ライフサイエンスコーパス: neuroglobin

1 ctivity or disruption of an interaction with neuroglobin.

2 geometry similar to that of the heme protein neuroglobin.

3 that observed for hemoglobin, myoglobin, and neuroglobin.

4 f an oxygen transport protein, akin to human neuroglobin.

5 n the other human hexacoordinate hemoglobin, neuroglobin.

6 Neuroglobin, a globin enriched in the brain, was reporte

7 eukaryote 3/3 globins, including vertebrate neuroglobins, alpha- and beta-globins, and cytoglobins.

8 Neuroglobin and cytoglobin display dramatic biphasic tim

9 finity constants for ligand binding in human neuroglobin and cytoglobin than in the plant hexacoordin

10 moglobins (hxHbs) are also found in animals (neuroglobin and cytoglobin) and some cyanobacteria, wher

11 four plant hexacoordinate hemoglobins, human neuroglobin and cytoglobin, and Synechocystis hemoglobin

12 hexacoordinate hemoglobins, including human neuroglobin and cytoglobin, and those from Synechocystis

13 tein exhibits spectral properties similar to neuroglobin and cytoglobin.

14 other bis-histidyl ligated globins, such as neuroglobin and cytoglobin.

15 tes via a mechanism similar to that of human neuroglobin and cytoglobin: the destabilization of one o

16 on rate constants for myoglobin, hemoglobin, neuroglobin, and flavohemoglobin are large at 38, 120, 2

17 In silico searches using these neuroglobins as queries revealed the presence of previou

18 Neuroglobin belongs to the family of hexacoordinate hemo

19 ease during hypoxic and metabolic stress; 2) neuroglobin binding to 14-3-3 stabilizes and increases t

20 insights into how the distal heme ligand in neuroglobin caps its reactivity toward H2S and identifie

21 We recently discovered that deoxygenated neuroglobin converts nitrite to nitric oxide (NO), an im

22 Here, we investigated the regulation of neuroglobin expression after transient global ischemia i

23 e results provide evidence for regulation of neuroglobin expression by at least 2 signal transduction

24 , indicating that hemin and hypoxia regulate neuroglobin expression by different mechanisms.

25 report that, like hemoglobin and myoglobin, neuroglobin expression can also be induced by hemin.

26 otodissociation and bimolecular rebinding to neuroglobin focusing on the ligand migration process and

27 rmination of an O(2) affinity that precludes neuroglobin from functioning in traditional O(2) storage

28 Like mammalian neuroglobin, GbX was first designated as a neuronal glob

29 he other metazoan globins, it is likely that neuroglobin gene duplication followed by co-option and s

30 Previous studies suggested that the neuroglobin GLB-5 genetically interacts with GCY-35, and

31 Neuroglobin has less than 25% identity with other verteb

32 used Caenorhabditis elegans to explore how a neuroglobin inhibits a complex of oxygen-sensing sGCs, i

33 show that the nitrite reductase activity of neuroglobin inhibits cellular respiration via NO binding

34 Neuroglobin is a highly conserved hemoprotein of uncerta

35 Neuroglobin is a nerve-specific respiratory protein that

36 Neuroglobin is a newly discovered mammalian hemoglobin t

37 Neuroglobin is a newly identified vertebrate globin that

38 s demonstrate that the inhibition of sGCs by neuroglobin is essential for rapid adaptation to either

39 tivity of the coordinately saturated heme in neuroglobin is expected a priori to be substantially low

40 Therefore, it is unlikely that neuroglobin is instrumental in the acute response of neu

41 Most of the neuroglobin is present in a hexacoordinate state with pr

42 Ferric neuroglobin is slowly reduced by H2S and catalyzes its i

43 e found recently that neuronal expression of neuroglobin is stimulated by hypoxia and ischemia and pr

44 the recombinant protein indicate that human neuroglobin is the first example of a hexacoordinate hem

45 s in metazoa, the constitutive expression of neuroglobin-like proteins strongly supports the notion o

46 aled the presence of previously unidentified neuroglobin-like sequences in most metazoan lineages.

