ライフサイエンスコーパス: neuromedin

1 ors for the mammalian bombesin-like peptides neuromedin B (NMB) and gastrin-releasing peptide.

2 o uncover the expression of the neuropeptide neuromedin B (NMB) in the trigeminal ganglia of mice.

3 Neuromedin B (NMB) is a mammalian member of the bombesin

4 opeptides gastrin-releasing peptide (GRP) or neuromedin B (NMB) produced a large membrane depolarizat

5 he gastrin-releasing peptide (GRP) receptor, neuromedin B (NMB) receptor, or BLP receptor subtype 3]

6 Neuromedin B (NMB) receptor-null and bombesin receptor s

7 gastrin-releasing peptide (GRP) receptor and neuromedin B (NMB) receptor.

8 Neuromedin B (NMB), a mammalian bombesin related peptide

9 eptides [gastrin-releasing peptide (GRP) and neuromedin B (NMB)] are important in numerous biological

10 of mRNA for the three BLP receptor subtypes (neuromedin B [NMB]) receptor, gastrin-releasing peptide

11 dization, we show here that a single marker, Neuromedin B mRNA (Nmb), identifies RTN neurons in roden

12 dentified with a single and specific marker, Neuromedin B mRNA (Nmb).

13 omedin B to Rat-1 cells transfected with the neuromedin B preferring receptor also activated p42(mapk

14 eptor number and receptor type (i.e., GRP or neuromedin B preferring).

15 pecifically to GRP-R (0.8 nmol/L) and to the neuromedin B receptor (NMB-R) (0.9 nmol/L), with no affi

16 hares high homology with bombesin receptors (neuromedin B receptor (NMB-R) and gastrin-releasing pept

17 gastrin-releasing peptide receptor (GRP-R), neuromedin B receptor (NMB-R), and bombesin receptor sub

18 trin-releasing peptide receptor (GRP-R), the neuromedin B receptor (NMB-R), and bombesin receptor sub

19 trin-releasing peptide receptor (GRP-R), the neuromedin B receptor (NMB-R), bombesin receptor subtype

20 , functions through a distinct receptor, the neuromedin B receptor (NMB-R), of which little is known

21 -releasing peptide receptor (GRP-R, or bb2), neuromedin B receptor (NMB-R, or bb1), and the bombesin

22 PD168368 was found to be a potent selective neuromedin B receptor (NMBR) antagonist.

23 electivity for GRPR over the closely related neuromedin B receptor (NMBR).

24 ma cells which possess native NMB-Rs and rat neuromedin B receptor (rNMR-R) transfected BALB 3T3 cell

25 gastrin-releasing peptide receptor (GRP-R), neuromedin B receptor, and bombesin receptor subtype 3.

26 hat antagonists of gastrin-releasing peptide/neuromedin B receptors (BB/BB) PD168368 [(S)-a-methyl-a-

27 Furthermore, addition of neuromedin B to Rat-1 cells transfected with the neurome

28 ignificant upregulation of 1080 genes (e.g., neuromedin B), and a significant downregulation of 518 g

29 r 15 (GDF15), angiopoietin-like 6 (Angptl6), neuromedin B, and nesfatin, linked to energy expenditure

30 ptides, including gastrin-releasing peptide, neuromedin B, neurotensin, gastrin, cholecystokinin and

31 ily, including gastrin-releasing peptide and neuromedin B, which are found in axons in the mediobasal

32 y conserved G-protein-coupled receptors: the neuromedin B-preferring, the gastrin-releasing peptide-p

33 eristic of the GRPr: bombesin > or = GRP > > neuromedin B.

34 esin(5-14) which has the sequence [Gln3,Arg6]neuromedin B.

35 chymase (CMA1), tryptase (TPS1) and mastin, neuromedin-B (NMB), nerve growth factor (NGF), and leuko

36 NAs encoding bombesin receptor subtype 3 and neuromedin-B receptor (NMB-R), but not gastrin-releasing

37 or subtype (BRS)-1 (GRP receptor) and BRS-2 (neuromedin-B receptor), but the mRNA for GRP ligand was

38 by coupling a Boc-protected N(4)-chelator to neuromedin C (human GRP(18-27)), which, after (99m)Tc-la

39 In current clamp doses of 10 and 100 nM neuromedin C (NMC) were shown to increase basal firing r

40 atching induced by three peptides (bombesin, neuromedin-C, and [Leu(8)]phyllolitorin).

