ライフサイエンスコーパス: neuromodulatory

1 In contrast to this state-dependent neuromodulatory action, we found that a previously descr

2 However, neuromodulatory actions are known to persist when neurom

3 Thus, differences in two neuromodulatory actions at one synapse may allow a serot

4 Thus, spike timing-dependent serotonergic neuromodulatory actions can impart temporal information

5 These neuromodulatory actions may have important behavioral fu

6 These results suggest that the neuromodulatory actions of NA and 5-HT are compartmental

7 ily, mediates many of the neuroendocrine and neuromodulatory actions of somatostatin, and it represen

8 al wing NOS neurons of the DRN express their neuromodulatory actions on discrete efferent targets via

9 stingly, despite the striking differences in neuromodulatory actions on output neurons, chemogenetic

10 at a serotonergic neuron evokes two distinct neuromodulatory actions with different state, timing, an

11 n has been shown to produce a diverse set of neuromodulatory actions, including augmentation of synap

12 lts revealed that the kinetics emerging from neuromodulatory activation of the signaling network were

13 new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.

14 in a nutritionally sensitive metabolite with neuromodulatory activity rather than indirect or seconda

15 ith a view to exploring common principles of neuromodulatory activity.

16 ndocrine, acting as a releasing hormone; and neuromodulatory, affecting neural activity in the periph

17 ts from extrinsic and intrinsic sources, and neuromodulatory afferents from cholinergic and monoamine

18 determine the pharmacological effect of this neuromodulatory agent.

19 rients (imino/amino acids) and orally active neuromodulatory agents (used to treat affective disorder

20 he process of synaptic plasticity induced by neuromodulatory agents might be unpredictable when the u

21 nsory network function that is contingent on neuromodulatory and behavioral state.

22 Rather, the neuromodulatory and electrophysiological events that cha

23 rate pathways controlling the development of neuromodulatory and endocrine GnRH cells.

24 tin 2A receptor (sst2A) mediates many of the neuromodulatory and neuroendocrine actions of somatostat

25 We studied the interaction of neuromodulatory and sensory inputs in determining the mo

26 Multiple points of interaction with other neuromodulatory and signaling systems have now been iden

27 cranial direct current stimulation (tDCS), a neuromodulatory approach that has previously been demons

28 tend the optogenetic toolset by developing a neuromodulatory approach using a rationale-based design

29 the safety and efficacy of neuroleptics and neuromodulatory approaches in treatment-resistant cases

30 Opioids exert neuromodulatory as well as immunomodulatory effects, whi

31 ual signals to anterior temporal regions and neuromodulatory back-projections from the amygdala to ea

32 hasic, pupil-linked responses of a number of neuromodulatory brainstem centers involved in the contro

33 about the rules that govern these widespread neuromodulatory branching patterns.

34 We identify orthogonal neuromodulatory cascades that oppositely control periphe

35 sed this method (MultiMAP) to record from 22 neuromodulatory cell types in behaving zebrafish during

36 next recorded from and controlled homologous neuromodulatory cells in mice; alertness-related cell-ty

37 cts the limbic basal forebrain with numerous neuromodulatory centers in the midbrain.

38 ons through the influence of the amygdala on neuromodulatory centers.

39 through global projections, arousal-related neuromodulatory changes can rapidly alter coordination o

40 c sleep restriction likely induces long-term neuromodulatory changes in brain physiology that could e

41 The slow temporal dynamics of this neuromodulatory circuit supplement fast motor circuits t

42 Here, we characterize a neuromodulatory circuit that generates long-lasting roam

43 Thus, the basal forebrain neuromodulatory circuit, which is known to be activated

44 s, the iTango platform allows for control of neuromodulatory circuits in a genetically and functional

45 ionship between the circadian system and the neuromodulatory circuits that govern motivational behavi

46 hese findings point to an important role for neuromodulatory circuits, probably involving the thalamu

47 Mapping neuromodulatory connections in this system thus defines

48 Here, we systematically map the patterns of neuromodulatory connectivity in a network that governs a

49 will be highlighted concerning the roles of neuromodulatory control and postsynaptic long-range proj

50 Neuromodulatory control by oxytocin is essential to a wi

51 ctivity of thalamocortical circuits is under neuromodulatory control by various brainstem nuclei as w

52 Dendritic amplification is subject to neuromodulatory control from the brainstem by axons rele

53 timing-dependent plasticity (STDP) is under neuromodulatory control, which is correlated with distin

54 le courtship drive is complex and subject to neuromodulatory control.

