ライフサイエンスコーパス: neurologic disease

1 g. cardiovascular complications, cancer, and neurologic disease).

2 genome stability pathways that prevent human neurologic disease.

3 implementation may help identify unsuspected neurologic disease.

4 ylation and splicing, and potential links to neurologic disease.

5 release of proinflammatory mediators causes neurologic disease.

6 broader functional deficits associated with neurologic disease.

7 mportant consideration for the patients with neurologic disease.

8 presents as uveitis, arthritis, myositis or neurologic disease.

9 clusions formed by FUS and other proteins in neurologic disease.

10 iated with leukemia/lymphoma and progressive neurologic disease.

11 ted with the development of life-threatening neurologic disease.

12 portant roles in acute and chronic models of neurologic disease.

13 ng that extracellular Tax may be relevant to neurologic disease.

14 d with the pathogenesis of HTLV-I-associated neurologic disease.

15 ost factors that contribute to virus-induced neurologic disease.

16 eath that may contribute to HIV-1-associated neurologic disease.

17 %) of 41 samples from patients without known neurologic disease.

18 d cell death may play a role in degenerative neurologic disease.

19 ce the incidence and severity of genital and neurologic disease.

20 neurobiology, tumor immunity, and autoimmune neurologic disease.

21 the role of CCR2 in a model of viral-induced neurologic disease.

22 not completely protected against genital and neurologic disease.

23 to the neuropathogenesis of HIV-1 associated neurologic disease.

24 assembly, and the emergence of diabetes and neurologic disease.

25 in humans at Xq13, a region associated with neurologic disease.

26 tein cause glutaric acidemia type I, a fatal neurologic disease.

27 ith end-stage pulmonary, cardiac, renal, and neurologic disease.

28 ) is expressed in the brain of patients with neurologic disease.

29 tric disease, or a movement-disorder type of neurologic disease.

30 tigating the mechanism of lentivirus-induced neurologic disease.

31 usceptibility of SJL mice to immune-mediated neurologic disease.

32 to this process in a model of viral-induced neurologic disease.

33 eir pivotal role in the pathogenesis of this neurologic disease.

34 he CNS but fails to induce clinical signs of neurologic disease.

35 ls may be required for induction of clinical neurologic disease.

36 es including infection, atherosclerosis, and neurologic disease.

37 cell vaccines do not cause infant deaths or neurologic disease.

38 e from the CNS but not for demyelination and neurologic disease.

39 issue is the use of this medical therapy in neurologic disease.

40 ed diagnosis of vision- and life-threatening neurologic disease.

41 ents as early-onset progressive visceral and neurologic disease.

42 controversial in patients with pre-existing neurologic disease.

43 ule organization, cell motility, cancer, and neurologic disease.

44 thout prior systemic treatment, dementia, or neurologic disease.

45 in attenuated derivatives that do not cause neurologic disease.

46 n reports, or investigations for undiagnosed neurologic disease.

47 lay an important role in preventing onset of neurologic disease.

48 rs have emerged as major causes of inherited neurologic disease.

49 isms attributed to progesterone treatment in neurologic disease.

50 a novel biological therapy for a progressive neurologic disease.

51 r's disease than the brains of women without neurologic disease.

52 t with a role for SIV in the pathogenesis of neurologic disease.

53 linked and may play a combined role in human neurologic disease.

54 r half of the macaques developed SIV-induced neurologic disease.

55 possibly induce, aggravate, and/or maintain neurologic disease.

56 e stroke patients and 17 individuals free of neurologic disease.

57 cruitment to the brain is a hallmark of many neurologic diseases.

58 is now applicable for the study of selected neurologic diseases.

59 patients with MS and 34 patients with other neurologic diseases.

60 of splicing may underlie many types of human neurologic diseases.

61 uding two (CACNA1A and PTPRZ1) implicated in neurologic diseases.

62 tment of patients with refractory autoimmune neurologic diseases.

63 thy brains, and brains of persons with other neurologic diseases.

64 ith ALS and only 1 of 29 subjects with other neurologic diseases.

65 s to the pathogenesis of a broad spectrum of neurologic diseases.

66 ntion of a broad spectrum of different human neurologic diseases.

67 nodeficiency virus, autoimmune diseases, and neurologic diseases.

68 30%) had findings attributable to coexisting neurologic diseases.

69 l control subjects or in patients with other neurologic diseases.