41 t (EC(50) = 5 nm) and specific in that other neuromedins did not induce a calcium flux in receptor-tr

42 Expression of the gene encoding neurotensin/neuromedin N (NT/N) is mostly limited to the brain and s

43 ns of neurotensin, expression of neurotensin/neuromedin N (NT/N) mRNA, and numbers of neurotensin-imm

44 The peptides neurotensin (NT) and neuromedin N exert effects on neurons by means of a high

45 ticotropin-releasing hormone and neurotensin/neuromedin N significantly increase in a restricted regi

46 Neuromedin N was identified as a metabolite significantl

47 of over 1000 ligands tested, including other neuromedins (NmB, C, L, K, N), induced a calcium flux in

48 Expression of the neurotensin/neuromedin (NT/N) gene in preoptic area neurons is drama

49 t of SCN neurons expressing the neuropeptide neuromedin S (NMS) plays an essential role in the genera

50 n of prolactin secretion diurnally, as their neuromedin S(+) inputs originate from neurons expressing

51 us with many synaptic afferents arising from neuromedin S(+) neurons of the suprachiasmatic nucleus.

52 Here, we report the identification of neuromedin U (NmU) as an extracellular biomarker in cell

53 nverse correlation between tumor RhoGDI2 and Neuromedin U (NMU) expression, suggesting that NMU might

54 Neuromedin U (NmU) is a 25 amino acid peptide prominentl

55 Here, we determined that the neuropeptide neuromedin U (NmU) is a c-Myb target gene.

56 Neuromedin U (NMU) is a highly conserved neuropeptide wi

57 Neuromedin U (NMU) is a neuropeptide enriched in the nuc

58 Neuromedin U (NMU) is a neuropeptide with potent activit

59 The effects of neuromedin U (NMU) on aqueous humor (AH) outflow were de

60 We found that the neuropeptide neuromedin U (Nmu) promotes hyperactivity and inhibits s

61 Neuromedin U (NmU), a peptide affecting calcium transpor

62 e also modulate physical activity, including neuromedin U (NMU), a peptide found in the gut and brain

63 utionarily related to the vertebrate peptide neuromedin U (NMU), or are related to arginine vasopress

64 Neuromedin U (NmU), originally isolated from porcine spi

65 Neuromedin U (NMU), the ligand of NMUR1, activated ILC2s

66 nergic neurons that express the neuropeptide neuromedin U (NMU).

67 om insects (Drosophila and Anopheles) and to neuromedin U and ghrelin receptors from vertebrates.

68 haracterized in this report are activated by neuromedin U at nanomolar potency in heterologous expres

69 y to mediate central nervous system-specific neuromedin U effects.

70 enes, as well as the 3' partial locus of the Neuromedin U gene; sequence analysis also suggests the p

71 Binding sites for neuromedin U have been characterized in rat uterus, howe

72 Neuromedin U is a neuropeptide prominently expressed in

73 In addition, we show that whereas neuromedin U is expressed by monocytes and dendritic cel

74 Hugin neuropeptide, a neuromedin U ortholog, also regulates behavioral rhythms

75 namely pyrokinins, as well as the vertebrate neuromedin U peptide also induced a calcium response.

76 ese data, we conclude that NmU-R2 is a novel neuromedin U receptor subtype that is likely to mediate

77 Identification of neuromedin U receptor subtypes will greatly aid in the d

78 GPCRs from Drosophila that are homologous to neuromedin U receptors in vertebrates.

79 ted to the thyrotropin-releasing hormone and neuromedin U receptors.

80 ous expression systems and bind radiolabeled neuromedin U with high affinity.

81 ptide Y, corticotropin-releasing factor, and neuromedin U) and peripheral (eg, gastrin, histamine, ac

82 tential PanIN biomarker candidates including Neuromedin U, a circulating peptide hormone.

83 peptide is highly related to neurotensin and neuromedin U, which are involved in blood pressure regul

84 S2, bone-morphogenetic protein 2A, MT1G, and neuromedin U, which showed frequent promoter hypermethyl

85 ion of perikarya and nerve fibers containing neuromedin U-like immunoreactivity in the brain of Rana

86 The distribution of neuromedin U-like immunoreactivity in the frog brain was

87 1) was identified as a specific receptor for neuromedin U.

88 obilize intracellular calcium in response to neuromedin U.

89 dentified as receptors for the neuropeptide, neuromedin U.