55 hese data establish a molecular basis of the neuromodulatory deficiency in BN rats, and further sugge

56 cortical populations and the crucial role of neuromodulatory drive in specific inhibitory-excitatory

57 with psychiatric disorders, where a putative neuromodulatory dysregulation provides the rationale for

58 Here we report a counter example: the neuromodulatory effect of a serotonergic neuron is depen

59 ompared with stDCS, reflecting the preserved neuromodulatory effect of atDCS in older adults.

60 A neuromodulatory effect of creatine via increased energy

61 (Cajal cells) of the olfactory bulb and its neuromodulatory effect on mitral cell (MC) first-order n

62 f the subregions may have a compensatory and neuromodulatory effect on tic-related symptoms.

63 parameters of stimulation, have improved its neuromodulatory effect thus resulting in larger clinical

64 n if the patient believes there is an actual neuromodulatory effect.

65 Such rapid neuromodulatory effects are likely mediated via membrane

66 Neuromodulatory effects can vary with their mode of tran

67 Thus, we studied the neuromodulatory effects of CD4(+) regulatory T cells (Tr

68 We then quantified the neuromodulatory effects of DBS and compared sixteen dyna

69 g PLE to neurons, VF-EX2 can interrogate the neuromodulatory effects of serotonin in cultured hippoca

70 acting through NK1 receptors can have direct neuromodulatory effects on SGNs.

71 w approach for quantitative investigation of neuromodulatory effects on signaling and electrophysiolo

72 in signaling and integrate how these various neuromodulatory effects shape and protect synapses.

73 ility to distinguish sensory processing from neuromodulatory effects.

74 incorporating both nicotinic and muscarinic neuromodulatory effects.

75 se inhibitor, did not block norepinephrine's neuromodulatory effects.

76 n the brain, thought to mediate a variety of neuromodulatory effects.

77 l signaling by Trk to the related but poorly neuromodulatory EGF-receptor, we find that Trk and EGF-r

78 Here we show that neuromodulatory electrical stimulation of the supplement

79 nectome provides a minimal structure and the neuromodulatory environment constructs and specifies the

80 Loss of tonic neuromodulatory excitation, mediated by nicotinic acetyl

81 consolidation process is thought to require neuromodulatory factors such as dopamine, noradrenaline,

82 that are probably based on, and mediated by, neuromodulatory factors.

83 an amidase signature enzyme that inactivates neuromodulatory fatty acid amides, including the endogen

84 e rapid recruitment of presynaptic proteins, neuromodulatory forms of plasticity, such as facilitatio

85 is clarified when considered within a larger neuromodulatory framework.

86 mpelling evidence that prefrontal control of neuromodulatory function can have a dramatic effect on m

87 This RFamide neuropeptide has neuromodulatory functions and controls the synthesis and

88 Our results reveal novel neuromodulatory functions for bursicon and support the h

89 urodegenerative disorders and appear to have neuromodulatory functions in the brain.

90 nnels, they are most adept at mediating slow neuromodulatory functions that are more widespread and m

91 .Certain neuropeptides, in addition to their neuromodulatory functions, display antibacterial activit

92 of GnRH release, providing insight into its neuromodulatory functions.

93 -stimulating hormone (TSH) levels as well as neuromodulatory functions.

94 enosine serves important neuroprotective and neuromodulatory functions.

95 pted in developing neurons by overexpressing neuromodulatory G-protein-coupled receptors GPCRs or by

96 To test the hypothesis that neuromodulatory GnRH cells of the midbrain also arise fr

97 e GnRH cells of the hypothalamus, but not of neuromodulatory GnRH cells of the midbrain and terminal

98 Previously, we showed that neuromodulatory GnRH cells of the terminal nerve arise f

99 Exogenous application of the neuromodulatory hormone oxytocin (OT) promotes prosocial

100 minal nerve and midbrain, which appear to be neuromodulatory in function.