70 emerged as an important therapy for various neurologic diseases.

71 on glial cells has been observed in several neurologic diseases.

72 on and the molecular pathophysiology of many neurologic diseases.

73 Abs are beneficial as therapeutic agents for neurologic diseases.

74 fication of human mutations and treatment of neurologic diseases.

75 oles in dendrites and dysregulation in major neurologic diseases.

76 ailable for studying RNA gain-of-function in neurologic diseases.

77 of cardiovascular, liver, kidney, bone, and neurologic diseases.

78 ay provide a novel therapy for TBI and other neurologic diseases.

79 studies using progesterone to treat several neurologic diseases.

80 main (NTD) aims for the treatment of various neurologic diseases.

81 nnitus, Williams syndrome, autism, and other neurologic diseases.

82 cur as part of the pathology of a variety of neurologic diseases.

83 in caregivers of patients with debilitating neurologic diseases.

84 osis (46.9%), in 3 of 329 persons with other neurologic diseases (0.9%), and in none of the 59 health

85 epidemiology and association with different neurologic diseases, 3) clinical presentation, 4) impact

86 For neurologic disease, 88% of patients received AMB, 78% wi

87 ychiatric disease, and numerous degenerative neurologic diseases, affect only the brain.

88 f PrP(d) accumulation in sheep succumbing to neurologic disease after blood transfusion from donors e

89 s as the pathogenic cell in the induction of neurologic disease after demyelination.

90 vasculature rather than on the phenotype of neurologic disease analyzed.

91 IV-infected PML patients who had progressive neurologic disease and an eventual fatal outcome.

92 Neurologic disease and bone disease are intriguing compl

93 h and arthritis, occasionally complicated by neurologic disease and chronic arthritis.

94 (PBMCs) from patients with HTLV-I-associated neurologic disease and defined a new CD8+ T-cell epitope

95 irulent HSV-2 showed more severe genital and neurologic disease and higher mortality rates than their

96 Somatic mutation in neurons is linked to neurologic disease and implicated in cell-type diversifi

97 of copper and iron roles in neurobiology and neurologic disease and may allow for the development of

98 ere is no question that it can also occur in neurologic disease and models thereof.

99 We investigated an outbreak of severe neurologic disease and pneumonia that occurred among stu

100 cription of an HTLV-II-infected patient with neurologic disease and presents the clinical and immunol

101 sitive results of the National Institutes of Neurologic Disease and Stroke tissue plasminogen activat

102 Stroke is the most common life-threatening neurologic disease and the leading cause of serious long

103 namics of brain physiology in the context of neurologic disease and therapeutic interventions, which

104 nic Th17 cells enter the CNS at the onset of neurologic disease and, in the absence of IL-10, appear

105 is by far the most important risk factor for neurologic disease and, once disease develops, for worse

106 chronic infections, autoimmune diseases, or neurologic diseases and 99 serum specimens from hospital

107 ne samples obtained from patients with other neurologic diseases and from healthy controls, resulting

108 ultiple sclerosis than in persons with other neurologic diseases and healthy donors (P<0.001 for both

109 ng on human disorders ranging from cancer to neurologic diseases and immunity.

110 Seropositivity is associated with neurologic diseases and malignancies.

111 arison group (normal MR images and no proved neurologic disease); and were expressed as a ratio.

112 rimary diagnosis of pulmonary disease, 14.2% neurologic disease, and 8.9% cardiac disease.

113 iruses that cause hemorrhagic, edematous, or neurologic disease, and as a result, our findings sugges

114 exerts a profound influence on development, neurologic disease, and cell stress.

115 h is associated with cardiovascular disease, neurologic disease, and early aging, is likely to be a m

116 ice had more neuronal apoptosis, more severe neurologic disease, and higher mortality than Bc mice.

117 ost often develops as a result of nongenetic neurologic disease, and it manifests in a variety of pat

118 roximal aortic atherosclerosis, a history of neurologic disease, and older age; predictors of type II

119 ctions are associated with birth defects and neurologic disease, and that the virus can be sexually t

120 Mortality, neurologic disease, and visceral dissemination of virus

121 es with both the severity of virally induced neurologic disease, and with the generation of neurotoxi

122 in patients with spinal cord injury or other neurologic diseases, and in critical care or perioperati

123 deaths attributed to cardiovascular disease, neurologic diseases, and suicide.

124 included asthma; diabetes; heart, lung, and neurologic diseases; and pregnancy.

