during early postnatal devel

19 Here we show that the proneural protein neurogenin 2 (Neurog2), which controls neurogenesis in t

20 system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1 are required for

21 The proneural transcription factor Neurogenin 2 (Ngn2) acts as a master regulator of neuron

22 Later the cultures express neurogenin 2 (Ngn2) and become neurogenic.

23 marked promoters of poised proneural genes [neurogenin 2 (Ngn2) and neurogenic differentiation 1 (Ne

24 und that two of these E-boxes are targets of Neurogenin 2 (Ngn2) and that this mechanism is important

25 The proneural factors Mash1 (Ascl1) and neurogenin 2 (Ngn2) are expressed during formation of th

26 The proneural protein neurogenin 2 (NGN2) is a key transcription factor in reg

27 orsomorphin) enable the transcription factor Neurogenin 2 (NGN2) to convert human fetal lung fibrobla

28 We found that the expression of neurogenin 2 (Ngn2), a basic helix-loop-helix transcript

29 conserved serine residues on the bHLH factor neurogenin 2 (Ngn2), S231 and S234, are phosphorylated d

30 IG2(S147A) prefers to form heterodimers with Neurogenin 2 or other bHLH partners, suggesting a molecu

31 and maturation by inducing the beta-catenin-neurogenin 2 pathway.

32 differentiation gene Neurog2 (Ngn2, Math4A, neurogenin 2) as a direct target of PTF1-J.

33 ion and neuronal differentiation mediated by Neurogenin 2, a transcription factor expressed in adult

34 elopment, we detected only a single-phase of Neurogenin 3 (NEUROG3) expression and endocrine differen

35 level production of the transcription factor Neurogenin 3 (Neurog3) in Sox9(+) bipotent epithelial ce

36 ryonic development, the transcription factor neurogenin 3 (Neurog3) initiates the differentiation of

37 The transcription factor Neurogenin 3 (Neurog3) is required for islet development

38 sin and immunostained for Musashi-1 (Msi-1), neurogenin 3 (NEUROG3), chromogranin A (CgA), serotonin,

39 tivate the proendocrine transcription factor neurogenin 3 (NEUROG3), exit the cell cycle, and differe

40 induction of the endocrine progenitor factor neurogenin 3 (NEUROG3).

41 ls expressing carboxypeptidase A1 (CPA1) and neurogenin 3 (NEUROG3).

42 age is dependent on the transcription factor Neurogenin 3 (Neurog3, Ngn3).

43 Mice deficient for the transcription factor neurogenin 3 (ngn3) fail to develop endocrine cells in t

44 Moreover, we demonstrated upregulation of neurogenin 3 (NGN3) in both proliferating ducts and pree

45 roliferating germ cells and colocalized with neurogenin 3 (Ngn3), a helix-loop-helix transcription fa

46 t protein (EGFP) inserted into one allele of neurogenin 3 (Ngn3), a marker for pancreatic endocrine p

47 Similarly, neurogenin 3 (Ngn3), a Math5 paralog expressed in pancre

48 We demonstrated that the expression of neurogenin 3 (ngn3), an islet- and neuron-specific basic

49 signaling and requires a threshold number of Neurogenin 3 (Ngn3)-expressing acinar cells.

50 alysis of e12.5-18.5 embryonic pancreas from neurogenin 3 (Ngn3)-null mice, a background that abrogat

51 3(zf/zf) mutant mice; however, the number of neurogenin 3 (Ngn3)-positive endocrine cell progenitors

52 coding the proendocrine transcription factor neurogenin 3 (Ngn3).

53 ull allele of the bHLH transcription factor, neurogenin 3 (ngn3).

54 ESIGN AND In order to separate the transient neurogenin 3 -expressing endocrine progenitor cells from

55 Thus, our data suggest that Neurogenin 3 can redirect the differentiation of bipoten

56 Severe deficiency of neurogenin 3 causes a rare novel subtype of permanent ne

57 n of this model defines the narrow window of neurogenin 3 expression in islet progenitor cells and pe

58 the mouse villin promoter was used to drive Neurogenin 3 expression throughout the developing epithe

59 ult to distinguish cells actively expressing neurogenin 3 from differentiated cells that have stopped

60 We screened the coding region of the human neurogenin 3 gene (NEUROG3) for mutations in a group of

61 transcriptional activity of the bHLH protein neurogenin 3 in complex with the coactivators p300 or CB

62 Neurogenin 3 is a bHLH transcription factor that is expr

63 Neurogenin 3 is essential for enteroendocrine cell devel

64 Because neurogenin 3 is required for the development of beta-cel

65 ucted a library in which fetal pancreas from Neurogenin 3 null mice, which consists of only exocrine

66 proportion of smaller islets, and increased neurogenin 3 or insulin expression in cells adjacent to

67 Neurog3 (Neurogenin 3 or Ngn3) is both necessary and sufficient t

68 Neurogenin 3 plays a pivotal role in pancreatic endocrin

69 increased in the transgenics suggesting that Neurogenin 3 stimulated a program of terminal enteroendo

70 lation of native pancreatic cells expressing neurogenin 3, an established marker of islet progenitors

71 In addition, we determined whether neurogenin 3-expressing cells respond to abnormal Wnt si

72 slet progenitors leads to an increase in the neurogenin 3-expressing precursor cell population, which

73 The Neurogenin 3-expressing transgenics had decreased number

74 e cells expressing the transcription factor, neurogenin 3.