101 To examine the neuromodulatory influence of brain extracellular fluid o

102 nected to other amygdala nuclei and is under neuromodulatory influence.

103 ovel framework for inferring, noninvasively, neuromodulatory influences on ion channel signaling via

104 This review describes unique neuromodulatory influences on working memory prefrontal

105 nce training, is influenced by post-training neuromodulatory influences within the BLA.

106 he balance of excitation and inhibition, and neuromodulatory influences, all of which interact with t

107 Neuromodulatory influences, exemplified by the effects o

108 he interaction of multiple physiological and neuromodulatory influences, the PLR reflects the action

109 solidation in the BLA is mediated in part by neuromodulatory inhibition of the M-current, which is co

110 Thus, variation between individuals in neuromodulatory input contributes to individuality in a

111 e find that variation between individuals in neuromodulatory input contributes to individuality in sh

112 pensation was achieved by stronger extrinsic neuromodulatory input from projection neurons or by augm

113 This is partly due to fluctuations in neuromodulatory input from regions such as the noradrene

114 t the Uva might serve as a hub to coordinate neuromodulatory input into the song system.

115 t can be conditionally provided by extrinsic neuromodulatory input that counterbalances temperature-i

116 c network, we discovered that the removal of neuromodulatory input to this network (decentralization)

117 Neuromodulatory input, acting on G protein-coupled recep

118 tonomously in vivo, but is likely induced by neuromodulatory input, which is consistent with the idea

119 in response to diverse sensory and top-down neuromodulatory input.

120 SPns receive thalamic and neuromodulatory inputs and project into the developing c

121 hreat (fear) conditioning (PTC), sensory and neuromodulatory inputs converge on post-synaptic neurons

122 could be stabilized by activating extrinsic neuromodulatory inputs from descending projection neuron

123 Their activity is also sensitive to neuromodulatory inputs from multiple respiratory centers

124 We show here that neuromodulatory inputs to area X however, exhibit a cons

125 when either neuromodulators were present or neuromodulatory inputs to the CPG were active.

126 We conclude that neuromodulatory inputs to the pyloric network have a nov

127 the mechanistic interaction of cholinergic, neuromodulatory inputs with signaling pathways underlyin

128 f not all, sensory networks receive multiple neuromodulatory inputs, and the mechanisms by which sens

129 and the modulation of STDP by inhibitory and neuromodulatory inputs.

130 uctances that, in vivo, can be influenced by neuromodulatory inputs.

131 ranslation of neuroimaging findings to novel neuromodulatory interventions capable of enhancing the t

132 s-level view also provides insights into how neuromodulatory interventions might target pathological

133 findings may be relevant for rehabilitative neuromodulatory interventions.

134 chidonoyl ethanolamide, AEA) is an uncharged neuromodulatory lipid that, similar to many neurotransmi

135 ch enables the direct overlaying of chemical neuromodulatory maps onto synaptic connectomic maps in t

136 ase to [K+]o accumulation represent a unique neuromodulatory mechanism and a brake on runaway excitat

137 synapses in the olfactory bulb, revealing a neuromodulatory mechanism for continued circuit plastici

138 ur findings illustrate a simple yet powerful neuromodulatory mechanism to shift the balance between b

139 r this effect is unclear, and the underlying neuromodulatory mechanisms are unknown.

140 Furthermore, the roles played by neuromodulatory mechanisms can be addressed directly thr

141 stigations of spatiotemporal dynamics in the neuromodulatory microcircuits involved in perceptual lea

142 I suggest a consensus effect of each neuromodulatory molecule on Drosophila aggression, as we

143 LPFC and thalamus, two key components of the neuromodulatory network.

144 echanism for behavioral flexibility in which neuromodulatory networks act with synaptic precision to

145 w work in Drosophila melanogaster shows that neuromodulatory neurons active during flight boost respo

146 r may illustrate a general strategy by which neuromodulatory neurons orchestrate behavior.

147 uit flies is coordinated by a single pair of neuromodulatory neurons with command-like function.

148 ies lacking the function of the command-like neuromodulatory neurons.

149 ike manner in order to distribute evenly the neuromodulatory neurotransmitter serotonin.