47 Hypoxia-regulated reactions of nitrite and neuroglobin may contribute to the cellular adaptation to

48 These studies suggest that neuroglobin may function as a physiological oxidative st

49 nt, with maximal (about 4-fold) increases in neuroglobin mRNA and protein levels occurring with 50 mi

50 While neuroglobin mRNA expression was significantly enhanced i

51 we did not find any significant increases in neuroglobin mRNA levels in the rat brain after transient

52 to a stable five-coordinated geometry; these neuroglobin mutants reduce nitrite to NO approximately 2

53 Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members

54 ation of the novel oxygen-binding molecules, neuroglobin (Ngb) and cytoglobin (Cygb), in mammalian re

55 The expression of neuroglobin (Ngb) and cytoglobin (Cygb), two recently di

56 The true function of neuroglobin (Ngb) and, particularly, human Ngb (NGB) has

57 Neuroglobin (Ngb) is a newly discovered globin in the ve

58 Neuroglobin (Ngb) is a newly discovered oxygen-binding h

59 Neuroglobin (Ngb) is a recently discovered monomeric glo

60 Neuroglobin (Ngb) is a recently discovered protein that

61 Neuroglobin (Ngb) is a recently discovered vertebrate gl

62 Neuroglobin (Ngb) is a vertebrate globin that is predomi

63 Neuroglobin (Ngb) is an O(2)-binding protein localized t

64 Neuroglobin (NGB) is predominantly expressed in the brai

65 The distribution of neuroglobin (Ngb) was investigated in the normal rat coc

66 e hydrophobic cavities and tunnel network in neuroglobin (Ngb), a hexacoordinated heme protein likely

67 Neuroglobin (NGB), a newly discovered member of the glob

68 Neuroglobin (Ngb), a protein in the globin family, is fo

69 Neuroglobin (Ngb), a protein related to myoglobin and he

70 Neuroglobin (Ngb), a recently discovered protein that is

71 Neuroglobin (Ngb), a recently discovered vertebrate glob

72 Neuroglobin (Ngb), a vertebrate globin expressed primari

73 n the structural fluctuations of the protein neuroglobin (Ngb).

74 For the neuroglobin of S. roscoffensis, a member of a lineage th

75 a marked decrease in Hba-a2 and Hbb but not neuroglobin or cytoglobin mRNA in transcriptome analyses

76 man hemoglobin and up to 50-fold higher than neuroglobin or cytoglobin.

77 Neuroglobin overexpression plays a neuroprotective role

78 To examine the anti-oxidative role of neuroglobin, PC12 cells were transfected with wild type

79 and glucose deprivation, we observed that 1) neuroglobin phosphorylation and protein-protein interact

80 Because the origin of neuroglobins predates the other metazoan globins, it is

81 Neuroglobins, previously thought to be restricted to ver

82 Neuroglobin protects neurons from hypoxia in vitro and i

83 We show that deoxygenated human neuroglobin reacts with nitrite to form nitric oxide (NO

84 rm that the six-to-five-coordinate status of neuroglobin regulates intracellular hypoxic NO-signaling

85 um, the concentration of the five-coordinate neuroglobin remains very low (0.1-5%).

86 nal analyses, we present the hypothesis that neuroglobin-sGC interactions may be generally important

87 also describe in situ hybridizations of two neuroglobins specifically expressed in differentiating n

88 that post-translational redox regulation of neuroglobin surface thiol disulfide formation increases

89 ependent post-translational modifications to neuroglobin that regulate the six-to-five heme pocket eq

90 ne residue in muting the reactivity of human neuroglobin toward H2S.

91 In contrast, hypoxic induction of neuroglobin was blocked by the mitogen-activated protein

92 addition, the brain oxygen-binding protein, Neuroglobin, was induced in mutant podocytes.

93 Neuroglobins were identified in choanoflagellates, spong

94 Neuroglobins were probably recruited in the first proton

95 rts the notion of an intimate association of neuroglobins with the evolution of animal neural systems