125 ent enterovirus 71 strain that causes severe neurologic disease are highlighted.

126 Animal models to study development of neurologic disease are needed.

127 Autoimmune neurologic diseases are being increasingly recognized, a

128 r brain, possibilities for new treatments of neurologic diseases are bound to emerge.

129 BAF subunits underlie widely different human neurologic diseases arising in different neuronal types,

130 retroviral therapy in reducing viral burden, neurologic disease associated with HIV-1 infection of th

131 paraparesis is a demyelinating inflammatory neurologic disease associated with HTLV-1 infection.

132 tic paraparesis (HAM/TSP) is an inflammatory neurologic disease associated with HTLV-I infection, in

133 The spectrum of neurologic disease associated with mutations in NBIA gen

134 he Notch pathway are involved in a number of neurologic diseases associated with mental retardation o

135 s, a group of rare, transmissible, and fatal neurologic diseases associated with the accumulation of

136 erlying pathology (such as cancer or serious neurologic disease) associated with urinary incontinence

137 iratory tract by PCR, 42 (11.5%) of whom had neurologic disease attributable to M. pneumoniae.

138 The spectrum of neurologic disease attributable to Mycoplasma pneumoniae

139 these mice eventually developed a late-onset neurologic disease because of accumulation of another cl

140 ciated conditions, including psychiatric and neurologic disease, brain lesions, drug effect, and hear

141 s parenteral immunizations protected against neurologic disease but did not entirely prevent infectio

142 e HS binding increased brain replication and neurologic disease but reduced lymphoid tissue replicati

143 e a target for pharmacologic intervention in neurologic disease, but compounds that promote this acti

144 tion less than 45%, atrial fibrillation, and neurologic disease, but not the type of TTS, were indepe

145 ith IVIg is effective for certain autoimmune neurologic diseases, but its spectrum of efficacy has no

146 munoglobulin is effective in many autoimmune neurologic diseases, but its spectrum of efficacy, espec

147 apoptosis is a key aspect of many different neurologic diseases, but the mechanisms remain unresolve

148 confer both susceptibility to infection and neurologic disease by this human virus.

149 type I (HTLV-I) is associated with a chronic neurologic disease called HTLV-I-associated myelopathy/t

150 Many neurologic diseases cause discrete episodic impairment i

151 tic paraparesis (HAM/TSP) is an inflammatory neurologic disease caused by HTLV-I infection and has be

152 Fragile X syndrome (FXS) is an inherited neurologic disease caused by loss of fragile X mental re

153 lonus myoclonus ataxia (POMA), an autoimmune neurologic disease characterized by abnormal motor inhib

154 Guillain-Barre syndrome (GBS), a neurologic disease characterized by acute paralysis, is

155 nally identified as targets in an autoimmune neurologic disease characterized by failure of motor inh

156 Both Fr98 and Fr98/SE induce a clinical neurologic disease characterized by hyperexcitability an

157 t VEGF may be a viable therapeutic target in neurologic disease characterized by inflammation-induced

158 ssociated myelopathy is a slowly progressive neurologic disease characterized by inflammatory infiltr

159 aparesis (HAM/TSP) is a chronic, progressive neurologic disease characterized by marked degeneration

160 Multiple sclerosis (MS) is a multifactorial neurologic disease characterized by modest but tractable

161 phalopathy (CADASIL) is a genetically linked neurologic disease characterized by recurrent strokes an

162 These results have implications for treating neurologic diseases characterized by inherited single ge

163 as seen in two of the 34 patients with other neurologic diseases, corresponding to the low percentage

164 White matter from other inflammatory neurologic diseases displayed glutaminase reactivity, wh

165 orsinA is the causative protein in the human neurologic disease early onset torsin dystonia, a moveme

166 evidence for the use of progesterone in each neurologic disease family.

167 athways has been suggested to play a role in neurologic diseases featuring cell death.

168 -third of CD4-depleted mice developed severe neurologic disease following infection, in contrast to v

169 rare variants identified in individuals with neurologic disease had complex, and sometimes opposing,

170 r periods of many years in the prevention of neurologic diseases has not been adequately explored.

171 ters, is neuroinvasive, and induces clinical neurologic disease in 100% of neonatally inoculated mice

172 opment of a novel virus isolate that induces neurologic disease in a high proportion of rhesus macaqu

173 orts including inflammatory and degenerative neurologic disease in a multicenter study involving 220

174 iled macaques resulted in the development of neurologic disease in addition to AIDS.