150 The cholinergic system is a neuromodulatory neurotransmitter system involved in a va

151 For example, damage to neuromodulatory neurotransmitter systems is common after

152 ortex and from the locus coeruleus (LC) (the neuromodulatory nucleus releasing norepinephrine) in ure

153 ll help advance our understanding on how the neuromodulatory or endocrine system controls reproductiv

154 These neuromodulatory or gain control processes are central to

155 However, the translation of neuromodulatory OXT effects to novel treatment approache

156 functional asymmetry in a major cholinergic neuromodulatory pathway of the vertebrate brain.

157 und of evolutionary conservation in the 5-HT neuromodulatory pathway.

158 g their neuromodulatory state: activation of neuromodulatory pathways establishes a dynamic coregulat

159 on, indicating differentiated involvement of neuromodulatory pathways in the ripple phenomenon mediat

160 for conveying neural activity downstream via neuromodulatory pathways that are distinct from classica

161 In contrast to the well-characterized neuromodulatory pathways that equally suppress or augmen

162 se of SNs to the activation of this or other neuromodulatory pathways upon noxious stimulation.

163 ic methods to stimulate prefrontal-brainstem neuromodulatory pathways while animals face environmenta

164 he substrate underlying such target-specific neuromodulatory patterns was investigated in the infragr

165 nous application of proctolin, an endogenous neuromodulatory peptide, to the pyloric network.

166 sequence that may be processed to generate a neuromodulatory peptide.

167 The neuromodulatory peptides orexin A and B are important ce

168 As CBI-2 contains two neuromodulatory peptides, FCAP (feeding circuit-activati

169 dihydroergotamine will soon be available and neuromodulatory procedures such as occipital nerve stimu

170 This suggests structural dependence by the neuromodulatory process to induce analgesia with potenti

171 It is therefore crucial to understand the neuromodulatory processes that regulate the function of

172 The neuromodulatory processes underlying these different phe

173 Its outputs to neuromodulatory projection systems likely converge with

174 re effectors of alpha7-nAChRs and that their neuromodulatory properties depend on phosphorylation of

175 ion can exhibit unique circuit functions and neuromodulatory properties dictated by disparate develop

176 signaling molecules, these G-protein-coupled neuromodulatory receptors are capable of recruiting a di

177 ulation are made complex by the diversity of neuromodulatory receptors expressed within a neural netw

178 memories of post-traumatic stress disorder, neuromodulatory receptors provide a potential pharmacolo

179 These neuromodulatory receptors, including those for glutamate

180 gered by activation of Hebbian processes and neuromodulatory receptors, interact to produce neural pl

181 anization of neurons that express individual neuromodulatory receptors.

182 acetylcholine system plays a central role in neuromodulatory regulation of cognitive control processe

183 These results support the idea that neuromodulatory regulation of ion channel activity and n

184 To determine the extent of neuromodulatory regulation of latency within the inferio

185 gnaling and may function in the DCV-mediated neuromodulatory regulation of locomotion rate.

186 iduals within a species, result in part from neuromodulatory regulation of these neural circuits, whi

187 actory conditioned stimulus (CS) inputs with neuromodulatory reinforcement (unconditioned stimuli, US

188 that some fornical fibres may instantiate a neuromodulatory reinforcement signal supporting memory a

189 nges in latency are an important part of the neuromodulatory repertoire of serotonin within the audit

190 ia (AIH) leads to fundamental changes in the neuromodulatory response of the respiratory network loca

191 y exhibit homogeneous developmental origins, neuromodulatory response profiles, morphological charact

192 external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by

193 data show that P2X receptors often underlie neuromodulatory responses on slower time scales of secon

194 ophysiological properties, excitability, and neuromodulatory responses to serotonin (5-HT) in mouse l

195 d receptor activation and by startle-induced neuromodulatory responses.

196 A fast, neuromodulatory role for estrogen signaling has been rep

197 Together, our data describe a novel neuromodulatory role for VAV-1-dependent signalling in t

198 atecholaminergic cell groups that may play a neuromodulatory role in behavioral and auditory selectiv

199 et al. (2017) demonstrate that IL-17 plays a neuromodulatory role in Caenorhabditis elegans by acting

200 /hypocretin peptide signaling system plays a neuromodulatory role in motivation and stress; two criti

201 previously thought, and that GABA may play a neuromodulatory role in the control of lens or pupil fun

202 l cholinergic interneurons with an intrinsic neuromodulatory role in the control of locomotor behavio

203 g adds to the complex picture of the central neuromodulatory role of aggression in human subjects.

