ライフサイエンスコーパス: neurogranin

1 dent protein kinase II in knockout models of neurogranin.

2 ctive staining for the pyramidal cell marker neurogranin.

3 another widely used selective PKC substrate (neurogranin((28-43)) and was a good substrate for human

4 e generated transgenic mice that overexpress neurogranin (a calmodulin-binding protein that facilitat

5 lack of morphine-induced phosphorylation of neurogranin and activation of CaMKII and CREB, and absen

6 ration of the apocalmodulin-binding proteins neurogranin and GAP-43, resulting in a low level of free

7 ncreased approximately 2-4 hr later, whereas neurogranin and gephyrin decreased during that time.

8 cium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associa

9 Male ICR mice were pretreated with neurogranin antisense or mismatch oligodeoxynucleotides

10 nal fluid levels of the postsynaptic protein neurogranin are increased in Alzheimer's disease, includ

11 They also implicate RC3/neurogranin as a downstream effector of PKC activity in

12 pport the hypothesis that phosphorylation of neurogranin at Ser-36 regulates its binding to CaM.

13 additional proteins that might interact with neurogranin by screening brain cDNA libraries.

14 phasis on the interaction of calmodulin with neurogranin, calcineurin, and CaMKII.

15 Gln and Ser-36 --> Asp point mutants reduced neurogranin/CaM interactions.

16 Thus, neurogranin can provide a molecular link between enhance

17 Importantly, CSF neurogranin complements the collective ability of these

18 the form of rapidly dissociating calmodulin-neurogranin complexes.

19 otein, amyloid beta, phosphorylated tau, and neurogranin concentrations in cerebrospinal fluid.

20 Antisense-pretreated mice showed decreased neurogranin expression, lack of morphine-induced phospho

21 Our results indicate that elevated neurogranin function within the PFC can enhance local pl

22 ophysin, PSD95, synapsin 1, synaptobrevin 1, neurogranin, GAP43 and synaptopodin (synaptic) were foun

23 ophysin, PSD95, synapsin 1, synaptobrevin 1, neurogranin, GAP43 and synaptopodin in brain tissues fro

24 Neurogranin has been suggested to serve as a common regu

25 An in-house immunoassay was used to analyse neurogranin in cerebrospinal fluid samples from a cohort

26 To elucidate the role of neurogranin in synaptic plasticity, we constructed a com

27 CaM is the major protein that interacts with neurogranin in vivo and support the hypothesis that phos

28 Our data illustrate that CaM binds to neurogranin in vivo and that CaM is the only neurogranin

29 e IQ domain are important for CaM binding to neurogranin in vivo.

30 neurogranin in vivo and that CaM is the only neurogranin-interacting protein isolated from brain cDNA

31 However, it has not been established that neurogranin interacts with CaM in vivo.

32 Neurogranin is a neural-specific, calmodulin (CaM)-bindi

33 Neurogranin is a postsynaptic neuronal protein that has

34 Neurogranin is a promising biomarker for AD because leve

35 Neurogranin is highly concentrated in dendritic spines.

36 se data demonstrate that cerebrospinal fluid neurogranin is increased already at the early clinical s

37 tsynaptic protein kinase (PKC) substrate RC3/neurogranin is increased in the maintenance phase of LTP

38 tested between baseline cerebrospinal fluid neurogranin levels and baseline and longitudinal cogniti

39 The CSF neurogranin levels correlated with brain atrophy (normal

40 The CSF neurogranin levels differentiated patients with early sy

41 addition, high baseline cerebrospinal fluid neurogranin levels in the mild cognitive impairment grou

42 ent group, high baseline cerebrospinal fluid neurogranin levels predicted cognitive decline as reflec

43 The CSF neurogranin levels predicted future cognitive impairment

44 pairment group, elevated cerebrospinal fluid neurogranin levels were associated with accelerated dete

45 Consequently, we hypothesize that neurogranin may function to concentrate CaM at specific

46 Neurogranin (NG) binding of calmodulin (CaM) at its IQ d

47 In neurons, neurogranin (Ng) binds calmodulin (CaM), and its binding

48 Neurogranin (Ng) is a brain-specific postsynaptic calmod

49 Neurogranin (Ng) is a brain-specific, postsynaptically l

50 Neurogranin (Ng) is a member of the IQ motif class of ca

51 Neurogranin (Ng) is a neuron-specific protein kinase C-s

52 Neurogranin (Ng) is a postsynaptic IQ-motif containing p

53 Neurogranin (Ng) is a prominent protein kinase C (PKC) s

54 Here, we report that neurogranin (Ng), a neuron-specific and postsynaptic pro

55 Neurogranin (Ng), a specific substrate of protein kinase

56 CaM-dependent protein kinase II (CaMKII) and neurogranin (Ng), as they both regulate CaM-dependent Ca

57 erived transcripts, along with the mRNAs for neurogranin (NGN, a protein kinase C substrate) and the

58 Neurogranin (NGRN) seems to be a promising novel cerebro

59 e vicinity of transcription factor 4 (TCF4), neurogranin (NRGN) and an extended region covering the M

60 pts associated with ZFP804A, a SZ risk gene, neurogranin (NRGN), is one of ZFP804A targets.

61 gr1), small GTP binding protein Rac1 (Rac1), neurogranin (Nrgn), sodium channel beta4 subunit (Scn4b)

62 The CSF levels of the synaptic marker neurogranin offer diagnostic and prognostic utility for

63 Neurogranin overexpression in the PFC enhanced long-term

64 milar IQ motif in PEP-19 and neuromodulin or neurogranin, PEP-19 was not a substrate for protein kina

65 The sustained increase in RC3/neurogranin phosphorylation requires ongoing protein kin

66 LTP induction can reverse the increased RC3/neurogranin phosphorylation.

67 Taken together, these data suggest that neurogranin plays an essential role in acute opioid depe

68 n, the microtubule-associated protein 2, and neurogranin (RC3) were evaluated for their ability to af

69 binding domains of neuromodulin (GAP-43) and neurogranin (RC3).

70 ted for their efficacies to modify rat brain neurogranin/RC3 (Ng) and neuromodulin/GAP-43 (Nm).

71 Neurogranin/RC3 (Ng), a postsynaptic neuronal protein ki

72 Neurogranin/RC3 is a neural-specific Ca(2+)-sensitive ca

73 In the model, knockout of neurogranin strongly diminishes the LTP induced by a sin

74 e-associated genes (neuron-specific enolase, neurogranin), suggesting that EGR1 overexpression may co

75 Moreover, it is noteworthy that neurogranin, the full-length protein of W-NG(28-43) and

76 Since CaM binds to neurogranin through the IQ domain, PKC phosphorylation a

77 ested the performance of cerebrospinal fluid neurogranin to predict cognitive decline and brain injur

78 cute opioid dependence, we directly targeted neurogranin using antisense oligodeoxynucleotides.

79 Cerebrospinal fluid neurogranin was increased in patients with Alzheimer's d

80 levels of synaptotagmin, synaptophysin, and neurogranin were decreased years before dementia in pati

81 tophysin, synaptopodin, synaptotagmin-2, and neurogranin were significantly lower in patients with FT

82 of the cells were positive for both P2Y1 and neurogranin, whereas 16% were only P2Y1 positive.

83 substantially increased was RC3 (also called neurogranin), which encodes a calmodulin binding protein