175 es severe and often fatal respiratory and/or neurologic disease in both animals and humans.

176 ral infarct (SCI) is the most common form of neurologic disease in children with sickle cell anemia (

177 cosis is now recognized as a common cause of neurologic disease in developing countries and the Unite

178 Outbreaks of neurologic disease in humans and horses were reported in

179 ue may have applications in the treatment of neurologic disease in humans.

180 arasitic nematode that causes a debilitating neurologic disease in many North American cervids and do

181 s were found in brains from subjects without neurologic disease in similar proportions to those repor

182 everal murine leukemia viruses (MuLV) induce neurologic disease in susceptible mice.

183 The frequency of severe neurologic disease in the current epidemic suggests a mo

184 LV FB29 induces both syncytium formation and neurologic disease in vivo.

185 sheath has been associated with a variety of neurologic diseases in which repair is limited, despite

186 rain atrophy is a common feature of numerous neurologic diseases in which the role of neuroinflammati

187 ted calcium channel, cause a number of human neurologic diseases including familial hemiplegic migrai

188 n activated brain endothelium contributes to neurologic disease, including cerebral ischemia and mult

189 Rare mitochondrial mutations cause neurologic disease, including ischemic stroke and MRI wh

190 nflammation has been associated with various neurologic diseases, including Alzheimer disease (AD).

191 issue suggests it may play a role in diverse neurologic diseases, including Alzheimer's disease, mult

192 disease and cognitive status in people with neurologic diseases, including Alzheimer's; disease and

193 eurotransmission has been implicated in many neurologic diseases, including epilepsy, intellectual di

194 Reactive astrocytosis develops in many neurologic diseases, including epilepsy.

195 ove outcomes in animal models of a number of neurologic diseases, including traumatic brain injury, i

196 se virus, our findings may have relevance to neurologic disease induced by MCF retroviruses in mice.

197 ated neuroinvasiveness, and induces clinical neurologic disease infrequently, with a relatively long

198 Neurologic disease is correlated with the relative numbe

199 re related to the pathogenesis of autoimmune neurologic disease is discussed.

200 An increasing number of neurologic diseases is associated with autoimmunity.

201 ygenase (COX-2) activity in stroke and other neurologic diseases is complex, as both activation and s

202 ST-segment depression, higher prevalence of neurologic diseases, less pronounced reduction in left v

203 risk factors for reintubation included acute neurologic disease, lower aPiMax, postextubation upper a

204 nduction, this restriction directly promotes neurologic disease manifestations characteristic of east

205 This study demonstrates that distinct neurologic disease manifestations develop during relapsi

206 BDV causes neurologic disease manifested by behavioral abnormalitie

207 ous variegate porphyria is a severe skin and neurologic disease manifesting in early infancy, and cha

208 intensive care monitoring for patients with neurologic disease may change patterns of intensive care

209 Minocycline is broadly protective in neurologic disease models featuring cell death and is be

210 ologic hallmark of the human immune-mediated neurologic disease multiple sclerosis, which may be trig

211 of MS (n=13), donors without any history of neurologic disease (n=20), and in platelets from healthy

212 n without clinical or pathologic evidence of neurologic disease (n=26), or women who had Alzheimer's

213 iseases (OIND; n = 19), and non-inflammatory neurologic diseases (NIND; n = 41).

214 ensive literature on innate inflammation and neurologic disease notwithstanding, three fundamental qu

215 xpressing mice showed no signs of the severe neurologic disease observed in completely deficient mice

216 dilatation disease (PDD), a frequently fatal neurologic disease of captive parrots.

217 ry systems, but the public health impact for neurologic disease of moderately low vitamin B-12 status

218 le sclerosis (MS), the most common disabling neurologic disease of young adults, is considered a clas

219 clerosis (PP-MS; n = 21), other inflammatory neurologic diseases (OIND; n = 19), and non-inflammatory

220 13 late Lyme disease patients, and 19 other neurologic disease (OND) controls.

221 c progressive MS (CPMS), patients with other neurologic disease (OND), patients with other autoimmune

222 is (SSPE), multiple sclerosis (MS), or other neurologic diseases (OND) by ELISA.