204 g adds to the complex picture of the central neuromodulatory role of aggression in humans.

205 g adds to the complex picture of the central neuromodulatory role of impulsive aggression in human su

206 s adds to the complex picture of the central neuromodulatory role of impulsive aggression in human su

207 on neuronal circuits where DAAO can exert a neuromodulatory role.

208 asynaptic sites where they presumably play a neuromodulatory role.

209 Collectively, these data uncover important neuromodulatory roles for TAAR1 and suggest that agonist

210 These data suggest important neuromodulatory roles for the CbAST-B family in the stom

211 Collectively, these data uncover essential neuromodulatory roles of TAAR 1 on cocaine abuse, and su

212 panded to include multiple postdevelopmental neuromodulatory roles, revealing an ever increasing body

213 ical models of the effects of stress-related neuromodulatory signaling at the cellular level to large

214 echolaminergic hyperactivation alters phasic neuromodulatory signaling in memory-related circuits, re

215 ur work elucidates the interplay between two neuromodulatory signaling systems in the brain through w

216 however, about the neural substrates or the neuromodulatory signaling that govern ELS-induced social

217 epresents a dynamic process that may require neuromodulatory signaling.

218 dopamine transients are accompanied by other neuromodulatory signals, such as acetylcholine and adeno

219 striatal circuits and ascending dopaminergic neuromodulatory signals.

220 In light of growing evidence that neuromodulatory specializations relate to neurochemical

221 es delta rhythms in conditions mimicking the neuromodulatory state during deep sleep (low cholinergic

222 coupled activity, synaptic connectivity, and neuromodulatory state, we determined that correlated cha

223 l networks are compensated by changing their neuromodulatory state: activation of neuromodulatory pat

224 ronal Kv2.1 channel by cholinergic and other neuromodulatory stimuli.

225 Although neuromodulatory strategies have targeted different sites

226 autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression o

227 timuli provides a physiological source for a neuromodulatory substance independent of efferent innerv

228 as allowed the systematic exploration of how neuromodulatory substances and the neurons that release

229 Neuromodulatory substances have profound effects on the

230 ir function in vivo is likely to be tuned by neuromodulatory substances in the brain extracellular fl

231 We now know that (a) neuromodulatory substances reconfigure circuit dynamics

232 urons and alter effective synaptic strength, neuromodulatory substances reconfigure neuronal circuits

233 known to contain a wide range of endogenous neuromodulatory substances, but their collective influen

234 Nevertheless, the neuromodulatory substrates of rejection experiences are

235 s the enhancement of prefrontal cortex (PFC)-neuromodulatory subsystem connectivity in ketamine-treat

236 age-dependent and -independent channels, and neuromodulatory synapses on the dendritic tree.

237 report suggestive of presynaptically silent neuromodulatory synapses.

238 forming symmetrical (putative inhibitory or neuromodulatory) synapses were unlabeled perikarya and M

239 on at three different levels: (i) underlying neuromodulatory (synaptic) mechanisms; (ii) cognitive an

240 l forebrain is an essential component of the neuromodulatory system controlling the behavioral state

241 ignal-to-noise conditions and down-regulated neuromodulatory system function in older brains.

242 brain cholinergic neurons constitute a major neuromodulatory system implicated in normal cognition an

243 e DDT represents an evolutionarily conserved neuromodulatory system that is necessary for normal vert

244 endocannabinoid system (ECS) is a widespread neuromodulatory system that plays important roles in cen

245 differences in molecular regulation of a key neuromodulatory system, the endocannabinoid system, in t

246 is powerfully controlled by the cholinergic neuromodulatory system.

247 imuli with activation of the nucleus basalis neuromodulatory system.