75 candidate islet progenitor cells expressing neurogenin 3.

76 ation of islet progenitor cells that express neurogenin 3.

77 Neurogenin-3 (NEUROG3) is expressed in endocrine progeni

78 The neurogenic differentiation-1 (NEUROD1), neurogenin-3 (NEUROG3), and hepatic nuclear factor-1alph

79 Neurogenin-3 (Ngn-3) is required for pancreas developmen

80 ta-cell size, islet size, islet density, and neurogenin-3 expression were analyzed.

81 ween HNF3 and basic helix-loop-helix factors neurogenin-3 or NeuroD1 binding to adjacent sites played

82 gamma-secretase inhibitor dibenzazepine and neurogenin-3 overexpression induced goblet cell and ente

83 We enforced Pdx1 expression from the Neurogenin-3-expressing endocrine commitment point onwar

84 Neurogenins act via a cascade of downstream transcriptio

85 eover, the ability of p27(Xic1) to stabilise neurogenin and enhance neurogenesis localises to an N-te

86 erminal neural differentiation is induced by neurogenin and neuro D overexpression but not when only

87 t evolutionarily conserved core mediators of Neurogenin and NeuroD activities.

88 y neuronal differentiation at a step between neurogenin and neuroD activity.

89 transcriptional targets of the bHLH proteins Neurogenin and NeuroD and found that primary roles of th

90 We defined consensus sequences for Neurogenin and NeuroD binding and identified responsive

91 Taken together, these data demonstrate that Neurogenin and NeuroD preferentially recognize neurogene

92 can differentially inhibit the activities of neurogenin and neuroD, both neurogenic bHLH molecules an

93 also revealed a crucial control step between neurogenin and neuroD.

94 included targets of the transcription factor neurogenin and previously uncharacterized, evolutionaril

95 ogenesis in the olfactory system upstream of neurogenin and Xebf2.

96 st, misexpression of Olig2 alone derepresses Neurogenins and promotes motoneuron differentiation.

97 lix-loop-helix transcription factors such as Neurogenin are activators of neuronal gene expression.

98 HES, Myc/USF, Hand, Mesp, Shout, p48, NeuroD/Neurogenin, Atonal and AS-C.

99 We show that Hes6 expression follows that of neurogenins but precedes that of the neuronal differenti

100 A single neurogenin gene, neurogenin1 (ngn1), is required for the

101 Overexpression of X-NGNR-1 (or NEUROGENIN) induces ectopic neurogenesis and ectopic exp

102 helix-loop-helix (bHLH) transcription factor Neurogenin/Math/atonal and Mash/achaete-scute family mem

103 computational approach to predict additional Neurogenin/NeuroD target genes involved in neurogenesis.

104 All such neurons require either neurogenin (ngn) 1 or 2, two neuronal determination gene

105 embryos, NKL is induced by overexpression of Neurogenin (Ngn), arguing that NKL is downstream of the

106 neurogenesis, the bHLH transcription factor neurogenin (Ngn1) inhibits the differentiation of neural

107 and represses neuron formation by binding to Neurogenin (Ngn2) and blocking its function.

108 loop-helix (bHLH) transcription factors, the Neurogenins (NGNs) and MASH-1, respectively.

109 The NEUROGENINS (NGNs) are neural-specific basic helix-loop-

110 ver, neither XFD nor N17Ras inhibits noggin, neurogenin, or XBF2 induction of anterior neural markers

111 Activating the neurogenin pathway in ferret progenitors promoted delami

112 is sufficient to induce phox2a-positive and neurogenin-positive cells.

113 h beta-catenin and Lef1 bind directly to the neurogenin promoter, and luciferase reporter assays demo

114 taposed to the expression domains of Xenopus Neurogenin related 1 and N-tubulin, markers of early neu

115 duces expression of the early proneural gene neurogenin-related 1 although not itself being induced b

116 Expression of Xenopus NEUROGENIN-related-1 (X-NGNR-1) defines the three prospe

117 The related basic/helix-loop-helix genes neurogenin-related-1 and neuroD are not induced in respo

118 In further contrast to neurogenin-related-1 and neuroD, high-level expression o

119 Transcription factors in the Neurogenin, Runt, ETS, and LIM families control sequenti

120 In particular, studies on NeuroD and Neurogenin suggest a regulatory pathway, providing power

121 e revealed more cells coexpressing proneural neurogenin targets in human than in other species, sugge

122 l to express the basic helix-loop-helix gene neurogenin that is essential for the formation of neuron

123 stoma specimens, whereas NEUROD2 and NEUROD3/neurogenin were expressed in partly overlapping subsets

124 moted by proneural bHLH proteins such as the neurogenins, which act as potent transcriptional activat

125 scribe a novel, NeuroD-related bHLH protein, NEUROGENIN, whose expression precedes that of NeuroD in

126 is finding, XDmrt4 is sufficient to activate neurogenin, Xebf2, and neural cell adhesion molecule exp