223 n=17) were compared with patients with other neurologic diseases (ONDs; n=13) with respect to cerebro

224 etic mechanisms for M. pneumoniae-associated neurologic disease, one related to direct infection of t

225 are innate inflammatory responses a cause of neurologic disease or merely a more sophisticated means

226 rains have seldom been associated with human neurologic disease or mortality, despite serological evi

227 stic disease (OR = 2.8; 95% CI, 2.4 to 3.1), neurologic disease (OR = 4.6; 95% CI, 2.3 to 8.9), bacte

228 flammatory agents effectively treat existing neurologic disease, or is a protective strategy in high-

229 of tarsal coalition, collagen abnormalities, neurologic disease, or other underlying condition.

230 itable bowel syndrome, anemia, osteoporosis, neurologic diseases, or malignancy.

231 of persons with multiple sclerosis or other neurologic diseases (P<0.001 for both comparisons).

232 ons in GABA receptor genes being involved in neurologic diseases, particularly the epilepsies.

233 had been presumptively diagnosed with other neurologic diseases prior to organ procurement.

234 Metallothioneins are potential markers of neurologic disease processes and treatment response in L

235 owever, their contribution to autoimmune and neurologic disease processes has not been investigated.

236 pper deficiency, the mechanisms resulting in neurologic disease remain unknown.

237 tion might fail in the setting of autoimmune neurologic disease remains to be explored.

238 he prion protein promoter develop widespread neurologic disease, reminiscent of juvenile forms of oth

239 African Americans were more likely to have neurologic disease, renal disease, and a higher SLAM sco

240 more than half received funding; cancer and neurologic disease research is relatively well funded.

241 ted diet during gestation developed a severe neurologic disease resulting from extensive myelin vacuo

242 This neurologic disease results from a defect in the lysosoma

243 using visual fields from subjects with known neurologic disease, subjects with glaucoma, and glaucoma

244 the prevalence of congestive heart failure, neurologic diseases such as dementia and stroke, renal a

245 atrophy is prominent in chronic progressive neurologic diseases such as human T-cell lymphotropic vi

246 to ALS but also to other fatal, progressive neurologic diseases such as Huntington's chorea and late

247 ce in healthy CNS, its role in BBB repair in neurologic diseases such as MS remains unclear.

248 vel approach for immunotherapy of autoimmune neurologic diseases, such as multiple sclerosis.

249 Guillain-Barre syndrome (GBS), a neurologic disease that produces ascending paralysis, af

250 n and South American strains of EEEV produce neurologic disease that resembles that associated with h

251 bules, has been associated with several rare neurologic diseases that clinically include parkinsonian

252 ay critical roles in synaptic modulation and neurologic disease, the nature of its substrates has not

253 homocysteine has been associated with other neurologic diseases, these pathways have not been evalua

254 ses consists primarily of viruses that cause neurologic disease; these viruses include Omsk hemorrhag

255 s play a key role in pathophysiology of many neurologic diseases/trauma, but the effect of immune cel

256 In biopsy specimens of patients with neurologic diseases, vascular EGFL7 expression rose with

257 To investigate the role of SIV in neurologic disease, virus was isolated from a lymph node

258 romaius novaehollandiae (emu), a progressive neurologic disease was recently discovered, which was ch

259 For initial therapy of patients with neurologic disease we use tetrathiomolybdate.

260 responses that may contribute to autoimmune neurologic disease, we compared the responses of SJL and

261 es, anthropomorphic measurements, cancer and neurologic disease were also observed.

262 ies of trauma, intracerebral hemorrhage, and neurologic disease were associated with lower hospital s

263 Interestingly, similar neurologic diseases were associated with both gain- and

264 pe develop severe demyelination with minimal neurologic disease when chronically infected with TMEV.

265 ting a broad range of acquired and inherited neurologic diseases, where the causative gene defect or

266 bigenic for the p35 and p40 genes, developed neurologic disease which correlated with the levels and

267 icing plays a particularly important role in neurologic disease, which is perhaps not surprising give

268 adult mice, nectin-1 is a major mediator of neurologic disease, while the absence of either receptor

269 re than 110 patients with various autoimmune neurologic diseases who received IVIg during the past 6

270 M83(+/-) mice developed progressive signs of neurologic disease with an incubation period of approxim

271 preclinical and clinical studies of several neurologic diseases with varying degrees of success.

272 brain tissue from donors with no history of neurologic disease, with TSPO-binding PET ligands other

273 Epilepsy is one of the most common chronic neurologic diseases, yet approximately one-third of affe