248 esis is intrathalamic and matches changes in neuromodulatory systems (exemplified by AChE activity an

249 It has been proposed that pupil-linked neuromodulatory systems are activated by the termination

250 Genetic components of neuromodulatory systems are highly conserved across anim

251 ections between these networks and brainstem neuromodulatory systems are likely to provide the signal

252 vo These results elucidate pathways by which neuromodulatory systems can dynamically regulate brain c

253 ve cues, but little is known about how other neuromodulatory systems contribute to cue-motivated beha

254 We conclude that the central neuromodulatory systems controlling pupil size are conti

255 Thus we show parallel neuromodulatory systems functionally reconfigure early o

256 netic bases of behaviors and in recent years neuromodulatory systems have been shown to play a major

257 However, it is unknown how neuromodulatory systems impact on the generation of opti

258 tions for thinking about the role of related neuromodulatory systems in mammals.

259 sely, but the specific role of the different neuromodulatory systems in motivation remains unclear.

260 Deciphering the role of neuromodulatory systems in motor network development has

261 Several neuromodulatory systems increase or decrease the degree

262 the hypothesis that subcortical and cortical neuromodulatory systems interact to guide aspects of goa

263 in pupil diameter, suggesting that ascending neuromodulatory systems may govern the transition betwee

264 e PIC is subject to regulation by descending neuromodulatory systems releasing the monoamines seroton

265 Neuromodulatory systems such as noradrenaline (NE), acet

266 Diffuse neuromodulatory systems such as norepinephrine (NE) cont

267 are embodied in complex circuits, including neuromodulatory systems such as the noradrenergic locus

268 he olfactory map is mediated by two parallel neuromodulatory systems that act in opposing directions

269 l an evolutionarily conserved set of diverse neuromodulatory systems that collectively govern interna

270 Evolutionarily conserved neuromodulatory systems that define neural states of nut

271 lineage, dopaminergic neurons form important neuromodulatory systems that influence motor behavior, m

272 d distribution of synapses from two powerful neuromodulatory systems that originate from noradrenergi

273 their receptors are evolutionarily conserved neuromodulatory systems that profoundly influence behavi

274 ive development of cortical oscillations and neuromodulatory systems that underlie them.

275 sticity, but it is uncertain how subcortical neuromodulatory systems, such as the cholinergic nucleus

276 te factors are subcortical catecholaminergic neuromodulatory systems, such as the locus ceruleus-nore

277 hanges in pupil size are mediated by central neuromodulatory systems, which also influence the intern

278 ase is emerging as a common theme of central neuromodulatory systems.

279 l habenula to increase the inhibition of the neuromodulatory systems.

280 motor networks that can also be affected by neuromodulatory systems.

281 ith a particular emphasis on the subcortical neuromodulatory systems.

282 anscranial electrical stimulation (tES) is a neuromodulatory technique in which low voltage constant

283 ranial direct current stimulation is a novel neuromodulatory technique with emerging evidence of pote

284 oid-induced constipation, the development of neuromodulatory techniques for severe constipation and n

285 Noninvasive neuromodulatory techniques such as transcranial direct c

286 ABSTRACT: Contemporary non-invasive neuromodulatory techniques, such as transcranial direct

287 Contemporary non-invasive neuromodulatory techniques, such as transcranial direct

288 with many conventional peripherally-focused neuromodulatory therapies.

289 Different levels of cholinergic neuromodulatory tone have been hypothesized to set the s

290 (DREADDs) have proven to be highly effective neuromodulatory tools for the investigation of neural ci

291 ncluding novel taste, requires activation of neuromodulatory transmission mediated, for example, by t

292 Together, our findings identify NA as a neuromodulatory transmitter capable of triggering epigen

293 Acetylcholine (ACh) is a neuromodulatory transmitter implicated in perception and

294 Dopamine is a key neuromodulatory transmitter in the brain.

295 novel function is regulated by a descending neuromodulatory transmitter indicates a conditional recr

296 o sensitively track the activity in multiple neuromodulatory transmitter systems as they control the

297 Acetylcholine is a neuromodulatory transmitter that controls synaptic plast

298 The neuromodulatory transmitters, biogenic amines, have prof

299 Psychotherapeutic, pharmacological, or neuromodulatory treatments of mental disorders can often

300 recruitment of presynaptic proteins, whereas neuromodulatory types of plasticity involve more delayed